Medical Reports最新文献_第8页

Medical Reports Pub Date : 2025-07-05 DOI: 10.1016/j.hmedic.2025.100308

Bipneet Singh , Jack Visser , Sakshi Bai , Jahnavi Ethakota , Palak Grover , Gurleen Kaur , Syed-Mohammed Jafri

{"title":"Intestinal spirochetosis","authors":"Bipneet Singh , Jack Visser , Sakshi Bai , Jahnavi Ethakota , Palak Grover , Gurleen Kaur , Syed-Mohammed Jafri","doi":"10.1016/j.hmedic.2025.100308","DOIUrl":"10.1016/j.hmedic.2025.100308","url":null,"abstract":"<div><div>Intestinal spirochetosis involves the colonization of the colonic epithelium by Brachyspira. Patients may be asymptomatic or present with diarrhea, abdominal pain, and bloating. It generally affects immunocompromised individuals. Diagnosis requires colonoscopy with biopsies and specific staining, often missed due to its rarity. Treatment typically involves metronidazole, with macrolides as alternatives, but relapse can occur, necessitating better follow-up and documentation. We present four cases that highlight diverse presentations and responses to treatment. A 36-year-old male with multiple sclerosis (MS) and psoriasis, who experienced symptom resolution with metronidazole; a 23-year-old male with abdominal pain and diarrhea, who improved with clarithromycin; an 86-year-old diabetic with chronic diarrhea who responded to metronidazole but experienced a relapse; and a 54-year-old male with HIV-AIDS, who was treated for concurrent H. pylori with no recurrence. Diagnostic challenges arise due to symptom variability and slow growth on culture. Treatment with metronidazole is effective but prone to relapse, possibly due to spirochete translocation within colonic crypts. More research is needed to establish clear diagnostic markers, understand epidemiological patterns, and develop effective long-term treatments.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100308"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoroquinolone-induced liver injury: A case report and literature review 氟喹诺酮致肝损伤1例报告并文献复习

Medical Reports Pub Date : 2025-07-05 DOI: 10.1016/j.hmedic.2025.100307

Srikar Anantha , Farzana Hoque

{"title":"Fluoroquinolone-induced liver injury: A case report and literature review","authors":"Srikar Anantha , Farzana Hoque","doi":"10.1016/j.hmedic.2025.100307","DOIUrl":"10.1016/j.hmedic.2025.100307","url":null,"abstract":"<div><div>Fluoroquinolones are commonly prescribed antibiotics known for their broad-spectrum coverage and high oral bioavailability. While generally well-tolerated, they have been associated with rare but potentially serious adverse effects, including drug-induced liver injury (DILI). We report the case of a 31-year-old female with a history of intravenous drug use and chronic hepatitis C who developed acute liver injury shortly after completing a course of ciprofloxacin for cystitis. She presented with jaundice, right upper quadrant abdominal pain, and markedly elevated liver enzymes. An extensive workup for alternative etiologies, including viral, autoimmune, and metabolic liver diseases, was unremarkable. Clinical improvement and a steady decline in transaminases were observed following the discontinuation of ciprofloxacin, supporting the diagnosis of fluoroquinolone-induced hepatocellular injury. This case underscores the diagnostic challenge of DILI, particularly in patients with underlying hepatic conditions. The proposed mechanisms of injury include the inflammatory stress hypothesis and the danger hypothesis, both of which may have been relevant in this patient given her chronic hepatitis C and recent infection. Although rare, fluoroquinolone-induced DILI should be considered in the differential diagnosis of acute liver injury, especially when other causes have been excluded. Early recognition and cessation of the offending agent remain critical to avoid progression to fulminant liver failure.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100307"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ewing sarcoma of maxilla masquerading as odontogenic lesion; And role of NKX2.2 for confirmatory diagnosis: A rare case report 假造牙源性病变的上颌骨尤文氏肉瘤NKX2.2在确诊中的作用：罕见病例报告

Medical Reports Pub Date : 2025-07-05 DOI: 10.1016/j.hmedic.2025.100306

Nikita Kashyap , Debarati Ray , Divya Nadiminti , S. Aravindan , Jay Gopal Ray

引用次数: 0

Disseminated intravascular coagulation: An unexpected signpost to ulcerative colitis: A case report 弥散性血管内凝血：溃疡性结肠炎的意外提示：1例报告

Medical Reports Pub Date : 2025-07-04 DOI: 10.1016/j.hmedic.2025.100304

Toni Habib , Chloe Lahoud , Zaid Khamis , Muhammad Abdullah , Hadi Itani , Hassan Al Moussawi

引用次数: 0

Progressive neck deformation after intramedular cervical tumor removal by laminoplasty approach 椎板成形术切除颈髓内肿瘤后进行性颈部变形

Medical Reports Pub Date : 2025-07-03 DOI: 10.1016/j.hmedic.2025.100305

Dmytro Ishchenko

{"title":"Progressive neck deformation after intramedular cervical tumor removal by laminoplasty approach","authors":"Dmytro Ishchenko","doi":"10.1016/j.hmedic.2025.100305","DOIUrl":"10.1016/j.hmedic.2025.100305","url":null,"abstract":"<div><div>Posterior approaches are usually used for the removal of tumors localized in the spinal canal, employing laminectomy techniques with the possibility of subsequent laminoplasty. However, even when bone defects are replaced with autografts, studies have shown a high likelihood of postoperative deformities, particularly in cases involving multisegment laminoplasty and radiotherapy. This risk increases with multisegmented laminoplasty and subsequent radiotherapy exposure. This study presents a clinical case of treating a patient with an intramedullary tumor from C2-Th1 after surgery using the laminoplasty technique, followed by adjuvant radiotherapy. After treatment, the patient developed pathological kyphosis of the cervical spine, with a Cobb angle of 82°. A comprehensive treatment approach was employed, which included fixation and traction in a HALO-vest apparatus, followed by anterior corporodesis and posterior occipitospinal fusion to achieve satisfactory correction and prevent further deformities and secondary spinal cord injuries. Deformities are a common complication of laminoplasty without additional stabilization. The contributing factors include the use of multilevel approaches, adjuvant radiotherapy, and pre-existing segmental instability. Careful planning is required to prevent pathological kyphosis and secondary spinal cord injury. This planning should consider the volume of bone defects, fixation techniques, subsequent treatment, initial range of motion, and type of primary physiological curvature.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distal limb ischemia from jellyfish envenomation: A case report 水母中毒致远端肢体缺血1例

Medical Reports Pub Date : 2025-07-02 DOI: 10.1016/j.hmedic.2025.100302

Eunizar Omar , Vanitha Porhcisaliyan , Sujata Sheth , Kunzang Norbu

{"title":"Distal limb ischemia from jellyfish envenomation: A case report","authors":"Eunizar Omar , Vanitha Porhcisaliyan , Sujata Sheth , Kunzang Norbu","doi":"10.1016/j.hmedic.2025.100302","DOIUrl":"10.1016/j.hmedic.2025.100302","url":null,"abstract":"<div><h3>Introduction</h3><div>This case report presents a rare instance of acute limb ischemia following jellyfish envenomation. Only 16 other documented cases have been reported worldwide.</div></div><div><h3>Case report</h3><div>Our patient is a 15-year-old male who was stung by a jellyfish while swimming in the sea off Langkawi. Six days after the sting, the patient developed significant numbness and cyanosis in his left hand, with CT angiography confirming compromised blood flow. Initial treatments included analgesics and tetanus prophylaxis. The patient ultimately required intravenous heparin, nitroglycerin, and alprostadil, and he achieved full recovery after three days of treatment. This case, along with the other 16 reported cases, highlights vasospasm and thrombosis as possible key mechanisms for distal limb ischemia secondary to jellyfish envenomation.</div></div><div><h3>Why should an emergency physician be aware of this?</h3><div>Jellyfish stings are fairly common, and patients may present to the Emergency Department or even primary care facilities. Although uncommon, physicians should be aware of potential complications in order to deliver timely and effective treatment.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of high dose IVIG, convalescent plasma combination, and dexmedetomidine in severe COVID ARDS during pregnancy: A retrospective case series 大剂量IVIG、恢复期血浆联合右美托咪定治疗妊娠期重症COVID - ARDS的疗效：回顾性病例系列

Medical Reports Pub Date : 2025-07-02 DOI: 10.1016/j.hmedic.2025.100301

Serdar Efe , Hulya Poyraz Efe

{"title":"The efficacy of high dose IVIG, convalescent plasma combination, and dexmedetomidine in severe COVID ARDS during pregnancy: A retrospective case series","authors":"Serdar Efe , Hulya Poyraz Efe","doi":"10.1016/j.hmedic.2025.100301","DOIUrl":"10.1016/j.hmedic.2025.100301","url":null,"abstract":"<div><h3>Objective</h3><div>Physiological and immunological changes during pregnancy may cause COVID-19 infection to progress more severely. This study presents the potential protective effect of the combination of intravenous immunoglobulin (IVIG) and convalescent plasma (CP) in preventing intubation in three pregnant patients who developed severe COVID-19-associated acute respiratory distress syndrome (CARDS).</div></div><div><h3>Methods</h3><div>During the early phase of the pandemic (2020–2021), three pregnant patients at the threshold of intubation were treated with high-dose IVIG (0.4 g/kg/day) and two doses of CP administered 48 h apart. All patients also received nasal high-flow oxygen (HFNC), low-molecular-weight heparin, antibiotics, and dexamethasone. Patients with severe back and chest pain received a short-term (24-hour) dexmedetomidine infusion to control anxiety and improve positional oxygenation. Patients were monitored for fetal well-being using NST and Doppler ultrasound.</div></div><div><h3>Results</h3><div>None of the cases required intubation and all were discharged from the intensive care unit. No serious side effects were observed except for transient and isolated troponin elevation associated with IVIG treatment. All mothers delivered healthy babies, and the neurodevelopmental follow-up of the infants was uneventful for 36 months.</div></div><div><h3>Conclusion</h3><div>This case series demonstrates that the combination of IVIG and convalescent plasma in pregnant women with severe CARDS may reduce the need for intubation and improve maternal and fetal outcomes. Additionally, the role of dexmedetomidine infusion in reducing the risk of intubation by facilitating positional oxygenation is noteworthy. Our findings may serve as a guide in similar clinical scenarios during future pandemics.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From rib to groin: An unusual case report of chest wall leiomyosarcoma with distant lymphatic spread 从肋骨到腹股沟：一例罕见的胸壁平滑肌肉瘤伴远处淋巴扩散

Medical Reports Pub Date : 2025-07-01 DOI: 10.1016/j.hmedic.2025.100300

Annmy Jose , Upinderjeet Singh , Priyadharshini Bargunam , Alfa Shamim Saifi , Prasath Rajendran

引用次数: 0

A case of STEC-negative hemolytic uremic syndrome with C2 gene mutation variant 伴有C2基因突变变异的stec阴性溶血性尿毒症综合征1例

Medical Reports Pub Date : 2025-07-01 DOI: 10.1016/j.hmedic.2025.100299

Daria Hoang , Farzana Hoque

{"title":"A case of STEC-negative hemolytic uremic syndrome with C2 gene mutation variant","authors":"Daria Hoang , Farzana Hoque","doi":"10.1016/j.hmedic.2025.100299","DOIUrl":"10.1016/j.hmedic.2025.100299","url":null,"abstract":"<div><div>Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury. While Shiga toxin-producing <em>E. coli</em> (STEC) remains the most common cause, atypical HUS (aHUS), driven by complement dysregulation, poses a significant diagnostic challenge, particularly in adults. We present the case of a 29-year-old female with no prior medical history who developed severe gastrointestinal symptoms, acute kidney injury, thrombocytopenia, and hemolytic anemia following suspected foodborne illness. Initial labs revealed schistocytosis, elevated LDH, low haptoglobin, and markedly impaired renal function. Given her high PLASMIC score (6), empiric plasmapheresis was initiated while awaiting ADAMTS13 results, which later returned normal. Despite negative testing for STEC, influenza, and other infectious etiologies, complement levels were borderline low, raising suspicion for aHUS. Although genetic testing revealed an equivocal C2 gene variant and common CFH polymorphisms statistically enriched in aHUS, the variant was classified as likely benign. The patient’s renal function improved significantly with supportive care and temporary hemodialysis, and ravulizumab was deferred. This case highlights the importance of early recognition and management of thrombotic microangiopathies, especially when infectious workup is negative and ADAMTS13 results are pending. Prompt initiation of plasmapheresis in cases with high PLASMIC scores remains critical, even in indeterminate presentations. Further investigation into the potential pathogenic role of rare complement gene variants such as C2 may refine our understanding of aHUS. This case underscores the need for rapid diagnostics and early resource mobilization in patients with suspected microangiopathic processes.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azithromycin-induced allergic reaction – A rare case report and review of literature 阿奇霉素致过敏反应1例报告及文献复习

Medical Reports Pub Date : 2025-06-29 DOI: 10.1016/j.hmedic.2025.100298

Abraham Sisay Abie , Eden Belay Tilahun , Nahom Desalegn Mekonen , Tamrat Petros Elias , Mikias Wondwesen Ayele

{"title":"Azithromycin-induced allergic reaction – A rare case report and review of literature","authors":"Abraham Sisay Abie , Eden Belay Tilahun , Nahom Desalegn Mekonen , Tamrat Petros Elias , Mikias Wondwesen Ayele","doi":"10.1016/j.hmedic.2025.100298","DOIUrl":"10.1016/j.hmedic.2025.100298","url":null,"abstract":"<div><h3>Introduction</h3><div>Macrolides are commonly prescribed antibiotics with rare adverse effects. We report the case of a 30-year-old female patient with bronchial asthma who developed azithromycin-induced allergic reaction.</div></div><div><h3>Case report</h3><div>A 30-year-old female patient with bronchial asthma presented to our hospital with a one week history of cough, low-grade fever with chills, myalgia, and fatigue. Vital signs showed a low grade fever; other parameters were normal. Chest auscultation revealed crackles over the left posterior chest with a few scattered wheezes. Her complete blood count was unremarkable. A clinical diagnosis of community-acquired pneumonia was made, and she was prescribed azithromycin 500 mg once daily for three days. Within an hour of taking the first dose, the patient had developed pruritus, swelling of the lips, and eyelid, but she did not experience any difficulty breathing or swallowing. Soon after the development of these symptoms, she had discontinued azithromycin on her own and visited our hospital the following day. On evaluation, she was clinically stable but had persistent pruritus and facial swelling. Pruritus was relieved with diphenhydramine, and the patient was monitored and subsequently discharged with instructions on danger signs. At her follow-up visit within a week, all symptoms had resolved.</div></div><div><h3>Discussion</h3><div>Azithromycin-induced allergic reactions can occur in rare circumstances. These reactions range from mild cutaneous reactions to life-threatening anaphylaxis, with immediate-type skin reactions and angioedema being the most commonly reported. To date, only a few successful cases of macrolide desensitization have been reported.</div></div><div><h3>Conclusion</h3><div>While azithromycin is one of the commonly prescribed antibiotics with rare adverse effects, clinicians should be vigilant, as serious reactions may still occur.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0