Medical Reports最新文献

{"title":"Vortioxetine-induced collagenous colitis: A rare case report","authors":"Yara Adra ,&nbsp;Karam Karam ,&nbsp;Elias Fiani","doi":"10.1016/j.hmedic.2025.100204","DOIUrl":"10.1016/j.hmedic.2025.100204","url":null,"abstract":"<div><h3>Background</h3><div>Vortioxetine is a newly approved antidepressant of the Serotonin Modulator and Stimulator family. Among its adverse events are nausea, headache, dizziness and increased risk of bleeding. It is not known to cause diarrhea or symptoms of colitis. However, in this article, a rare case of vortioxetine-induced microscopic colitis is presented.</div></div><div><h3>Case</h3><div>The patient is a 28-year-old female, previously healthy, who was recently diagnosed with major depressive disorder (MDD) and was started on vortioxetine 5 mg, once daily, which was gradually increased to 10 mg, once daily (OD). She soon complained of chronic watery, non-bloody diarrhea that was more severe with higher dosage of vortioxetine and improved only when the dose was reduced. Extensive work-up ruled out infectious and malabsorptive etiologies. No macroscopic changes were seen on colonoscopy, only thickening of the sub-epithelial collagen band was evident on histology which is compatible with microscopic colitis-collagenous type.</div></div><div><h3>Conclusion</h3><div>Although collagenous colitis is not a known side effect of vortioxetine, physicians should pay attention to the signs and symptoms of this conditions and should stop it immediately if such case is suspected. More research and investigations are needed to study the pathophysiology of microscopic colitis and the role of vortioxetine in the development of this condition.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating diagnostic quandaries: A case series of diagnostic dilemmas in central nervous system (CNS) infections resolved by molecular sequencing","authors":"Sreethish Sasi ,&nbsp;Fatma Ben Abid ,&nbsp;Maisa Ali ,&nbsp;Junais Koleri ,&nbsp;Jabeed Parengal ,&nbsp;Waleed Awouda ,&nbsp;Manal Hamed ,&nbsp;Faiha Eltayeb ,&nbsp;Andrez Perez-Lopez ,&nbsp;Muna Al-Maslamani ,&nbsp;Abdullatif Al-Khal ,&nbsp;Mohamed Abukhattab","doi":"10.1016/j.hmedic.2025.100202","DOIUrl":"10.1016/j.hmedic.2025.100202","url":null,"abstract":"<div><h3>Background</h3><div>Central nervous system (CNS) infections present a significant diagnostic challenge due to their diverse etiologies and the limitations of conventional diagnostic methods. Standard cerebrospinal fluid (CSF) culture and polymerase chain reaction (PCR) assays often fail to identify causative pathogens, particularly in patients who have received prior antimicrobial therapy. The advent of 16S and 18S ribosomal RNA (rRNA) sequencing has revolutionized microbial identification by enabling the detection of a wide range of bacterial and fungal pathogens with high sensitivity and specificity.</div></div><div><h3>Case presentations</h3><div>We present a retrospective case series of six patients with CNS infections that remained undiagnosed using conventional microbiological methods but were successfully identified using molecular sequencing. Clinical presentations, CSF findings, imaging studies, and treatment outcomes were analyzed to assess the impact of 16S/18S rRNA sequencing on diagnosis and patient management.</div></div><div><h3>Discussion</h3><div>Pathogens identified through sequencing included <em>Klebsiella pneumoniae</em>, <em>Moraxella osloensis</em>, <em>Streptococcus intermedius</em>, <em>Candida albicans</em>, <em>Streptococcus pneumoniae</em>, <em>Brucella melitensis</em>, and <em>Brucella abortus</em>. In all cases, sequencing enabled targeted antimicrobial therapy, leading to favorable clinical outcomes. This method proved particularly useful in cases of partially treated bacterial meningitis, fungal CNS infections, and neurobrucellosis, where standard diagnostics failed.</div></div><div><h3>Conclusion</h3><div>Molecular sequencing serves as a powerful diagnostic tool for CNS infections, especially in culture-negative cases. Its implementation enhances pathogen detection, guides appropriate antimicrobial therapy, and improves clinical outcomes. As sequencing technology becomes more accessible, its integration into routine diagnostic workflows may redefine the approach to CNS infection management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal metastasis in pleomorphic liposarcoma: A rare location for a rare malignancy","authors":"Neha Lall ,&nbsp;Anand Kumar ,&nbsp;Deepika Joshi ,&nbsp;Varun Kumar Singh ,&nbsp;Ipsita Dhal ,&nbsp;Ashish Verma","doi":"10.1016/j.hmedic.2025.100203","DOIUrl":"10.1016/j.hmedic.2025.100203","url":null,"abstract":"<div><h3>Introduction</h3><div>Soft tissue sarcomas are rare mesenchymal tumors originating from non-epithelial connective tissue. The most common subtype of liposarcoma is a well-differentiated, dedifferentiated type, and pleomorphic liposarcoma (PLPS) is quite a rare subtype, constituting only about 5–10 %. The most common site of PLPS is the lower extremities, but the abdominal wall is a rare site of origin in this rarer subtype.</div></div><div><h3>Case report</h3><div>We present a rare case of a 58-year-old male who presented with a painless lump in the lower left abdomen for six months. An 18FDG PET CT scan showed an enhancing soft tissue mass with central necrosis at the subcutaneous plane of the left iliac fossa on the anterior abdominal wall, measuring 6.5 (AP) x 5.3 (T) x 6.0 (CC) cm (SUV max-13.41). The patient underwent a wide excision of the mass, and a histopathological examination along with immunohistochemistry confirmed the diagnosis of pleomorphic liposarcoma. The patient then received adjuvant radiotherapy. Within a week of completing the radiotherapy, the patient developed acute backache at the lower dorsal area, with pain radiating lower down at lumbo-sacral area of back. Soon afterwards, within a week, the patient developed acute paraparesis. An MRI of the dorso-lumbar spine revealed altered marrow signals with a soft tissue component at the D10 vertebra level, extending into the spinal canal and causing cord compression, likely due to a metastatic lesion. The patient underwent palliative radiotherapy at the affected site. Three months after radiotherapy, the patient reported a significant improvement in pain and partial improvement in sensory and motor deficits.</div></div><div><h3>Conclusion</h3><div>This unique case of localized abdominal wall PLPS exhibited early dissemination to the D10 vertebra, resulting in acute paraparesis for the patient. The poor prognosis associated with the histological subtype of PLPS, despite timely surgical excision and adjuvant radiotherapy, emphasises the need for new targeted therapies. Advances in molecular biology and cytogenetics will further improve clinical outcomes for PLPS patients.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the mysterious link: Thromboembolic events following COVID-19 vaccination – A comprehensive case report","authors":"Jawad Shafqat ,&nbsp;Zainab Shehzadi ,&nbsp;Muhammad Usama bin Shabbir ,&nbsp;Maira Ramzan ,&nbsp;Muhammad Umer Javaid ,&nbsp;Sundas Ali","doi":"10.1016/j.hmedic.2025.100198","DOIUrl":"10.1016/j.hmedic.2025.100198","url":null,"abstract":"<div><div>This case report delves into the intriguing phenomenon of post-vaccination thrombosis, shedding light on the unexpected thromboembolic events that have surfaced following the administration of COVID-19 vaccines. With the rise in reports of venous thromboembolism, particularly following the AstraZeneca and mRNA vaccines, Herein, we report a case of RPF following Vaxzevria-AstraZeneca COVID-19 mRNA vaccination. A 34-year-old male patient with no history of autoimmune diseases presented with acute onset of epigastric pain two weeks post-vaccination.Laboratory findings reveal thrombocytopenia and elevated D-dimers. Imaging through abdominal CT and CT venography confirmed extensive thrombosis in the IVC, iliac veins, renal veins, and hepatic vein. This report underscores the need for heightened awareness of potential venous thromboembolism, particularly IVC thrombosis, in patients presenting with abdominal pain following COVID-19 vaccination.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary pulmonary choriocarcinoma: A case report","authors":"Anirudh Singh,&nbsp;Anuja Kapoor,&nbsp;Muthu Manikandan,&nbsp;Jaspreet Kaur","doi":"10.1016/j.hmedic.2025.100201","DOIUrl":"10.1016/j.hmedic.2025.100201","url":null,"abstract":"<div><div>Primary Pulmonary Choriocarcinoma (PPC) is an extremely rare and aggressive malignancy originating in the lung parenchyma. This case report describes a 38-year-old female who presented with sudden-onset, progressive chest pain and breathing difficulty. Initial evaluation revealed a lung mass, elevated lactate dehydrogenase, and markedly elevated beta-human chorionic gonadotropin (βhCG). PET-CT imaging showed a large hypermetabolic mass in the right upper lobe with mediastinal extension and lymph node involvement. Biopsy confirmed choriocarcinoma, with immunohistochemistry positive for CK7 and βhCG. The patient received four cycles of cisplatin and etoposide chemotherapy, resulting in partial response with a decrease in tumor size, βhCG and resolution of mediastinal lymphadenopathy. This case highlights the diagnostic challenges and management approach for PPC, emphasizing the importance of considering this rare entity in patients presenting with lung masses and elevated βhCG. The partial response to chemotherapy underscores the potential efficacy of this treatment modality in PPC management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A lipomatous intussusception in a 52-year-old man: A case report","authors":"Sarah Saleh ,&nbsp;Houssein Chebbo ,&nbsp;Amer yazbak ,&nbsp;Karam Karam ,&nbsp;Sarah Jalloul ,&nbsp;Lamia Azizi ,&nbsp;Pierre Hani","doi":"10.1016/j.hmedic.2025.100200","DOIUrl":"10.1016/j.hmedic.2025.100200","url":null,"abstract":"<div><div>Intussusception is a rare cause of abdominal pain in adults accounting to only 5 % of all intussusception cases. Most cases of adult intussusception are linked to an underlying lead point including neoplasm, polyps, Meckel’s diverticulum, strictures, and benign neoplasms. Colonic lipomas (CL) are a type of benign tumor of the colon composed of adipose tissue encapsulated by a fibrous layer that may result in intussusception, most commonly in the ascending colon. We herein present a case of a 52-year-old male patient presenting with diffuse abdominal pain, where further investigations revealed the diagnosis of colonic intussusception secondary to a 5 cm colon lipoma. Of note, the patient underwent colonoscopy a year ago and was normal. Subsequently, the patient underwent surgical removal of the lipoma through an ileo-cecal resection technique.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious colitis exacerbation following a single dose of Kayexalate","authors":"Philippe Attieh ,&nbsp;Karim Zodeh ,&nbsp;Antonio Al Hazzouri ,&nbsp;Sandra Rizk ,&nbsp;Karam Karam ,&nbsp;Mirna Fares ,&nbsp;Elias Fiani","doi":"10.1016/j.hmedic.2025.100199","DOIUrl":"10.1016/j.hmedic.2025.100199","url":null,"abstract":"<div><div>Kayexalate, an important treatment for hyperkalemia, especially in chronic renal failure, can be administered orally or as an enema. Potential side effects include constipation, vomiting, diarrhea, and nausea, with the most significant being colitis due to ulceration and wall perforation. This effect is most commonly observed in patients with chronic kidney disease. We report a case of a 76-year-old man known to have heart failure, hemiplegia and no history of chronic renal failure (CRF) who presented with septic shock and fever. A CT scan and colonoscopy revealed infectious colitis. He was admitted to the intensive care unit for monitoring and further management. One day later, laboratory results showed hyperkalemia that was likely due to acute renal failure (ARF) secondary to septic shock, and a single dose of 30 g of Kayexalate was administered to prevent life-threatening arrhythmias. However, two days later, the patient experienced worsening abdominal pain. A follow-up colonoscopy revealed worsening colitis, indicating an exacerbation of his condition due to Kayexalate. Medical management with antibiotics and adequate hydration was continued, leading to an improvement in his abdominal pain, then the patient was discharged. This case report highlights a rare occurrence of Kayexalate-worsening colitis after just a single dose in a patient with no history of kidney disease. It aims to raise awareness about avoiding even one dose of Kayexalate in patients with pre-existing colitis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the storm: A case of severe theophylline toxicity and its management","authors":"Vasudha Dinesh ,&nbsp;D.R. Varshini ,&nbsp;Arun A. Mohanan ,&nbsp;V.T. Amrithanand","doi":"10.1016/j.hmedic.2025.100191","DOIUrl":"10.1016/j.hmedic.2025.100191","url":null,"abstract":"<div><h3>Background</h3><div>Theophylline poisoning can lead to toxic effects on multiple organ systems. Management of theophylline overdose is focused on early detection, stabilizing cardiovascular and pulmonary function, GI decontamination to interrupt continued absorption, and minimizing end organ effects. We present a case of theophylline overdose with hemodynamic instability and metabolic derangements and review the literature to update the management of theophylline toxicity.</div></div><div><h3>Case presentation</h3><div>An 80 year old Indian gentleman presented with dizziness and vomiting after deliberate ingestion of 20 tablets of theophylline. He was resuscitated successfully, and subsequently given supportive care. Serum theophylline levels were estimated to confirm theophylline toxicity.</div></div><div><h3>Conclusion</h3><div>Diagnosis of theophylline poisoning requires high degree of suspicion and needs prompt and appropriate treatment. Initial treatment consists of fluid resuscitation, correction of electrolyte abnormalities and hyperglycemia. Supportive treatment plays a key role. Multidose activated charcoal for elimination of drug should be administered in severe theophylline poisoning.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment resistant hyperammonemia in beta ketothiolase deficiency in an infant: A case report","authors":"Ifra Ahmed ,&nbsp;Jameela Anwar ,&nbsp;Munazza Iqbal ,&nbsp;Rana Uzair Ahmad ,&nbsp;Fatima Aslam","doi":"10.1016/j.hmedic.2025.100195","DOIUrl":"10.1016/j.hmedic.2025.100195","url":null,"abstract":"<div><h3>Background</h3><div>Beta-keto thiolase deficiency, also known as Alpha-methyl acetoacetic aciduria, T2 deficiency, 2-methyl acetoacetyl-CoA thiolase (MAT) deficiency, is a rare genetic organic aciduria caused by mitochondrial enzyme acetoacetyl-CoA thiolase (T2) deficiency that affects both ketone body metabolism and the catabolism of isoleucine, both of which are crucial for energy production.</div></div><div><h3>Case presentation</h3><div>A 12-month-old baby girl, meeting typical developmental milestones, presented with a wide range of symptoms, including altered sensorium, fever, rapid breathing, lethargy, and irritability over three days. History revealed consanguineous marriage between her parents and the death of an undiagnosed sibling. Physical examination showed a lethargic, pale, and dehydrated child with tachypnea and characteristic acidotic breath. Laboratory tests revealed anemia, severe metabolic acidosis with a high anion gap, hyperkalemia, and high serum ammonia. Urine organic acids analysis showed elevated levels of 2-methyl-3-hydroxybutyric acid and 3-hydroxybutyric acid, which confirmed the diagnosis of beta-keto thiolase deficiency.Genetic testing further supported this diagnosis by identifying an ANTXR2 gene mutation.</div></div><div><h3>Discussion</h3><div>A supportive treatment plan included adequate fluid to correct dehydration, bicarbonate to correct metabolic acidosis, and sodium benzoate to reduce ammonia levels. The patient was also advised to follow a protein-restricted diet and take biotin and sodium bicarbonate in the long run to manage the condition. With treatment, the patient's condition improved, and she began to achieve developmental milestones. However, the crisis affected her speech, and speech therapy was recommended.</div></div><div><h3>Conclusion</h3><div>This case report highlights the importance of early neonatal screening in Pakistan, particularly in light of the increasing rate of consanguineous marriages and the rising incidence of organic acidemias, which can lead to early diagnosis and prompt management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical stress cardiomyopathy associated with intraoperative catecholamine administration: A case report","authors":"Syed H. Ali ,&nbsp;Huynh Pham ,&nbsp;Jamon Patterson ,&nbsp;Shangir Siddique ,&nbsp;Steven A. Alexander","doi":"10.1016/j.hmedic.2025.100197","DOIUrl":"10.1016/j.hmedic.2025.100197","url":null,"abstract":"<div><h3>Background</h3><div>Takotsubo syndrome (TTS), also known as stress cardiomyopathy, typically presents as apical ballooning in response to physical or emotional stress. However, atypical forms of stress cardiomyopathy can occur, such as mid-ventricular akinesis with apical sparing. Excessive catecholamine administration, particularly in a perioperative setting, is a known precipitant of this rare condition.</div></div><div><h3>Case presentation</h3><div>We present a case of a 48-year-old Caucasian woman who developed atypical stress cardiomyopathy following the administration of high-dose catecholamines to treat intraoperative hypotension during an elective esophageal myotomy. The patient received multiple intravenous vasopressors, including epinephrine, norepinephrine, phenylephrine, and vasopressin, resulting in severe myocardial stress. Postoperatively, the patient experienced hemodynamic instability with ECG changes and troponin elevation suggestive of non-ST elevation myocardial infarction (NSTEMI). However, coronary angiography revealed no obstructive coronary artery disease, and transthoracic echocardiogram (TTE) demonstrated mid-ventricular akinesis with preserved apical function, consistent with atypical TTS. The patient was managed conservatively with beta-blockers and ACE inhibitors, leading to recovery of left ventricular function on repeat imaging.</div></div><div><h3>Conclusion</h3><div>This case underscores the potential for high-dose catecholamines to induce atypical stress cardiomyopathy in the perioperative setting. Given the lack of obstructive coronary artery disease, the myocardial dysfunction was likely caused by catecholamine-induced myocardial stunning and excessive adrenergic stimulation. Recognition of this phenomenon is crucial for managing perioperative hypotension without exacerbating myocardial injury. Careful selection and titration of vasopressors may prevent the development of iatrogenic TTS in high-risk patients.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"11 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}