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A rare co-occurrence of Guillain-Barré Syndrome and spinal tuberculosis: A case report 罕见的格林-巴- <s:1>综合征合并脊柱结核1例报告

Medical Reports Pub Date : 2025-05-05 DOI: 10.1016/j.hmedic.2025.100241

Ephrem Micheale Atsbha , Tekiy Markos Badore , Tesfaye Getachew Shawel , Yemane Gebremedhin Tesfay

{"title":"A rare co-occurrence of Guillain-Barré Syndrome and spinal tuberculosis: A case report","authors":"Ephrem Micheale Atsbha , Tekiy Markos Badore , Tesfaye Getachew Shawel , Yemane Gebremedhin Tesfay","doi":"10.1016/j.hmedic.2025.100241","DOIUrl":"10.1016/j.hmedic.2025.100241","url":null,"abstract":"<div><h3>Introduction</h3><div>The association of Guillain-Barré Syndrome (GBS) and spinal tuberculosis (TB) is rare. Sputum-positive pulmonary tuberculosis as a precipitant of GBS is a rare case report, even in developing countries like Ethiopia, where TB is common. We report a rare case of GBS and spinal TB in a 60-year-old Ethiopian male who experienced back pain and swelling, and bilateral lower extremity weakness. He struggled with bowel and urine control but had no history of head injury, vision blurring, or other medical issues. His neurological exam revealed gibbus deformity on his upper back and 0/5 power on his bilateral lower extremities. CSF analysis showed no cells, with a high protein count. Acute Inflammatory Demyelinating Polyneuropathy (AIDP) and T4/T5 Spondylodiscitis with the paravertebral collection were revealed on Nerve Conduction tests (NCTs), and Magnetic Resonance Imaging (MRI) respectively. The patient was diagnosed with GBS and spinal TB and started on anti-TB for 12 months with Prednisolone. He remained adherent, and he is now ambulating unaided and doing well. Due to financial challenges, intravenous immunoglobulin or plasmapheresis was not given as a treatment option for GBS.</div></div><div><h3>Conclusion</h3><div>We reported a rare case of GBS and TB, with the possibility of tubercular radiculomyelitis. The co-occurrence of spinal tuberculosis and GBS has been rare globally, and clinicians and researchers should consider tuberculosis as a potentially related illness.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon pathogen in an unexpected place: A case of Oligella urethralis bacteremia linked to retained IUD 不寻常的病原体在一个意想不到的地方：一例寡菌尿道菌血症与保留宫内节育器

Medical Reports Pub Date : 2025-05-03 DOI: 10.1016/j.hmedic.2025.100233

Dileep Kumar Reddy Regalla

引用次数: 0

Novel ANK1 mutation in hereditary spherocytosis in a northeastern Thai patient: A case report 泰国东北部患者遗传性球形红细胞增多症的新ANK1突变：一例报告

Medical Reports Pub Date : 2025-05-03 DOI: 10.1016/j.hmedic.2025.100239

Suwadee Laithaisong , Kanha Muisuk , Patcharee Komwilaisak , Napat Laoaroon , Kunanya Suwannaying , Aree Rattanathongkom , Kanda Sornkayasit , Khunton Wichajarn

{"title":"Novel ANK1 mutation in hereditary spherocytosis in a northeastern Thai patient: A case report","authors":"Suwadee Laithaisong , Kanha Muisuk , Patcharee Komwilaisak , Napat Laoaroon , Kunanya Suwannaying , Aree Rattanathongkom , Kanda Sornkayasit , Khunton Wichajarn","doi":"10.1016/j.hmedic.2025.100239","DOIUrl":"10.1016/j.hmedic.2025.100239","url":null,"abstract":"<div><div>Hereditary spherocytosis (HS) is the most common hereditary red blood cell membrane defect, characterized by hemolytic anemia, jaundice, and splenomegaly. While HS is well-documented in North America, Europe, and Japan, it is less common in Southeast Asia. This study reports a novel heterozygous <em>ANK1</em> gene mutation (c.1638 C>A, p.Tyr546*) in a 5-year-old boy from northeastern Thailand, presenting with chronic anemia, hepatosplenomegaly, and gallstones. The mutation leads to a truncated ankyrin-1 protein, contributing to vertical linkage instability of the red cell membrane and resulting in moderate to moderately severe HS. The patient's condition improved following splenectomy, with the cessation of regular transfusion requirements and the development of reactive erythrocytosis. Genetic analysis through whole-genome sequencing (WGS) did not identify additional pathogenic mutations. The correlation between genotype and disease severity suggests that this specific <em>ANK1</em> mutation contributes to the moderate to moderately severe disease phenotype. Further studies are needed to explore genotype-phenotype correlations in Thai HS patients.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD-1 inhibitor‐induced cytomegalovirus esophagitis in a patient with metastatic urothelial carcinoma: A case report 转移性尿路上皮癌患者发生PD-1抑制剂诱导巨细胞病毒食管炎1例报告

Medical Reports Pub Date : 2025-05-03 DOI: 10.1016/j.hmedic.2025.100232

Mark Tawfik , Angelica Rozenfeld , Chloé Lahoud , Sumeyye Ozer , Omer Alomari , Vincent DeChavez

引用次数: 0

Spontaneous retinal venous pulsations for evaluation of intracranial pressure after endoscopic third ventriculostomy 自发性视网膜静脉脉动对内镜下第三脑室造口术后颅内压的评估

Medical Reports Pub Date : 2025-05-02 DOI: 10.1016/j.hmedic.2025.100235

Jacqueline Boyle , William Miller , Andres Maldonado , Jorge Kattah

{"title":"Spontaneous retinal venous pulsations for evaluation of intracranial pressure after endoscopic third ventriculostomy","authors":"Jacqueline Boyle , William Miller , Andres Maldonado , Jorge Kattah","doi":"10.1016/j.hmedic.2025.100235","DOIUrl":"10.1016/j.hmedic.2025.100235","url":null,"abstract":"<div><h3>Introduction</h3><div>Accurate and timely diagnosis of cerebrospinal fluid (CSF) diversion failure, including shunt or ventriculostomy failure, remains challenging. Classically, ophthalmologic evaluation of intracranial pressure (ICP) is based on papilledema, however, spontaneous retinal venous pulsations (SVP) may be another valuable, underutilized tool. We seek to present the case of a patient who underwent endoscopic third ventriculostomy with neuroophthalmological monitoring throughout her post-operative course and provide a brief literature review on the use of SVP for monitoring ICP.</div></div><div><h3>Case presentation</h3><div>Post-operatively, our patient noted improvement of her symptoms and confirmation of successful ventriculostomy on MRI CSF flow studies. There was a monitorable, gradual return of SVP, which supports the use of SVPs as a clinical surrogate to MRI CSF flow study. Literature review suggests that SVP loss is more sensitive than papilledema for elevated ICP, though return of SVP may be delayed in patients post-operatively given CSF dynamics.</div></div><div><h3>Conclusion</h3><div>Based on our clinical findings and literature review, SVP may be an excellent, more sensitive screening test, especially in the absence of papilledema, to evaluate for CSF diversion failure. Ophthalmologic monitoring is cost-effective and non-invasive, and clinical incorporation of SVP could reduce unnecessary testing, hospitalizations, invasive procedures, and patient discomfort.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune checkpoint inhibitor-related nephrotoxicity: Pembrolizumab-induced acute interstitial nephritis 免疫检查点抑制剂相关肾毒性：派姆单抗诱导的急性间质性肾炎

Medical Reports Pub Date : 2025-05-02 DOI: 10.1016/j.hmedic.2025.100240

Sakshi Bai , Isha Luthra , Haseeb Khan Tareen , Jahnavi Ethakota , Kavita Luthra , Muhammad Fawad Ashraf , Hafsa Fayyaz

{"title":"Immune checkpoint inhibitor-related nephrotoxicity: Pembrolizumab-induced acute interstitial nephritis","authors":"Sakshi Bai , Isha Luthra , Haseeb Khan Tareen , Jahnavi Ethakota , Kavita Luthra , Muhammad Fawad Ashraf , Hafsa Fayyaz","doi":"10.1016/j.hmedic.2025.100240","DOIUrl":"10.1016/j.hmedic.2025.100240","url":null,"abstract":"<div><div>Pembrolizumab, an immune checkpoint inhibitor targeting Programmed Cell Death-1 (PD-1), has transformed the treatment landscape for various malignancies. While its efficacy is well-documented, immune-related adverse events (irAEs), including renal toxicities, are emerging concerns. This case series presents three patients who developed significant renal complications, specifically acute interstitial nephritis (AIN) and distal renal tubular acidosis (RTA), following pembrolizumab therapy. Case 1 involved a 40-year-old male with non-Hodgkin’s lymphoma who developed AIN and distal RTA seven months post-therapy, responding well to corticosteroids and supportive care. Case 2 described a 61-year-old female with triple-negative breast cancer who developed AIN during active treatment, requiring dialysis and prolonged corticosteroid therapy. Case 3 involved a 65-year-old male with metastatic non–small cell lung cancer who developed AIN three months after initiation of pembrolizumab and showed gradual recovery with high-dose corticosteroids. These three cases highlight the importance of vigilant renal monitoring in patients receiving pembrolizumab and the need for awareness of potential renal irAEs.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent struggle: Undiagnosed dyslexia in a child in rural area of Indonesia 无声的挣扎：印度尼西亚农村地区一名儿童未确诊的阅读障碍

Medical Reports Pub Date : 2025-05-02 DOI: 10.1016/j.hmedic.2025.100234

Purboyo Solek , Indra Sahril , Kevin Gunawan

引用次数: 0

Imaging-guided percutaneous trans-coccygeal drainage of a presacral abscess: A technical report 影像学引导下经皮经尾骨引流术治疗骶前脓肿：一份技术报告

Medical Reports Pub Date : 2025-05-02 DOI: 10.1016/j.hmedic.2025.100238

Rocco Corso , Cesare Maino , Antonio Rovere , Nicola Zarpellon , Davide Ippolito , Davide Leni

引用次数: 0

Pramipexole induced hallucinations in a patient with restless leg syndrome: A case report 普拉克索致不宁腿综合征患者出现幻觉1例

Medical Reports Pub Date : 2025-05-01 DOI: 10.1016/j.hmedic.2025.100231

Gautam Agrawal , Bhawna Agarwal , Taranjit Singh Gill , Sourabh Khatri

引用次数: 0

Uncommon presentation of urinary bladder calculus in an 18 months old child: A rare case report 一个18个月大的孩子膀胱结石的罕见表现：一个罕见的病例报告

Medical Reports Pub Date : 2025-05-01 DOI: 10.1016/j.hmedic.2025.100236

Umer Iqbal , Aashish Kumar , Syed Ali Arsal , Mehwish Soomro , Shafin Bin Amin , Sameeka Waqas , Inibehe Ime Okon

{"title":"Uncommon presentation of urinary bladder calculus in an 18 months old child: A rare case report","authors":"Umer Iqbal , Aashish Kumar , Syed Ali Arsal , Mehwish Soomro , Shafin Bin Amin , Sameeka Waqas , Inibehe Ime Okon","doi":"10.1016/j.hmedic.2025.100236","DOIUrl":"10.1016/j.hmedic.2025.100236","url":null,"abstract":"<div><div>Bladder stones even if applicable are seldom present in children under the age of 5, and the majority are likely to be attributable to a problem related to the child’s diet or hydration. These stones can be classified as primary which are common in children, secondary or migratory. The case is about an 18-month-old child who presented atypically as having dysuria, partial urinary retention, and effusion from the ears. Imaging showed a bladder stone and open cystolithotomy was done without any complications. In children, bladder stones usually develop due to metabolic or structural abnormalities and as such, investigations and treatment plans need to be individualized. Minimally invasive procedures such as transurethral lithotripsy and percutaneous stone removal are advancing, open surgery is however still required in circumstances where the stone is too complicated or there are few resources available. This case demonstrates the significance of multidisciplinary care, particularly in rural areas, where uncommon presentations need to be managed effectively to achieve good outcomes in pediatric cases of bladder stones. This conditions need a proper investigation to hypothesize the causes or the measures that can be employed to enhance prevention of these conditions in young children.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0