Medical Reports最新文献_第7页

Giant breast tumors: A case series of six patients management 巨大乳腺肿瘤：6例患者的治疗

Medical Reports Pub Date : 2025-07-18 DOI: 10.1016/j.hmedic.2025.100291

Ibrahim Boulayoun , Zaineb Chatbi , Ibtissam Bellajdel , Hafsa Taheri , Hanane Saadi , Ahmed Mimouni

{"title":"Giant breast tumors: A case series of six patients management","authors":"Ibrahim Boulayoun , Zaineb Chatbi , Ibtissam Bellajdel , Hafsa Taheri , Hanane Saadi , Ahmed Mimouni","doi":"10.1016/j.hmedic.2025.100291","DOIUrl":"10.1016/j.hmedic.2025.100291","url":null,"abstract":"<div><h3>Background</h3><div>Giant breast tumors are rare and heterogeneous, encompassing various histological subtypes with different clinical behaviors. Their management remains challenging due to diagnostic and therapeutic uncertainties.</div></div><div><h3>Objective</h3><div>To describe the clinical presentation, histopathological features, treatment strategies, and outcomes of six cases of giant breast tumors managed at a tertiary care hospital in Morocco.</div></div><div><h3>Methods</h3><div>This retrospective case series includes six female patients diagnosed with giant breast tumors between 2018 and 2023 at the Gynecology-Obstetrics Department of CHU Mohammed VI, Oujda. Data were collected from clinical records, imaging, pathology reports, and follow-up evaluations.</div></div><div><h3>Results</h3><div>The median age at diagnosis was 36 years (range 23–45). Four patients had phyllodes tumors (1 benign, 1 borderline, 2 malignant), one patient had a primary breast angiosarcoma, and one had squamous cell carcinoma. All patients underwent mastectomy, with axillary dissection in three cases. Radiotherapy was administered in three cases. Two patients developed metastases: one hepatic and one pulmonary. One patient died within two years.</div></div><div><h3>Conclusion</h3><div>Giant breast tumors are rare but potentially aggressive. Phyllodes tumors may recur or progress histologically. Angiosarcoma and squamous cell carcinoma are associated with poor prognosis. Surgical resection is the mainstay of treatment, while the role of adjuvant therapy remains to be clarified.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Apixaban induced spontaneous muscular hematoma in a patient with inclusion body myositis 病例报告：阿哌沙班诱导包涵体肌炎患者自发性肌肉血肿

Medical Reports Pub Date : 2025-07-17 DOI: 10.1016/j.hmedic.2025.100317

Francis Sto. Domingo , Allan Gutierrez , Mrudula Thiriveedi , Siddharth Patel , Rafik ElBeblawy

{"title":"Case Report: Apixaban induced spontaneous muscular hematoma in a patient with inclusion body myositis","authors":"Francis Sto. Domingo , Allan Gutierrez , Mrudula Thiriveedi , Siddharth Patel , Rafik ElBeblawy","doi":"10.1016/j.hmedic.2025.100317","DOIUrl":"10.1016/j.hmedic.2025.100317","url":null,"abstract":"<div><h3>Background</h3><div>Direct oral anticoagulants, including apixaban, are widely prescribed for stroke prevention in atrial fibrillation. While gastrointestinal and intracranial hemorrhages are the most common adverse events, apixaban can also cause spontaneous intramuscular hematomas which are rare, especially in the absence of trauma or clear predisposing factors.</div></div><div><h3>Case presentation</h3><div>We describe a 69-year-old Caucasian female with a history of hypertension, atrial fibrillation on apixaban, inclusion body myositis, and osteoporosis, who presented with acute onset left flank pain and extensive bruising of one week duration. Initial treatment for presumed musculoskeletal strain was followed by discovery of significant anemia (hemoglobin 8.3 g/dL). Initial Computed Tomography revealed a large posterior flank hematoma (15.9 × 8.2 × 5.5 cm). Despite stable hemodynamics and absence of active extravasation, surgical evacuation was required due to hematoma expansion. Anticoagulation was held during hospitalization, and apixaban discontinuation was recommended postoperatively, with future evaluation for left atrial appendage closure.</div></div><div><h3>Conclusion</h3><div>This case highlights an unusual but serious complication of apixaban therapy. Inclusion body myositis and osteoporosis, associated with drug-drug interactions, chronic inflammation and impaired tissue repair, may have predisposed the patient to spontaneous muscular bleeding. The interplay between neuromuscular disease and DOAC therapy warrants further investigation, particularly in elderly patients with multiple comorbidities.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric DYT-TOR1A dystonia presenting as functional neurological disorder: A case report 小儿DYT-TOR1A肌张力障碍表现为功能性神经障碍1例报告

Medical Reports Pub Date : 2025-07-16 DOI: 10.1016/j.hmedic.2025.100314

Philip R. Fischer , Paul E. Youssef , Joline E. Brandenburg , Farwa Ali , Jenny L. Wilson

引用次数: 0

Safety of onasemnogene abeparvovec in an infant with spinal muscular atrophy type 1 and severe neutropenia: A case report and literature review 阿巴伐韦治疗1型脊髓性肌萎缩伴严重中性粒细胞减少症婴儿的安全性：1例报告并文献复习

Medical Reports Pub Date : 2025-07-11 DOI: 10.1016/j.hmedic.2025.100315

Maria Moutafi , Nikolaos Gkiourtzis , Maria Papadopoulou , Efterpi Dalpa , Athanassios Evangeliou , Paraskevi Panagopoulou

{"title":"Safety of onasemnogene abeparvovec in an infant with spinal muscular atrophy type 1 and severe neutropenia: A case report and literature review","authors":"Maria Moutafi , Nikolaos Gkiourtzis , Maria Papadopoulou , Efterpi Dalpa , Athanassios Evangeliou , Paraskevi Panagopoulou","doi":"10.1016/j.hmedic.2025.100315","DOIUrl":"10.1016/j.hmedic.2025.100315","url":null,"abstract":"<div><div>Spinal muscular atrophy (SMA) is an autosomal recessive, neurodegenerative disorder resulting in severe, progressive hypotonia and muscular weakness. Spinal muscular atrophy is a multisystem disease, however limited information is available regarding its effect on the immune system, bone marrow and the myeloid cell development and function. Currently, three disease-modifying treatments that increase survival motor neuron (SMN) protein expression are available. Among them onasemnogene abeparvovec, an adeno-associated virus-based gene replacement therapy, delivers functional human SMN by a single-dose intravenous infusion and transient transaminasemia is the most significant adverse event. There are no reported cases of patients with SMA and severe hematological abnormalities who received the specific gene therapy. We describe a 10-month-old boy with SMA type 1 and severe neutropenia who was successfully administered onasemnogene abeparvovec, focusing on the investigational and post-treatment challenges as well as his outcome. The treatment was tolerated well, the patient showed neurological improvement and neutropenia resolved confirming the diagnosis of chronic benign neutropenia.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confronting a colossal challenge: A case report and literature review on the diagnosis and management of a 40 cm, 3.3 kg phyllodes tumor 面对巨大的挑战：40 cm， 3.3 kg叶状肿瘤的诊断和治疗的病例报告和文献综述

Medical Reports Pub Date : 2025-07-09 DOI: 10.1016/j.hmedic.2025.100311

Ahmad Jradi , Mohamad Al Qassab , Sereina Ghattas , Nadim Chaarani , Philippe Attieh , Karam Karam , Walid Salamoun

{"title":"Confronting a colossal challenge: A case report and literature review on the diagnosis and management of a 40 cm, 3.3 kg phyllodes tumor","authors":"Ahmad Jradi , Mohamad Al Qassab , Sereina Ghattas , Nadim Chaarani , Philippe Attieh , Karam Karam , Walid Salamoun","doi":"10.1016/j.hmedic.2025.100311","DOIUrl":"10.1016/j.hmedic.2025.100311","url":null,"abstract":"<div><div>With a peak incidence in women of 45–49 years old, phyllodes tumors (PT) are uncommon fibroepithelial neoplasms that make up less than 1 % of all breast tumors. Based on histological features, these tumors are categorized into benign, borderline, and malignant subtypes, with the malignant subtype having the worst prognosis and highest chance of recurrence. Diagnosing PT remains challenging due to its similarities with fibroadenomas (FA), necessitating the use of core needle biopsy for accurate differentiation. Our 59-year-old female patient described in this report had a borderline PTs that had grown to a remarkable 40 × 35 × 10 cm size and was causing serious clinical issues, such as skin ulceration. Following a modified mastectomy, an intermediate-grade PT with negative surgical margins was verified by histological examination. Since the tumor was within 1 mm from the posterior margin, adjuvant radiation therapy was recommended. A comprehensive review of the literature was performed to explore the diagnostic challenges, imaging modalities, histopathological features, and treatment approaches for PT, including surgical resection, the role of radiation therapy, and the limited efficacy of chemotherapy. To guarantee the best possible results for patients with PTs, this case emphasizes the need of early detection and the necessity for precise surgical intervention.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100311"},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polypoid mucosa-associated lymphoid tissue lymphoma causing gastric outlet obstruction: A case report and literature review 息肉样黏膜相关淋巴组织淋巴瘤引起胃出口梗阻1例报告并文献复习

Medical Reports Pub Date : 2025-07-09 DOI: 10.1016/j.hmedic.2025.100313

Chakib Khoury , Rebal Nahas , Karam Karam , Emanuel-Youssef Dib , Elias Fiani

引用次数: 0

Spontaneous passage of a retained endoscopic capsule prior to scheduled surgery in a Crohn’s disease patient: A case report 克罗恩病患者预定手术前保留内窥镜胶囊的自然通过：一例报告

Medical Reports Pub Date : 2025-07-08 DOI: 10.1016/j.hmedic.2025.100312

Salma Barakat , Sarah Ahmed , Ahmed Rafei , Rawan A. Bedab , Abdelmounem E. Abdo

{"title":"Spontaneous passage of a retained endoscopic capsule prior to scheduled surgery in a Crohn’s disease patient: A case report","authors":"Salma Barakat , Sarah Ahmed , Ahmed Rafei , Rawan A. Bedab , Abdelmounem E. Abdo","doi":"10.1016/j.hmedic.2025.100312","DOIUrl":"10.1016/j.hmedic.2025.100312","url":null,"abstract":"<div><h3>Background</h3><div>Video capsule endoscopy (VCE) is a noninvasive tool used to evaluate small bowel diseases, including Crohn’s disease, suspected small bowel bleeding, malabsorption, and chronic diarrhea. A known complication is capsule retention (CR), particularly in patients with established Crohn’s disease and undetected strictures. While CR often requires endoscopic or surgical removal, spontaneous passage has been reported following medical therapy.</div></div><div><h3>Case summary</h3><div>We present the first documented case in Sudan of a 28-year-old male with Crohn’s disease who experienced capsule retention, followed by spontaneous passage. The patient had a 7-year history of chronic diarrhea, weight loss, and post-defecation abdominal pain. Initial imaging and endoscopy were inconclusive. A small bowel follow-through confirmed luminal patency, and VCE was performed, revealing classic Crohn’s features and suggesting a terminal ileal stricture. Two weeks later, X-ray showed the capsule retained in the right colon, and surgery was planned. However, a follow-up radiograph before surgery confirmed spontaneous passage, likely aided by corticosteroid and mesalamine therapy.</div></div><div><h3>Conclusion</h3><div>This case underscores the importance of evaluating for strictures before VCE in Crohn’s patients. Conservative treatment may promote capsule passage in selected cases, avoiding invasive intervention. Use of patency capsules and cross-sectional imaging is recommended to minimize retention risk.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurosarcoidosis masquerading as cerebral metastasis lesion: Case report 以脑转移灶为伪装的神经结节病1例

Medical Reports Pub Date : 2025-07-07 DOI: 10.1016/j.hmedic.2025.100310

O. Lahjouji , I. Chaouche , H. Ouazzani , A. Akammar , N. El Bouardi , M. Haloua , M.Y. Alaoui Lamrani , M. Boubbou , M. Maâroufi , B. Alami

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Spinal epidural abscess in infants: Case report and review of the literature 婴儿脊髓硬膜外脓肿：病例报告及文献复习

Medical Reports Pub Date : 2025-07-05 DOI: 10.1016/j.hmedic.2025.100303

Tomas Leng , Ayesha Ali

{"title":"Spinal epidural abscess in infants: Case report and review of the literature","authors":"Tomas Leng , Ayesha Ali","doi":"10.1016/j.hmedic.2025.100303","DOIUrl":"10.1016/j.hmedic.2025.100303","url":null,"abstract":"<div><div>Spinal epidural abscess (SEA) is an uncommon but serious condition in children, where timely diagnosis is essential to avoid permanent neurological complications. Diagnosing SEA in pediatric patients, particularly in infants, is challenging due to nonspecific symptoms such as fever and pain, which are often difficult to interpret and can lead to delayed or missed diagnoses. This report details the case of a 10-month-old otherwise healthy infant with an extensive SEA, where fluorine-18 fluorodeoxyglucose PET/CT (F-FDG PET CT) was effectively used to confirm the diagnosis. Additionally, we conducted a comprehensive literature review from January 2000 to October 2024 to explore clinical presentations and imaging considerations unique to infants with SEA. Of the 124 cases reviewed, 13 met our inclusion criteria. The most common symptoms were fever and irritability, followed by motor deficits. The primary pathogen was MSSA, affecting the cervical spine in most cases, and the majority of infants received antibiotics, with most undergoing neurosurgical intervention, and no deaths were reported in the cohort. This case, along with the review, underscores the importance of early recognition and advanced imaging approaches in enhancing diagnostic accuracy and improving outcomes for pediatric SEA. F-FDG PET CT can be diagnostically useful in certain infant cases of occult bacteremia where no obvious infection source is identified.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericardial decompression syndrome after small-volume pericardiocentesis: A case report when even less is too much 小容积心包穿刺后心包减压综合征1例

Medical Reports Pub Date : 2025-07-05 DOI: 10.1016/j.hmedic.2025.100309

Ahmed Basuoni , Marwa Ahmed , Karim Abdel Hakim , Sulaiman Al Maqbali , Waleed DawElbeit

{"title":"Pericardial decompression syndrome after small-volume pericardiocentesis: A case report when even less is too much","authors":"Ahmed Basuoni , Marwa Ahmed , Karim Abdel Hakim , Sulaiman Al Maqbali , Waleed DawElbeit","doi":"10.1016/j.hmedic.2025.100309","DOIUrl":"10.1016/j.hmedic.2025.100309","url":null,"abstract":"<div><h3>Background</h3><div>Pericardial decompression syndrome (PDS) is a rare but potentially life-threatening complication following pericardial drainage, typically associated with large-volume effusion removal of more than 1 L within 1 h.</div></div><div><h3>Case summary</h3><div>We report the case of a 62-year-old man with metastatic thymic carcinoma and severe mitral regurgitation who developed acute pulmonary edema and transient left ventricular dysfunction following pericardiocentesis. Despite draining only 600 mL of pericardial fluid, the patient developed respiratory failure, pulmonary edema and required mechanical ventilation. Echocardiography revealed a drop in ejection fraction and elevated filling pressures. Prompt recognition and supportive management, including diuresis and intensive care monitoring, led to full recovery of cardiac function within days.</div></div><div><h3>Conclusion</h3><div>This case highlights that PDS may develop even after small-volume pericardial drainage in patients with compromised cardiac reserve. Proposed mechanisms include preload-afterload mismatch, myocardial stunning, and adrenergic withdrawal. Awareness, early diagnosis, and careful pericardial fluid removal are key to preventing and managing PDS even in draining small amount especially with underlying structural heart disease or baseline reduced left ventricular function.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100309"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0