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Pulmonary splenosis mimicking lung metastases in a breast cancer patient: A diagnostic trap 肺性脾肿大模拟乳腺癌患者的肺转移：一个诊断陷阱

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100223

Seif Haddaoui , Nesrine Mejri , Myriam Saadi , Ahmed Anas Haouari , Ines Baccouche , Haifa Rachdi , Yosra Berrazega

{"title":"Pulmonary splenosis mimicking lung metastases in a breast cancer patient: A diagnostic trap","authors":"Seif Haddaoui , Nesrine Mejri , Myriam Saadi , Ahmed Anas Haouari , Ines Baccouche , Haifa Rachdi , Yosra Berrazega","doi":"10.1016/j.hmedic.2025.100223","DOIUrl":"10.1016/j.hmedic.2025.100223","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary splenosis (PS) is a benign condition resulting from ectopic implantation of splenic tissue following splenic trauma or splenectomy. It can mimic metastatic disease, posing a significant diagnostic challenge, particularly in oncologic patients. We present a case of PS in a breast cancer patient initially misdiagnosed with lung metastases.</div></div><div><h3>Case presentation</h3><div>A 43-year-old female patient with a history of splenectomy was diagnosed with grade III hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) invasive ductal carcinoma. Imaging suggested metastatic disease, with lung nodules and left subphrenic lesions. First-line treatment with letrozole and ribociclib was initiated. Subsequent imaging revealed stable disease and doubts about the metastatic nature of the lesions were raised. A history of prior splenic trauma and metabolic imaging consistent with splenosis led to a diagnosis of PS. The patient was reclassified as early-stage breast cancer, underwent right mastectomy with axillary lymph node dissection, and achieved a pathological complete response in the primary tumor.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of considering PS in differential diagnoses for metastatic-like lesions, particularly in patients with a history of splenic trauma, to prevent misdiagnosis and unnecessary treatment.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of small cell carcinoma of the ovary, hypercalcemic type – Diagnostic and therapeutic challenges 罕见的卵巢小细胞癌，高钙血症型-诊断和治疗的挑战

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100220

Jahnavi Ethakota , Bipneet Singh , Haseeb Khan Tareen , Sakshi Bai , Muhammad Fawad Ashraf , Danesh Kumar , Hafsa Ahmed , Fayyaz Hafsa , Granowicz Eric

{"title":"A rare case of small cell carcinoma of the ovary, hypercalcemic type – Diagnostic and therapeutic challenges","authors":"Jahnavi Ethakota , Bipneet Singh , Haseeb Khan Tareen , Sakshi Bai , Muhammad Fawad Ashraf , Danesh Kumar , Hafsa Ahmed , Fayyaz Hafsa , Granowicz Eric","doi":"10.1016/j.hmedic.2025.100220","DOIUrl":"10.1016/j.hmedic.2025.100220","url":null,"abstract":"<div><div>Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), also known as small cell Müllerian ovarian cancer, is a rare and aggressive cancer that primarily affects young women. It contributes to less than 0.1 % of all ovarian cancers and is associated with hypercalcemia in two-thirds of patients. This case report describes a 40-year-old patient presenting with shortness of breath who was ultimately diagnosed with SCCOHT. Laboratory studies demonstrated hypercalcemia and imaging revealed bilateral pulmonary emboli, a mass in the uterus and left adnexa, and peritoneal carcinomatosis. Biopsy revealed a poorly differentiated carcinoma and genetic testing further revealed SMARCA4 mutations, which are seen in cases of SCCOHT. She also had germline ATM and FANCC heterozygous mutations, there is no clear relation established between these mutations and SCCOHT in the literature so far, it would be interesting to see if these mutations can increase the risk of development of SCCOHT and the role of genetic counseling in such cases. Due to its rarity, there is no standard treatment protocol for SCCOHT. She was started on carboplatin/paclitaxel and was referred to a gynecologic oncologist for possible cytoreductive surgery. Reporting such rare cases not only adds to the existing literature but also highlights the importance of further research and the need for defined management guidelines.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of gallbladder adenomyomatosis and acute gangrenous cholecystitis: A causal or coincidental relationship? 胆囊腺肌瘤病与急性坏疽性胆囊炎1例：因果关系还是巧合关系？

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100227

Amir Omar , Rayane Salameh , Karam Karam , Mahmoud Othman

引用次数: 0

Successful Pregnancy 4 Years After Liver Transplant for Hepatocellular Carcinoma: A Case Report 肝癌肝移植术后4年妊娠成功1例报告

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100209

Soheila Aminimoghaddam , Roghayeh Pourali , Mehrsa Shiasi

{"title":"Successful Pregnancy 4 Years After Liver Transplant for Hepatocellular Carcinoma: A Case Report","authors":"Soheila Aminimoghaddam , Roghayeh Pourali , Mehrsa Shiasi","doi":"10.1016/j.hmedic.2025.100209","DOIUrl":"10.1016/j.hmedic.2025.100209","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) is frequently associated with chronic hepatitis and cirrhosis, most commonly affecting men between the ages of 50 and 67. However, certain histological subtypes, such as fibrolamellar HCC, can occur in younger individuals with no gender predilection. Chronic liver disease often leads to amenorrhea and reduced fertility in young women, but liver transplantation has the potential to restore reproductive function. This case report presents a successful pregnancy following liver transplantation for HCC, contributing to the limited literature on pregnancy outcomes in this patient population.</div></div><div><h3>Case Presentation</h3><div>A 27-year-old woman, gravida 1, with a history of liver transplantation for HCC, presented with a positive pregnancy test. Her liver function remained stable while on immunosuppressive therapy with tacrolimus and everolimus. A multidisciplinary team provided comprehensive care, including regular prenatal monitoring and adjustments to immunosuppressive medications to balance the risk of rejection and fetal health. The patient’s liver function remained stable throughout the pregnancy. Delivery was scheduled at 38 weeks due to fetal growth restriction and borderline amniotic fluid index. Labor induction was attempted, but a cesarean section was performed due to active phase arrest. A healthy infant weighing 2,450 g was delivered, and postpartum follow-up confirmed stable liver function for both mother and child.</div></div><div><h3>Conclusion</h3><div>This case highlights that successful pregnancy is possible in liver transplant recipients with a history of HCC when appropriate medical management is provided. It underscores the importance of a multidisciplinary approach to optimize maternal and neonatal outcomes. Further studies are warranted to establish standardized guidelines for managing pregnancies in this unique patient population.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Unmasking disseminated tuberculosis: A challenging case of neurological, gastrointestinal manifestations, and deep vein thrombosis in a pediatric patient 病例报告：揭露播散性肺结核：一个具有挑战性的病例，神经系统，胃肠道表现，深静脉血栓形成的儿科患者

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100226

Sushmita Bhattarai , Raghab Adhikary , Sanjit Kumar Shah , Kanchan Duwadi

{"title":"Case Report: Unmasking disseminated tuberculosis: A challenging case of neurological, gastrointestinal manifestations, and deep vein thrombosis in a pediatric patient","authors":"Sushmita Bhattarai , Raghab Adhikary , Sanjit Kumar Shah , Kanchan Duwadi","doi":"10.1016/j.hmedic.2025.100226","DOIUrl":"10.1016/j.hmedic.2025.100226","url":null,"abstract":"<div><div>Disseminated tuberculosis can affect multiple organ systems, including the CNS and gastrointestinal tract, and can be associated with thrombotic complications such as DVT. Early diagnosis is critical to reducing morbidity and mortality. This case report discusses the presentation, diagnostic challenges, management, and the rare occurrence of DVT in a child with disseminated TB. A 10-year-old male presented with a month-long history of fever, difficulty walking, slurred speech, and projectile vomiting. Neurological exam revealed left-sided hemiparesis and a GCS of 15/15. Imaging showed hypodense lesions with a mass effect, and CSF Gene Xpert and RT PCR confirmed tubercular meningitis. He later developed gastrointestinal symptoms, diagnosed as granulomatous colitis. On day 12, ultrasound revealed a right iliac vein thrombus, confirming DVT. He improved clinically and was discharged on ATT with steroids. This case underscores the importance of recognizing the diverse presentations of disseminated TB, particularly in children with a history of exposure. The diagnostic delay may lead to severe complications, necessitating a high index of suspicion for TB in atypical presentations. The link between DVT and disseminated TB emphasizes the importance of monitoring for thrombotic events. Timely diagnosis and management of disseminated TB can significantly impact patient outcomes. This case highlights the need for awareness among healthcare providers to consider TB in differential diagnoses, especially in children presenting with neurological and gastrointestinal symptoms, as well as the potential for thrombotic complications.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endovascular Glubran 2 and coiling embolization of a pulmonary artery pseudoaneurysm: A case report 血管内Glubran 2和螺旋栓塞术治疗肺动脉假性动脉瘤1例

Medical Reports Pub Date : 2025-04-24 DOI: 10.1016/j.hmedic.2025.100228

Marco Nezzo , Beatrice Carreri , Matteo Madonna , Daniele Morosetti , Renato Argirò , Valerio Da Ros , Federico Sabuzi , Francesco Garaci

{"title":"Endovascular Glubran 2 and coiling embolization of a pulmonary artery pseudoaneurysm: A case report","authors":"Marco Nezzo , Beatrice Carreri , Matteo Madonna , Daniele Morosetti , Renato Argirò , Valerio Da Ros , Federico Sabuzi , Francesco Garaci","doi":"10.1016/j.hmedic.2025.100228","DOIUrl":"10.1016/j.hmedic.2025.100228","url":null,"abstract":"<div><div>Pulmonary artery pseudoaneurysm (PAP) is a rare but potentially life-threatening condition that necessitates prompt diagnosis and intervention. PAP is commonly associated with hemoptysis, which, when massive (>300 ml/day), carries a 50 % mortality rate. We present the case of a 63-year-old male with a history of chronic obstructive pulmonary disease (COPD) associated with recent episodes of pneumonia, tobacco use and hypertension who was admitted to the emergency department with high fever, productive cough, dyspnea, chest pain and hypoxia with subsequent development of hemoptysis. An urgent chest CT angiogram (CTA) revealed a 15-by-17 mm central enhancing area arising from the right pulmonary artery in the upper-to-mid right lobe within a cavitating pneumonitis parenchymal lung consolidation, compatible with a pulmonary artery pseudoaneurysm. The patient underwent successful endovascular embolization using Glubran 2 and metallic coils. Post-procedural imaging confirmed complete occlusion of the pseudoaneurysm, with no residual flow and resolution of hemoptysis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From darkness to light: A child`s battle for the sight–A rare case report with review of literature 从黑暗到光明：一个孩子为视力而战——一个罕见的病例报告与文献回顾

Medical Reports Pub Date : 2025-04-23 DOI: 10.1016/j.hmedic.2025.100216

Ankur Vivek, Arpan Mitra, Akansha Jain, Nayana Bhuyan, Vijaya Nath Mishra, Abhishek Pathak

{"title":"From darkness to light: A child`s battle for the sight–A rare case report with review of literature","authors":"Ankur Vivek, Arpan Mitra, Akansha Jain, Nayana Bhuyan, Vijaya Nath Mishra, Abhishek Pathak","doi":"10.1016/j.hmedic.2025.100216","DOIUrl":"10.1016/j.hmedic.2025.100216","url":null,"abstract":"<div><div>Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological entity marked by distinctive clinical features and corroborated by Magnetic Resonance Imaging. Despite its alarming presentation, PRES is often reversible with appropriate management, showing favourable radiographic and clinical outcomes. Scorpion bite leading to PRES is a rare clinical presentation. Here we have described a case of 4 year old girl with a history of scorpion bite presented with headache, vomiting and seizure with altered sensorium. Based on imaging findings and excluding all other possible causes, diagnosis of PRES was considered. With appropriate treatment there was significant improvement in her symptoms. This is the first case reported from Asia, and it aligns with previous documented reports indicating the potential for scorpion bite to induce PRES. In the context of scorpion stings, PRES is hypothesized to result from a catecholamine surge causing endothelial dysfunction, blood-brain barrier disruption, and autonomic dysregulation. This case underscores the potential of scorpion stings to cause PRES, emphasizing the importance of early recognition and intervention. Further research is required to know the underlying mechanisms and improve management strategies.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical retrieval of fractured guidewire during percutaneous coronary intervention: A case report 经皮冠状动脉介入治疗中导丝断裂的手术复位一例

Medical Reports Pub Date : 2025-04-23 DOI: 10.1016/j.hmedic.2025.100219

Wajiha Arshad , Alifa Sabir , Sahab Ahmad , Muhammad Azam , Abdur Rehman , Arham Ihtesham , Shahzaib Maqbool , Saba Shafiq

{"title":"Surgical retrieval of fractured guidewire during percutaneous coronary intervention: A case report","authors":"Wajiha Arshad , Alifa Sabir , Sahab Ahmad , Muhammad Azam , Abdur Rehman , Arham Ihtesham , Shahzaib Maqbool , Saba Shafiq","doi":"10.1016/j.hmedic.2025.100219","DOIUrl":"10.1016/j.hmedic.2025.100219","url":null,"abstract":"<div><div>Percutaneous coronary intervention (PCI) is a common treatment for coronary artery disease, but rare complications, such as guidewire fracture, can occur. This report describes a 63-year-old Southeast Asian male with inferior wall myocardial infarction (IWMI) who underwent primary PCI at a secondary care center. While revascularizing the right coronary artery (RCA), the guidewire fractured during left circumflex artery (LCX) stenting. Transferred to a tertiary unit in an unstable condition, redo-angiography revealed the fractured guidewire lodged in the distal left main stem (LMS). After unsuccessful percutaneous retrieval attempts, the patient underwent coronary artery bypass grafting (CABG). The guidewire was successfully retrieved from the LMS and aorta. Although rare, guidewire fractures during PCI can cause severe complications like vessel perforation, thrombus, and embolization. Early detection and management, including surgical intervention when required, are vital to prevent life-threatening outcomes.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking tuberculosis - Immune reconstitution inflammatory syndrome manifested as meningitis 揭露结核——表现为脑膜炎的免疫重建炎症综合征

Medical Reports Pub Date : 2025-04-23 DOI: 10.1016/j.hmedic.2025.100214

Luis E. Martínez-Bravo , Diego A. Hidalgo-Díaz , Ricardo Téllez-Marroquín

引用次数: 0

Combination of airway pressure release ventilation and furosemide-induced metabolic alkalosis in a pediatric patient with severe acute respiratory distress syndrome: A case report 气道压力释放通气联合速尿引起的代谢性碱中毒患儿合并严重急性呼吸窘迫综合征1例报告

Medical Reports Pub Date : 2025-04-23 DOI: 10.1016/j.hmedic.2025.100217

Norihiko Tsuboi, Kaoru Tsuboi, Eisaku Nashiki, Shotaro Matsumoto, Satoshi Nakagawa

引用次数: 0