Medical ReportsPub Date : 2025-06-21DOI: 10.1016/j.hmedic.2025.100293
Abdul Qadir , Mamunul Islam , Riyadh Ali Mohammed Hammamy , Mohammed Kays Issa Alattiya , Hafsah Iqbal
{"title":"Idiopathic hypereosinophilic syndrome presenting with eosinophilic pleural and pericardial effusions: A case report","authors":"Abdul Qadir , Mamunul Islam , Riyadh Ali Mohammed Hammamy , Mohammed Kays Issa Alattiya , Hafsah Iqbal","doi":"10.1016/j.hmedic.2025.100293","DOIUrl":"10.1016/j.hmedic.2025.100293","url":null,"abstract":"<div><div>Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent eosinophilia and multi-organ involvement, often mimicking common conditions. We report a 36-year-old male with fever, cough, and pleuritic chest pain, initially diagnosed with community-acquired pneumonia. His condition deteriorated despite antibiotic therapy, leading to further evaluation revealing marked peripheral eosinophilia (3.79 × 10⁹/L) and eosinophilic pleural effusions. Extensive workup excluded secondary causes, leading to a diagnosis of idiopathic HES. The patient responded rapidly to corticosteroid therapy, with clinical and radiological improvement. This case highlights the importance of considering HES in patients with unexplained eosinophilic effusions and the role of early corticosteroid intervention in management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ertapenem-induced delirium in a patient with preserved renal function: A case report and review","authors":"Sneha Kumar , Harmanjeet Singh , Aiden Bowers , Selcuk Akturan , Abhineet Kumar","doi":"10.1016/j.hmedic.2025.100287","DOIUrl":"10.1016/j.hmedic.2025.100287","url":null,"abstract":"<div><div>Ertapenem induced Encephalopathy (EIE) is a well documented but uncommon side effect of ertapenem mostly reported in patients with renal impairment leading to prolonged recovery periods of upto 2 weeks. The goal of this case report is to report a patient with no renal impairment who developed ertapenem-induced encephalopathy and had rapid recovery after stopping ertapenem. The case highlights the need for clinicians to consider ertapenem induced neurotoxicty in patients with preserved renal function<span><span>[1]</span></span>, <span><span>[2]</span></span>. Given the strong clinical evidence indicating ertapenem as the likely cause, we applied the Naranjo Scale to assess the probability of an adverse drug reaction. Our patient received a Naranjo Scale score of 7, indicating a probable adverse drug reaction, with a logical temporal sequence supporting this conclusion.<span><span>[3]</span></span>, <span><span>[4]</span></span></div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100287"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-12DOI: 10.1016/j.hmedic.2025.100286
Lauren Shute , Elly Trepman , Derek Bueddefeld , Gerhard Bock , John M. Embil
{"title":"Bone marrow edema syndrome of the foot misdiagnosed as infection: Case report","authors":"Lauren Shute , Elly Trepman , Derek Bueddefeld , Gerhard Bock , John M. Embil","doi":"10.1016/j.hmedic.2025.100286","DOIUrl":"10.1016/j.hmedic.2025.100286","url":null,"abstract":"<div><div>Bone marrow edema syndrome is a rare, self-limited clinical entity of unknown etiology and may be misdiagnosed as an infection. A 62-year-old man developed left foot pain with no prior trauma. Within 2 weeks, he was unable to walk because of increased pain. At 5 weeks, he developed left foot swelling. Radiographs showed midfoot osteopenia. He was treated for presumed gout and infection with nonsteroidal anti-inflammatory drugs, vancomycin, and ceftriaxone but had no improvement. Magnetic resonance imaging showed bone marrow edema and indistinct cortices. Single-photon emission computed tomography–computed tomography and bone scintigraphy showed intense osseous uptake, patchy demineralization, and erosive changes at the left midfoot. The diagnosis of bone marrow edema syndrome was made, based on review of imaging findings and persistent symptoms despite previous treatment. After treatment with analgesics and off-loading devices, he had complete resolution of pain and improvement of midfoot osteopenia by 5 months after symptom onset. In summary, bone marrow edema syndrome in the foot is rare, and awareness of this syndrome is necessary to avoid diagnostic error and unnecessary treatment. If magnetic resonance imaging is not available, single-photon emission computed tomography–computed tomography may be a useful adjunct toward the diagnosis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-09DOI: 10.1016/j.hmedic.2025.100285
El Yacoubi Oumayma, Znati Kaoutar, Taleb Bouchra
{"title":"Extranodal non-Hodgkin lymphoma mimicking an endodontic periapical lesion: Case report and literature review","authors":"El Yacoubi Oumayma, Znati Kaoutar, Taleb Bouchra","doi":"10.1016/j.hmedic.2025.100285","DOIUrl":"10.1016/j.hmedic.2025.100285","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Endodontic periapical lesions are the most commonly observed radiolucencies in this region. Nonetheless, studies highlight that between 0.65 % and 4.22 % of periapical conditions may have non-endodontic origins, including cystic formations and benign or malignant tumors.</div><div>Intraosseous non-Hodgkin lymphoma (NHL) is a rare entity with nonspecific clinical and radiographic features, often causing misdiagnosis, particularly when it occurs near the apex of teeth with necrotic pulp or prior endodontic treatment.</div><div>The objective of this paper is first to present a clinical case of non-Hodgkin lymphoma in a periapical location, followed by a comprehensive review of the literature focusing on the clinical, radiological, and histopathological features of this entity to improve diagnostic accuracy and guide practitioners in their therapeutic decisions.</div></div><div><h3>Observation</h3><div>This report details a new case of non-Hodgkin lymphoma (NHL) diagnosed in a 37-year-old man who exhibited a right maxillary swelling that progressively developed over 8 months. Complementary examinations, including radiographic and histological analyses, confirmed a diagnosis of diffuse B-cell NHL. Furthermore, a literature review was conducted using databases such as PubMed, Web of Science, and Scopus to analyze previously reported cases of NHL in periapical locations.</div></div><div><h3>Conclusion</h3><div>Non-Hodgkin lymphomas (NHL) are a group of disorders involving malignant monoclonal proliferation of lymphoid cells, occurring in extranodal sites in approximately 40 % of cases, particularly in the gastrointestinal tract.</div><div>Intraosseous lymphomas in the head and neck region are rare, and their radiolucency in maxillary locations can mimic other benign pathologies, leading to delayed diagnosis in unaware practitioners.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-09DOI: 10.1016/j.hmedic.2025.100284
Abhishek Dixit
{"title":"Holmes tremor following thalamic hemorrhagic stroke","authors":"Abhishek Dixit","doi":"10.1016/j.hmedic.2025.100284","DOIUrl":"10.1016/j.hmedic.2025.100284","url":null,"abstract":"<div><h3>Background</h3><div>Holmes tremor (HT) is a rare movement disorder characterized by low-frequency (<4.5 Hz) tremors affecting the upper limbs, exacerbated by posture and voluntary movements. It typically arises from lesions to the brainstem, cerebellum, or thalamus, with stroke being a common etiology. The tremor usually emerges weeks to months after the initial insult due to aberrant neural pathway reorganization.</div></div><div><h3>Case presentation</h3><div>A 67-year-old man with hypertension presented with Right-sided numbness and dysarthria from a left thalamic hemorrhagic stroke with intraventricular extension. Ten days post-discharge, he developed a low-frequency (3–4 Hz) left arm tremor with rest, postural, and kinetic components. Neurological examination revealed mild dysmetria without bradykinesia or rigidity. Treatment with trihexyphenidyl and gabapentin provided minimal benefit, while levodopa 100<!--> <!-->mg three times daily yielded substantial improvement in limb control. The delayed onset, tremor characteristics, and localization to the thalamus supported the diagnosis of Holmes tremor.</div></div><div><h3>Discussion</h3><div>This case highlights the complex pathophysiology of HT involving disruption of cerebello-thalamo-cortical and dentato-rubro-olivary pathways. The rarity of HT (2–4 % of all tremor cases) and its variable response to pharmacotherapy underscore the need for multidisciplinary management. Current literature supports levodopa as a primary treatment option, with response rates exceeding 50 % in some studies. This patient's positive response to levodopa further confirms dopaminergic pathway involvement in the pathophysiology. For refractory cases, deep brain stimulation (DBS) targeting the ventral intermediate nucleus of the thalamus can be considered, with recent evidence suggesting superior tremor suppression compared to pharmacotherapy alone. This case emphasizes the importance of recognizing HT and its manifestations for proper diagnosis and management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-07DOI: 10.1016/j.hmedic.2025.100282
William Bleifuss , Elizabeth DeYoung , Benjamin Willenbring , Sean Boley , Brad Hernandez
{"title":"Physo’s back: A case report and brief review of the safety of physostigmine in the management of antimuscarinic delirium","authors":"William Bleifuss , Elizabeth DeYoung , Benjamin Willenbring , Sean Boley , Brad Hernandez","doi":"10.1016/j.hmedic.2025.100282","DOIUrl":"10.1016/j.hmedic.2025.100282","url":null,"abstract":"<div><div>Antimuscarinic delirium is a commonly encountered condition. Physostigmine is an effective antidote with a well established safety profile, though use has waned following a supply shortage. Both antihistamines and atypical antipsychotics are frequently implicated in antimuscarinic delirium, and quetiapine in particular may cause prolonged symptoms. We present a case of delirium precipitated by quetiapine refractory to repeated physostigmine administration, highlighting both its safety of use and limitations. As physostigmine supply is renewed, clinicians should again become familiar with its applications, while acknowledging therapeutic limits and the necessity of adjuncts in the delivery of care in severe cases.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100282"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-06DOI: 10.1016/j.hmedic.2025.100283
Blanca Tomás Soldevilla , José Manuel Marco Sánchez , Cristina Beléndez Bieler , Carolina Agra Pujol , Javier Orcajo Rincón , Ángel Miguel Lancharro Zapata , Elena Cela de Julián , María Cristina Mata Fernández
{"title":"Very early secondary acute myeloid leukemia in an adolescent patient with Ewing sarcoma of the sacrum: A case report and review of the literature","authors":"Blanca Tomás Soldevilla , José Manuel Marco Sánchez , Cristina Beléndez Bieler , Carolina Agra Pujol , Javier Orcajo Rincón , Ángel Miguel Lancharro Zapata , Elena Cela de Julián , María Cristina Mata Fernández","doi":"10.1016/j.hmedic.2025.100283","DOIUrl":"10.1016/j.hmedic.2025.100283","url":null,"abstract":"<div><div>Treatment-related malignant neoplasms can darken the prognosis of a cancer patient. The previous chemotherapy load renders treatment challenging, especially when the second neoplasm develops shortly after the first one. We report the case of a 17-year-old male with Ewing sarcoma (ES) who developed what appeared to be treatment-related acute myeloid leukemia 2 months after the end of ES treatment and recurrence of ES during treatment of leukemia. We discuss the different therapeutic options considered.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-06DOI: 10.1016/j.hmedic.2025.100280
A. Hemalatha , Gooty Shanaz , J.M. Bhavana , Mohammed Azhar Hussain , B.N. Raghavendra Prasad
{"title":"Severe byssinosis with Cor pulmonale and pulmonary arterial hypertension-textile industry: A case report","authors":"A. Hemalatha , Gooty Shanaz , J.M. Bhavana , Mohammed Azhar Hussain , B.N. Raghavendra Prasad","doi":"10.1016/j.hmedic.2025.100280","DOIUrl":"10.1016/j.hmedic.2025.100280","url":null,"abstract":"<div><div>Byssinosis is an occupational respiratory disease caused by prolonged exposure to cotton dust. It is a significant health concern in the textile industry, particularly in developing countries, and may lead to severe complications if undiagnosed and untreated. We report the case of a 47-year-old Indian male textile worker with advanced Byssinosis, presenting with progressive breathlessness, wheezing, and a two-year history of Cor-Pulmonale and Pulmonary Arterial Hypertension. Clinical findings included clubbing, bilateral pedal edema, and oxygen desaturation (75 %). Treatment involved oxygen therapy, bronchodilators, corticosteroids, and supportive care, with significant symptomatic improvement. This case discusses the severe consequences of chronic Byssinosis due to prolonged occupational exposure. It emphasizes the importance of early detection and preventive strategies, such as personal protective equipment and workplace safety regulations, to mitigate disease progression. Effective management of Byssinosis requires a multifaceted approach to occupational health. Strong preventive measures, early and accurate diagnosis, and evidence-based treatments are essential, particularly in the textile industry.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-06DOI: 10.1016/j.hmedic.2025.100268
Bipneet Singh , Muhammad Zarrar Khan , Palak Patel Rodriguez , Beena Ahsan , Jason Schairer
{"title":"Gastric siderosis in the setting of oral iron intake- A Case report and literature review","authors":"Bipneet Singh , Muhammad Zarrar Khan , Palak Patel Rodriguez , Beena Ahsan , Jason Schairer","doi":"10.1016/j.hmedic.2025.100268","DOIUrl":"10.1016/j.hmedic.2025.100268","url":null,"abstract":"<div><div>In this case report, we present a 70-year-old lady with a history of progressively worsening watery diarrhea, who was found to have gastric siderosis on upper endoscopy. We explore the clinical implications of gastric siderosis, its association with oral iron supplementation, and its diverse endoscopic and histological manifestations. Through a comprehensive review of the literature and discussion of relevant clinical findings, we aim to enhance our understanding of this intriguing entity and its diagnostic and therapeutic implications in clinical practice.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100268"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-06-06DOI: 10.1016/j.hmedic.2025.100281
S. Maragatham , Christinal Thomas , Duraisami Dhamodharan
{"title":"Adolescent HSP: A case report from a South Indian tertiary hospital","authors":"S. Maragatham , Christinal Thomas , Duraisami Dhamodharan","doi":"10.1016/j.hmedic.2025.100281","DOIUrl":"10.1016/j.hmedic.2025.100281","url":null,"abstract":"<div><div>Henoch-Schönlein purpura (HSP) is an uncommon autoimmune vasculitis that primarily affects the skin, kidneys, and joints. It is characterized by leukocytoclastic vasculopathy, often involving the skin and gastrointestinal system. Here we report the case of a 12-year-old girl who presented with a history of abdominal pain for 8 days and 7 days of vomiting, followed by the development of purpuric rashes on her legs and hands. After comprehensive investigations, the patient was diagnosed with HSP based on characteristics of Schonlein, which includes the presence of purpuric rash, arthritis, and abdominal pain. This case highlights the importance of early diagnosis and a comprehensive, interdisciplinary approach to healthcare, which can aid in effective management and reduce the risk of complications associated with HSP.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100281"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}