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Small bowel intussusception and GI bleed secondary to metastatic melanoma: A case report and literature review 转移性黑色素瘤继发于小肠肠套叠和消化道出血:1例报告并文献复习
Medical Reports Pub Date : 2025-05-31 DOI: 10.1016/j.hmedic.2025.100266
Philippe Attieh , Karam Karam , Elias Fiani , Ihab I. El Hajj
{"title":"Small bowel intussusception and GI bleed secondary to metastatic melanoma: A case report and literature review","authors":"Philippe Attieh ,&nbsp;Karam Karam ,&nbsp;Elias Fiani ,&nbsp;Ihab I. El Hajj","doi":"10.1016/j.hmedic.2025.100266","DOIUrl":"10.1016/j.hmedic.2025.100266","url":null,"abstract":"<div><div>Malignant melanoma (MM) is the most common malignancy to metastasize to the gastrointestinal (GI) tract, with the small bowel being the most frequently affected site. GI metastases often remain asymptomatic but can present with abdominal pain, weight loss, obstruction, or bleeding. Diagnosis relies on imaging and endoscopic techniques, with PET-CT being the most sensitive. We report a case of a 58-year-old woman with a history of cutaneous melanoma in situ excised 26 years ago, now presenting with a 3-month history of abdominal symptoms, melena, and weight loss. Work-up revealed anemia and positive occult blood, with negative gastroscopy and colonoscopy. CT confirmed jejuno-jejunal intussusception, and enteroscopy identified multiple pigmented lesions. Biopsy confirmed malignant melanoma, and PET-CT showed multifocal involvement. The patient underwent laparotomy with bowel resection and jejunostomy, followed by immunotherapy, leading to complete tumor resolution and no recurrence on follow-up PET-CT. This case report highlights a very rare finding of small bowel metastasis after cutaneous melanoma-in situ excision leading to jejuno-jejunal intussusception, with disease free interval of over 25 years.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ceftriaxone-induced hypersensitivity in pregnancy: Insights from a case of variable reactions to different brands 妊娠期头孢曲松致超敏反应:对不同品牌不同反应的个案分析
Medical Reports Pub Date : 2025-05-30 DOI: 10.1016/j.hmedic.2025.100263
Mohammad Ashraful Amin , Sadia Monami , Tasnim Zerin Shama , Sabrina Nahin , Mohammad Delwer Hossain Hawlader
{"title":"Ceftriaxone-induced hypersensitivity in pregnancy: Insights from a case of variable reactions to different brands","authors":"Mohammad Ashraful Amin ,&nbsp;Sadia Monami ,&nbsp;Tasnim Zerin Shama ,&nbsp;Sabrina Nahin ,&nbsp;Mohammad Delwer Hossain Hawlader","doi":"10.1016/j.hmedic.2025.100263","DOIUrl":"10.1016/j.hmedic.2025.100263","url":null,"abstract":"<div><div>Ceftriaxone, a third-generation cephalosporin, is widely used for its broad-spectrum antibacterial activity but poses challenges in managing hypersensitivity reactions, particularly in pregnant patients. This case study explores a 35-year-old woman in her second trimester of a twin pregnancy with a history of gestational diabetes mellitus and pregnancy-induced hypertension. She was referred for a urinary tract infection (UTI) caused by Klebsiella pneumoniae. Initial treatments with erythromycin and sulbactam/cefoperazone were ineffective, leading to the use of ceftriaxone. A skin test revealed severe hypersensitivity to ceftriaxone from one manufacturer (\"Brand A\") but not to another (\"Brand B\"). After careful consideration, a 10-day course of parenteral ceftriaxone from Brand B was administered without adverse reactions. The observed variability in hypersensitivity reactions between different brands of ceftriaxone highlights the potential influence of formulation differences on patient tolerance. This underscores the importance of individualized patient assessment, including skin testing necessary, to ensure both safety and efficacy, particularly in high-risk populations such as pregnant patients. This finding emphasizes the necessity for skin testing in pregnant patients where treatment options are limited and both maternal and fetal safety are paramount.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impending gastric volvulus with multifactorial etiology – A case report 多因素病因的临发性胃扭转1例
Medical Reports Pub Date : 2025-05-30 DOI: 10.1016/j.hmedic.2025.100261
Bipneet Singh , Zachary Saleh , Syed Adil , Palak Grover , Suraj Suresh
{"title":"Impending gastric volvulus with multifactorial etiology – A case report","authors":"Bipneet Singh ,&nbsp;Zachary Saleh ,&nbsp;Syed Adil ,&nbsp;Palak Grover ,&nbsp;Suraj Suresh","doi":"10.1016/j.hmedic.2025.100261","DOIUrl":"10.1016/j.hmedic.2025.100261","url":null,"abstract":"<div><div>Gastric volvulus is a rare diagnosis, often missed, but fatal in the setting of gastric ischemia. People with a surgical abdomen or with anatomic disturbances are at higher risk and should be evaluated when nausea and vomiting go unexplained. People might get labelled with functional disorders, preventing further investigation. Lastly, if and when diagnosed, aggressive management, including surgical management, should be undertaken. In our case the patient presented with recurrent nausea and vomiting. She had been treated for reflux disease in the past with fundoplication and had been treated for cyclic vomiting, gastroparesis without much relief. Endoscopies were unremarkable till a study done during an active episode demonstrated volvulus. This highlights the importance of high suspicion amongst surgical cases since the endoscopic studies are non-revealing outside of the episode. Endoscopy also holds therapeutic value with detorsion techniques. Surgical fixation is considered the definitive treatment to avoid potential complications, including bowel ischemia/necrosis and death. The patient finally underwent anterior gastropexy with symptom resolution.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMPAR encephalitis in a child with short-term amnesia after COVID-19 vaccination – A case report COVID-19疫苗接种后儿童出现短期遗忘的AMPAR脑炎1例报告
Medical Reports Pub Date : 2025-05-29 DOI: 10.1016/j.hmedic.2025.100264
Melina Alves da Frota , Denise Mendonça Borges , Caroline Corrêa Maranhão , Lidiane Indiani , Marcelo Melo Aragão , Ricardo Silva Pinho
{"title":"AMPAR encephalitis in a child with short-term amnesia after COVID-19 vaccination – A case report","authors":"Melina Alves da Frota ,&nbsp;Denise Mendonça Borges ,&nbsp;Caroline Corrêa Maranhão ,&nbsp;Lidiane Indiani ,&nbsp;Marcelo Melo Aragão ,&nbsp;Ricardo Silva Pinho","doi":"10.1016/j.hmedic.2025.100264","DOIUrl":"10.1016/j.hmedic.2025.100264","url":null,"abstract":"<div><div>We report a 12-year-old boy that developed α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) encephalitis, a rare condition in children, 15 days after receiving the Pfizer-BioNTech COVID-19 vaccine. Initially presenting with short-term amnesia, he showed normal results on EEG and brain MRI. Antibodies against AMPAR were found in his cerebrospinal fluid (CSF). Cancer screenings were normal. The patient was treated with intravenous human immunoglobulin (IVIG) for five days, but relapsed 45 days later. Upon relapse, he received IVIG, dexamethasone, and rituximab, leading to full recovery. While a temporal connection suggests a potential link between vaccination and encephalitis, this has not been previously documented and could be coincidental. Further studies are needed to confirm any causation. Early suspicion and treatment of this condition are crucial for a better prognosis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eagle's syndrome: A case report on rare sequela following head and neck radiotherapy 头颈部放射治疗后罕见后遗症1例
Medical Reports Pub Date : 2025-05-29 DOI: 10.1016/j.hmedic.2025.100267
Samreen Zaheer, Aditi Agrawal, Nida Asif, Mohammad Akram
{"title":"Eagle's syndrome: A case report on rare sequela following head and neck radiotherapy","authors":"Samreen Zaheer,&nbsp;Aditi Agrawal,&nbsp;Nida Asif,&nbsp;Mohammad Akram","doi":"10.1016/j.hmedic.2025.100267","DOIUrl":"10.1016/j.hmedic.2025.100267","url":null,"abstract":"<div><div>Eagle’s syndrome is a rare clinical condition characterized by either elongated styloid process (greater than 2.5 cm) or a calcified stylohyoid ligament. The diagnosis is confirmed when an abnormal styloid process is associated with symptoms which usually result from irritation of cranial nerves. We present the case of a 45 year male diagnosed with carcinoma base of tongue with stage T4N1M0 treated with concurrent chemoradiation in our institute. He presented with elongated styloid process post treatment completion. Radiation therapy to the head and neck has been found to cause potential long-term side effects like trismus, osteoradionecrosis, secondary cancer, and tissue fibrosis. Ionizing radiation activates the proinflammatory cascade ultimately leading to fibrosis and calcification. We suggest that Eagle’s syndrome should be considered as one the differential diagnosis of neck pain or facial pain developing after radiotherapy. The treatment modalities considered for this rare entity are conservative management of the symptoms and surgery in cases where conservative treatment fails.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100267"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basal cell ameloblastoma: A rare variant with a comprehensive literature review 基底细胞成釉细胞瘤:一种罕见的变异,文献综述
Medical Reports Pub Date : 2025-05-28 DOI: 10.1016/j.hmedic.2025.100258
Nikita Kashyap , Sudipta Rakshit , S. Aravindan , S. Srihari
{"title":"Basal cell ameloblastoma: A rare variant with a comprehensive literature review","authors":"Nikita Kashyap ,&nbsp;Sudipta Rakshit ,&nbsp;S. Aravindan ,&nbsp;S. Srihari","doi":"10.1016/j.hmedic.2025.100258","DOIUrl":"10.1016/j.hmedic.2025.100258","url":null,"abstract":"<div><div>Ameloblastomas represent a diverse and mystifying group of odontogenic tumors. Basal cell ameloblastoma (BCA) is the rarest histological variant, characterized by densely packed nests and strands of primitive basaloid cells with inconspicuous stellate reticulum-like areas. Histopathologically, it closely resembles cutaneous basal cell carcinoma, basaloid squamous cell carcinoma and intraosseous adenoid cystic carcinoma posing a diagnostic challenge. Although primarily reported in peripheral locations, intraosseous occurrences are exceptionally rare, with only 30 cases documented in the literature to date. Here, we present a unique case of intraosseous basal cell ameloblastoma in a 60-year-old patient with a mandibular lesion. Given its rarity, this case contributes to the expanding knowledge of BCA and emphasize the importance of recognizing its distinct clinicopathological features for accurate diagnosis and management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report on isolated dysphagia: An uncommon presentation of myasthenia gravis 孤立性吞咽困难1例:重症肌无力的罕见表现
Medical Reports Pub Date : 2025-05-27 DOI: 10.1016/j.hmedic.2025.100262
Mazen Farhat , Jessy Fadel , Karam Karam , Elias Fiani , Ihab I. El Hajj
{"title":"A case report on isolated dysphagia: An uncommon presentation of myasthenia gravis","authors":"Mazen Farhat ,&nbsp;Jessy Fadel ,&nbsp;Karam Karam ,&nbsp;Elias Fiani ,&nbsp;Ihab I. El Hajj","doi":"10.1016/j.hmedic.2025.100262","DOIUrl":"10.1016/j.hmedic.2025.100262","url":null,"abstract":"<div><div>Etiologies of dysphagia are variable including neuromuscular disorders. The clinical manifestations vary according to the group of muscles being involved. We herein present the case of a patient where dysphagia was the sole manifestation of an underlying myasthenia gravis. Our case highlights the importance of having a high suspicion for neuromuscular disorders in middle aged patients presenting with dysphagia, especially when the work-up for an underlying primary GI pathology is negative.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic prevertebral emphysema: Report of 5 cases 外伤性椎前肺气肿5例报告
Medical Reports Pub Date : 2025-05-25 DOI: 10.1016/j.hmedic.2025.100257
Shafi Ahmed , Upal Chowdhury , Raihana Ahmed , Rivu Raj Chakraborty
{"title":"Traumatic prevertebral emphysema: Report of 5 cases","authors":"Shafi Ahmed ,&nbsp;Upal Chowdhury ,&nbsp;Raihana Ahmed ,&nbsp;Rivu Raj Chakraborty","doi":"10.1016/j.hmedic.2025.100257","DOIUrl":"10.1016/j.hmedic.2025.100257","url":null,"abstract":"<div><div>Prevertebral emphysema following blunt trauma is an unusual condition that may indicate underlying life-threatening conditions like esophageal perforation and tracheobronchial injury. Since it is less common than other post-traumatic conditions such as pneumothorax, hemothorax, pneumomediastinum, or lung contusion, it is often overlooked in emergency care, especially in resource-limited settings. Here, we present five cases of prevertebral emphysema diagnosed and managed in a low-resource setting following trauma and propose a diagnostic algorithm.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric CML progression to blast crisis: A case report and review 儿童慢性粒细胞白血病进展到爆炸危机:一个病例报告和回顾
Medical Reports Pub Date : 2025-05-25 DOI: 10.1016/j.hmedic.2025.100260
Abdul Moiz, Zayed Mohiyuddin, Azan E Bilal Maqbool
{"title":"Pediatric CML progression to blast crisis: A case report and review","authors":"Abdul Moiz,&nbsp;Zayed Mohiyuddin,&nbsp;Azan E Bilal Maqbool","doi":"10.1016/j.hmedic.2025.100260","DOIUrl":"10.1016/j.hmedic.2025.100260","url":null,"abstract":"<div><h3>Background</h3><div>Chronic Myeloid Leukemia (CML) is a rare malignancy among children, having an incidence of 1 in a million. It is driven by the Philadelphia chromosome, resulting in the BCR-ABL1 fusion gene. Pediatric cases typically present in the chronic phase and are managed with tyrosine kinase inhibitors (TKIs) like imatinib. However, some cases progress to blast crisis, leading to life-threatening complications such as ARDS as in our case.</div></div><div><h3>Case discussion</h3><div>We report the case of a 14-year-old female with previously undiagnosed chronic myeloid leukemia (CML), who presented with acute symptoms including bleeding gums, fever, cough, jaundice, and respiratory distress. She had a 1.5-year history of progressive fatigue, abdominal pain, and weight loss, managed symptomatically without definitive diagnosis. On admission, she was found to be in blast crisis with a WBC count of 31.3 × 10⁹/L and &gt; 20 % blasts. Imaging revealed hepatosplenomegaly and features of ARDS. Bone marrow biopsy confirmed CML with Philadelphia chromosome positivity. She was treated in the ICU with Imatinib, hydroxyurea, antibiotics, oxygen therapy, and transfusions. Her condition stabilized after three weeks, and she was discharged for follow-up and continued therapy.</div></div><div><h3>Conclusion</h3><div>This case highlights the rarity of chronic myeloid leukemia (CML) in pediatric patients, which can present with severe symptoms and life-threatening complications like ARDS. Physicians should maintain a high suspicion for underlying malignancy in children with unexplained progressive illness, as early detection and intervention are critical for preventing fatal outcomes.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presentation of clinical features of microcephalic primordial dwarfism associated with a rare variant in the DNMT3A gene and synchronous epiglottic and esophageal cancers 与DNMT3A基因罕见变异相关的小头型原始侏儒症的临床特征和同步会声和食道癌
Medical Reports Pub Date : 2025-05-23 DOI: 10.1016/j.hmedic.2025.100259
Iole Ribizzi-Akhtar , Shaolei Lu , Maania Naseem
{"title":"Presentation of clinical features of microcephalic primordial dwarfism associated with a rare variant in the DNMT3A gene and synchronous epiglottic and esophageal cancers","authors":"Iole Ribizzi-Akhtar ,&nbsp;Shaolei Lu ,&nbsp;Maania Naseem","doi":"10.1016/j.hmedic.2025.100259","DOIUrl":"10.1016/j.hmedic.2025.100259","url":null,"abstract":"<div><div>Microcephalic primordial dwarfism (MPD) has been associated with germline gain-of-function of DNMT3A which is a gene encoding for a DNA methyltransferase 3 alpha, involved in epigenetic regulation, especially during embryonic development (Tenorio et al., 2020 [1]). Somatic variants in DNMT3A have been widely studied in different types of tumors, including acute myeloid leukemia, hematopoietic and lymphoid cancers. This report describes the case of a 37-year-old male with clinical features of MPD and heterozygous for a variant in the DNMT3A gene, c.911_913del:p.(Ser304del) in exon 8, who presented with severe weight loss and dysphagia and found with two synchronous distinct masses in the epiglottis and upper esophagus. Endoscopy guided biopsies of the epiglottic mass showed a poorly differentiated squamous cell carcinoma (SCC), and esophageal biopsy was consistent with a well to moderately differentiated SCC with keratinization. Next Generation sequence analysis (NGS) of both cancers showed overlapping pathways involving TP53 and MUTYH and similar PD-L1 combined positive score (CPS). The patient was treated with palliative radiation according to the Quad Shot regimen on the epiglottic and esophageal masses. Unfortunately, he deteriorated rapidly, and the family decided to transition to hospice care. This is the first case of a patient with clinical features of MPD and heterozygous for an in-frame deletion of DNMT3A, developing two synchronous cancers.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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