Medical ReportsPub Date : 2025-05-03DOI: 10.1016/j.hmedic.2025.100232
Mark Tawfik , Angelica Rozenfeld , Chloé Lahoud , Sumeyye Ozer , Omer Alomari , Vincent DeChavez
{"title":"PD-1 inhibitor‐induced cytomegalovirus esophagitis in a patient with metastatic urothelial carcinoma: A case report","authors":"Mark Tawfik , Angelica Rozenfeld , Chloé Lahoud , Sumeyye Ozer , Omer Alomari , Vincent DeChavez","doi":"10.1016/j.hmedic.2025.100232","DOIUrl":"10.1016/j.hmedic.2025.100232","url":null,"abstract":"<div><h3>Introduction</h3><div>Immune checkpoint inhibitors (ICIs), such as Pembrolizumab, have revolutionized cancer treatment. However, they pose challenges, specifically in the form of immune-related adverse events (irAEs). Although cases of gastrointestinal irAEs have been well-documented, the occurrence of cytomegalovirus (CMV) esophagitis months after immunotherapy discontinuation, has not been well reported.</div></div><div><h3>Case presentation</h3><div>We report a case of immune-related CMV esophagitis three months after discontinuing pembrolizumab therapy, which had been administered for metastatic urothelial cancer.</div></div><div><h3>Conclusion</h3><div>IrAE and their timing remain a challenge in patients receiving ICI therapy. CMV esophagitis is a rare irAE associated with ICIs and further investigation is needed to better develop effective treatment and prevention strategies.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-05-02DOI: 10.1016/j.hmedic.2025.100235
Jacqueline Boyle , William Miller , Andres Maldonado , Jorge Kattah
{"title":"Spontaneous retinal venous pulsations for evaluation of intracranial pressure after endoscopic third ventriculostomy","authors":"Jacqueline Boyle , William Miller , Andres Maldonado , Jorge Kattah","doi":"10.1016/j.hmedic.2025.100235","DOIUrl":"10.1016/j.hmedic.2025.100235","url":null,"abstract":"<div><h3>Introduction</h3><div>Accurate and timely diagnosis of cerebrospinal fluid (CSF) diversion failure, including shunt or ventriculostomy failure, remains challenging. Classically, ophthalmologic evaluation of intracranial pressure (ICP) is based on papilledema, however, spontaneous retinal venous pulsations (SVP) may be another valuable, underutilized tool. We seek to present the case of a patient who underwent endoscopic third ventriculostomy with neuroophthalmological monitoring throughout her post-operative course and provide a brief literature review on the use of SVP for monitoring ICP.</div></div><div><h3>Case presentation</h3><div>Post-operatively, our patient noted improvement of her symptoms and confirmation of successful ventriculostomy on MRI CSF flow studies. There was a monitorable, gradual return of SVP, which supports the use of SVPs as a clinical surrogate to MRI CSF flow study. Literature review suggests that SVP loss is more sensitive than papilledema for elevated ICP, though return of SVP may be delayed in patients post-operatively given CSF dynamics.</div></div><div><h3>Conclusion</h3><div>Based on our clinical findings and literature review, SVP may be an excellent, more sensitive screening test, especially in the absence of papilledema, to evaluate for CSF diversion failure. Ophthalmologic monitoring is cost-effective and non-invasive, and clinical incorporation of SVP could reduce unnecessary testing, hospitalizations, invasive procedures, and patient discomfort.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-05-02DOI: 10.1016/j.hmedic.2025.100238
Rocco Corso , Cesare Maino , Antonio Rovere , Nicola Zarpellon , Davide Ippolito , Davide Leni
{"title":"Imaging-guided percutaneous trans-coccygeal drainage of a presacral abscess: A technical report","authors":"Rocco Corso , Cesare Maino , Antonio Rovere , Nicola Zarpellon , Davide Ippolito , Davide Leni","doi":"10.1016/j.hmedic.2025.100238","DOIUrl":"10.1016/j.hmedic.2025.100238","url":null,"abstract":"<div><div>A 78-years-old male affected by prostate cancer was referred for intermittent sacral pain. Due to septic shock, he underwent contrast-enhanced CT, showing a large abscess (5 cm) with inhomogeneous enhancement located in the presacral space, associated with osteomyelitis. The abscess was treated by interventional radiology techniques by placing a trans-coccygeal drainage, which led to relief of symptoms and recovery from sepsis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pramipexole induced hallucinations in a patient with restless leg syndrome: A case report","authors":"Gautam Agrawal , Bhawna Agarwal , Taranjit Singh Gill , Sourabh Khatri","doi":"10.1016/j.hmedic.2025.100231","DOIUrl":"10.1016/j.hmedic.2025.100231","url":null,"abstract":"<div><div>Restless leg syndrome (RLS), a common sleep-related movement disorder, is highly prevalent in patients with end-stage renal disease (ESRD) due to various risk factors such as uremia, anemia, iron deficiency, diabetes mellitus, elevated parathyroid hormone levels, and neuropathy. Pramipexole, a dopamine agonist, is approved for the treatment of both RLS and Parkinson’s disease. While neuropsychiatric side effects like hallucinations can occur, they are more commonly seen with the higher doses used to treat Parkinson’s disease and are rare with the lower doses used for RLS. The risk of hallucinations appears to be dose-dependent and increases with age. We present the case of a 76-year-old female with a history of ESRD on dialysis and RLS, who developed visual hallucinations after pramipexole dose titration. The hallucinations resolved after discontinuing the medication. Clinicians should closely monitor patients, particularly the elderly and those with ESRD, for the development of hallucinations, and consider dose reduction or discontinuation if they occur.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-05-01DOI: 10.1016/j.hmedic.2025.100236
Umer Iqbal , Aashish Kumar , Syed Ali Arsal , Mehwish Soomro , Shafin Bin Amin , Sameeka Waqas , Inibehe Ime Okon
{"title":"Uncommon presentation of urinary bladder calculus in an 18 months old child: A rare case report","authors":"Umer Iqbal , Aashish Kumar , Syed Ali Arsal , Mehwish Soomro , Shafin Bin Amin , Sameeka Waqas , Inibehe Ime Okon","doi":"10.1016/j.hmedic.2025.100236","DOIUrl":"10.1016/j.hmedic.2025.100236","url":null,"abstract":"<div><div>Bladder stones even if applicable are seldom present in children under the age of 5, and the majority are likely to be attributable to a problem related to the child’s diet or hydration. These stones can be classified as primary which are common in children, secondary or migratory. The case is about an 18-month-old child who presented atypically as having dysuria, partial urinary retention, and effusion from the ears. Imaging showed a bladder stone and open cystolithotomy was done without any complications. In children, bladder stones usually develop due to metabolic or structural abnormalities and as such, investigations and treatment plans need to be individualized. Minimally invasive procedures such as transurethral lithotripsy and percutaneous stone removal are advancing, open surgery is however still required in circumstances where the stone is too complicated or there are few resources available. This case demonstrates the significance of multidisciplinary care, particularly in rural areas, where uncommon presentations need to be managed effectively to achieve good outcomes in pediatric cases of bladder stones. This conditions need a proper investigation to hypothesize the causes or the measures that can be employed to enhance prevention of these conditions in young children.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-05-01DOI: 10.1016/j.hmedic.2025.100230
Vanisha Pundir , Naveen Kumar Kushwaha , Sri Devi
{"title":"Eosinophilic cholangitis: A benign condition masquerading as biliary malignancy","authors":"Vanisha Pundir , Naveen Kumar Kushwaha , Sri Devi","doi":"10.1016/j.hmedic.2025.100230","DOIUrl":"10.1016/j.hmedic.2025.100230","url":null,"abstract":"<div><div>Eosinophilic cholangitis is a rare, benign condition of the biliary tract that often causes obstructive jaundice and poses a significant diagnostic challenge due to its close resemblance to malignancy. It should be considered when imaging shows a biliary stricture, especially if malignancy cannot be definitively diagnosed preoperatively, alongside peripheral eosinophilia and the absence of typical malignancy symptoms. We present a rare case of a young male with painless obstructive jaundice caused by a biliary stricture in the distal common bile duct, masquerading as biliary malignancy and ultimately diagnosed as idiopathic hypereosinophilic syndrome with eosinophilic cholangitis. The case underscores the diagnostic and therapeutic challenges involved and highlights the importance of a multidisciplinary approach and strict adherence to treatment protocols to achieve a favorable outcome.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single coronary artery anomaly with critical left anterior descending artery stenosis: A case of percutaneous intervention in congenital right coronary artery agenesis","authors":"Ofe Eugene Kwaku , Hao Luo , Cong Wen , Rongchuan Yue","doi":"10.1016/j.hmedic.2025.100229","DOIUrl":"10.1016/j.hmedic.2025.100229","url":null,"abstract":"<div><div>Congenital agenesis of the right coronary artery (RCA) is a rare coronary anomaly that may coexist with atherosclerotic disease and pose unique diagnostic and therapeutic challenges. We present the case of a 60-year-old woman with a 10-year history of hypertension who experienced refractory nocturnal angina despite optimal medical therapy. Coronary computed tomography angiography (CCTA) revealed congenital RCA agenesis and critical (70–80 %) narrowing of the proximal-to-mid left anterior descending artery (LAD). Invasive angiography confirmed a single coronary artery system (L-I type classification) with severe (80–85 %) LAD stenosis. Percutaneous coronary intervention using a drug-eluting stent was performed to resolve symptoms and restore flow. At 6-month follow-up, the patient remained asymptomatic on guideline-directed therapy. This case underscores two critical points: (1) RCA agenesis exacerbates ischemia in atherosclerotic LAD disease by forcing the left coronary system to perfuse an expanded myocardial territory without collateral compensation, and (2) PCI offers targeted revascularization in anatomically complex congenital anomalies. Noninvasive imaging (CCTA) and invasive angiography remain pivotal for delineating the coronary anatomy and guiding intervention.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diffuse leptomeningeal glioneuronal tumor in a 4-year-old child with urinary tract infection: A case report","authors":"Parsa Yousefichaijan , Mahbod Soltani , Ali Rahnama Sisakht , Negar PoorAhmadian , Zahra Tavassoli","doi":"10.1016/j.hmedic.2025.100224","DOIUrl":"10.1016/j.hmedic.2025.100224","url":null,"abstract":"<div><div>Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare pediatric neoplasm characterized by diffuse leptomeningeal enhancement. Patients may present with a range of symptoms, including headaches, vomiting, seizures, and signs of increased intracranial pressure, such as hydrocephalus. Most of these tumors show slow progression and are usually managed through surgical resection, radiation therapy, and/or chemotherapy. Tumors located along the neural axis can interfere with the pathways that control bladder storage and voiding mechanisms. As a result, children with central nervous system (CNS) tumors may encounter different levels of bladder dysfunction. This case report describes a 4-year-old girl who was admitted due to dysuria and lower abdominal pain. Her mother reported that she had paraplegia in her lower extremities, which was accompanied by claudication for 2 days. The patient underwent an MRI following confirmation of the DLGNT diagnosis and exclusion of other etiologies, and Our patient underwent surgical resection of the mass 5 days after admission to the hospital. Remarkably, the patient experienced no complications. Follow-up MRI scans were obtained in two stages, 4 months apart, which demonstrated no evidence of contrast enhancement. Furthermore, this case highlights the possible genetic factors involved in the development of DLGNT, underscoring the need for further exploration of the genetic landscape associated with this rare tumor.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-04-26DOI: 10.1016/j.hmedic.2025.100212
Venkata Surabhi Rayal Akepati, Navaudhayam Ranganathan, Anu Agrawal, Raja Shekar C H T, Vikas Yadav
{"title":"Nasal epithelioid hemangioendothelioma - A rare case report and review of literature","authors":"Venkata Surabhi Rayal Akepati, Navaudhayam Ranganathan, Anu Agrawal, Raja Shekar C H T, Vikas Yadav","doi":"10.1016/j.hmedic.2025.100212","DOIUrl":"10.1016/j.hmedic.2025.100212","url":null,"abstract":"<div><h3>Aim</h3><div>To understand the complexities in diagnosing and managing a rare case of Nasal epithelioid hemangioendothelioma, which can be clinically misdiagnosed as benign inflammatory conditions.</div></div><div><h3>Background</h3><div>Epithelioid hemangioendothelioma (EHE) is a rare locally invasive vascular tumor and it is characterized by proliferation of endothelial cells with epithelioid morphology. It is slow growing tumor with borderline malignant potential and has high chances of recurrence. Mostly seen in soft tissues of extremities, lungs and very rarely seen in head and neck. There are very few cases reported of EHE in nasal cavity.</div></div><div><h3>Case Description</h3><div>The present case report describes an unusual case of EHE of nasal cavity in a 37 year old male with 2 months history of nasal mass, obstruction and intermittent epistaxis. Patient underwent wide local excision of tumor and histopathology confirmed the diagnosis.</div></div><div><h3>Conclusion</h3><div>Usually wide local excision is the treatment of choice. Routinely regular follow up is advised. In cases of multiple recurrences and incompletely excised tumors radiation therapy is considered.</div></div><div><h3>Clinical Significance</h3><div>It is an indolent tumor which has potential for recurrence that is known to appear during adult life and unlikely to metastasize.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical ReportsPub Date : 2025-04-26DOI: 10.1016/j.hmedic.2025.100211
Eljazouli Ali, Drighil Abdenasser
{"title":"Remarkable recovery of a multicomplicated infective endocarditis due to Bartonella henselae a case report","authors":"Eljazouli Ali, Drighil Abdenasser","doi":"10.1016/j.hmedic.2025.100211","DOIUrl":"10.1016/j.hmedic.2025.100211","url":null,"abstract":"<div><h3>Background</h3><div>Culture-negative infective endocarditis poses a substantial challenge in medical practice, accounting for 75 % of infective endocarditis cases in developed countries. This condition stems from diverse causative agents, with Bartonella emerging as the most prevalent culprit. Owing to limited comprehensive studies and established guidelines, the diagnosis of this condition remains intricate and often relies on anecdotal case reports and small series.</div></div><div><h3>Case presentation</h3><div>We present a compelling case of a 60-year-old male patient who presented with severe chest pain, dyspnea, fever, and an array of additional symptoms. The clinical presentation eventually led to a diagnosis of infective endocarditis, which was unveiled through acute coronary syndrome concomitant with nephrotic syndrome, renal failure, and pancytopenia. Despite the initiation of the initial treatment regimen, the patient exhibited an inadequate response. Subsequent investigations revealed an underlying <em>Bartonella henselae</em> infection. Administration of doxycycline elicited notable improvements in both the patient's clinical status and pertinent laboratory parameters.</div></div><div><h3>Conclusion</h3><div>This case underscores the significance of broadening the scope of diagnostic considerations to encompass less common agents such as Bartonella in cases of culture-negative infective endocarditis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"12 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}