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Oral manifestations as the first sign of Granulomatosis with polyangiitis – A case report 作为多血管炎肉芽肿病首发症状的口腔表现--病例报告

Medical Reports Pub Date : 2024-11-03 DOI: 10.1016/j.hmedic.2024.100129

Yousra Akhlef , Ulrik Ørsø Andersen , Preben Homøe

引用次数: 0

Deciphering a potential causality between autoimmune atrophic gastritis and Crohn’s disease: A report of two cases 解读自身免疫性萎缩性胃炎与克罗恩病之间的潜在因果关系：两个病例的报告

Medical Reports Pub Date : 2024-11-03 DOI: 10.1016/j.hmedic.2024.100130

Karam Karam , Houssein Chebbo , Sarah Saleh , Elias Fiani

引用次数: 0

US medical education landscape: Now and beyond 美国医学教育格局：现在和未来

Medical Reports Pub Date : 2024-10-30 DOI: 10.1016/j.hmedic.2024.100127

Farzana Hoque

引用次数: 0

Recurrent cerebral venous thrombosis in a child due to Factor V Leiden mutation leading to activated protein C resistance: A case report 因子 V Leiden 突变导致活化蛋白 C 抗性，导致一名儿童反复出现脑静脉血栓：病例报告

Medical Reports Pub Date : 2024-10-28 DOI: 10.1016/j.hmedic.2024.100126

S. El Gazzane , G. Jaabouti , S. Aminou , N. El Hafidi , A. Masrar , H. Andour , L. Chat , C. Mahraoui , S. Benchekroun

{"title":"Recurrent cerebral venous thrombosis in a child due to Factor V Leiden mutation leading to activated protein C resistance: A case report","authors":"S. El Gazzane , G. Jaabouti , S. Aminou , N. El Hafidi , A. Masrar , H. Andour , L. Chat , C. Mahraoui , S. Benchekroun","doi":"10.1016/j.hmedic.2024.100126","DOIUrl":"10.1016/j.hmedic.2024.100126","url":null,"abstract":"<div><h3>Background</h3><div>Because of the Factor V Leiden Mutation, activated protein C resistance is the most common hereditary condition predisposing individuals to venous thrombosis in infancy and childhood. The prevalence of this mutation varies among ethnic groups and geographical regions. Laboratory tests for thrombophilic markers, including Activated Protein C Resistance (APCR) and Factor V Leiden, are essential for diagnosis. While genetic tests are essential for confirming the diagnosis, determining homozygous or heterozygous status, and assessing recurrence risk, coagulation methods often use APCR detection as the primary screening approach.</div></div><div><h3>Case presentation</h3><div>We describe a 10-year-old North African male patient with recurrent thrombosis of the right internal jugular vein who was found to have protein C resistance. Further genetic testing revealed that the patient is heterozygous for the Factor V Leiden mutation.</div></div><div><h3>Conclusions</h3><div>This case highlights the importance of considering the Factor V Leiden mutation in pediatric patients presenting with recurrent venous thrombosis. Early detection and accurate diagnosis are critical for effective management and prevention of future thrombotic events.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"8 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal lymphangiectasia secondary to chronic midgut volvulus: A rare childhood presentation case report 继发于慢性中肠下垂的肠淋巴管扩张症：罕见的儿童病例报告

Medical Reports Pub Date : 2024-10-28 DOI: 10.1016/j.hmedic.2024.100125

Jasmin Martin , Narayanan Venkatasubramani , Nancy McGreal

引用次数: 0

A challenge to clinical management: A case of expanded dengue syndrome co-infection with dengue 1 and dengue 3 serotypes in Nepal 临床管理的挑战：尼泊尔一例登革1型和登革3型血清型合并感染的登革热综合征扩大病例

Medical Reports Pub Date : 2024-10-24 DOI: 10.1016/j.hmedic.2024.100123

Sabin Shrestha , Milan Bajracharya , Sandesh Rimal , Rajshree Bhujel , Bimal Chalise , Yuba Nidhi Basaula , Prasanna Amatya , Shrijana Pandey , Pratik Joshi , Nabaraj Adhikari , Mya Myat Ngwe Tun , Kouichi Morita , Shyam Prakash Dumre , Basu Dev Pandey

{"title":"A challenge to clinical management: A case of expanded dengue syndrome co-infection with dengue 1 and dengue 3 serotypes in Nepal","authors":"Sabin Shrestha , Milan Bajracharya , Sandesh Rimal , Rajshree Bhujel , Bimal Chalise , Yuba Nidhi Basaula , Prasanna Amatya , Shrijana Pandey , Pratik Joshi , Nabaraj Adhikari , Mya Myat Ngwe Tun , Kouichi Morita , Shyam Prakash Dumre , Basu Dev Pandey","doi":"10.1016/j.hmedic.2024.100123","DOIUrl":"10.1016/j.hmedic.2024.100123","url":null,"abstract":"<div><div>Rapid progression to fatal expanded dengue syndrome is unusual, presenting a challenge for clinical management. We present a case of a 32-year-old female with atypical dengue manifestations who underwent extensive evaluation at a Kathmandu infectious disease hospital, including vital signs assessment, clinical scoring, and routine and advanced laboratory analyses. Severe abdominal pain, disorientation, and abnormal hemodynamics with multi-organ involvement were noted with a secondary dengue virus (DENV) infection. Co-infection of DENV-1 and DENV-3, exhibiting high viral loads, was observed, marking the first fatal case of its kind in Nepal. Despite intensive care management, the patient’s condition rapidly deteriorated, leading to fatal expanded dengue syndrome within four days of a hospital visit. This poses a serious challenge to clinicians. Heightened vigilance from the onset of DENV infection is imperative, regardless of serotypes or viral load levels. Predictive markers for early detection and management strategies are urgently needed to achieve the WHO's goal of zero dengue-related deaths by 2030.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"8 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive ductal carcinoma in a male patient: A case report 一名男性患者的浸润性导管癌：病例报告

Medical Reports Pub Date : 2024-10-23 DOI: 10.1016/j.hmedic.2024.100122

Muhammad Usama Bin Shabbir , Muhammad Bilal , Sikandar Ajmal Abbasi , Afaq Ahmad , Ahmad Abubakr

{"title":"Invasive ductal carcinoma in a male patient: A case report","authors":"Muhammad Usama Bin Shabbir , Muhammad Bilal , Sikandar Ajmal Abbasi , Afaq Ahmad , Ahmad Abubakr","doi":"10.1016/j.hmedic.2024.100122","DOIUrl":"10.1016/j.hmedic.2024.100122","url":null,"abstract":"<div><h3>Introduction and importance</h3><div><em>Male breast cancer</em> is a rare condition, representing less than one per cent of all breast cancer cases. It is characterized by late presentation and a higher incidence of metastatic disease due to diagnostic delays. In Pakistan, male breast cancer tends to appear at a younger age than in Western countries. Risk factors include advancing age, hormonal imbalances, and family history. Despite the proven effectiveness of neoadjuvant chemotherapy, its adoption in clinical practice is limited.</div></div><div><h3>Case presentation</h3><div>This case involves a fifty-six-year-old Pakistani man presenting with a lump in his right breast. The physical examination showed a lump with axillary lymphadenopathy and skin changes. Laboratory tests were within normal ranges, and imaging revealed a highly suspicious lesion in the right breast. After a modified radical mastectomy, the biopsy confirmed grade two invasive ductal carcinoma with lymph node metastasis.</div></div><div><h3>Clinical discussion</h3><div>The case highlights the need to consider male breast cancer in diagnoses. Male breast cancer differs from female breast cancer in its pathology, with a higher expression of the estrogen receptor-beta. The patient, who tested negative for BRCA1 and BRCA2 mutations, received chemotherapy followed by surgery, underscoring the importance of personalized treatment.</div></div><div><h3>Conclusion</h3><div>Male breast cancer is among the rarest cancers globally, requiring more research and awareness to improve management and outcomes. Dispelling the myth that breast cancer is a female-only disease is vital for early detection and treatment, which could enhance survival rates.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"8 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal type of sinonasal adenocarcinoma with condylar metastases: A case report 伴有髁状突转移的肠型鼻窦腺癌：病例报告

Medical Reports Pub Date : 2024-10-23 DOI: 10.1016/j.hmedic.2024.100124

Karpagaselvi Sanjai , Sumana Bukanakere Sangappa , Divya Shivalingaiah , Anjum Baker , Roopa Rao

{"title":"Intestinal type of sinonasal adenocarcinoma with condylar metastases: A case report","authors":"Karpagaselvi Sanjai , Sumana Bukanakere Sangappa , Divya Shivalingaiah , Anjum Baker , Roopa Rao","doi":"10.1016/j.hmedic.2024.100124","DOIUrl":"10.1016/j.hmedic.2024.100124","url":null,"abstract":"<div><div>Intestinal type sinonasal adenocarcinoma (ITAC) is a locally aggressive, rare malignancy occurring mostly in elderly males. It is the second most common sinonasal adenocarcinoma, with characteristic microscopic features in their marked resemblance to intestinal mucosa. It also has a well-documented association with prolonged occupational exposure to wood dust. Here we report a case of papillary variant of ITAC originating in the ethmoid sinus with metastasis to the mandibular condyle. A 53 year old male, bookseller by profession reported to outpatient department with difficulty in mouth opening since five months. On examination, he had swelling with pain and tenderness on the right side of face and the right temporomandibular joint (TMJ) area. The radiographs revealed a destructive mass in the right ethmoid sinus, encroaching into the maxillary antrum, orbit and nasal cavity along with beak like erosion of anteromedial aspect of the right condyle. The hematoxylin and eosin stained sections showed presence of glandular structures, recapitulating intestinal mucosal morphology and papillary arrangement of stratified tall columnar cells with dysplastic features. Immunohistochemical stain with CK20, CD-X2, CK7 and villin was positive. The patient was referred to oncology department for further treatment. This case reiterates the importance of proper clinical evaluation of the patient to consider profession related lesions. Metastases from Sinonasal adenocarcinomas can be considered for differential diagnosis for inability to open mouth.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"8 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evans syndrome: An uncommon hematological conundrum in a young adult: A case report 埃文斯综合征：一名年轻成人的罕见血液学难题：病例报告

Medical Reports Pub Date : 2024-10-17 DOI: 10.1016/j.hmedic.2024.100121

Faryal Afridi , Tooba Fida , Muhammad Usama Bin Shabbir , Hasban Ahmad Halim , Ishwa Ghouri , Muhammad Fawad Ashraf

引用次数: 0

Colon cancer disguised as intussusception in a young adult: A case report 伪装成肠套叠的年轻成人结肠癌：病例报告

Medical Reports Pub Date : 2024-10-15 DOI: 10.1016/j.hmedic.2024.100119

Anthony El Dada , Yara El Ratel , Mandy El Khoury , Karam Karam , Mahmoud Othman

{"title":"Colon cancer disguised as intussusception in a young adult: A case report","authors":"Anthony El Dada , Yara El Ratel , Mandy El Khoury , Karam Karam , Mahmoud Othman","doi":"10.1016/j.hmedic.2024.100119","DOIUrl":"10.1016/j.hmedic.2024.100119","url":null,"abstract":"<div><h3>Background</h3><div>Intussusception is exceedingly rare in adults and is often unthought off as a differential diagnosis for abdominal pain. Here, we describe the case of intussusception in a young female unveiling colon adenocarcinoma.</div></div><div><h3>Case presentation</h3><div>A 36-year-old female, previously healthy, presented for abdominal pain and bloody diarrhea of 2 days duration. The patient was initially treated for Amebiasis. She sought medical care the next day with tenesmus and lancinating abdominal pain, leading to hospitalization for further work-up. Computed tomography (CT) scan revealed an obstruction of the large bowel with dilation of the transverse colon reaching 6 cm. The obstruction was caused by a collapsed, intussuscepted descending colon, with mesenteric fat and vessels telescoped into its lumen along with a 3.7 cm wall thickening. She was scheduled for surgical repair.</div></div><div><h3>Conclusion</h3><div>A well-timed CT scan is necessary for favorable patient outcomes. Due to their rare occurrence in young adults, intussusception and colon cancer, could potentially go undiagnosed.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"8 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0