Medical Reports最新文献_第3页

The forgotten double J ureteral stent complicated with large urinary bladder calculus formation: A case report 遗忘双J输尿管支架合并大膀胱结石1例

Medical Reports Pub Date : 2025-09-03 DOI: 10.1016/j.hmedic.2025.100360

Naqiuddin Mohd Fazali , Zaitul Azra Mohd Nasir , Mohamed Ashraf Mohamed Daud , Wan Fatihah Wan Sohaimi , Nur Asma Sapiai

引用次数: 0

When common diagnoses fail: The complexity of sarcoidosis in the elderly: Case report 常见诊断失败时：老年结节病的复杂性：病例报告

Medical Reports Pub Date : 2025-09-03 DOI: 10.1016/j.hmedic.2025.100361

Farah Ghanim , Sari Zraiq , Nizar Abu Hamdeh , Mohammed Sweilih , Haitham Abu Khadija , Mohammad Alnees

{"title":"When common diagnoses fail: The complexity of sarcoidosis in the elderly: Case report","authors":"Farah Ghanim , Sari Zraiq , Nizar Abu Hamdeh , Mohammed Sweilih , Haitham Abu Khadija , Mohammad Alnees","doi":"10.1016/j.hmedic.2025.100361","DOIUrl":"10.1016/j.hmedic.2025.100361","url":null,"abstract":"<div><div>Sarcoidosis is a rare but complex multisystem granulomatous disease that can mimic common respiratory conditions, leading to delayed diagnosis. We present a 75-year-old female with type 2 diabetes and hypertension who experienced persistent cough, fatigue, and occasional unconsciousness for months. Initial workups, including chest X-rays and tuberculosis screening, were inconclusive, and empirical treatments for pneumonia failed to provide relief. Her condition progressed to significant weight loss, night sweats, and lymphadenopathy. High-resolution computed tomography (HRCT) later revealed mediastinal lymphadenopathy, bilateral infiltrates, and pulmonary nodules, strongly suggesting sarcoidosis. Due to biopsy refusal, histological confirmation was unavailable, yet her dramatic response to corticosteroids and methotrexate solidified the diagnosis. This case highlights the importance of early suspicion, serial imaging, and clinical response in diagnosing sarcoidosis, especially in elderly patients, where histopathological confirmation may not be feasible.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical adult-onset Henoch-Schönlein purpura in a female patient from Bangladesh: Post-streptococcal vasculitis without IgA deposition – A case report 孟加拉国女性患者的非典型成人发病Henoch-Schönlein紫癜：链球菌感染后血管炎无IgA沉积- 1例报告

Medical Reports Pub Date : 2025-09-02 DOI: 10.1016/j.hmedic.2025.100359

Zahin Shahriar, Sakib Abrar , Soumik Roy, Shaimul Reza, Fabiha Rahman, Tushar Kanti Bhadra

引用次数: 0

Septo-optic dysplasia: A case report and systematic literature review 视隔发育不良1例报告及系统文献复习

Medical Reports Pub Date : 2025-08-30 DOI: 10.1016/j.hmedic.2025.100357

Y. Mouhcine , S. Beyyato , H. Ouazzani , I. Chaouche , A. Akammar , N. EL Bouardi , B. Alami , Y.Alaoui Lamrani , M. Maaroufi , M. Boubbou

引用次数: 0

Late-onset afebrile neonatal bacteremia due to nontypeable Haemophilus influenzae: A case report 不可分型流感嗜血杆菌引起的迟发性发热新生儿菌血症：1例报告

Medical Reports Pub Date : 2025-08-29 DOI: 10.1016/j.hmedic.2025.100356

Wataru Anzai, Yoshitaka Watanabe, Naomi Yagi, Masaki Yamaguchi, Nobuhiro Kawai, Hirokazu Ikeda

{"title":"Late-onset afebrile neonatal bacteremia due to nontypeable Haemophilus influenzae: A case report","authors":"Wataru Anzai, Yoshitaka Watanabe, Naomi Yagi, Masaki Yamaguchi, Nobuhiro Kawai, Hirokazu Ikeda","doi":"10.1016/j.hmedic.2025.100356","DOIUrl":"10.1016/j.hmedic.2025.100356","url":null,"abstract":"<div><div><em>Haemophilus influenzae</em> type b (Hib) vaccine has significantly reduced invasive <em>Haemophilus influenzae</em> disease (IHD) in Japan, but it has no effect on nontypeable <em>Haemophilus influenzae</em> (NTHi). IHD caused by NTHi remains a common issue among neonates. This report presents a case of neonatal late-onset bacteremia caused by NTHi without typical symptoms such as fever and elevated serum C-reactive protein (CRP) levels. A Japanese girl, born prematurely as the first twin, was hospitalized for lip cyanosis and a cough. Initial hematological and radiological investigations revealed no significant abnormalities except for hypocomplementemia. However, she experienced frequent apneic attacks with bradycardia and cyanosis on the first night. NTHi bacteremia, diagnosed by blood culture was identified in subsequent diagnostic procedures. Clinical improvement was observed with antibiotic treatment, despite afebrile and no elevated CRP levels during hospitalization. Previous reports indicate that late-onset IHD at > 48 h of age is rare with unclear clinical course. This case underscores the importance of considering NTHi as a potential pathogen in neonatal bacteremia, even without typical symptoms like fever and elevated CRP levels. blood samples for culture remain crucial for diagnosing bacteremia, particularly in atypical presentations.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100356"},"PeriodicalIF":0.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of glyphosate poisoning with continuous renal replacement therapy (CRRT): A case report 持续肾替代治疗（CRRT）治疗草甘膦中毒1例报告

Medical Reports Pub Date : 2025-08-28 DOI: 10.1016/j.hmedic.2025.100355

Ramesh Yelanati , Dharanindra Moturu , Ramesh Babu Potineni , Supriya Rayana , Kondaveeti Devaki , Mohammad Noor Shaik

引用次数: 0

Homozygous DEAF1 mutation with developmental delay, microcephaly, and optic atrophy – A case report 纯合子DEAF1突变伴发育迟缓、小头畸形和视神经萎缩1例报告

Medical Reports Pub Date : 2025-08-28 DOI: 10.1016/j.hmedic.2025.100349

Aisha Shahid , Umer Shahid , Reet Ramani , Zubaid Moazzam Sheikh , Ubaid Shahid , Saba Safdar

{"title":"Homozygous DEAF1 mutation with developmental delay, microcephaly, and optic atrophy – A case report","authors":"Aisha Shahid , Umer Shahid , Reet Ramani , Zubaid Moazzam Sheikh , Ubaid Shahid , Saba Safdar","doi":"10.1016/j.hmedic.2025.100349","DOIUrl":"10.1016/j.hmedic.2025.100349","url":null,"abstract":"<div><h3>Background</h3><div>Significant developmental difficulties are frequently caused by neurodevelopmental diseases, which are frequently brought on by environmental causes and genetic mutations. The DEAF1 gene is associated with serious neurological disorders and is essential for brain development. The purpose of this study is to investigate the potential effects of a homozygous mutation in the DEAF1 gene on developmental delays, specifically in consanguineous families, using the example of a 1.5-year-old boy.</div></div><div><h3>Methods and results</h3><div>A harmful mutation in the DEAF1 gene (c.1051C>T p.(Arg351Ter)) was discovered by genetic research. The child had generalized epileptic activity, optic atrophy, microcephaly, and global developmental delay. There was no discernible developmental improvement even after getting antiepileptic medication, occupational therapy, and physical therapy. Similar developmental difficulties were also shown by a first cousin, suggesting a close genetic connection. Genetic testing and thorough neurological examinations were among the evaluations.</div></div><div><h3>Conclusions</h3><div>The difficulties in treating neurodevelopmental abnormalities linked to the DEAF1 gene are highlighted by this example. The particular mutation emphasizes how important it is for developmental outcomes. The results highlight the value of preventive testing and genetic counseling in consanguineous relationships. Because of the severity of the mutation, the prognosis is still unknown even after intensive multidisciplinary care. All things considered, this instance highlights the need for more research in this field and offers insightful information on how DEAF1 mutations affect neurodevelopmental diseases.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute liver injury following a single dose of celecoxib: A rare case of rapid-onset hepatotoxicity 单剂量塞来昔布引起的急性肝损伤：一例罕见的快速肝毒性病例

Medical Reports Pub Date : 2025-08-28 DOI: 10.1016/j.hmedic.2025.100353

Maria Emilia Adenike V. Adedoja , Lovell B. Gatchalian

{"title":"Acute liver injury following a single dose of celecoxib: A rare case of rapid-onset hepatotoxicity","authors":"Maria Emilia Adenike V. Adedoja , Lovell B. Gatchalian","doi":"10.1016/j.hmedic.2025.100353","DOIUrl":"10.1016/j.hmedic.2025.100353","url":null,"abstract":"<div><div>Celecoxib is a widely prescribed drug for symptomatic pain control. Data regarding its potential to cause deleterious hepatotoxicity is limited. This case report presents a 42-year old man who developed jaundice within 24 h after intake of one tablet of celecoxib (200 mg) for a tooth extraction. He did not have signs of hepatic encephalopathy, fever or rash. There was no previous drug allergy, herbal medicine or alcohol intake. Laboratory workup showed ALT 699, AST 631 U/L, Total bilirubin 5.17 mg/dL, alkaline phosphatase was elevated at 195 U/L and INR 1.2 with an R factor of 9 indicating a hepatocellular pattern of injury. Serologic tests for Hepatitis A, B & C were non-reactive. Antinuclear Antibody (ANA), anti-smooth muscle antibody (anti-SMA), serum immunoglobulin G, anti-mitochondrial antibody (AMA), and perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) were all negative. Imaging tests of the liver such as triphasic CT scan and Magnetic Resonance Cholangiopancreatography (MRCP) showed no evidence of biliary obstruction and dilatation. His cholestasis and course of liver disease were prolonged, and ultimately he underwent liver biopsy which showed portal and lobular inflammation and hepatocanalicular cholestasis favoring drug-induced liver injury. Celecoxib was withdrawn, ursodeoxycholic acid 300 mg/tab twice times daily and cetirizine 10 mg/tab OD were started to address his persistent pruritus. His liver biochemical and function tests gradually normalized with symptom resolution after 4 months. Conventional non-steroidal anti-inflammatory drugs like celecoxib may still be associated with significant hepatotoxicity. Swift recognition and cessation of the drug's use are crucial. This case highlights the potential for severe hepatotoxicity even with minimal exposure to celecoxib, underscoring the importance of recognizing this rare but serious adverse reaction.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100353"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empyema caused by Parvimonas micra: A case report 微小细小单胞菌致脓胸1例

Medical Reports Pub Date : 2025-08-26 DOI: 10.1016/j.hmedic.2025.100354

Yali Qiu , Xiwei Zhang , Ying Feng , Lifei Wang

引用次数: 0

Persistent crisis of fetal alcohol spectrum disorder in South Africa: Time for decisive action 南非胎儿酒精谱系障碍的持续危机：采取果断行动的时候了

Medical Reports Pub Date : 2025-08-26 DOI: 10.1016/j.hmedic.2025.100352

Babatope O. Adebiyi , Ferdinand C. Mukumbang

{"title":"Persistent crisis of fetal alcohol spectrum disorder in South Africa: Time for decisive action","authors":"Babatope O. Adebiyi , Ferdinand C. Mukumbang","doi":"10.1016/j.hmedic.2025.100352","DOIUrl":"10.1016/j.hmedic.2025.100352","url":null,"abstract":"<div><div>Fetal Alcohol Spectrum Disorder (FASD) represents a critical public health challenge in South Africa (SA), where the prevalence is among the highest worldwide. This commentary highlights the urgent need for coordinated, multifaceted approaches to address FASD, with prevalence rates as high as 310 per 1000 individuals, particularly in rural communities. Factors contributing to this high prevalence include historical practices like the \"dop system,\" pervasive poverty, limited healthcare access, and social norms around alcohol use. The consequences of FASD are profound, leading to lifelong impairments and significant economic impacts. Alcohol-related harms cost SA around 65–104 billion Rand annually. Despite the magnitude of the issue, SA lacks a comprehensive national strategy, resulting in fragmented services and care gaps. To mitigate this crisis, a combination of prevention, early diagnosis, and community-based interventions is essential. Suggested strategies include public awareness campaigns, integration of FASD prevention into primary healthcare, enhanced diagnostic services, and community empowerment initiatives. A national response involving government agencies, healthcare providers, educational institutions, community organizations, and private sector stakeholders is imperative. With sustained commitment, South Africa can substantially reduce the burden of FASD, ensuring a healthier future for its communities.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100352"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0