An unusual case of doxycycline-induced pancreatitis

Abstract

Doxycycline is a widely used antibiotic known for its effectiveness in treating various bacterial infections. While generally well-tolerated, it has been implicated in rare instances of drug-induced pancreatitis. Early recognition is crucial, as discontinuation of the offending agent typically leads to resolution of symptoms. We present the case of a 46-year-old female with doxycycline-induced pancreatitis, highlighting the diagnostic challenges and emphasizing the importance of considering drug-induced etiologies in patients with unexplained pancreatitis. The absence of other common causes, such as a triglyceride level > 500, gallstones, alcohol use, trauma, or recent procedures, combined with the timing of doxycycline initiation, strongly supports this etiology. Although it is uncommon, physicians should be aware of this possible side effect of doxycycline, especially in patients who are experiencing unexplained abdominal pain. Early recognition and withdrawal of the offending agent are crucial to prevent further complications and future administration of doxycycline should also be avoided.