Menorrhagia as an initial presentation of metastatic malignant melanoma: Case report

Malignant melanoma (MM), an aggressive neural crest derived tumor, is the deadliest form of skin cancer accounting for 1 % of total cancer-related deaths. MM metastases to the female reproductive organs are rare, and the uterus is even less common as a site for these lesions. Following a diagnosis of uterine metastasis from MM, dacarbazine monotherapy, targeted immunotherapies, or potentially radical hysterectomy with bilateral salpingectomy and pelvic lymphadenectomy are the suggested treatment options depending on the patient’s menopausal status and extent of metastatic spread. We describe our experience managing a tricenarian with diffuse metastatic melanoma to the uterus, lung and brain.