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Rapid diagnosis of gastrointestinal perforated viscus in pediatrics: Role of point-of-care ultrasonography 儿科胃肠道穿孔的快速诊断：即时超声检查的作用

Medical Reports Pub Date : 2025-06-05 DOI: 10.1016/j.hmedic.2025.100273

Abdulaziz Hussein

引用次数: 0

Adult-onset still's disease with atypical presentation: A case report 表现不典型的成人发病still病1例报告

Medical Reports Pub Date : 2025-06-04 DOI: 10.1016/j.hmedic.2025.100272

Sila Mateo Faxas , Kim Yen Thi Nguyen

{"title":"Adult-onset still's disease with atypical presentation: A case report","authors":"Sila Mateo Faxas , Kim Yen Thi Nguyen","doi":"10.1016/j.hmedic.2025.100272","DOIUrl":"10.1016/j.hmedic.2025.100272","url":null,"abstract":"<div><div>Adult-Onset Still's Disease (AOSD) is a rare systemic inflammatory disorder with diagnostic challenges due to its non-specific symptoms. This case presents a rarely documented manifestation of sensorineural hearing loss, while demonstrating the utility of novel biomarker interleukin-18 (IL-18) for diagnosis and successful management with modern biologic therapy. The patient initially presented with persistent sore throat, generalized weakness, diffuse synovitis, and an atypical urticarial rash. Notably, he developed left-sided hearing loss. Laboratory findings showed elevated inflammatory markers, including white blood cell count, liver enzymes, creatine kinase, C-reactive protein, erythrocyte sedimentation rate, and ferritin. Elevated interleukin-18 (IL-18) levels played a crucial role in confirming the diagnosis. After a six-year diagnostic journey, treatment progressed from high-dose steroids to biologic therapies. While the patient showed intolerance to Anakinra, he achieved remission with Canakinumab. This case underscores the importance of recognizing uncommon AOSD manifestations such as hearing loss, and demonstrates how novel biomarkers and targeted biologic therapies can improve diagnosis and management of this complex disorder. The case also suggests potential environmental triggers in AOSD, as symptom exacerbation occurred with alcohol and marijuana use.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraventricular neurocysticercosis-induced obstructive hydrocephalus: A case report of cyst migration and multidisciplinary management 脑室内神经囊虫引起的阻塞性脑积水：囊肿迁移和多学科治疗1例报告

Medical Reports Pub Date : 2025-06-04 DOI: 10.1016/j.hmedic.2025.100274

Syed H. Ali , Umer Khan , Youssef Abdullah , Haritha Saikumar

引用次数: 0

Acute Non‐Immune Hemolytic Anemia Secondary to Coronavirus Disease 2019 Infection: A Pediatric Case Report 2019冠状病毒病感染继发急性非免疫性溶血性贫血：一份儿科病例报告

Medical Reports Pub Date : 2025-06-04 DOI: 10.1016/j.hmedic.2025.100276

Einas Mohamed Mahgoub Karar , Eltahir Ahmed Eltahir , Moneer Ali Abdallah , Amel Ahmed Elobied Ali , Muna Mohammed Ahmed Hamid

{"title":"Acute Non‐Immune Hemolytic Anemia Secondary to Coronavirus Disease 2019 Infection: A Pediatric Case Report","authors":"Einas Mohamed Mahgoub Karar , Eltahir Ahmed Eltahir , Moneer Ali Abdallah , Amel Ahmed Elobied Ali , Muna Mohammed Ahmed Hamid","doi":"10.1016/j.hmedic.2025.100276","DOIUrl":"10.1016/j.hmedic.2025.100276","url":null,"abstract":"<div><h3>Background</h3><div>The Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, has emerged as a global health crisis. While primarily known for its respiratory symptoms, COVID-19 can also manifest with a wide range of extrapulmonary complications, including hematological disorders.</div></div><div><h3>Case report</h3><div>This case involves an otherwise healthy 8-year-old child who was admitted to the hospital with symptoms of irritability, fatigue, and red-coloured urine lasting for one day. He was found to be hemodynamically stable, though laboratory tests revealed low hemoglobin levels with signs consistent with hemolysis. A COVID-19 PCR test returned positive. After ruling out immune-mediated causes of hemolysis, a diagnosis of non-immune hemolytic anemia associated with COVID-19 infection was established. The patient was successfully treated with a blood transfusion and supportive measures, leading to a complete recovery. This case highlights the potential for COVID-19 to trigger non-immune hemolytic anemia in pediatric patients.</div></div><div><h3>Conclusion</h3><div>Hemolytic anemia following COVID-19, as an extrapulmonary complication, can manifest as either immune-mediated or non-immune hemolysis. Both forms of Hemolytic anemia in COVID-19 have been observed to respond rapidly to symptomatic treatment, underscoring the significance of prompt therapeutic intervention in managing this rare hematologic complication.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinoglenoid notch cyst: An unusual cause of atrophy – A case report and literature review 脊髓鞘突切迹囊肿：一种罕见的萎缩原因- 1例报告及文献复习

Medical Reports Pub Date : 2025-06-03 DOI: 10.1016/j.hmedic.2025.100269

Wajahat Mirza , Muhammad Sajeel Turab , Atif Iqbal Rana , Sundus Dadan , Hafiz Javaid Iqbal

{"title":"Spinoglenoid notch cyst: An unusual cause of atrophy – A case report and literature review","authors":"Wajahat Mirza , Muhammad Sajeel Turab , Atif Iqbal Rana , Sundus Dadan , Hafiz Javaid Iqbal","doi":"10.1016/j.hmedic.2025.100269","DOIUrl":"10.1016/j.hmedic.2025.100269","url":null,"abstract":"<div><h3>Introduction</h3><div>Spinoglenoid notch cysts are an uncommon clinical-pathologic entity that can result in suprascapular nerve compression and subsequent muscle atrophy, abnormal shoulder movements, and function. Although often seen in association with labral tears, cysts may occur independently and can mimic other more common shoulder problems, resulting in diagnostic dilemmas.</div></div><div><h3>Case presentation</h3><div>A 24-year-old male attended the Orthopedic outpatient department with the complaint of decreased movements and weakness in his right shoulder. MRI showed the presence of a well-defined, lobulated ganglion cyst at the Spinoglenoid notch with associated edema and moderate-grade muscle atrophy in the infraspinatus and teres minor, suggesting compressive neuropathy over the suprascapular nerve. Although surgical decompression is the conventional approach, successful symptom control and functional recovery were obtained by aspiration of the cyst plus steroid injection with an ultrasound-guided procedure.</div></div><div><h3>Management and outcome</h3><div>The patient underwent the procedure in the left lateral decubitus position with sterile preparation and draping. A 16-G LP (16-gauge lumbar puncture needle) was used to aspirate a few millimeters of gelatinous cyst fluid. 2 ml of Bupivacaine (0.5 %), followed by the injection of Depo-Medrol (40 mg), was made into the cyst. There were no adverse effects, and the patient tolerated the procedure very well.</div></div><div><h3>Conclusion</h3><div>The case emphasizes the need for including Spinoglenoid notch cysts in the differential diagnosis of shoulder pain and muscle atrophy without known etiology. Surgery is the most commonly recommended intervention, but percutaneous ultrasound-guided aspiration may be a good alternative treatment option.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary fibrous tumor in the lower limb: A rare case report emphasizing the importance of long-term surveillance 下肢孤立性纤维性肿瘤：罕见病例报告，强调长期监测的重要性

Medical Reports Pub Date : 2025-06-02 DOI: 10.1016/j.hmedic.2025.100270

Giovanna Mafra e Silva , Geovanna Maria Malachias-Pires , Pablo Andre Brito de Souza , Ana Cássia Silva Oliveira , Jessica Vanina Ortiz , Bruna Kempfer Bossoli , Felipe Augusto Cerni , Luis Enrique Bermejo Galan , Roberto Carlos Cruz Carbonell , Manuela Berto Pucca

引用次数: 0

Bilateral pulmonary infiltrates without lymphadenopathy: A fatal case of lung adenocarcinoma and amivantamab-induced pneumonitis 双侧肺浸润无淋巴结病变：肺腺癌合并阿米万他单抗致肺炎1例死亡

Medical Reports Pub Date : 2025-06-02 DOI: 10.1016/j.hmedic.2025.100271

Sathish Kumar Krishnan , Vijaya Sivalingam Ramalingam , Melissa Johnson , Venu Pararath Gopalakrishnan

{"title":"Bilateral pulmonary infiltrates without lymphadenopathy: A fatal case of lung adenocarcinoma and amivantamab-induced pneumonitis","authors":"Sathish Kumar Krishnan , Vijaya Sivalingam Ramalingam , Melissa Johnson , Venu Pararath Gopalakrishnan","doi":"10.1016/j.hmedic.2025.100271","DOIUrl":"10.1016/j.hmedic.2025.100271","url":null,"abstract":"<div><div>Lung cancer can present radiologically as diffuse lung infiltrates, often mimicking pneumonia or interstitial lung disease (ILD). This atypical presentation may result in prolonged treatment with antibiotics or corticosteroids before malignancy is considered. Amivantamab, an EGFR-MET bispecific antibody, is an effective treatment of EGFR exon 20-mutated non-small cell lung cancer (NSCLC), but carries a risk of drug-induced pneumonitis, a rare yet potentially fatal complication. In our case, a 72-year-old woman presented with a persistent six-month cough, initially treated as bronchitis without imaging. Despite multiple antibiotic courses, her symptoms worsened, leading to imaging that revealed bilateral lung infiltrates without lymphadenopathy, lowering clinical suspicion for malignancy. An initial bronchoscopy with bronchoalveolar lavage (BAL) cytology was negative for malignancy, further delaying oncologic evaluation. Ultimately, a surgical lung biopsy confirmed the diagnosis of lung adenocarcinoma. She was diagnosed with stage IV disease and treated with carboplatin, pemetrexed, and pembrolizumab, but tumor progression led to amivantamab initiation. After six months of therapy, she developed progressive dyspnea and diffuse ground-glass opacities, consistent with drug-induced pneumonitis. Despite high-dose corticosteroids, her respiratory status rapidly deteriorated, ultimately resulting in fatal respiratory failure.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small bowel intussusception and GI bleed secondary to metastatic melanoma: A case report and literature review 转移性黑色素瘤继发于小肠肠套叠和消化道出血：1例报告并文献复习

Medical Reports Pub Date : 2025-05-31 DOI: 10.1016/j.hmedic.2025.100266

Philippe Attieh , Karam Karam , Elias Fiani , Ihab I. El Hajj

{"title":"Small bowel intussusception and GI bleed secondary to metastatic melanoma: A case report and literature review","authors":"Philippe Attieh , Karam Karam , Elias Fiani , Ihab I. El Hajj","doi":"10.1016/j.hmedic.2025.100266","DOIUrl":"10.1016/j.hmedic.2025.100266","url":null,"abstract":"<div><div>Malignant melanoma (MM) is the most common malignancy to metastasize to the gastrointestinal (GI) tract, with the small bowel being the most frequently affected site. GI metastases often remain asymptomatic but can present with abdominal pain, weight loss, obstruction, or bleeding. Diagnosis relies on imaging and endoscopic techniques, with PET-CT being the most sensitive. We report a case of a 58-year-old woman with a history of cutaneous melanoma in situ excised 26 years ago, now presenting with a 3-month history of abdominal symptoms, melena, and weight loss. Work-up revealed anemia and positive occult blood, with negative gastroscopy and colonoscopy. CT confirmed jejuno-jejunal intussusception, and enteroscopy identified multiple pigmented lesions. Biopsy confirmed malignant melanoma, and PET-CT showed multifocal involvement. The patient underwent laparotomy with bowel resection and jejunostomy, followed by immunotherapy, leading to complete tumor resolution and no recurrence on follow-up PET-CT. This case report highlights a very rare finding of small bowel metastasis after cutaneous melanoma-in situ excision leading to jejuno-jejunal intussusception, with disease free interval of over 25 years.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100266"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ceftriaxone-induced hypersensitivity in pregnancy: Insights from a case of variable reactions to different brands 妊娠期头孢曲松致超敏反应：对不同品牌不同反应的个案分析

Medical Reports Pub Date : 2025-05-30 DOI: 10.1016/j.hmedic.2025.100263

Mohammad Ashraful Amin , Sadia Monami , Tasnim Zerin Shama , Sabrina Nahin , Mohammad Delwer Hossain Hawlader

{"title":"Ceftriaxone-induced hypersensitivity in pregnancy: Insights from a case of variable reactions to different brands","authors":"Mohammad Ashraful Amin , Sadia Monami , Tasnim Zerin Shama , Sabrina Nahin , Mohammad Delwer Hossain Hawlader","doi":"10.1016/j.hmedic.2025.100263","DOIUrl":"10.1016/j.hmedic.2025.100263","url":null,"abstract":"<div><div>Ceftriaxone, a third-generation cephalosporin, is widely used for its broad-spectrum antibacterial activity but poses challenges in managing hypersensitivity reactions, particularly in pregnant patients. This case study explores a 35-year-old woman in her second trimester of a twin pregnancy with a history of gestational diabetes mellitus and pregnancy-induced hypertension. She was referred for a urinary tract infection (UTI) caused by Klebsiella pneumoniae. Initial treatments with erythromycin and sulbactam/cefoperazone were ineffective, leading to the use of ceftriaxone. A skin test revealed severe hypersensitivity to ceftriaxone from one manufacturer (\"Brand A\") but not to another (\"Brand B\"). After careful consideration, a 10-day course of parenteral ceftriaxone from Brand B was administered without adverse reactions. The observed variability in hypersensitivity reactions between different brands of ceftriaxone highlights the potential influence of formulation differences on patient tolerance. This underscores the importance of individualized patient assessment, including skin testing necessary, to ensure both safety and efficacy, particularly in high-risk populations such as pregnant patients. This finding emphasizes the necessity for skin testing in pregnant patients where treatment options are limited and both maternal and fetal safety are paramount.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impending gastric volvulus with multifactorial etiology – A case report 多因素病因的临发性胃扭转1例

Medical Reports Pub Date : 2025-05-30 DOI: 10.1016/j.hmedic.2025.100261

Bipneet Singh , Zachary Saleh , Syed Adil , Palak Grover , Suraj Suresh

{"title":"Impending gastric volvulus with multifactorial etiology – A case report","authors":"Bipneet Singh , Zachary Saleh , Syed Adil , Palak Grover , Suraj Suresh","doi":"10.1016/j.hmedic.2025.100261","DOIUrl":"10.1016/j.hmedic.2025.100261","url":null,"abstract":"<div><div>Gastric volvulus is a rare diagnosis, often missed, but fatal in the setting of gastric ischemia. People with a surgical abdomen or with anatomic disturbances are at higher risk and should be evaluated when nausea and vomiting go unexplained. People might get labelled with functional disorders, preventing further investigation. Lastly, if and when diagnosed, aggressive management, including surgical management, should be undertaken. In our case the patient presented with recurrent nausea and vomiting. She had been treated for reflux disease in the past with fundoplication and had been treated for cyclic vomiting, gastroparesis without much relief. Endoscopies were unremarkable till a study done during an active episode demonstrated volvulus. This highlights the importance of high suspicion amongst surgical cases since the endoscopic studies are non-revealing outside of the episode. Endoscopy also holds therapeutic value with detorsion techniques. Surgical fixation is considered the definitive treatment to avoid potential complications, including bowel ischemia/necrosis and death. The patient finally underwent anterior gastropexy with symptom resolution.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100261"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0