Rare coinheritance of HbQ India trait and sickle cell trait (HbS): A novel co-inheritance documented in pregnancy

Kartavya Kumar Verma
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Abstract

Globally, hemoglobinopathies are among the most widespread inherited genetic disorders affecting red blood cells. However, the co-inheritance of HbQ India and HbS is a rare occurrence and has been infrequently reported in the medical literatures. Our case study describes a 38-year-old pregnant woman with sickle cell trait along with HbQ India co-inheritance. We hypothesized that, owing to the absence of changes in charge or morphology of red blood cells, the HBQ India trait whether expressed independently or through co-inheritance does not lead to hemolytic anemia. In this case, the hemogram findings revealed pregnancy-associated iron deficiency anemia, with no severe hemolytic complications experienced during the eighth month of pregnancy. No cases have been reported involving this co-inheritance during pregnancy, making this case particularly unique and insightful regarding its implications in that context. Investigating these co-inheritances appears feasible in regions with a high incidence of sickle cell disease, such as central India, particularly in Chhattisgarh. However, to date, no significant hemolytic activity has been reported in the absence of any secondary causes related to this condition, indicating a need for further research.
HbQ印度性状和镰状细胞性状(HbS)的罕见共遗传:妊娠中记录的一种新的共遗传
在全球范围内,血红蛋白病是影响红细胞的最普遍的遗传性疾病之一。然而,HbQ印度和HbS的共同遗传是一种罕见的现象,在医学文献中很少报道。我们的案例研究描述了一名38岁的孕妇,患有镰状细胞特征和HbQ印度共遗传。我们假设,由于红细胞的电荷或形态没有变化,HBQ印度性状无论是独立表达还是通过共遗传都不会导致溶血性贫血。在本例中,血象检查结果显示妊娠相关性缺铁性贫血,妊娠第8个月期间没有出现严重的溶血并发症。没有关于怀孕期间这种共同遗传的病例报告,这使得本病例在这方面的影响特别独特和有见地。在镰状细胞病高发地区,如印度中部,特别是恰蒂斯加尔邦,调查这些共遗传似乎是可行的。然而,到目前为止,在没有任何与这种情况相关的继发原因的情况下,没有明显的溶血活动的报道,这表明需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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