Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-07-25DOI: 10.1016/j.cclet.2025.111636
Pengwei Tan , Shuyang Shen , Yuanyuan Luo , Guotao Duan
{"title":"In-situ growth of high-crystallinity M3(hexaaminotriphenylene)2 (M = Co, Ni) thin film for field-effect transistor-based glucose biosensor","authors":"Pengwei Tan , Shuyang Shen , Yuanyuan Luo , Guotao Duan","doi":"10.1016/j.cclet.2025.111636","DOIUrl":"10.1016/j.cclet.2025.111636","url":null,"abstract":"<div><div>The integration of advanced sensing materials as channel layers in devices is essential for constructing field-effect transistor (FET) biosensors. In this study, we synthesized high-crystallinity bimetallic M<sub>3</sub>(hexaaminotriphenylene)<sub>2</sub> (M = Co, Ni) thin films as FET channel materials <em>via</em> an <em>in-situ</em> growth method using a mixed solvent system of water and <em>N,N</em>-dimethylformamide (DMF). This bimetallic metal-organic framework (MOF)-based FET then served as a glucose biosensor, achieving a high sensitivity and an ultra-wide detection range from 10 nmol/L to 10 mmol/L. Further studies reveal that the success of <em>in-situ</em> growth of the high-crystalline bimetallic MOF film can be attributed to the coordination solvent exchange reaction between the metal atomic center, DMF, and water. Furthermore, the introduction of bimetallic centers enhances the number of active sites within the MOF, thereby achieving an ultra-low detection limit and an ultra-wide detection range. This work presents a versatile approach for constructing high performance FET biosensors.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111636"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-07-23DOI: 10.1016/j.cclet.2025.111619
Siyi Zou , Ali Hammad , Jiahao Huang , Yuzhuo Jiang , Bin Tian , Fandi Ning , Wei Li , Qinglin Wen , Xingyu Zhu , Xiaochun Zhou
{"title":"Gel/nonwoven composite membrane with dual water transport pathways for controlling hydrogen production by regulating water vapor absorption and diffusion","authors":"Siyi Zou , Ali Hammad , Jiahao Huang , Yuzhuo Jiang , Bin Tian , Fandi Ning , Wei Li , Qinglin Wen , Xingyu Zhu , Xiaochun Zhou","doi":"10.1016/j.cclet.2025.111619","DOIUrl":"10.1016/j.cclet.2025.111619","url":null,"abstract":"<div><div>Calcium hydride (CaH<sub>2</sub>) is a hydrogen storage material with high hydrogen storage density that is easy to transport and store. However, its hydrogen generation process is intense and liquid water causes uneven reactions in CaH<sub>2</sub>. These two issues make the reaction of CaH<sub>2</sub> hard to control. To resolve the issues, a gel/nonwoven fabric composite material was prepared using nonwoven fabric and poly(vinyl alcohol)/polyacrylamide (PVA/PAM) hydrogel, and applied to a compact hydrogen generator. Water absorption and evaporation tests on composite membranes confirm that the membrane can control the water transport rate by adjusting the gel content, thereby regulating the hydrogen production of CaH<sub>2</sub>. During the hydrolysis of CaH<sub>2</sub>, the heat released promotes water evaporation, which absorbs some of this heat and helps maintain both temperature and water balance. When the gel content was 10 %, the height of the separator was 1 mm, and the mass of CaH<sub>2</sub> was 1.5 g, the hydrogen generator achieved the fastest hydrogen production rate of 58.7 mL/min. Moreover, after expanding the size of the hydrogen generator, it can continuously produce hydrogen for over 260 min at room temperature. Finally, hydrogen was supplied to a proton exchange membrane fuel cell (PEMFC) stack. This research provides a new concept for controllable hydrogen production and portable fuel cells.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111619"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-04-16DOI: 10.1016/j.cclet.2025.111225
Shihaozhi Wang, Jia-Hui Shi, Shan Xu, Xue-Jing Zhang, Ming Yan
{"title":"Palladium-catalyzed carbene CH insertion reaction of non-activated arenes","authors":"Shihaozhi Wang, Jia-Hui Shi, Shan Xu, Xue-Jing Zhang, Ming Yan","doi":"10.1016/j.cclet.2025.111225","DOIUrl":"10.1016/j.cclet.2025.111225","url":null,"abstract":"<div><div>In this study, we report a palladium-catalyzed carbene C<img>H insertion reaction of non-activated arenes using <em>N</em>-tosylhydrazones as both carbene and olefin precursors. This method consists of a two-step, one-pot process, where the arenes are first thianthrenated and then undergo migratory insertion/<em>β</em>-H elimination with <em>N</em>-tosylhydrazones to form aryl alkenes. This highly site-selective C<img>H alkenylation of arenes demonstrates a relatively broad substrate scope and exhibits high tolerance for halogen substituents. Importantly, this transformation allows for the modification of the arene moiety in commercially available bioactive molecules, underscoring its significant potential for late-stage functionalization of arene-containing pharmaceuticals.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111225"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-08-26DOI: 10.1016/j.cclet.2025.111754
Qiao Li , Yijian Chen , Meihua Zhu , Houhou Huang , Fu-Quan Bai , Linglong Hu , Rui Gao , Hongji Xu , Chaoqun Qu , Ming Feng
{"title":"Constructing robust anode/electrolyte interface by additive in hydrogel to achieve high utilization of Zn anode","authors":"Qiao Li , Yijian Chen , Meihua Zhu , Houhou Huang , Fu-Quan Bai , Linglong Hu , Rui Gao , Hongji Xu , Chaoqun Qu , Ming Feng","doi":"10.1016/j.cclet.2025.111754","DOIUrl":"10.1016/j.cclet.2025.111754","url":null,"abstract":"<div><div>Hydrogel electrolyte have attracted widely interest for aqueous zinc-ion batteries because of their multi-functionality and intrinsic safety. However, the unstable anode/electrolyte interface by dendrite and side reaction (HER) restricted the cycling of Zn anode, especially at high utilization. Herein, we propose an interface engineering strategy by introducing dimethylformamide (DMF) to polyacrylamide (PAM) electrolyte which could construct the polymer-inorganic bilayer solid electrolyte interphase (SEI) to improve the interface stability and compatibility. Internal Zn<sub>5</sub>(OH)<sub>6</sub>(CO<sub>3</sub>)<sub>2</sub> provided high modulus to suppress the dendrite physically and external polymer exhibited flexibility to accommodate the volume change of Zn during cycles. Meanwhile, larger polymer clusters were induced by enhanced hydrogen-bond interactions, resulted in higher shear strength and interfacial adhesion. Additionally, DMF regulated the crystal orientation along (100) crystal plane and solvation structure of Zn<sup>2+</sup> with PAM, enabling dense deposition and reduced by-products. Consequently, the Zn anode could provide an impressive lifespan (0.5 mA/cm<sup>2</sup>@0.5 mAh/cm<sup>2</sup>, 4000 h; 30 mA/cm<sup>2</sup>@15 mAh/cm<sup>2</sup>, 650 h). More importantly, high utilization (68 %) was achieved using ultra-thin Zn (10 μm) with superior stability (2 mA/cm<sup>2</sup>@4 mAh/cm<sup>2</sup>, 1200 h). Coupled with iodine cathode, the Zn-I<sub>2</sub> cell could provide an initial capacity of 184.5 mAh/g at the low ratio of anode/cathode capacity (N/P: 4.3) and ∼86.4 % retention over 500 cycles. This work provides a promising approach to construct robust interface by hydrogel electrolyte towards practical zinc-ion batteries.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111754"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-08-11DOI: 10.1016/j.cclet.2025.111705
Xinrui Zhang , Hui Chen , Tingting Fan , Xueming Zhu , Ying Tan , Dan Gao
{"title":"A microfluidic biosensor based on multiple signal amplification for rapid and sensitive detection of E. coli O157:H7 and Staphylococcus aureus","authors":"Xinrui Zhang , Hui Chen , Tingting Fan , Xueming Zhu , Ying Tan , Dan Gao","doi":"10.1016/j.cclet.2025.111705","DOIUrl":"10.1016/j.cclet.2025.111705","url":null,"abstract":"<div><div><em>E. coli</em> O157:H7 and <em>Staphylococcus aureus</em> have emerged as significant foodborne pathogens, characterized by considerable incidence rates and mortality. Despite advancements, current detection methods are hindered by challenges in enhancing specificity and sensitivity. Herein, we introduced a cutting-edge biosensor that employs a novel CHA-coupled CRISPR multi-stage signal amplification technique for the rapid and ultra-sensitive detection of these two pathogens. This microfluidic device consisted of an upstream serpentine mixing channel and a downstream boat-shaped microcavity equipped with a micro-column array, facilitating efficient reagent mixing, robust CHA amplification, and CRISPR reactions. Multiple signal amplification was achieved through bacterial competitive binding triggered by catalytic hairpin assembly (CHA) and crRNA-mediated CRISPR reactions. Based on this platform, the detection of target bacteria is transformed into nucleic acid detection, with a maximum detection range of 134 CFU/mL for <em>E. coli</em> O157:H7 and 181 CFU/mL for <em>Staphylococcus aureus</em>, which were better or comparable to previously reported biosensors. The entire assay was completed within approximately 1.5 h, with a minimal sample volume requirement of just 10 µL. The biosensor exhibited a high recovery rate, ranging from 95% to 115%, and demonstrated excellent specificity towards the target bacteria. In summary, this biosensor offers a rapid, accurate, and highly sensitive tool for food safety and clinical diagnostics.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111705"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-06-13DOI: 10.1016/j.cclet.2025.111463
Sijia Zhang , Guangyu Bi , Wen-Qiang Li , Yang Wang , Xian-Yang Shi
{"title":"Activated energy transfer pathway in carbon nitride nanosheets promotes molecular oxygen activation for robust and efficient water decontamination","authors":"Sijia Zhang , Guangyu Bi , Wen-Qiang Li , Yang Wang , Xian-Yang Shi","doi":"10.1016/j.cclet.2025.111463","DOIUrl":"10.1016/j.cclet.2025.111463","url":null,"abstract":"<div><div>Carbon nitride (CN)-based photocatalytic processes hold promise for water decontamination, during which the widely acknowledged charge transfer pathway is unfortunately characterized by severe chemical stability challenges. Herein, the intensive yet underestimated energy transfer pathway is achieved in CN nanosheets for durable, efficient, and sustainable water purification. Upon simple oxygen activation in air, the synthesized nanosheets come with an optimal pollutant removal rate constant of 0.18 min<sup>−1</sup> under visible light irradiation, far exceeding that of state-of-the-art photocatalysts. It is revealed that the enhanced exciton binding energy inside the CN nanosheets triggers strong exciton effects, promoting the accumulation of triplet-state excitons by regulating the energy gap. The accumulated triplet excitons almost accomplish the transition from oxygen exclusively to singlet oxygen <em>via</em> the energy transfer pathway, which ultimately contributes to the robust degradation of the pollutants. This work proposes a viable strategy to enhance the exciton effect within CN, upon which efficient water treatment technology driven by energy transfer pathways can be expected.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111463"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-07-24DOI: 10.1016/j.cclet.2025.111627
Ying Li , Zelin Wu , Xiaoyu Liu , Bingkun Huang , Jing Zhang , Yanbiao Shi , Chuan-Shu He , Zhaokun Xiong , Xingxing An , Bo Lai
{"title":"Matching molecular scale with active site spacing induces distinct mechanisms in single-atom catalysts for persulfate activation","authors":"Ying Li , Zelin Wu , Xiaoyu Liu , Bingkun Huang , Jing Zhang , Yanbiao Shi , Chuan-Shu He , Zhaokun Xiong , Xingxing An , Bo Lai","doi":"10.1016/j.cclet.2025.111627","DOIUrl":"10.1016/j.cclet.2025.111627","url":null,"abstract":"<div><div>Extensive research has been devoted to single-atom activation of persulfates in recent years. However, mechanistic understanding of the distinct interactions between different persulfates (<em>i.e.</em>, peroxymonosulfate (PMS) and peroxydisulfate (PDS)) and the coordination environments of single-atom catalysts (SACs) remains critical for advancing their practical applications. Herein, we developed a Fe-N<sub>4</sub> SAC exhibiting dual activation capabilities for both PMS and PDS. Intriguingly, experimental results revealed divergent activation mechanisms: PMS activation was predominantly mediated <em>via</em> single-site reactions generating singlet oxygen (<sup>1</sup>O<sub>2</sub>), whereas PDS activation proceeded through both dual-site and single-site pathways involving concurrent <sup>1</sup>O<sub>2</sub> generation and electron transfer processes. Density functional theory calculations further demonstrated that the geometric alignment between the inter-site distances of Fe-N<sub>4</sub> centers and the molecular dimensions of PDS serves as the key determinant for enabling the electron transfer pathway. This fundamental structure-reactivity correlation suggests that the intrinsic molecular-scale differences between PMS and PDS govern their distinct interaction mechanisms with Fe-N<sub>4</sub> SACs. Finally, the scale-up experiments realized nearly complete sulfamethoxazole degradation during 120 h continuous operation without obvious decline in both the Fe-N<sub>4</sub>/PMS and Fe-N<sub>4</sub>/PDS systems. This work provides fundamental insights into molecular-scale effects on persulfate activation mechanisms, establishing new design principles for SACs optimization in advanced oxidation processes.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111627"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-07-05DOI: 10.1016/j.cclet.2025.111547
Ruijing Wang , Shixuan Wang , Chenghui Zhu , Jianze Zhang , Richard N. Zare , Chongqin Zhu , Xinxing Zhang
{"title":"Increased acidity of nitrogen heterocyclic compounds on water microdroplets facilitates CO2 capture","authors":"Ruijing Wang , Shixuan Wang , Chenghui Zhu , Jianze Zhang , Richard N. Zare , Chongqin Zhu , Xinxing Zhang","doi":"10.1016/j.cclet.2025.111547","DOIUrl":"10.1016/j.cclet.2025.111547","url":null,"abstract":"<div><div>Species at the air-water interface of microdroplets often display distinct acidity compared to the bulk. In this study, we report that pyrrole, imidazole, pyrazole, and 2<em>H</em>-1,2,3-triazole, a group of five-membered, planar, aromatic, nitrogen heterocyclic compounds that are basic in bulk water, exhibit strong acidity on microdroplets. The deprotonated anions of pyrrole, imidazole, and pyrazole can further react with CO<sub>2</sub> to generate the corresponding carboxylic acids, but the triazole anion does not react with CO<sub>2</sub>. Calculation shows that partial solvation and the electric field on the air-water interface of the microdroplets are the main causes for the increased acidity, and the unique solvation structure of the triazole anion at the interface causes the reactive sites to be shielded by interfacial water molecules, thereby hindering reaction with CO<sub>2</sub>. These results demonstrate that the electric field and solvation structure of ions at the air-water interface play a decisive role in microdroplet chemistry for these compounds. We anticipate that the unique acidity and reactivity on microdroplets provide a new avenue that is rich in opportunities for green chemistry.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111547"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-05-20DOI: 10.1016/j.cclet.2025.111352
Zheng-Yi Li, Tao Li, Zuquan Wang, Yi Zhao, Jing Shi, Xiaoqiang Sun, Ke Yang
{"title":"Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst","authors":"Zheng-Yi Li, Tao Li, Zuquan Wang, Yi Zhao, Jing Shi, Xiaoqiang Sun, Ke Yang","doi":"10.1016/j.cclet.2025.111352","DOIUrl":"10.1016/j.cclet.2025.111352","url":null,"abstract":"<div><div>The cycloaddition of epoxides and CO<sub>2</sub> has been achieved by using the designed upper-rim functionalized calix[4]arene organocatalyst in aqueous at a mild temperature under normal pressure. The upper rim of this novel calix[4]arene organocatalyst contains two hemisquaramides at the 1,4-positions. A variety of cyclic carbonate derivatives were obtained in good yields, demonstrating excellent compatibility with various functional groups. The π···π supramolecular interaction between the calixarene cavity and epoxide substrate may also play a significant role in facilitating this cycloaddition process. Additionally, this novel reaction offers a valuable complementary approach to synthesizing cyclic carbonates from epoxides and CO<sub>2</sub>.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111352"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese Chemical LettersPub Date : 2026-04-01Epub Date: 2025-04-18DOI: 10.1016/j.cclet.2025.111235
Kairong Yang , Bingbing Zheng , Fapu Wu , Bijia Zhou , Lijun Li , Hu Xiong
{"title":"H2S-activated near-infrared fluorescent probe for detecting colon cancer and rapid fecal analysis","authors":"Kairong Yang , Bingbing Zheng , Fapu Wu , Bijia Zhou , Lijun Li , Hu Xiong","doi":"10.1016/j.cclet.2025.111235","DOIUrl":"10.1016/j.cclet.2025.111235","url":null,"abstract":"<div><div>Colon cancer is one of the malignant tumors with high morbidity and mortality worldwide, and its etiology is closely related to high levels of hydrogen sulfide (H<sub>2</sub>S). To date, H<sub>2</sub>S-activated near-infrared (NIR) fluorescent (FL) probes with high tumor tropism are still scarce. In this work, we created a new NIR FL probes (Cy-DG) that enables colon cancer targeted imaging and rapid fecal optical analysis by introducing an H<sub>2</sub>S-recognition moiety and two <span>d</span>-glucosamine fragments on the scaffold of QCy7. Cy-DG exhibits excellent properties, including specific \"off-on\" response toward H<sub>2</sub>S, intense NIR emission at 703 nm, large Stokes shift (118 nm), and high sensitivity (limit of detection (LOD), 0.48 µmol/L). Notably, the presence of <span>d</span>-glucosamine allows Cy-DG to be preferentially taken up by cancer cells. After intravenous administration, Cy-DG was able to efficiently accumulate in a MC38 intestinal cancer model and sensitively detect endogenous H<sub>2</sub>S <em>in vivo</em>, showing 5.94-fold higher fluorescence intensity in small tumors <5 mm. Furthermore, Cy-DG was successfully used to detect H<sub>2</sub>S in feces samples from colon cancer-bearing mice. We believe that Cy-DG has great potential as a powerful diagnostic tool for H<sub>2</sub>S-related disorder and stool examinations in the future.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111235"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}