Chinese Chemical Letters最新文献

{"title":"NIR-enhanced oxidase-like activity of manganese dioxide nanoparticles for combating subcutaneous methicillin-resistant Staphylococcus aureus infections","authors":"Jing Zhao ,&nbsp;Tian Huang ,&nbsp;Dongyang Zhang ,&nbsp;Jianliang Shen ,&nbsp;Jintao Wang","doi":"10.1016/j.cclet.2025.111199","DOIUrl":"10.1016/j.cclet.2025.111199","url":null,"abstract":"<div><div>The inappropriate use of antibiotics has led to the emergence of drug-resistant bacteria and the formation of persistent biofilms, rendering conventional antibiotics ineffective against these infections. To address this challenge, the enzyme-like activity of nanozymes, particularly those with photothermal effects, is being explored. However, the development of nanozymes is hindered by the complex synthesis processes involved and the consumption of reactive oxygen species (ROS) by reducing products in bacteria. This article presents an interesting strategy utilizing near-infrared laser-enhanced oxidase-like (OXD-like) activity of manganese dioxide nanoparticles (MnO₂ NPs) to combat subcutaneous infections caused by methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). MnO₂ NPs, characterized by flower-like morphology and broad near-infrared absorption, exhibited favorable OXD-like activity and a stable photothermal effect. Experiments <em>in vitro</em> revealed that the combined high thermal effect and the substantial production of ROS effectively targeted MRSA and disrupted biofilm. The efficacy of MnO₂ <em>in vivo</em> was validated through the establishment of a subcutaneous abscess model. Additionally, a series of biosafety tests, including routine blood tests and blood biochemistry analyses, confirmed the safety of MnO₂ <em>in vivo</em>. Collectively, these findings suggest that combination therapy involving MnO₂ presents a promising therapeutic approach for addressing infections associated with biofilms and drug-resistant bacteria.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111199"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for fabrication and potential applications of conjugated microporous polymer films","authors":"Wang Wang ,&nbsp;Miao Feng ,&nbsp;Shuqi Zou ,&nbsp;Chunxia Chen ,&nbsp;Jinsong Peng ,&nbsp;Xiaobai Li ,&nbsp;Shitong Zhang ,&nbsp;Xin Ai ,&nbsp;Hongwei Ma","doi":"10.1016/j.cclet.2025.111611","DOIUrl":"10.1016/j.cclet.2025.111611","url":null,"abstract":"<div><div>Conjugated microporous polymers (CMPs) are a class of materials characterized by their rigid <em>π</em>-conjugated network, adjustable microporous structures, and high mechanical strength. Due to these exceptional structural features, CMPs have demonstrated outstanding potential and performance in molecular separation, energy storage, sensors, optoelectronic devices, and catalysts. It has garnered significant attention. However, despite the considerable attention and work paid to synthesizing CMP, the challenges associated with processing it in powders are frequently disregarded. Thus, future advancements must focus on developing strategies to obtain CMPs as film form and how they performed when they are integrated in devices such as batteries, LEDs, supercapacitors, sensors, and solar cells. This paper provides a comprehensive and detailed review of the most recent advances in fabrication strategies and their applications for CMP films as well as the challenges.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111611"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of theoretical calculations in alkali metal-ion battery investigation","authors":"Hanmei Zhang ,&nbsp;Xiaoxu Liu ,&nbsp;Tianyi Ji ,&nbsp;Jianxin Ran ,&nbsp;Yang Li ,&nbsp;Zexiang Shen ,&nbsp;Xiaofeng Wang","doi":"10.1016/j.cclet.2024.110790","DOIUrl":"10.1016/j.cclet.2024.110790","url":null,"abstract":"<div><div>Alkali metal-ion batteries, such as lithium-ion and sodium-ion batteries, have been widely recognized by both academia and industry for their high energy density, long cycle life, low self-discharge rate, and environmental friendliness. Theoretical calculations are crucial in elucidating the energy storage mechanism of alkali metal-ion batteries and in designing the next generation of high-performance energy storage systems. This article reviews the application of theoretical calculations in alkali metal-ion batteries. These calculations are instrumental for experimental researchers in understanding the microscopic design of electrode materials, optimizing various interfaces and electrolyte structures, and clarifying ion and electron transport behaviors as well as electrochemical reaction mechanisms. Specifically, researchers typically calculate the reduction reactions, charge state changes, and structural changes of cathode materials to predict their electrochemical reactivity and optimize their performance and stability. Calculations and simulations of alkali metal batteries focus on ion transport dynamics within the electrolyte, including energy level distribution, solvation structure, and molecular dynamics simulations. Analyzing oxidation reactions, ion diffusion, and volume changes in various alkali metal-ion battery anode materials enables the screening and design of new anode materials with superior electrochemical properties. This review also discusses the challenges of applying theoretical calculations in alkali metal-ion batteries and provides an outlook for future research. Critical insights are offered for advancing research paradigms that integrate theoretical and experimental approaches in the development of energy storage electrode materials.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 110790"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An erucin-anchored polymer with excellent amyloidosis inhibition and direct cell membrane penetration ability for intracellular protein delivery","authors":"Le Chen ,&nbsp;Hui Wang ,&nbsp;Yiyun Cheng","doi":"10.1016/j.cclet.2025.111172","DOIUrl":"10.1016/j.cclet.2025.111172","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, marked by a variety of pathological hallmarks such as oxidative stress (OS), metal accumulation, and the aggregation of amyloid-beta (A<em>β</em>) proteins. Erucin, a natural compound present in cruciferous plants, has demonstrated promising therapeutic potential in modulating neurodegenerative diseases, hinting at its neuroprotective capabilities. In this study, we engineered an innovative intracellular protein delivery system centered around erucin. This delivery platform operates through a cell membrane perforation mechanism, enabling the swift translocation of target proteins into the cytoplasm. As a result, it substantially shortens the time required for the proteins to exert their functions. Significantly, this delivery system inherently possesses the capacity to inhibit A<em>β</em> aggregation. In PC12 cell models, the delivery of the antioxidant enzyme superoxide dismutase (SOD) successfully mitigated the OS triggered by A<em>β</em> aggregation and decreased cytotoxicity. This multifaceted therapeutic strategy holds great promise as an effective approach for the treatment of AD.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111172"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanodelivery strategies modulating tumor stromal cells for reverting the immunosuppressive tumor microenvironment","authors":"Jiayi Sun ,&nbsp;Luyao Huang ,&nbsp;Wenfeng Jia ,&nbsp;Yitong Liu ,&nbsp;Li Xiang ,&nbsp;Xing Yang ,&nbsp;Fan Tong ,&nbsp;Xiaobo Wang ,&nbsp;Huile Gao ,&nbsp;Yi Zhang","doi":"10.1016/j.cclet.2025.112036","DOIUrl":"10.1016/j.cclet.2025.112036","url":null,"abstract":"<div><div>In contrast to conventional cancer treatment modalities, cancer immunotherapy has increasingly emerged as one of the most promising therapeutic approaches for cancer, owing to its capacity to elicit long-lasting immune memory and its favorable safety profile. However, the immunosuppressive tumor microenvironment (ITME) significantly hinders its progression. While tumor stromal cells play a crucial role in the formation of the ITME, they also offer several potential targets for interventions aimed at reshaping this suppressive milieu. In clinical practice, the modulating of tumor stromal cells overcomes resistance mechanisms, exhibits broader therapeutic potential, and allows for more manageable toxicity profiles. Owing to the capacity of nanodrug delivery systems (nano-DDS) to facilitate accurate targeting and integrate multiple functions, a growing number of researchers are employing nano-DDS in the immunotherapy modulated to tumor stromal cells. This review begins by elucidating the roles played by different tumor stromal cells in the formation of the ITME. Subsequently, we provide the nanodelivery strategies modulating distinct tumor stromal cells. Finally, we propose the current challenges and discuss potential future development directions in this field.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 112036"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism and origins of enantioselectivity of iridium-catalyzed atroposelective intermolecular C(sp2)-H silylation: A ligand-enabled axial chirality transfer strategy","authors":"Deng Pan ,&nbsp;Chuan He ,&nbsp;Genping Huang","doi":"10.1016/j.cclet.2025.111217","DOIUrl":"10.1016/j.cclet.2025.111217","url":null,"abstract":"<div><div>Density functional theory calculations were performed to investigate the iridium-catalyzed atroposelective intermolecular C<img>H silylation of 2-arylisoquinolines. The Ir(III) hydride species was identified as the active catalyst species of the reaction. The computations show that the reaction occurs through the Ir(III)/Ir(V) catalytic cycle. The C(sp²)-H oxidative addition represents the rate- and enantioselectivity-determining step. The distortion/interaction and structural analyses reveal that the BINEPINE skeleton of the PSiSi ligand creates an axially chiral pocket for the C<img>H oxidative addition, providing a ligand-enabled axial chirality transfer strategy responsible for the observed enantioselectivity. The match/mismatch in axial chirality between reacting 2-arylisoquinolines and the BINEPINE skeleton of the PSiSi ligand plays a key role in governing enantioselectivity.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111217"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co–activation of periodate by plasma/Fe2+ for efficient degradation of emerging contaminants: More radical generation and lower activation barrier","authors":"Liangrui Xiang ,&nbsp;Tianyu Lu ,&nbsp;Wenxuan Jiang ,&nbsp;Yexiang Yang ,&nbsp;Shuang Yang ,&nbsp;Chendong Puyang ,&nbsp;He Guo ,&nbsp;Shoufeng Tang ,&nbsp;Tiecheng Wang","doi":"10.1016/j.cclet.2025.111708","DOIUrl":"10.1016/j.cclet.2025.111708","url":null,"abstract":"<div><div>Dielectric barrier discharge (DBD) plasma combined with Fe²⁺ for periodate (PI) activation was proposed for emerging contaminants treatment. The feasible, activation mechanism, degradation mechanism were comprehensively analyzed. Results showed that within 6 min treatment time, the degradation efficiency of sulfadiazine (SDZ) could reach 68.1%, 78.5% and 90.2% in DBD, DBD/PI and DBD/PI/Fe²⁺, respectively. The energy efficiency can also be improved from 47.24 mg/kWh (DBD) to 78.43 mg/kWh (DBD/PI/Fe²⁺). Compared with DBD system, the PI activation energy barrier in DBD/Fe²⁺ system is significantly decreased. Electron spin resonance (ESR) proved the existence of ^•OH, ¹O₂ and ^•O₂⁻ in DBD/PI/Fe²⁺ system, and the corresponding intensity are higher than that of DBD/PI system. The quenching experiments shown that ^•OH, ¹O₂, ^•O₂⁻ and electron play important role for SDZ degradation. Reactive species dominant to SDZ degradation was explored by LC–MS and density functional theory (DFT) analysis. Higher input power, acid condition and higher conductivity were favorable to SDZ degradation. DBD/PI/Fe²⁺ system has good effect in treating other emerging contaminants and obtains good environmental adaptability.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111708"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene-encapsulated ruthenium as efficient electrocatalyst for high-temperature polymer electrolyte membrane fuel cells","authors":"Jiuli Xia ,&nbsp;Shiqian Du ,&nbsp;Liang Zhang ,&nbsp;Peng Ye ,&nbsp;Huasheng Lin ,&nbsp;Shanhu Chen ,&nbsp;Yangyang Zhou ,&nbsp;Miaoyu Li ,&nbsp;Yabin Xu ,&nbsp;Qie Liu ,&nbsp;Tehua Wang ,&nbsp;Peng Long ,&nbsp;Li Tao ,&nbsp;Shuangyin Wang","doi":"10.1016/j.cclet.2024.110754","DOIUrl":"10.1016/j.cclet.2024.110754","url":null,"abstract":"<div><div>Ruthenium, possessing a comparable metal-hydrogen bond energy to Pt, has emerged as a promising electrocatalyst for the hydrogen oxidation reaction (HOR), but its practical applications are hindered by susceptibility to deactivation or dissolution under operating conditions of fuel cells. Herein, graphene-encapsulated Ru nanoparticles (Ru@NG) was employed as the HOR catalyst for high-temperature polymer electrolyte membrane fuel cells (HT-PEMFCs). The graphene shells on the Ru can block effectively the surface adsorption of phosphoric acid in electrolyte and CO in anode fuel, but does not affect H₂ free access to Ru sites, thus increase the activity expression and stability of catalysts under the high temperature, strong acid, and oxidation conditions of the HT-PEMFCs. With Ru@NG as the anode catalyst, the fuel cell delivers a peak power density of 760 mW/cm² with pure H₂, and additionally, it shows better tolerance to CO that the performance is 1.5 times that of the Pt/C catalysts with H₂ fuel containing 1 % CO. This work provides an alternative strategy to design the electrocatalysts for HT-PEMFCs.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 110754"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmentally friendly Bpy-COF/PThC all-organic heterojunction for efficient removing antibiotic-resistant bacteria and organic pollutants","authors":"Feng Liu ,&nbsp;Liaofang Shang ,&nbsp;Yao Liu ,&nbsp;Xinyue Zhang ,&nbsp;Chunbo Liu ,&nbsp;Guangbo Che ,&nbsp;Haiyong Guo ,&nbsp;Yaqian Lan","doi":"10.1016/j.cclet.2025.111805","DOIUrl":"10.1016/j.cclet.2025.111805","url":null,"abstract":"<div><div>The extensive use of various antibiotics and organic dyes has led to increasingly severe environmental issues and posed a significant threat to human health. Developing an efficient and safe dual-functional photocatalytic material for degradation and antibacterial purposes is the key to solving environmental pollution problems. Polythiophene and covalent organic frameworks (COFs) possess excellent photophysical properties, high stability, and ease of modification, offering broad application prospects and significant development potential in the removal of organic pollutants and antibiotic-resistant bacteria (ARB). A high-performance conductive polymer PTET-T-COOH (PThC) was prepared via the Stille coupling reaction, and a bipyridine (Bpy) covalent organic framework Bpy-COF was synthesized through acid-catalyzed imine condensation. By utilizing the <em>π</em>-<em>π</em> stacking and hydrogen bonding interactions between Bpy-COF and PThC, a novel Bpy-COF/PThC all-organic heterojunction was successfully fabricated. Compared to Bpy-COF and PThC, the composite exhibits a broadened spectral response range and higher carrier separation efficiency. The 30 % Bpy-COF/PThC demonstrates the best photocatalytic performance, achieving a 99.96 % inactivation rate of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) with a cell density of 7.23 log and a 95.28 % bactericidal rate of <em>Escherichia coli</em> (<em>E. coli</em>) with a cell density of 7.50 log within 60 min. Under natural light, it not only exhibits good inactivation effects on both MRSA and <em>E. coli</em>, but also shows excellent degradation performance for rhodamine B, methylene blue, and tetracycline. The cytotoxicity experiment demonstrates that the composite exhibits good biocompatibility and potential for practical applications. The research results provide new design ideas for constructing efficient and safe organic photocatalysts, and offer a theoretical basis for the treatment of water pollution.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111805"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired high-entropy metal-organic frameworks towards boosted CO2 photoconversion","authors":"Xiaohong Li ,&nbsp;Limin Jin ,&nbsp;Haihui Yu ,&nbsp;Yuteng Zhang ,&nbsp;Haifeng Zhang ,&nbsp;Yanbiao Liu","doi":"10.1016/j.cclet.2025.111626","DOIUrl":"10.1016/j.cclet.2025.111626","url":null,"abstract":"<div><div>Sustainable photochemical CO₂ conversion represents a promising strategy for mitigating excess CO₂ emissions and achieving “carbon neutrality”. The development of advanced catalysts with an abundance of active sites and efficient separation of photo-generated charge carriers remains a significant challenge. Here, we present a high-entropy (HE) photocatalyst by integrating five metals into Prussian blue (PB) to afford K<em>_x</em>(MnFeCoNiCu)[Fe(CN)₆] (HE-PBA) which exhibits a high concentration of active centers and rapid electron transfer, enabling superior CO₂-to-CO photoreduction performance. The HE-PBA composite catalyst delivered a high CO yield (up to 1220.5 μmol g^-1 h^-1), achieving near 100 % product selectivity. A mechanistic analysis has revealed strong coupling and overlapping multi-atomic orbitals, which facilitates local electron redistribution and a readjustment of electron density. This effect serves to generate abundant reactive sites with CO₂ interactions that facilitate C-O bond activation. Additionally, an efficient electron transfer driven by the disparity in metal electronegativity inhibits unwanted recombination of electron-hole pairs. More significantly, the photoelectrons migrate and accumulate on the HE-PBA surface, exhibiting extended long lifetimes and robust reduction ability. The findings of this study provide important insights that can contribute to the development of high-entropy materials rich in transition metals with far-ranging potential applications.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111626"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}