Chinese Chemical Letters最新文献_第10页

A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes 以线粒体为靶点的Ir(III)复合物可引发铁变态反应和自噬，用于癌症治疗：金属复合物的聚集增强型 PDT 策略案例

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-06-06 DOI: 10.1016/j.cclet.2024.110099

{"title":"A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes","authors":"","doi":"10.1016/j.cclet.2024.110099","DOIUrl":"10.1016/j.cclet.2024.110099","url":null,"abstract":"<div><div>Metal complexes hold significant promise in tumor diagnosis and treatment. However, their potential applications in photodynamic therapy (PDT) are hindered by issues such as poor photostability, low yield of reactive oxygen species (ROS), and aggregation-induced ROS quenching. To address these challenges, we present a molecular self-assembly strategy utilizing aggregation-induced emission (AIE) conjugates for metal complexes. As a proof of concept, we synthesized a mitochondrial-targeting cyclometalated Ir(III) photosensitizer Ir-TPE. This approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE groups. Ir-TPE readily self-assembles into nanoaggregates in aqueous solution, leading to a significant production of ROS upon light irradiation. Photoirradiated Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria, resulting in mitochondrial DNA damage. This damage can lead to ferroptosis and autophagy, two forms of cell death that are highly cytotoxic to cancer cells. The aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS, leading to a more pronounced cytotoxic effect. <em>In vitro</em> and <em>in vivo</em> experiments demonstrate this aggregation-enhanced PDT approach achieves effective <em>in situ</em> tumor eradication. This study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 1","pages":"Article 110099"},"PeriodicalIF":9.4,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring synthetic strategy for stabilizing nickel-rich layered oxide cathodes through structural design 通过结构设计探索稳定富镍层状氧化物阴极的合成策略

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-06-04 DOI: 10.1016/j.cclet.2024.110089

引用次数: 0

Deuterated chloroform replaces ultra-dry chloroform to achieve high-efficient organic solar cells 氘化氯仿取代超干氯仿，实现高效有机太阳能电池

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-06-03 DOI: 10.1016/j.cclet.2024.110083

{"title":"Deuterated chloroform replaces ultra-dry chloroform to achieve high-efficient organic solar cells","authors":"","doi":"10.1016/j.cclet.2024.110083","DOIUrl":"10.1016/j.cclet.2024.110083","url":null,"abstract":"<div><div>Chloroform is a common and excellent solvent for preparing high-efficient organic solar cells (OSCs), however, it is toxic and poisonable chemical. In comparisons, deuterated chloroform (DC) is less toxic and costly, and particularly, it is non-poisonable chemical. In this paper, we use DC to replace ultra-dry chloroform (UC) as the processing solvent for preparation of active layers of organic solar cells. First, we selected PM6:BTP-eC9 as the basic binary and counted 100 solar cells’ data, from which comparable device performance were obtained with use of DC and UC. Interestingly, DC showed better reproducibility, superior storage under a nitrogen atmosphere and a little better performance than UC. Both DC and UC gave rise of comparable hole and electron mobilities and similar charge recombination losses. Second, we based PM6:Y6 and D18-Cl:Y6 as the binaries and similar effects were obtained from both UC and DC when counting 30 devices for each binary. Third, the universality of the use of DC for preparing high-efficient OSCs were again checked with several binary and ternary systems. In all, this study demonstrate that DC can replace UC for use in the field of OSCs.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 1","pages":"Article 110083"},"PeriodicalIF":9.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and properties of tetraphenylethene cationic cyclophanes based on o-carborane skeleton 基于邻碳硼烷骨架的四苯基乙烯阳离子环烷的合成及其特性

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-31 DOI: 10.1016/j.cclet.2024.110074

Rongjian Chen , Jiahui Liu , Caixia Lin , Yuanming Li , Yanhou Geng , Yaofeng Yuan

引用次数: 0

Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus 用于经上皮治疗角膜炎的超分子组装纳米粒子

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-31 DOI: 10.1016/j.cclet.2024.110060

Wenlong Li , Feishi Shan , Qingdong Bao , Qinghua Li , Hua Gao , Leyong Wang

引用次数: 0

Built-in electric field and core-shell structure of the reconstructed sulfide heterojunction accelerated water splitting 内置电场和核壳结构的重构硫化物异质结加速水分裂

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-29 DOI: 10.1016/j.cclet.2024.110068

Shudi Yu , Jie Li , Jiongting Yin , Wanyu Liang , Yangping Zhang , Tianpeng Liu , Mengyun Hu , Yong Wang , Zhengying Wu , Yuefan Zhang , Yukou Du

{"title":"Built-in electric field and core-shell structure of the reconstructed sulfide heterojunction accelerated water splitting","authors":"Shudi Yu , Jie Li , Jiongting Yin , Wanyu Liang , Yangping Zhang , Tianpeng Liu , Mengyun Hu , Yong Wang , Zhengying Wu , Yuefan Zhang , Yukou Du","doi":"10.1016/j.cclet.2024.110068","DOIUrl":"10.1016/j.cclet.2024.110068","url":null,"abstract":"<div><p>The rational design of high-performance bifunctional electrocatalysts for overall water splitting (OWS) is the key to popularize hydrogen production technology. The active metal oxyhydroxide (MOOH) formed after surface self-reconfiguration of transition metal sulfide (TMS) electrocatalyst is often regarded as the \"actual catalyst\" in oxygen evolution reaction (OER). Herein, an Fe doped CoS<sub>2</sub>/MoS<sub>2</sub> hollow TMS polyhedron (Fe-CoS<sub>2</sub>/MoS<sub>2</sub>) with rich Mott-Schottky heterojunction is reported and directly utilized as an OWS electrocatalyst. The spontaneous built-in electric field (BEF) at the heterogeneous interface regulates the electronic structure and D-band center of the catalyst. More importantly, the “TMS-MOOH” core-shell structure obtained in the KOH electrolyte shows enhanced OER properties. And the introduction of Fe ions activates the inert basal plane of MoS<sub>2</sub>, which greatly steps up the performance of HER. Hence, the preferable Fe-CoS<sub>2</sub>/MoS<sub>2</sub>–400 presents superior OER activity (<em>η</em><sub>10</sub> = 178 mV, <em>η</em><sub>100</sub> = 375 mV), HER activity (<em>η</em><sub>10</sub> = 92 mV) and ultra-high stability for 50 h. This work has deeply explored the catalytic mechanism of TMS and provided a new idea for the construction of efficient bifunctional catalysts.</p></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"35 12","pages":"Article 110068"},"PeriodicalIF":9.4,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders 基于苯并[4,5]咪唑并[1,2-a]嘧啶结构的固有靶向荧光传感器，用于溶酶体粘度成像和溶酶体贮积症诊断

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-28 DOI: 10.1016/j.cclet.2024.110050

Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li

{"title":"Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders","authors":"Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li","doi":"10.1016/j.cclet.2024.110050","DOIUrl":"10.1016/j.cclet.2024.110050","url":null,"abstract":"<div><p>Benzo[4,5]imidazo[1,2-<em>a</em>]pyrimidine-based derivatives play crucial roles in medicines, pesticides, tracers and photoelectric materials. However, their synthesis approach still needs to be optimized, and their fluorescent properties in intracellular microenvironment are unclear. Here, a Cu(II)-catalyzed cascade coupling cyclization reaction was successfully developed to synthesize benzo[4,5]imidazo[1,2-<em>a</em>]pyrimidine scaffold with mild reaction conditions, broad substrate scopes and high yields. After a system study, we found that compound <strong>4aa</strong> displayed an optimal viscosity-specific response with remarkable fluorescence enhancement (102-fold) for glycerol at 490 nm. Particularly, <strong>4aa</strong> possessed excellent structure-inherent targeting (SIT) capability for lysosome (<em>P</em> = 0.95) with high pH stability and large Stokes shift. Importantly, <strong>4aa</strong> was validated for its effectiveness in diagnosing lysosomal storage disorders (LSD) in living cells. The <strong>4aa</strong> also showed its potential to map the micro-viscosity and its metabolism process in zebrafish. This work not only affords an efficient protocol to fabricate benzo[4,5]imidazo[1,2-<em>a</em>]pyrimidine derivatives, reveals this skeleton has excellent SIT features for lysosome, but also manifests that <strong>4aa</strong> can serve as a practical tool to monitor lysosomal viscosity and diagnose LSD.</p></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"35 11","pages":"Article 110050"},"PeriodicalIF":9.4,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible phosphorescence in pseudopolyrotaxane elastomer 伪多聚氧乙烯醚弹性体中的可逆磷光

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-28 DOI: 10.1016/j.cclet.2024.110061

Fengyao Cui , Qiaona Zhang , Tangxin Xiao , Zhouyu Wang , Leyong Wang

引用次数: 0

Electricity-driven enantioselective cross-dehydrogenative coupling of two C(sp3)-H bonds enabled by organocatalysis 通过有机催化实现两个 C（sp3）-H 键的电驱动对映选择性交叉脱氢偶联

IF 9.1 1区化学

Chinese Chemical Letters Pub Date : 2024-05-28 DOI: 10.1016/j.cclet.2023.109445

Yuemin Chen, Yunqi Wu, Guoao Wang, Feihu Cui, Haitao Tang, Yingming Pan

引用次数: 0

Recent progress on surface chemistry I: Assembly and reaction 表面化学的最新进展 I：组装与反应

IF 9.4 1区化学

Chinese Chemical Letters Pub Date : 2024-05-27 DOI: 10.1016/j.cclet.2024.110055

Xin Li , Zhen Xu , Donglei Bu , Jinming Cai , Huamei Chen , Qi Chen , Ting Chen , Fang Cheng , Lifeng Chi , Wenjie Dong , Zhenchao Dong , Shixuan Du , Qitang Fan , Xing Fan , Qiang Fu , Song Gao , Jing Guo , Weijun Guo , Yang He , Shimin Hou , Yongfeng Wang

引用次数: 0