Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics

IF 9.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chinese Chemical Letters Pub Date : 2025-01-10 DOI:10.1016/j.cclet.2025.110832

Yaojun Li , Yun Li , Shenglong Liao , Yang Li , Shouchun Yin

{"title":"Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics","authors":"Yaojun Li , Yun Li , Shenglong Liao , Yang Li , Shouchun Yin","doi":"10.1016/j.cclet.2025.110832","DOIUrl":null,"url":null,"abstract":"<div><div>The integration of advanced diagnostic and therapeutic capabilities in oncology has given rise to phototheranostics, a field that combines the precision of imaging with the selectivity of light-activated treatments. Due to their pronounced near-infrared (NIR) absorption, tunable molecular structures, and commendable stability, organic photovoltaic non-fullerene acceptors (NFAs) represent a promising frontier in cancer management. Despite the great potential of NFAs in phototheranostics, there is currently a lack of systematic reviews in this field. This review provides a meticulous examination of the current state of NFAs in the field of phototheranostics, highlighting the strategic approaches to spectral red-shifting that enhance tissue penetration and therapeutic efficacy. It dissects the link between molecular architecture and performance across key therapeutic and diagnostic modalities, including photothermal therapy (PTT), photodynamic therapy (PDT), and fluorescence imaging (FLI). In addition, the review presents a concise analysis of the challenges and milestones in the clinical translation of NFAs, offering insights into the innovations required to overcome existing barriers.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 8","pages":"Article 110832"},"PeriodicalIF":9.4000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Chemical Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1001841725000191","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The integration of advanced diagnostic and therapeutic capabilities in oncology has given rise to phototheranostics, a field that combines the precision of imaging with the selectivity of light-activated treatments. Due to their pronounced near-infrared (NIR) absorption, tunable molecular structures, and commendable stability, organic photovoltaic non-fullerene acceptors (NFAs) represent a promising frontier in cancer management. Despite the great potential of NFAs in phototheranostics, there is currently a lack of systematic reviews in this field. This review provides a meticulous examination of the current state of NFAs in the field of phototheranostics, highlighting the strategic approaches to spectral red-shifting that enhance tissue penetration and therapeutic efficacy. It dissects the link between molecular architecture and performance across key therapeutic and diagnostic modalities, including photothermal therapy (PTT), photodynamic therapy (PDT), and fluorescence imaging (FLI). In addition, the review presents a concise analysis of the challenges and milestones in the clinical translation of NFAs, offering insights into the innovations required to overcome existing barriers.

Abstract Image

查看原文本刊更多论文

用有机光伏非富勒烯受体革新癌症治疗：深入研究先进光疗的分子工程

肿瘤学中先进的诊断和治疗能力的整合产生了光疗学，这是一个结合了成像精度和光激活治疗选择性的领域。由于其明显的近红外（NIR）吸收，可调节的分子结构和良好的稳定性，有机光伏非富勒烯受体（nfa）在癌症治疗中代表了一个有前途的前沿。尽管NFAs在光疗学中具有巨大的潜力，但目前在该领域缺乏系统的综述。本文综述了光疗领域中nfa的现状，重点介绍了光谱红移的策略方法，以提高组织穿透性和治疗效果。它剖析了分子结构与关键治疗和诊断模式之间的联系，包括光热疗法（PTT）、光动力疗法（PDT）和荧光成像（FLI）。此外，该综述还简要分析了nfa临床翻译中的挑战和里程碑，为克服现有障碍所需的创新提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.