{"title":"AL5E: A breakthrough in broad-spectrum coronavirus inactivation through structure-guided design","authors":"Heng Gao, Jiwei Zhang, Peng Zhan, Xinyong Liu","doi":"10.1016/j.cclet.2025.111221","DOIUrl":"10.1016/j.cclet.2025.111221","url":null,"abstract":"","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 7","pages":"Article 111221"},"PeriodicalIF":9.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shenghui Tu , Anru Liu , Hongxiang Zhang , Lu Sun , Minghui Luo , Shan Huang , Ting Huang , Honggen Peng
{"title":"Corrigendum to “Oxygen vacancy regulating transition mode of MIL-125 to facilitate singlet oxygen generation for photocatalytic degradation of antibiotics” [Chinese Chemical Letters 35 (2024) 109761]","authors":"Shenghui Tu , Anru Liu , Hongxiang Zhang , Lu Sun , Minghui Luo , Shan Huang , Ting Huang , Honggen Peng","doi":"10.1016/j.cclet.2025.110868","DOIUrl":"10.1016/j.cclet.2025.110868","url":null,"abstract":"","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 6","pages":"Article 110868"},"PeriodicalIF":9.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingyuan Luo , Liping Wu , Jinxi Yan , Xintong Lv , Yuqi Luo , Wei Jiang , Zhiqiang Xiong , Anqi Ni , Chongbo Liu , Renchao Che
{"title":"Radar-stealth and thermal-insulating MOF-derived cellulose-carbon aerogels for broadband electromagnetic wave absorption","authors":"Jingyuan Luo , Liping Wu , Jinxi Yan , Xintong Lv , Yuqi Luo , Wei Jiang , Zhiqiang Xiong , Anqi Ni , Chongbo Liu , Renchao Che","doi":"10.1016/j.cclet.2025.111065","DOIUrl":"10.1016/j.cclet.2025.111065","url":null,"abstract":"<div><div>Considering the challenges posed by severe electromagnetic wave pollution and escalating international tensions, there is a critical need to develop advanced electromagnetic wave absorbing (EMWA) materials that integrate radar stealth and thermal insulation capabilities. In this study, we have synthesized three-dimensional (3D) porous composites comprising V<sub>2</sub>O<sub>3</sub> nanoparticles embedded in <em>Juncus effusus</em> cellulose-derived carbon aerogels (VCA) using a self-templating method followed by high-temperature pyrolysis. The V<sub>2</sub>O<sub>3</sub> nanoparticles possess a 3D V-V framework and a relatively narrow bandgap, facilitating the Mott transition for enhanced conductivity. Furthermore, their uniform dispersion on hollow carbon tubes of <em>Juncus effusus</em> promotes efficient electron transfer and creates numerous heterogeneous interfaces. Consequently, VCA-2 demonstrates outstanding EMWA performance, achieving a minimum reflection loss of −63.92 dB at a matching thickness of 2.0 mm and a maximum effective absorption bandwidth of 8.24 GHz at a thickness of 2.44 mm, covering nearly half of the tested frequency range. Additionally, the radar cross-section reduction reaches a peak value of 29.40 dB m<sup>2</sup>, underscoring the excellent radar stealth capabilities of the material. In summary, VCA exhibits exceptional EMWA, radar stealth, and thermal insulation properties, highlighting its potential for multifunctional applications in EMWA material development.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 7","pages":"Article 111065"},"PeriodicalIF":9.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenjuan Liu , Shanshan Zhang , Yu Wang , Bin Fang , Weirui Wang , Shujing Song , Tomohiro Hakozaki
{"title":"Three-channel imaging reveals the comprehensive protein modifications and their impact on skin appearance induced by multiple stimuli","authors":"Wenjuan Liu , Shanshan Zhang , Yu Wang , Bin Fang , Weirui Wang , Shujing Song , Tomohiro Hakozaki","doi":"10.1016/j.cclet.2025.111182","DOIUrl":"10.1016/j.cclet.2025.111182","url":null,"abstract":"<div><div>Protein damage repair and prevention are important objectives in skin care industry. Skin protein damage or modifications such as glycation, carbonylation or oxidation, have a significant impact on its function, therefore directly influencing various skin functions or properties including skin appearance. However, there is a lack of comprehensive methods to visualize and assess the protein damage. In this article, we present a three-channel imaging approach to simultaneously visualize and quantitatively evaluate protein oxidation, protein glycation and carbonylation in a full-thickness skin model. We successfully visualized and quantified the impact of the multiple stimuli (ultraviolet radiation A (UVA) and/or methylglyoxal) as well as treatment effect of positive control (vitamins C and E) with this method. Our findings indicate that multiple stimuli exhibit synergistic effects on protein damage. Furthermore, we evaluated a unique combination of skin care ingredients which demonstrated an excellent efficacy in resisting protein damage. Further research revealed that three ingredients of the combination upregulate autophagy in cells, which may contribute to remove damaged proteins and maintain protein quality homeostasis. This method provides a holistic assessment of protein damages and can be employed to evaluate the impact of various stimuli or to assess the efficacy of skin care ingredients in mitigating such damage.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 6","pages":"Article 111182"},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanyong Wang , Weijia Zhang , Chenlu Huang, Xinyu Yang, Qingyu Yu, Hai Wang, Wen Li, Linhua Zhang, Dunwan Zhu
{"title":"Personalized tumor vaccines based on carrier-free double-adjuvant nanoparticles and tumor-associated antigens for enhancing immune responses","authors":"Hanyong Wang , Weijia Zhang , Chenlu Huang, Xinyu Yang, Qingyu Yu, Hai Wang, Wen Li, Linhua Zhang, Dunwan Zhu","doi":"10.1016/j.cclet.2025.111092","DOIUrl":"10.1016/j.cclet.2025.111092","url":null,"abstract":"<div><div>Immune adjuvants are extremely important in tumor vaccines, which can amplify antigen-specific immune responses and enhance anti-tumor efficacy. Nevertheless, well-designed adjuvants and rational combination of adjuvants and antigens still remain a challenge in tumor vaccines. In this study, we designed and formulated carrier-free double-adjuvant nanoparticles (FPC-NPs) by self-assembling of fluoroalkane-grafted polyethylenimide (PEI) (Toll-like receptor 4 (TLR4) agonist) and cytosine-phosphate-guanine (CpG) (TLR9 agonist), and then obtained personalized tumor vaccines (FPC-NPs@TAAs) by electrostatic adsorption of tumor-associated antigens (TAAs) on the surface of FPC-NPs. The results showed that FPC-NPs@TAAs could promote cellular internalization of adjuvants, deliver antigens and adjuvants to the same antigen-presenting cell, which can effectively activate dendritic cells, encourage cross-presentation of antigens, and reduce the proportion of M2-type macrophages. Our work presents a simple method to realize the dual adjuvant combination of TLR4 and TLR9 <em>via</em> well-designed carrier-free nanoparticles, showing great promise for developing personalized tumor vaccines to enhance the efficacy of immunotherapy.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 7","pages":"Article 111092"},"PeriodicalIF":9.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing Li , Yumei Feng , Yuhua Xie , Qi Xu , Yifei Li , Yingjie Yu , Fang Luo , Zehui Yang
{"title":"MOF derived RuO2/V2O5 nanoneedles for robust and stable water oxidation in acid","authors":"Qing Li , Yumei Feng , Yuhua Xie , Qi Xu , Yifei Li , Yingjie Yu , Fang Luo , Zehui Yang","doi":"10.1016/j.cclet.2025.111074","DOIUrl":"10.1016/j.cclet.2025.111074","url":null,"abstract":"<div><div>A stable and efficient oxygen evolution reaction (OER) electrocatalyst in acidic medium is strongly required for the industrialization of polymer electrolyte membrane water splitting (PEMWS) technology. Herein, we devise the formation of nanoneedle-like RuO<sub>2</sub>/V<sub>2</sub>O<sub>5</sub> heterostructure with the template of MIL 88B. The incorporation of V<sub>2</sub>O<sub>5</sub> to RuO<sub>2</sub> significantly increases the deprotonation capability resulting in a better OER performance demanding 216 mV overpotential at 10 mA/cm<sup>2</sup>, lowered by 27 mV with relative to benchmarked RuO<sub>2</sub>. Moreover, the electronic interplay between RuO<sub>2</sub> and V<sub>2</sub>O<sub>5</sub> contributes to an increment in oxidation of Ru to high valance state; thereby, a robust stability is achieved for RuO<sub>2</sub>/V<sub>2</sub>O<sub>5</sub>. From the theoretical calculation, it is noticed that the d band center of Ru is downshifted after V<sub>2</sub>O<sub>5</sub> decoration; moreover, the e<sub>g</sub> filling of Ru is simultaneously increased; in this regard, the adsorption of OH* specie is weakened, in accordance to methanol detection, resulting in a higher OER performance.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 7","pages":"Article 111074"},"PeriodicalIF":9.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Zhang , Chuang Shen , Jiaxu Zhang , Qi Shen , Fei Xu , Shengheng Wang , Jiuyi Hu , Faisal Saleem , Feng Huang , Zhimin Luo
{"title":"Ultrasmall PtCu nanosheets as a broadband phototheranostic agent in near-infrared biowindow","authors":"Ying Zhang , Chuang Shen , Jiaxu Zhang , Qi Shen , Fei Xu , Shengheng Wang , Jiuyi Hu , Faisal Saleem , Feng Huang , Zhimin Luo","doi":"10.1016/j.cclet.2025.111059","DOIUrl":"10.1016/j.cclet.2025.111059","url":null,"abstract":"<div><div>Broadband photothermal and photoacoustic agents in the near-infrared (NIR) biowindow are of significance for cancer phototheranostics. In this work, PtCu nanosheets with an average lateral size of less than 10 nm are synthesized as NIR photothermal and photoacoustic agents <em>in vivo</em>, which show strong light absorption from NIR-I to NIR-II biowindows with the photothermal conversion efficiencies of 20.4% under 808 nm laser and 32.7% under 1064 nm laser. PtCu nanosheets functionalized with folic acid-modified thiol-poly(ethylene glycol) (SH-PEG-FA) present good biocompatibility and 4T1 tumor-targeted effect, which give high-contrast photoacoustic imaging and efficient photothermal ablation of 4T1 tumor in both NIR-I and NIR-II biowindows. Our work significantly broadens applications of noble metal-based nanomaterials in the fields of cancer phototheranostics by rationally designing their structures and modulating their physicochemical properties.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 6","pages":"Article 111059"},"PeriodicalIF":9.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}