Chinese Chemical Letters最新文献

Screening of glial fibrillary acidic protein specific aptamer and application in the development of fluorescent biosensor based on isothermal amplification strategy 胶质原纤维酸性蛋白特异性适配体的筛选及其在等温扩增荧光生物传感器开发中的应用

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-19 DOI: 10.1016/j.cclet.2025.111616

Yue Cao , Yue Lin , Li Chen , Huimin Niu , Renli Wei , Shuqian Qiu , Anjie Wang , Xiaoai Cao , Xiaofeng Lai , Yongshou Chen , Juanjuan Lin , Shuiliang Wang , Zhenyu Lin , Shenghang Zhang

{"title":"Screening of glial fibrillary acidic protein specific aptamer and application in the development of fluorescent biosensor based on isothermal amplification strategy","authors":"Yue Cao , Yue Lin , Li Chen , Huimin Niu , Renli Wei , Shuqian Qiu , Anjie Wang , Xiaoai Cao , Xiaofeng Lai , Yongshou Chen , Juanjuan Lin , Shuiliang Wang , Zhenyu Lin , Shenghang Zhang","doi":"10.1016/j.cclet.2025.111616","DOIUrl":"10.1016/j.cclet.2025.111616","url":null,"abstract":"<div><div>Glial fibrillary acidic protein (GFAP) can serve as a promising early blood biomarker for Alzheimer's disease (AD). Existing assays mostly rely on antibody-based detection technologies, the preparation of antibodies is relatively complex, costly, and requires high storage conditions. In this study, we screened an aptamer specifically targeting GFAP (<em>K</em><sub>D</sub> = 0.621 µmol/L) through systematic evolution of ligands by exponential enrichment (SELEX) technique for the first time and then applied which to develop a simple but sensitive fluorescent sensor by combining isothermal exponential amplification reaction (EXPAR) with hybridization chain reaction (HCR). The platform achieved a broad linear detection range (10 pg/mL to 10 µg/mL) and a low detection limit (0.24 pg/mL). The results detected by the proposed sensor were highly correlated with that detected by ELISA method (<em>R</em> = 0.9989, <em>P</em> < 0.0001). The work overcomes the limitations of antibody-based technologies and provides a promising solution for early diagnosis of AD.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111616"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances in heterogeneous catalysts based on hypercrosslinked polymers for transesterification in biodiesel production: A comprehensive review 基于高交联聚合物的生物柴油酯交换多相催化剂研究进展综述

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-10-15 DOI: 10.1016/j.cclet.2025.111960

Yuheng Wen , Zeyu Wang , Jingli Li , Chengyao Xue , Haobo Wang , Xingrui Li , Hao Zhang , Yang Lu , Yu Zhang , Qing Hou , Wenliang Song

{"title":"Current advances in heterogeneous catalysts based on hypercrosslinked polymers for transesterification in biodiesel production: A comprehensive review","authors":"Yuheng Wen , Zeyu Wang , Jingli Li , Chengyao Xue , Haobo Wang , Xingrui Li , Hao Zhang , Yang Lu , Yu Zhang , Qing Hou , Wenliang Song","doi":"10.1016/j.cclet.2025.111960","DOIUrl":"10.1016/j.cclet.2025.111960","url":null,"abstract":"<div><div>The growing global demand for sustainable energy makes biodiesel an important renewable alternative to alleviate the energy crisis and reduce greenhouse gas emissions. Therefore, there is an urgent need to develop efficient, environmentally friendly and economically viable biodiesel production methods. Hypercrosslinked polymers (HCPs), as aromatic porous organic polymers, are solid frameworks that can be used as heterogeneous catalyst, and they are a promising platform for biodiesel catalytic conversion due to their low cost, highly accessible active site, tunable catalytic site types. In addition, innovative green synthesis strategies make environmentally begin production of HCPs possible. In recent years, HCPs has developed rapidly in the field of biomass catalysis. Unfortunately, to the best of our knowledge, there are no publications focusing on the green synthesis and application of HCPs-based materials for biodiesel production. This review provides an update on the synthesis and utilisation of green and efficient HCPs for catalytic biodiesel production. Initially, the green routes for HCPs synthesis are described, followed by a comprehensive summary of the various approaches to biodiesel production. The primary focus is on the utilisation of HCPs as carriers of active sites in the catalytic conversion of biodiesel, with particular emphasis on catalyst design, morphology control, and intelligent management in terms of application extension. Ultimately, thought-provoking recommendations are proposed to utilize improved green HCPs in combination with advanced production processes to achieve more efficient and sustainable development.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111960"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent site-selective synthesis of deuterated pyrroles from radical initiated cyclizations of N-propargyl enamines n -丙炔胺基环化反应中氘化吡咯的歧异位点选择性合成

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-05 DOI: 10.1016/j.cclet.2025.111544

Baihui Zheng, Dandan Zhang, Baoping Ren, Yifei Li, Qun Liu, Ling Pan

引用次数: 0

Flexible two-dimensional uranium-organic framework with upgraded radiation resistant for X-ray imaging 柔性二维铀有机框架与升级的抗辐射x射线成像

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-20 DOI: 10.1016/j.cclet.2025.111614

Jueqiong Wang , Liwei Cheng , Yang Yang , Dewen He , Yingtong Fan , Zhiwei Li , Junhao Lu , Yumin Wang , Jia Lei , Zhiyong Peng , Aiping Jin , Dan Zhou , Zhizai Li , Shuaihua Wang , Lixi Chen , Yaxing Wang , Yanlong Wang , Shuao Wang

{"title":"Flexible two-dimensional uranium-organic framework with upgraded radiation resistant for X-ray imaging","authors":"Jueqiong Wang , Liwei Cheng , Yang Yang , Dewen He , Yingtong Fan , Zhiwei Li , Junhao Lu , Yumin Wang , Jia Lei , Zhiyong Peng , Aiping Jin , Dan Zhou , Zhizai Li , Shuaihua Wang , Lixi Chen , Yaxing Wang , Yanlong Wang , Shuao Wang","doi":"10.1016/j.cclet.2025.111614","DOIUrl":"10.1016/j.cclet.2025.111614","url":null,"abstract":"<div><div>The intrinsic scintillation property of uranium has recently endowed this heaviest naturally occurring element with new opportunities for X-ray radiation detection and visualization. However, the low radiation stability of most uranium compounds hinders their practical application, particularly in X-ray imaging. Here, we presented a flexible two-dimensional uranium-organic framework (UOF, SCU-334) as an air-stable scintillating material for X-ray detection and, for the first time, a systematic investigation of X-ray imaging in UOFs. Following continuous high dose rate X-ray irradiation exceeding 50 Gy, which equals thousands of chest X-ray diagnoses, SCU-334 retains over 90 % of its initial performance, representing a significant improvement over previously reported scintillating UOFs. The upgraded radiation resistance of SCU-334 is attributed to its flexible structure that dissipates energy more efficiently under high-energy particle bombardment through conformation fluctuation and relaxation. This work offers a promising approach to improve the radiation resistance of uranium-based scintillators.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111614"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols 由甘醛与羧酸和醇合成光诱导立体选择性2-脱氧糖苷

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-21 DOI: 10.1016/j.cclet.2025.111615

Xianrong Zeng , Hui-Ying Shi , Huiqian Huang , Zhaobin Wang

{"title":"Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols","authors":"Xianrong Zeng , Hui-Ying Shi , Huiqian Huang , Zhaobin Wang","doi":"10.1016/j.cclet.2025.111615","DOIUrl":"10.1016/j.cclet.2025.111615","url":null,"abstract":"<div><div>Synthesizing 2-deoxyglycosides, prevalent motifs in bioactive molecules, presents significant challenges in stereocontrol and functional group tolerance. We report a metal-free, photo-induced <em>O</em>-glycosylation of glycals using acridinium salts under visible light. This method effectively couples diverse glycals with both carboxylic acids and alcohols, providing facile access to <em>α</em>-2-deoxyglycosides under mild conditions with broad substrate scope and functional group compatibility. The protocol exhibits high <em>α</em>-stereoselectivity with carboxylic acids and moderate <em>α</em>-selectivity with alcohols, enabling late-stage functionalization of complex molecules, including amino acids, peptides, and drugs. Mechanistic experiments implicate the possible involvement of radical intermediates, potentially operating via a chain reaction. Notably, 2-deoxyglycosylation of NSAIDs using this method enhanced their neuroprotective properties <em>in vitro</em>. This photo-induced strategy offers a practical and versatile platform for accessing complex 2-deoxyglycans relevant to medicinal chemistry and chemical biology.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111615"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereoconvergent synthesis of chiral sulfonyl phthalide containing two chiral centers from Z/E mixed alkenes via copper catalysis 铜催化Z/E混合烯烃立体聚合合成双手性磺酰酞

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-06-10 DOI: 10.1016/j.cclet.2025.111405

Zhiqian Chang , Xiaochun He , Xuemei Zhang , Zhong Lian

{"title":"Stereoconvergent synthesis of chiral sulfonyl phthalide containing two chiral centers from Z/E mixed alkenes via copper catalysis","authors":"Zhiqian Chang , Xiaochun He , Xuemei Zhang , Zhong Lian","doi":"10.1016/j.cclet.2025.111405","DOIUrl":"10.1016/j.cclet.2025.111405","url":null,"abstract":"<div><div>Chiral phthalides are present in numerous natural products and bioactive molecules. Synthesizing phthalides from alkenes is an effective strategy. However, the challenges of facial-selectivity in the addition to <em>Z/E</em> mixed alkenes and diastereoselectivity at vicinal stereogenic centers have prevented the achievement of a highly selective stereoconvergent synthesis of chiral sulfonyl phthalides from <em>Z/E</em> alkene mixtures. Therefore, we have developed an efficient methodology for the stereoconvergent synthesis of chiral sulfonyl phthalides, using the Cu/PyBim catalytic system. This method enables the asymmetric construction of sulfonyl phthalides with multiple stereocenters for the first time. It exhibits broad applicability across various terminal and internal alkene substrates, and accommodates a diverse array of aryl, alkyl, and nitrogen radical precursors, all under exceptionally mild reaction conditions. The experimental results indicate that the reaction utilizes a Curtin-Hammett kinetic control strategy, leading to the stereoconvergent synthesis of <em>Z/E</em> internal alkene substrates with significant enantioselectivity and diastereoselectivity in the asymmetric construction of chiral sulfonyl phthalides.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111405"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PIII/PV-catalytic platform enabling N-fluoro-thiocarbonylation of diaryl amines for modular synthesis of tertiary N-trifluoromethylamines PIII/ pv催化平台使二芳胺的n -氟硫代羰基化用于叔氮-三氟甲基胺的模块化合成

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-06-14 DOI: 10.1016/j.cclet.2025.111461

Dongke Zhang, Li-Ao Ding, Qiuyu Xiang, Zhuojun Li, Qian Wu

引用次数: 0

Crystal hydrogels: Strategies, properties, and applications 晶体水凝胶：策略、性质和应用

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-08-11 DOI: 10.1016/j.cclet.2025.111707

Qianwei Liu , Xinhong Xiong , Numan Ahmed , Peisong Tang , Jiaxi Cui

引用次数: 0

[7]Cyclophenoxathiin: A heptagonal frustum-shaped nanobelt container for fullerenes [7]环苯氧嘧啶：富勒烯的七方锥状纳米带容器

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-06-24 DOI: 10.1016/j.cclet.2025.111499

Zhenglin Du , Weijie Zhang , Yisong Tang , Xia Li , Jialin Xie , Kelong Zhu

{"title":"[7]Cyclophenoxathiin: A heptagonal frustum-shaped nanobelt container for fullerenes","authors":"Zhenglin Du , Weijie Zhang , Yisong Tang , Xia Li , Jialin Xie , Kelong Zhu","doi":"10.1016/j.cclet.2025.111499","DOIUrl":"10.1016/j.cclet.2025.111499","url":null,"abstract":"<div><div>Nanobelts have attracted significant attention in both synthetic and supramolecular chemistry due to their distinctive structures and promising applications. However, their synthesis remains challenging due to the high strain inherent in their ribbon-like configurations. A promising approach to mitigate this strain involves incorporating heteroatoms, such as sulfur and oxygen, which not only alleviate strain but also introduce new functionalities. In this study, we report the synthesis of a novel <em>C</em><sub>2</sub>-symmetric nanobelt, [7]cyclophenoxathiin (<strong>[7]CP</strong>), through a multi-step process. The structure of <strong>[7]CP</strong> was confirmed using NMR, mass spectrometry, and single-crystal X-ray diffraction, revealing a heptagonal frustum-shaped geometry. Host-guest interactions between <strong>[7]CP</strong> and selected fullerenes were investigated using UV–vis absorption, <sup>1</sup>H NMR, and X-ray crystallography. Our findings demonstrate that <strong>[7]CP</strong> forms 1:1 complexes with fullerenes, exhibiting moderate binding through <em>π</em>−<em>π</em> interactions, with binding constants of 1638, 2534, and 3682 L/mol for C<sub>60</sub>, C<sub>70</sub>, and PC<sub>61</sub>BM, respectively. The reduced cavity size of <strong>[7]CP</strong> prevents the formation of dimeric complexes observed with [7]cyclophenoxathiin, while still allowing it to function effectively as a molecular container.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111499"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile and regioselective B–H bond functionalization of carboranes via cage···I(III) interaction 通过笼···I（III）相互作用实现碳硼烷B-H键的简单和区域选择性功能化

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-21 DOI: 10.1016/j.cclet.2025.111617

Ping Zhang , Hongyuan Ren , Zhaofeng Sun , Hou-Ji Cao , Deshuang Tu , Chang-Sheng Lu , Jordi Poater , Miquel Solà , Hong Yan

{"title":"Facile and regioselective B–H bond functionalization of carboranes via cage···I(III) interaction","authors":"Ping Zhang , Hongyuan Ren , Zhaofeng Sun , Hou-Ji Cao , Deshuang Tu , Chang-Sheng Lu , Jordi Poater , Miquel Solà , Hong Yan","doi":"10.1016/j.cclet.2025.111617","DOIUrl":"10.1016/j.cclet.2025.111617","url":null,"abstract":"<div><div>The development of innovative strategies for inert B–H bond functionalization of carboranes and exploration of their potential applications represents a central task in organic chemistry. Here, we demonstrate the facile B–H bond functionalization in carboranes through a cage···I(III) interaction between a <em>nido</em>‑carborane cluster and a hypervalent iodine(III) unit. Both experimental and theoretical investigations reveal that the cage···I(III) interaction induces a charge transfer from the boron cage to the iodine moiety, which leads to a significant decrease of the negative charge at the B(9)–H site of <em>nido</em>‑carborane. This facilitates the activation of the B–H bond and subsequent chemical transformations. The unprecedented cage···I(III) interaction offers a similar B–H bond activation mode as metal mediation. Furthermore, the treatment of <em>nido</em>‑carboranes with the iodide(III) reagent of PhI(OAc)<sub>2</sub> affords <em>nido</em>‑carborane-phenyl iodonium zwitterions as versatile synthons, which enable the modular construction of exopolyhedral B–O, B–N, B–P, and B–S bonds of carborane derivatives. This approach provides an efficient and scalable synthetic platform for metal-free and site-selective B–H bond functionalization of <em>nido</em>‑carboranes under mild conditions. Notably, the developed 2D-3D fused structures can be used as ligands for the facile construction of novel boron cluster-fused hetero-polycyclic metal complexes in one step. These compounds demonstrate intriguing photophysical properties including aggregation-induced emission, tunable emission wavelength, and oxygen sensing.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111617"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0