Chinese Chemical Letters最新文献

Strained carbon nanorings via intramolecular coupling of macrocyclic arenes 通过大环芳烃分子内偶联的应变碳纳米化

IF 9.5 1区化学

Chinese Chemical Letters Pub Date : 2026-06-23 DOI: 10.1016/j.cclet.2026.113114

Xu Zhao, Qi Liu, Youzhi Xu

引用次数: 0

Plasma-calcium imide coupled pathway: A dual-mechanism strategy for ultra-efficient electro-driven nitrogen reduction 等离子体-亚胺钙偶联途径：超高效电驱动氮还原的双机制策略

IF 9.5 1区化学

Chinese Chemical Letters Pub Date : 2026-06-15 DOI: 10.1016/j.cclet.2026.113084

Shijian Luo, Hao Chen, Yuran Yang, Yang Song, Yongduo Liu, Daojun Long, Siguo Chen, Zidong Wei

{"title":"Plasma-calcium imide coupled pathway: A dual-mechanism strategy for ultra-efficient electro-driven nitrogen reduction","authors":"Shijian Luo, Hao Chen, Yuran Yang, Yang Song, Yongduo Liu, Daojun Long, Siguo Chen, Zidong Wei","doi":"10.1016/j.cclet.2026.113084","DOIUrl":"10.1016/j.cclet.2026.113084","url":null,"abstract":"<div><div>Plasma-catalytic ammonia (NH<sub>3</sub>) synthesis has recently emerged as a promising complementary approach to the Haber–Bosch process for mild and electro-driven NH<sub>3</sub> production. However, its efficiency is severely limited by the incomplete utilization of plasma-generated reactive species and the lack of tailored catalysts capable of integrating both surface and gas-phase N<sub>2</sub> activation pathways within plasma-catalyst coupled systems. In this study, we present Ca<sub>2</sub>NH, a metal imide catalyst that enables ultra-efficient NH<sub>3</sub> synthesis <em>via</em> a dual-mechanism strategy. Owing to its integrated nitride-hydride structure, Ca<sub>2</sub>NH simultaneously facilitates a surface Mars–van Krevelen pathway for lattice-nitrogen hydrogenation and a gas-phase radical pathway driven by hydrogen radicals released from lattice hydrogen. This coupled mechanism ensures comprehensive N<sub>2</sub> activation throughout the reaction space and achieves a remarkable NH<sub>3</sub> synthesis rate of 371.8 mg h<sup>–1</sup> g<sup>–1</sup> under room temperature and atmospheric pressure, outperforming most reported electro–driven catalytic systems. These findings provide an effective strategy for integrating heterogeneous surface reactions with homogeneous radical–mediated pathways to achieve ultra-efficient activation of N<sub>2</sub> molecules.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 12","pages":"Article 113084"},"PeriodicalIF":9.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148870722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting and replacing a single carbon: tryptamine-directed photochemistry edits the indole skeleton 切割和替换单个碳：色胺定向光化学编辑吲哚骨架

IF 9.5 1区化学

Chinese Chemical Letters Pub Date : 2026-05-27 DOI: 10.1016/j.cclet.2026.113008

Lixin Duan, Xin He, Haibo Zhu, Caiyun Fang, Tao Tu

引用次数: 0

Screening of glial fibrillary acidic protein specific aptamer and application in the development of fluorescent biosensor based on isothermal amplification strategy 胶质原纤维酸性蛋白特异性适配体的筛选及其在等温扩增荧光生物传感器开发中的应用

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-19 DOI: 10.1016/j.cclet.2025.111616

Yue Cao , Yue Lin , Li Chen , Huimin Niu , Renli Wei , Shuqian Qiu , Anjie Wang , Xiaoai Cao , Xiaofeng Lai , Yongshou Chen , Juanjuan Lin , Shuiliang Wang , Zhenyu Lin , Shenghang Zhang

{"title":"Screening of glial fibrillary acidic protein specific aptamer and application in the development of fluorescent biosensor based on isothermal amplification strategy","authors":"Yue Cao , Yue Lin , Li Chen , Huimin Niu , Renli Wei , Shuqian Qiu , Anjie Wang , Xiaoai Cao , Xiaofeng Lai , Yongshou Chen , Juanjuan Lin , Shuiliang Wang , Zhenyu Lin , Shenghang Zhang","doi":"10.1016/j.cclet.2025.111616","DOIUrl":"10.1016/j.cclet.2025.111616","url":null,"abstract":"<div><div>Glial fibrillary acidic protein (GFAP) can serve as a promising early blood biomarker for Alzheimer's disease (AD). Existing assays mostly rely on antibody-based detection technologies, the preparation of antibodies is relatively complex, costly, and requires high storage conditions. In this study, we screened an aptamer specifically targeting GFAP (<em>K</em><sub>D</sub> = 0.621 µmol/L) through systematic evolution of ligands by exponential enrichment (SELEX) technique for the first time and then applied which to develop a simple but sensitive fluorescent sensor by combining isothermal exponential amplification reaction (EXPAR) with hybridization chain reaction (HCR). The platform achieved a broad linear detection range (10 pg/mL to 10 µg/mL) and a low detection limit (0.24 pg/mL). The results detected by the proposed sensor were highly correlated with that detected by ELISA method (<em>R</em> = 0.9989, <em>P</em> < 0.0001). The work overcomes the limitations of antibody-based technologies and provides a promising solution for early diagnosis of AD.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111616"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances in heterogeneous catalysts based on hypercrosslinked polymers for transesterification in biodiesel production: A comprehensive review 基于高交联聚合物的生物柴油酯交换多相催化剂研究进展综述

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-10-15 DOI: 10.1016/j.cclet.2025.111960

Yuheng Wen , Zeyu Wang , Jingli Li , Chengyao Xue , Haobo Wang , Xingrui Li , Hao Zhang , Yang Lu , Yu Zhang , Qing Hou , Wenliang Song

{"title":"Current advances in heterogeneous catalysts based on hypercrosslinked polymers for transesterification in biodiesel production: A comprehensive review","authors":"Yuheng Wen , Zeyu Wang , Jingli Li , Chengyao Xue , Haobo Wang , Xingrui Li , Hao Zhang , Yang Lu , Yu Zhang , Qing Hou , Wenliang Song","doi":"10.1016/j.cclet.2025.111960","DOIUrl":"10.1016/j.cclet.2025.111960","url":null,"abstract":"<div><div>The growing global demand for sustainable energy makes biodiesel an important renewable alternative to alleviate the energy crisis and reduce greenhouse gas emissions. Therefore, there is an urgent need to develop efficient, environmentally friendly and economically viable biodiesel production methods. Hypercrosslinked polymers (HCPs), as aromatic porous organic polymers, are solid frameworks that can be used as heterogeneous catalyst, and they are a promising platform for biodiesel catalytic conversion due to their low cost, highly accessible active site, tunable catalytic site types. In addition, innovative green synthesis strategies make environmentally begin production of HCPs possible. In recent years, HCPs has developed rapidly in the field of biomass catalysis. Unfortunately, to the best of our knowledge, there are no publications focusing on the green synthesis and application of HCPs-based materials for biodiesel production. This review provides an update on the synthesis and utilisation of green and efficient HCPs for catalytic biodiesel production. Initially, the green routes for HCPs synthesis are described, followed by a comprehensive summary of the various approaches to biodiesel production. The primary focus is on the utilisation of HCPs as carriers of active sites in the catalytic conversion of biodiesel, with particular emphasis on catalyst design, morphology control, and intelligent management in terms of application extension. Ultimately, thought-provoking recommendations are proposed to utilize improved green HCPs in combination with advanced production processes to achieve more efficient and sustainable development.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111960"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent site-selective synthesis of deuterated pyrroles from radical initiated cyclizations of N-propargyl enamines n -丙炔胺基环化反应中氘化吡咯的歧异位点选择性合成

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-05 DOI: 10.1016/j.cclet.2025.111544

Baihui Zheng, Dandan Zhang, Baoping Ren, Yifei Li, Qun Liu, Ling Pan

引用次数: 0

Flexible two-dimensional uranium-organic framework with upgraded radiation resistant for X-ray imaging 柔性二维铀有机框架与升级的抗辐射x射线成像

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-20 DOI: 10.1016/j.cclet.2025.111614

Jueqiong Wang , Liwei Cheng , Yang Yang , Dewen He , Yingtong Fan , Zhiwei Li , Junhao Lu , Yumin Wang , Jia Lei , Zhiyong Peng , Aiping Jin , Dan Zhou , Zhizai Li , Shuaihua Wang , Lixi Chen , Yaxing Wang , Yanlong Wang , Shuao Wang

{"title":"Flexible two-dimensional uranium-organic framework with upgraded radiation resistant for X-ray imaging","authors":"Jueqiong Wang , Liwei Cheng , Yang Yang , Dewen He , Yingtong Fan , Zhiwei Li , Junhao Lu , Yumin Wang , Jia Lei , Zhiyong Peng , Aiping Jin , Dan Zhou , Zhizai Li , Shuaihua Wang , Lixi Chen , Yaxing Wang , Yanlong Wang , Shuao Wang","doi":"10.1016/j.cclet.2025.111614","DOIUrl":"10.1016/j.cclet.2025.111614","url":null,"abstract":"<div><div>The intrinsic scintillation property of uranium has recently endowed this heaviest naturally occurring element with new opportunities for X-ray radiation detection and visualization. However, the low radiation stability of most uranium compounds hinders their practical application, particularly in X-ray imaging. Here, we presented a flexible two-dimensional uranium-organic framework (UOF, SCU-334) as an air-stable scintillating material for X-ray detection and, for the first time, a systematic investigation of X-ray imaging in UOFs. Following continuous high dose rate X-ray irradiation exceeding 50 Gy, which equals thousands of chest X-ray diagnoses, SCU-334 retains over 90 % of its initial performance, representing a significant improvement over previously reported scintillating UOFs. The upgraded radiation resistance of SCU-334 is attributed to its flexible structure that dissipates energy more efficiently under high-energy particle bombardment through conformation fluctuation and relaxation. This work offers a promising approach to improve the radiation resistance of uranium-based scintillators.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111614"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols 由甘醛与羧酸和醇合成光诱导立体选择性2-脱氧糖苷

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-07-21 DOI: 10.1016/j.cclet.2025.111615

Xianrong Zeng , Hui-Ying Shi , Huiqian Huang , Zhaobin Wang

{"title":"Photo-induced stereoselective 2-deoxyglycoside synthesis from glycals with carboxylic acids and alcohols","authors":"Xianrong Zeng , Hui-Ying Shi , Huiqian Huang , Zhaobin Wang","doi":"10.1016/j.cclet.2025.111615","DOIUrl":"10.1016/j.cclet.2025.111615","url":null,"abstract":"<div><div>Synthesizing 2-deoxyglycosides, prevalent motifs in bioactive molecules, presents significant challenges in stereocontrol and functional group tolerance. We report a metal-free, photo-induced <em>O</em>-glycosylation of glycals using acridinium salts under visible light. This method effectively couples diverse glycals with both carboxylic acids and alcohols, providing facile access to <em>α</em>-2-deoxyglycosides under mild conditions with broad substrate scope and functional group compatibility. The protocol exhibits high <em>α</em>-stereoselectivity with carboxylic acids and moderate <em>α</em>-selectivity with alcohols, enabling late-stage functionalization of complex molecules, including amino acids, peptides, and drugs. Mechanistic experiments implicate the possible involvement of radical intermediates, potentially operating via a chain reaction. Notably, 2-deoxyglycosylation of NSAIDs using this method enhanced their neuroprotective properties <em>in vitro</em>. This photo-induced strategy offers a practical and versatile platform for accessing complex 2-deoxyglycans relevant to medicinal chemistry and chemical biology.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111615"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereoconvergent synthesis of chiral sulfonyl phthalide containing two chiral centers from Z/E mixed alkenes via copper catalysis 铜催化Z/E混合烯烃立体聚合合成双手性磺酰酞

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-06-10 DOI: 10.1016/j.cclet.2025.111405

Zhiqian Chang , Xiaochun He , Xuemei Zhang , Zhong Lian

{"title":"Stereoconvergent synthesis of chiral sulfonyl phthalide containing two chiral centers from Z/E mixed alkenes via copper catalysis","authors":"Zhiqian Chang , Xiaochun He , Xuemei Zhang , Zhong Lian","doi":"10.1016/j.cclet.2025.111405","DOIUrl":"10.1016/j.cclet.2025.111405","url":null,"abstract":"<div><div>Chiral phthalides are present in numerous natural products and bioactive molecules. Synthesizing phthalides from alkenes is an effective strategy. However, the challenges of facial-selectivity in the addition to <em>Z/E</em> mixed alkenes and diastereoselectivity at vicinal stereogenic centers have prevented the achievement of a highly selective stereoconvergent synthesis of chiral sulfonyl phthalides from <em>Z/E</em> alkene mixtures. Therefore, we have developed an efficient methodology for the stereoconvergent synthesis of chiral sulfonyl phthalides, using the Cu/PyBim catalytic system. This method enables the asymmetric construction of sulfonyl phthalides with multiple stereocenters for the first time. It exhibits broad applicability across various terminal and internal alkene substrates, and accommodates a diverse array of aryl, alkyl, and nitrogen radical precursors, all under exceptionally mild reaction conditions. The experimental results indicate that the reaction utilizes a Curtin-Hammett kinetic control strategy, leading to the stereoconvergent synthesis of <em>Z/E</em> internal alkene substrates with significant enantioselectivity and diastereoselectivity in the asymmetric construction of chiral sulfonyl phthalides.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 5","pages":"Article 111405"},"PeriodicalIF":8.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PIII/PV-catalytic platform enabling N-fluoro-thiocarbonylation of diaryl amines for modular synthesis of tertiary N-trifluoromethylamines PIII/ pv催化平台使二芳胺的n -氟硫代羰基化用于叔氮-三氟甲基胺的模块化合成

IF 8.9 1区化学

Chinese Chemical Letters Pub Date : 2026-05-01 Epub Date: 2025-06-14 DOI: 10.1016/j.cclet.2025.111461

Dongke Zhang, Li-Ao Ding, Qiuyu Xiang, Zhuojun Li, Qian Wu

引用次数: 0