Chinese Chemical Letters最新文献

{"title":"A novel mitochondria-targeted nanoprodrug amplifies oxidative stress to enhance cisplatin chemotherapy for the treatment of hepatocellular carcinoma","authors":"Huiyang Chen ,&nbsp;Zibo Li ,&nbsp;Xiaoying Li ,&nbsp;Chenhong Tang ,&nbsp;Xiaoyu Liu ,&nbsp;Minyi Nie ,&nbsp;Ying Huang ,&nbsp;Xiaoyu Chen ,&nbsp;Kuncai Liu ,&nbsp;Yilan Dai ,&nbsp;Qiaoling Zhang ,&nbsp;Ling Lin ,&nbsp;Siming Zhang ,&nbsp;Bingchen Zhang ,&nbsp;Zhiqiang Yu","doi":"10.1016/j.cclet.2025.111313","DOIUrl":"10.1016/j.cclet.2025.111313","url":null,"abstract":"<div><div>Liposomal drugs have significantly improved cancer treatment in recent years. However, the clinical application of conventional liposomes is limited by factors such as the complexity of the preparation process and the multitude of auxiliary components. By replacing phospholipids and cholesterol with vitamin E succinate (VES), this study addresses these shortcomings by developing a novel modified nanoprodrug, and the new formulation is used to deliver cisplatin. Concurrently, liposomes encapsulating cisplatin were prepared by conventional formulations for comparative experiments. Moreover, VES can inhibit the expression of mitochondrial uncoupling protein 2 (UCP2), further enhancing mitochondrial damage in tumor cells within the tumor microenvironment (TME) and suppressing the tricarboxylic acid cycle, thereby reducing ATP production. Additionally, cisplatin damages DNA structure, affecting the binding of Nrf2 to the antioxidant response element (ARE), thereby inhibiting the signaling expression of heme oxygenase 1 (HO-1). The combined action of cisplatin and VES disrupts the redox balanceleading to a significant accumulation of reactive oxygen species (ROS). The nanoprodrug effectively alters the redox state of the TME and inhibits antioxidant defenses, thereby amplifying oxidative stress damage and enhancing the efficacy of cisplatin. Notably, compared to free cisplatin, the nanoprodrug demonstrates greater efficacy in both cell line-derived xenograft (CDX) and patient-derived tumor xenograft (PDX) liver cancer models. Overall, this study successfully develops a novel mitochondrial-targeted nanoprodrug by modifying the conventional liposome formulation. This provides a new strategy for amplifying oxidative stress in order to disrupt redox balance, and enhance cisplatin efficacy.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111313"},"PeriodicalIF":9.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric effect synergistically boosted NIR-driven photothermal-assisted photocatalytic hydrogen evolution","authors":"Zhouze Chen ,&nbsp;Yujie Yan ,&nbsp;Jun Luo ,&nbsp;Pengnian Shan ,&nbsp;Changyu Lu ,&nbsp;Feng Guo ,&nbsp;Weilong Shi","doi":"10.1016/j.cclet.2025.111302","DOIUrl":"10.1016/j.cclet.2025.111302","url":null,"abstract":"<div><div>The synergistic effects of piezoelectric catalysis and plasmonic photocatalysis hold significant promise for achieving high-efficiency solar energy conversion. Herein, SnFe₂O₄@ZnIn₂S₄ (SFO@ZIS) composites were prepared by a facile low-temperature water bath method, and an efficient and stable near-infrared (NIR) photothermal-assisted piezoelectric photocatalytic system was successfully constructed. The system achieved a synergistic effect of ultrasonic vibration and NIR illumination, driving a photocatalytic hydrogen (H₂) production rate of 17.9 μmol g^-1 h^-1. Related photothermal test results demonstrate that the localized surface plasmon (LSPR) resonance effect of SFO not only significantly broadens the NIR light absorption of ZIS, but also improves the reaction temperature and reduces the activation energy of the reaction by efficiently converting the light energy into heat energy. In addition, photoelectrochemical analyses revealed that the SFO with excellent piezoelectric activity effectively facilitated carrier separation by transferring the energetic hot electrons generated by the LSPR effect to the conduction band of ZIS under external mechanical pressure. This study presents an effective design strategy and theoretical basis for constructing an efficient and robust NIR-driven photothermally assisted piezoelectric photo-catalytic system.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111302"},"PeriodicalIF":9.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the catalytic active site of durable Ru-based liquid-phase catalyst for acetylene hydrochlorination","authors":"Linfeng Li ,&nbsp;Bao Wang ,&nbsp;Tiantong Zhang ,&nbsp;Xinyuan Wang ,&nbsp;Dingqiang Feng ,&nbsp;Wei Li ,&nbsp;Jiangjiexing Wu ,&nbsp;Jinli Zhang","doi":"10.1016/j.cclet.2025.111303","DOIUrl":"10.1016/j.cclet.2025.111303","url":null,"abstract":"<div><div>A comprehensive understanding of the structure and dynamic evolution of catalytic active sites is vital for advancing the study of liquid-phase acetylene hydrochlorination. Here, we successfully developed a Ru-DIPEA/TMS catalyst optimised through systematic composition and condition tuning, demonstrating exceptional performance with 95.5 % C₂H₂ conversion and sustaining over 91.1 % activity along with nearly 100 % selectivity for VCM during a continuous 900-h test. Using a combination of characterisation techniques, including UV–vis spectroscopy, FT-IR spectroscopy, X-ray photoelectron spectroscopy, single-crystal X-ray diffraction, and X-ray absorption spectroscopy, along with density functional theory (DFT) calculations, the structure and dynamic behaviour of the active sites were thoroughly investigated under the synergistic influence of ligands and HCl. The results revealed that HCl activation induces a significant structural transformation of the active sites, leading to the formation of a hexacoordinate complex, Ru(CO)₂C_l2(C₆H₁₅N·HCl)₂. DFT calculations further elucidated the mechanism underlying active site formation, revealing that an increased electron density around the Ru centre and corresponding changes in its coordination environment play critical roles in enhancing catalyst stability and activity. This study contributes to a deeper understanding of the structural basis of active site evolution during acetylene hydrochlorination, offering both practical insights into industrial applications and foundational knowledge for advancing liquid-phase catalysis.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111303"},"PeriodicalIF":9.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reinforced nitrogen fixation via synergistic Ru-Ni dual sites","authors":"Tan Zhang ,&nbsp;Zhikai Che ,&nbsp;Yuru Song ,&nbsp;Jinping Li ,&nbsp;Yuhan Sun ,&nbsp;Guang Liu","doi":"10.1016/j.cclet.2025.111295","DOIUrl":"10.1016/j.cclet.2025.111295","url":null,"abstract":"<div><div>The electrocatalytic nitrogen reduction reaction (NRR) is challenging but crucial for the sustainable development of both industry and agriculture. To enhance NRR performance, it is critically important to construct advanced electrocatalysts that offer satisfactory performance containing high activity and selectivity. However, the strong affinity of nitrogen-containing species on the Ru surface resulted in suboptimal NRR activity. Herein, we propose a dual-site catalyst, RuNi, to optimize the binding strength, which leads to superior electrocatalytic performance, achieving a high NH₃ yield rate of 5.07 µg h^-1 cm^-2 at -0.2 V <em>vs.</em> RHE and a Faradaic efficiency (FE) of 26.2 % at -0.1 V <em>vs.</em> RHE in 0.1 mol/L Na₂SO₄. Owing to the synergistic interaction between Ru and Ni, a remarkable performance is realized over the RuNi catalyst. In-situ characterization evidenced that hydrogen radicals (H*) on the Ni site of the RuNi catalyst participate in the dissociation of N₂ adsorbed on the Ru site, and theoretical investigations indicated that RuNi reduces the adsorption strength of intermediates. This offers an effective approach to the synthesis of dual-site catalysts for electrocatalytic ammonia synthesis.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 9","pages":"Article 111295"},"PeriodicalIF":9.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A zinc-nitrate battery for efficient ammonia electrosynthesis and energy output by a high entropy hydroxide catalyst","authors":"Mingxing Chen,&nbsp;Xue Li,&nbsp;Nian Liu,&nbsp;Zihe Du,&nbsp;Zhitao Wang,&nbsp;Jing Qi","doi":"10.1016/j.cclet.2025.111294","DOIUrl":"10.1016/j.cclet.2025.111294","url":null,"abstract":"<div><div>Zinc-nitrate battery could produce electrical power, remove pollutant nitrate and obtain value-added ammonia, where the cathodic reaction of converting nitrate to ammonia is sluggish and complex due to the involvement of multi-electron transfer. Thus, highly efficient catalysts for nitrate reduction reaction (NO₃RR) are greatly needed. In this work, we report a high entropy hydroxide (HE-OH) as an excellent NO₃RR catalyst, which could achieve high NH₃ Faradaic efficiencies (<em>e.g.</em>, nearly 100 % at −0.3 V <em>versus</em> reversible hydrogen electrode) and high yield rates (<em>e.g.</em>, 30.4 mg h⁻¹cm⁻² at −0.4 V). Moreover, HE-OH could also deliver a current density of 10 mA/cm² at an overpotential of 260 mV for oxygen evolution reaction. The assembled zinc-nitrate battery using HE-OH as the cathode demonstrates a high power density (<em>e.g.</em>, 3.62 mW/cm²), rechargeability and stability.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111294"},"PeriodicalIF":9.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graded nitro-engineering strategy: Tuning surface states and sp² conjugated domains of carbon quantum dots for full-color emission","authors":"Chunyan Wang ,&nbsp;Chen Wei ,&nbsp;Hongyang Niu ,&nbsp;Ligang Xu ,&nbsp;Xue Liu","doi":"10.1016/j.cclet.2025.111296","DOIUrl":"10.1016/j.cclet.2025.111296","url":null,"abstract":"<div><div>Precise control of luminescence in carbon quantum dots (CQDs), from single-color to full-color emission, is crucial for advancing their applications in biomedical imaging and display technologies. While CQDs luminescence is primarily influenced by conjugated domains and surface states, the underlying interaction mechanisms remain poorly understood. This study explores a graded nitro-engineering approach to simultaneously regulate surface states and sp² conjugated domains through nitro (-NO₂) modulation, enabling comprehensive color tuning. Using <em>o</em>-phenylenediamine (<em>o</em>-PD) as the carbon source and adjusting nitric acid (HNO₃) concentrations, we synthesized tricolor-emitting nitro-functionalized CQDs (NO₂-CQDs). At lower -NO₂ concentrations, luminescence is mainly influenced by surface states, where the electron-withdrawing effect of -NO₂ enhances <em>π</em>-electron delocalization and stabilizes sp² conjugation. With increasing -NO₂ content, the lowest unoccupied molecular orbital (LUMO) energy level decreases (-2.12 eV to -3.39 eV), resulting in a red-shift in fluorescence. At higher -NO₂ concentrations, luminescence is primarily affected by the sp² conjugated domain, where steric hindrance reduces molecular planarity and conjugation, leading to a blue-shift in fluorescence as the sp² domain size decreases (4.03 nm to 2.83 nm). Combining experimental results with density functional theory (DFT) calculations, we reveal the dual role of -NO₂ in modulating CQDs luminescence, an approach rarely achieved through surface functionalization. This work presents a novel strategy for precise tuning of CQDs luminescence across the visible spectrum.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111296"},"PeriodicalIF":9.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Groups 3 and 4 single-site catalysts for olefin-polar monomer copolymerization","authors":"Chengkai Li,&nbsp;Guoqiang Fan,&nbsp;Gang Zheng,&nbsp;Rong Gao,&nbsp;Li Liu","doi":"10.1016/j.cclet.2025.111297","DOIUrl":"10.1016/j.cclet.2025.111297","url":null,"abstract":"<div><div>Introducing functional polar groups into polyolefins can significantly improve the material properties, but there are still challenges in achieving this goal, with the core difficulty being that polar groups are prone to interact with metal active species, affecting the efficiency of the copolymerization. With the rapid advancement in catalyst, a variety of copolymerization strategies are developed aimed at producing more versatile polyolefin materials. Although early transition metal catalysts play an indispensable role in the traditional polyolefin industry, their inherent strong oxophilicity becomes a significant constraint in copolymerization involving polar olefins, limiting their application scope. This review summarizes the progress made in recent years in the efficient copolymerization of non-polar olefins with polar comonomers catalyzed by groups 3 and 4 single-site catalysts. We classify the catalysts into four categories, Sc-, Ti-, Zr-, Hf-, based on the type of metal centers, and provide insights into the influence of catalyst structures and the type of comonomers on the copolymerization behavior. The introduction of polar monomers fundamentally improves the comprehensive performance of the products, greatly broadens the application scope of polyolefin materials, and meets the growing market demand for multifunctional and high-performance materials.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 9","pages":"Article 111297"},"PeriodicalIF":9.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchical work function programming for optimizing interfacial polarization in electromagnetic wave absorber","authors":"Jinkun Liu ,&nbsp;Xuelian Yang ,&nbsp;Wenxuan Chen ,&nbsp;Pingan Zhu ,&nbsp;Guanglei Wu ,&nbsp;Jing Zheng ,&nbsp;Xu Hou","doi":"10.1016/j.cclet.2025.111293","DOIUrl":"10.1016/j.cclet.2025.111293","url":null,"abstract":"<div><div>The development of next-generation electromagnetic wave (EMW) absorbers requires a shift in interface design. By employing hierarchical work function programming, we propose an approach to tune interfacial polarization dynamics. This method utilizes multi-gradient work functions to guide carrier migration and polarization effectively, thereby enhancing energy dissipation under alternating electromagnetic fields. Here, we constructed a 1T/2H-MoS₂/PPy/VS₂ composite absorber with integrated gradient interfaces. The composite achieved a powerful absorption (RL_min) of -58.59 dB at 2.3 mm, and an effective absorption bandwidth (EAB) of 7.44 GHz at 2.5 mm, demonstrating improved broadband absorption. Radar cross-section (RCS) simulations show an EMW loss of -7.2 dB m² at 0°, highlighting its potential for stealth and communication applications. This study introduces hierarchical work function programming as a promising strategy in EMW absorber design, contributing to advancements in material performance and functionality.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 10","pages":"Article 111293"},"PeriodicalIF":9.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of mesopore-rich hollow carbon nanospheres as headspace solid-phase microextraction coating to extract PAHs from water and honey","authors":"Jiawen Zhu ,&nbsp;Yingge Hao ,&nbsp;Zhen Song ,&nbsp;Huina Zhou ,&nbsp;Youmei Wang ,&nbsp;Ling Yan ,&nbsp;Minghua Lu","doi":"10.1016/j.cclet.2025.111290","DOIUrl":"10.1016/j.cclet.2025.111290","url":null,"abstract":"<div><div>The coating material is considered as the key of solid-phase microextraction (SPME) due to the fact that which has much effect on the selectivity and sensitivity of the analytical method. Herein, the porous hollow carbon nanospheres (PHCNs) were synthesized by selectively removing the interior part of solid inhomogeneous nanospheres with acetone. Using PHCNs as new coating material, a SPME fiber was prepared. To the best of our knowledge, PHCNs was utilized as a SPME fiber coating for the first time. The fiber coating material PHCNs demonstrated excellent thermal stability (&gt;800 ℃) and long usage lifespan (≥60 times). A headspace SPME (HS-SPME) was established to non-contact extract and enrich polycyclic aromatic hydrocarbons (PAHs) prior to gas chromatography-flame ionization detector (GC-FID) analysis. The HS-SPME not only can eliminate non-volatile interferences from matrix, but also be able to protect fiber coating and prolong lifespan of fiber prober. The linearity in the linear range of 0.01–30 ng/mL and limits of detection from 0.003 ng/mL to 0.006 ng/mL were obtained by HS-SPME-GC-FID with PHCNs as fiber coating. The enrichment factors were calculated as 5420–9211 compared with conventional direct introduce analysis. The spiked recoveries of real samples including campus lake water and lime tree honey were obtained from 80.93 % to 118.0 % with relative standard deviation no higher than 10.6 %. The <em>π</em>-<em>π</em> stacking interaction, CH/<em>π</em> interaction, and unique built-in cavities significantly enhance the extraction performance of PHCNs coating fiber to PAHs. This work demonstrated that the PHCNs as fiber coating materials present good application prospects for the extraction and enrichment of trace PAHs from complex matrixes.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 12","pages":"Article 111290"},"PeriodicalIF":8.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly regioselective hydrogermylation of unsaturated C-C bonds over ligand-control single atom palladium catalysts","authors":"Junyou Ding,&nbsp;Xiaotong Li,&nbsp;Hongmin Lin,&nbsp;Bochao Ye,&nbsp;Xing Zhou,&nbsp;Feihu Cui,&nbsp;Yingming Pan,&nbsp;Haitao Tang","doi":"10.1016/j.cclet.2025.111286","DOIUrl":"10.1016/j.cclet.2025.111286","url":null,"abstract":"<div><div>The selective addition reaction of unsaturated C<img>C bonds has always been a classic and constant research topic. Different from well-developed hydroboration, hydrosilylation, and hydrostannylation reaction, hydrogermylation reaction remains challenging which hasn't been much reported. Herein, we developed a new metal-porous ligand polymers Pd₁@POL-PPh_nCy_m (<em>n</em> + <em>m</em> = 3) with monoatomic dispersion characteristics for highly selective and efficient hydrogermylation of unsaturated C<img>C bonds, including alkynes, alkenes, and allenes. X-ray photoelectron spectroscopy and theoretical calculations further proved the introduction of cyclohexyl could gently adjust the charge on monoatomic Pd center which effectively facilitate the recognition and transformation of various substrates. With the electrically fine-tuned single atom palladium catalysts, we realized the <em>α</em>-germanium addition for the first time, obtaining corresponding allyl germanium and alkyl germanium compounds.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 11","pages":"Article 111286"},"PeriodicalIF":8.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}