Chao Chen , Wang Geng , Ke Li , Qiong Lei , Zhichao Jin , Xiuhai Gan
{"title":"吡嗪:21世纪杀虫剂开发中的一个特殊支架","authors":"Chao Chen , Wang Geng , Ke Li , Qiong Lei , Zhichao Jin , Xiuhai Gan","doi":"10.1016/j.cclet.2025.110902","DOIUrl":null,"url":null,"abstract":"<div><div>Pyridazine has garnered increasing attention as a privileged scaffold and bioisosterism in drug discovery due to its unique structural characteristics. It can serve as a hydrogen bond acceptor when interacting with receptors due to its two adjacent nitrogen atoms. Upon conversion to pyridazinone, it exhibits the ability to act as both a hydrogen bond acceptor and donor, showcasing its versatility. This inherent flexibility has prompted extensive research exploring its bioactivity in pesticides and pharmaceuticals. In order to promote the development of pyridazine-based pesticides, this review provides a comprehensive summary of advancements for pyridazine-based pesticides on herbicidal (36.9 %), insecticidal (26.2 %), antifungal and antibacterial (24.6 %), plant growth regulatory (10.8 %), and antiviral activities (1.5 %) from 2000 to 2024. It serves as an invaluable reference and source of inspiration for agricultural scientists conducting future research.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 8","pages":"Article 110902"},"PeriodicalIF":9.4000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pyridazine: A privileged scaffold in the development of 21st-century pesticides\",\"authors\":\"Chao Chen , Wang Geng , Ke Li , Qiong Lei , Zhichao Jin , Xiuhai Gan\",\"doi\":\"10.1016/j.cclet.2025.110902\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Pyridazine has garnered increasing attention as a privileged scaffold and bioisosterism in drug discovery due to its unique structural characteristics. It can serve as a hydrogen bond acceptor when interacting with receptors due to its two adjacent nitrogen atoms. Upon conversion to pyridazinone, it exhibits the ability to act as both a hydrogen bond acceptor and donor, showcasing its versatility. This inherent flexibility has prompted extensive research exploring its bioactivity in pesticides and pharmaceuticals. In order to promote the development of pyridazine-based pesticides, this review provides a comprehensive summary of advancements for pyridazine-based pesticides on herbicidal (36.9 %), insecticidal (26.2 %), antifungal and antibacterial (24.6 %), plant growth regulatory (10.8 %), and antiviral activities (1.5 %) from 2000 to 2024. It serves as an invaluable reference and source of inspiration for agricultural scientists conducting future research.</div></div>\",\"PeriodicalId\":10088,\"journal\":{\"name\":\"Chinese Chemical Letters\",\"volume\":\"36 8\",\"pages\":\"Article 110902\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2025-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Chemical Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1001841725000890\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Chemical Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1001841725000890","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Pyridazine: A privileged scaffold in the development of 21st-century pesticides
Pyridazine has garnered increasing attention as a privileged scaffold and bioisosterism in drug discovery due to its unique structural characteristics. It can serve as a hydrogen bond acceptor when interacting with receptors due to its two adjacent nitrogen atoms. Upon conversion to pyridazinone, it exhibits the ability to act as both a hydrogen bond acceptor and donor, showcasing its versatility. This inherent flexibility has prompted extensive research exploring its bioactivity in pesticides and pharmaceuticals. In order to promote the development of pyridazine-based pesticides, this review provides a comprehensive summary of advancements for pyridazine-based pesticides on herbicidal (36.9 %), insecticidal (26.2 %), antifungal and antibacterial (24.6 %), plant growth regulatory (10.8 %), and antiviral activities (1.5 %) from 2000 to 2024. It serves as an invaluable reference and source of inspiration for agricultural scientists conducting future research.
期刊介绍:
Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.