吡嗪:21世纪杀虫剂开发中的一个特殊支架

IF 9.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Chao Chen , Wang Geng , Ke Li , Qiong Lei , Zhichao Jin , Xiuhai Gan
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引用次数: 0

摘要

吡嗪由于其独特的结构特点,作为一种特殊的支架和生物同构体在药物发现中越来越受到关注。由于它的两个相邻的氮原子,当与受体相互作用时,它可以作为氢键受体。在转化为吡啶嗪酮后,它显示出作为氢键受体和供体的能力,展示了它的多功能性。这种固有的灵活性促使人们对其在农药和药品中的生物活性进行了广泛的研究。为了促进吡嗪类农药的发展,本文对2000 - 2024年吡嗪类农药在除草(36.9%)、杀虫(26.2%)、抗真菌和抗菌(24.6%)、植物生长调节(10.8%)和抗病毒(1.5%)方面的研究进展进行了综述。它为农业科学家进行未来研究提供了宝贵的参考和灵感来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pyridazine: A privileged scaffold in the development of 21st-century pesticides

Pyridazine: A privileged scaffold in the development of 21st-century pesticides
Pyridazine has garnered increasing attention as a privileged scaffold and bioisosterism in drug discovery due to its unique structural characteristics. It can serve as a hydrogen bond acceptor when interacting with receptors due to its two adjacent nitrogen atoms. Upon conversion to pyridazinone, it exhibits the ability to act as both a hydrogen bond acceptor and donor, showcasing its versatility. This inherent flexibility has prompted extensive research exploring its bioactivity in pesticides and pharmaceuticals. In order to promote the development of pyridazine-based pesticides, this review provides a comprehensive summary of advancements for pyridazine-based pesticides on herbicidal (36.9 %), insecticidal (26.2 %), antifungal and antibacterial (24.6 %), plant growth regulatory (10.8 %), and antiviral activities (1.5 %) from 2000 to 2024. It serves as an invaluable reference and source of inspiration for agricultural scientists conducting future research.
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来源期刊
Chinese Chemical Letters
Chinese Chemical Letters 化学-化学综合
CiteScore
14.10
自引率
15.40%
发文量
8969
审稿时长
1.6 months
期刊介绍: Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.
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