Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2026-02-19DOI: 10.1016/j.hybadv.2026.100627
Ahmed Kateb Jumaah Al-Nussairi , Ali.B.M. Ali , Mohammad Aljaidi , Yasser Taha Alzubaidi , Arunkumar Munimathan , Mohammad Khishe
{"title":"Machine learning-driven performance and emission optimization of cerium oxide nano-enhanced tobacco biodiesel in CI engines","authors":"Ahmed Kateb Jumaah Al-Nussairi , Ali.B.M. Ali , Mohammad Aljaidi , Yasser Taha Alzubaidi , Arunkumar Munimathan , Mohammad Khishe","doi":"10.1016/j.hybadv.2026.100627","DOIUrl":"10.1016/j.hybadv.2026.100627","url":null,"abstract":"<div><div>As fossil fuel reserves continue to diminish and environmental concerns intensify, the search for renewable, sustainable, and cleaner alternatives has gained momentum. Biodiesel derived from tobacco seed oil offers an eco-friendly and non-edible option for compression ignition (CI) engines. In this study, tobacco seed oil methyl ester (TSOME) was blended with diesel at B10, B20, B30, and B40 ratios, each supplemented with 0.5 wt% cerium oxide (CeO<sub>2</sub>) nanoparticles to enhance combustion efficiency and emission behavior. A combined framework of experimental evaluation, machine learning (ML) prediction, and response surface methodology (RSM) optimization was employed. Performance and emission characteristics were assessed using a single-cylinder, four-stroke, water-cooled Kirloskar CI engine under varying loads (25–100%). Standard instrumentation measured brake thermal efficiency (BTE), brake specific fuel consumption (BSFC), oxides of nitrogen (NOx), carbon monoxide (CO), hydrocarbons (HC), smoke opacity, and exhaust gas temperature (EGT). Results showed that B10 and B20 blends achieved efficiencies comparable to diesel at higher loads, with <1% deviation in BTE and BSFC. All biodiesel blends exhibited substantial reductions in CO, HC, and smoke emissions, although NOx emissions increased due to higher in-cylinder temperatures. Among the ML models, artificial neural networks (ANN) outperformed random forest (RF) and support vector regression (SVR), achieving R<sup>2</sup> values above 0.99 in the experimentally studied operational field. RSM optimization identified B20–B30 blends at 75–100% engine load as the optimum operating range, balancing efficiency and emissions. The findings indicate that biodiesel mixtures in which the CeO<sub>2</sub> nano-additive TSOME is used are a feasible and compatible partial diesel replacement in compression-ignition engines that are run under controlled conditions, and hence investments into the real-time combustion diagnostics, adaptive injection sets, and tailored fuel-nanoparticle complexes are justified.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2025-12-04DOI: 10.1016/j.hybadv.2025.100590
Salma Dehhaoui , Fatima El Hajri , Driss Rair , Driss El Mekkaoui , Youssef Lemallam , Said Boukhris , Touriya Jermoumi , Abdelillah Shaim , Rui Galhano dos Santos , Abdelkrim Chahine
{"title":"Unlocking new catalytic pathways with phosphate-zirconia hybrid prepared via the sol-gel method","authors":"Salma Dehhaoui , Fatima El Hajri , Driss Rair , Driss El Mekkaoui , Youssef Lemallam , Said Boukhris , Touriya Jermoumi , Abdelillah Shaim , Rui Galhano dos Santos , Abdelkrim Chahine","doi":"10.1016/j.hybadv.2025.100590","DOIUrl":"10.1016/j.hybadv.2025.100590","url":null,"abstract":"<div><div>This study focuses on synthesising a ZrO<sub>2</sub>–P<sub>2</sub>O<sub>5</sub> xerogel by the sol–gel process and evaluating it as a heterogeneous catalyst for the efficient and environmentally friendly synthesis of 2,3-dihydroquinazolin-4(1H)-one (DHQs), a class of compounds with significant pharmacological relevance. While both oxide materials and their catalytic applications are well established, the originality of our work lies in the rational design of a ZrO<sub>2</sub>–P<sub>2</sub>O<sub>5</sub> catalyst via a sol–gel co-condensation route. This method enables precise control over the distribution and balance of Lewis and Brønsted acid sites, a level of regulation rarely achieved in conventional oxide systems. Such fine structural control fosters an optimised acid–base synergy that directly enhances catalytic efficiency. Consequently, the material achieves a 93 % yield in only 8 min with minimal catalyst loading and exhibits excellent recyclability, demonstrating both the scientific novelty and practical significance of this approach.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2026-02-18DOI: 10.1016/j.hybadv.2026.100626
Feni Istikharoh , Yuanita Lely Rachmawati , Mas Jaffri Masarudin
{"title":"Phyto-nanotechnology for biofilm-associated periodontitis: Quantitative evidence and translational roadmap from laboratory to clinic","authors":"Feni Istikharoh , Yuanita Lely Rachmawati , Mas Jaffri Masarudin","doi":"10.1016/j.hybadv.2026.100626","DOIUrl":"10.1016/j.hybadv.2026.100626","url":null,"abstract":"<div><div>Periodontal disease affects >50% of adults globally, yet current therapies fail due to antimicrobial resistance and inadequate biofilm penetration in deep pockets (>6 mm). Despite two decades of nanotechnology research yielding 50+ approved nanomedicines, no phyto-nanotechnology product has achieved regulatory approval for periodontal therapy, representing a critical translational gap that this review systematically addresses. This PRISMA 2020-compliant systematic review analyzed 32 studies (in vitro: 53.13%; animal: 34.38%; clinical: 12.5%) to establish the first comprehensive quantitative benchmarks for phyto-nanoformulations: 6.2–18.4-fold MIC reductions and 2.8–4.6-fold enhanced biofilm penetration versus conventional preparations. Nano-propolis demonstrated 10 × superior antimicrobial potency with unprecedented biofilm penetration (180–240 μm vs. 40–65 μm). Curcumin nanocrystals achieved 47–127-fold solubility enhancement and 32–64-fold MIC reduction. Uniquely, naringin nanoparticles activated osteogenic pathways (BMP2/Runx2/Osterix), positioning phyto-nanotechnology as a disease-modifying rather than merely antimicrobial therapy. This review is the first to integrate antimicrobial, immunomodulatory, and osteogenic dimensions while providing an evidence-based translational roadmap from bench to bedside. We systematically identify barriers preventing clinical translation: pharmaceutical-grade manufacturing challenges, regulatory pathway ambiguities, and economic sustainability questions. Our translational framework provides actionable guidance for researchers, regulatory scientists, and pharmaceutical developers to advance phyto-nanotechnology from promising laboratory findings to economically viable clinical solutions for 3.5 billion patients worldwide suffering from periodontal disease.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PBAT-based biodegradable triboelectric nanogenerators for sustainability in energy, environment, and health","authors":"Kariyappa Gowda Guddenahalli Shivanna , Vishnu Kadabahalli Thammannagowda , Smitha Ankanahalli Shankaregowda , Prashantha Kalappa","doi":"10.1016/j.hybadv.2026.100602","DOIUrl":"10.1016/j.hybadv.2026.100602","url":null,"abstract":"<div><div>The increasing demand for portable and sustainable power sources has accelerated research into triboelectric nanogenerators (TENGs), which convert mechanical energy from the environment into electrical energy. However, the widespread use of non-degradable materials in conventional TENGs raises serious environmental concerns. This review highlights the potential of biodegradable poly(butylene adipate-co-terephthalate) (PBAT) as a triboelectric material for the development of eco-friendly TENGs. Various fabrication techniques, including solvent casting and electrospinning, are discussed for the preparation of PBAT-based TENGs. According to current literature, the incorporation of nanomaterials into the PBAT matrix significantly enhances output performance, mechanical properties, and environmental compatibility. Additionally, this review explores the applications of PBAT-based TENGs in energy harvesting, self-powered sensors, biodegradable electronics, and environmental monitoring, emphasizing PBAT's contribution to sustainable TENG technology. The primary focus of this review is to explore solvent-free methods such as compression molding and 3D printing for fabricating PBAT films, which are then utilized in TENG device development.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100602"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the effectiveness of an aromatic derivative with a calix[4]arene structure as a corrosion inhibitor for extra-mild steel in acidic medium (1 M HCl)","authors":"Majda Raid , Hammadi El Harmouchi , Omar Belhadj , Yasmine Fernine , Moussa Ouakki , Rajesh Haldhar , Avni Berisha , Zouhair Asfari , Elhossein Rifi , Mohammed Cherkaoui","doi":"10.1016/j.hybadv.2025.100570","DOIUrl":"10.1016/j.hybadv.2025.100570","url":null,"abstract":"<div><div>Corrosion is a natural phenomenon that poses a major challenge for many materials, especially metals, due to its adverse effects on their durability and performance. This study investigates the effectiveness of an organic substance derived from calix[4]arene, specifically: 1<sup>2</sup>,3<sup>2</sup>,5<sup>2</sup>,7<sup>2</sup>-tetrakis(benzyloxy)-1<sup>5</sup>,3<sup>5</sup>,5<sup>5</sup>,7<sup>5</sup>-tetra-<em>tert</em>-butyl-1,5(1,3),3,7(1,4)-tetrabenzenacyclooctaphane (Calix-L2), as a corrosion inhibitor for extra-mild steel (EMS) in a 1 M hydrochloric acid (HCl) solution. A variety of experimental techniques were employed, including weight loss (WL) measurements to evaluate corrosion reduction, along with electrochemical methods such as electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP). The results indicate that increasing the concentration of Calix-L2 enhances its corrosion inhibition performance, with the highest recorded inhibition efficiency reaching 93 %. Electrochemical PDP analysis reveals that Calix-L2 acts as a mixed-type inhibitor. Adsorption of Calix-L2 on the steel surface follows the Langmuir adsorption isotherm. Surface characterization using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) confirms the formation of a protective coating on the steel surface. Additionally, theoretical studies using quantum chemical simulations and molecular modeling support the experimental findings, this confirms the adsorption of Calix-L2 onto the EMS surface and supports its effectiveness as a corrosion inhibitor.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100570"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2025-12-17DOI: 10.1016/j.hybadv.2025.100595
Wan Noor Hin Mior Sani , Ramadhansyah Putra Jaya , Indra Mawardi , Zaid Hazim Al-Saffar , Haryati Yaacob
{"title":"The modelling and design optimisation of sawdust, garnet waste, and palm oil fuel ash-based hybrid asphalt binders using response surface methodology","authors":"Wan Noor Hin Mior Sani , Ramadhansyah Putra Jaya , Indra Mawardi , Zaid Hazim Al-Saffar , Haryati Yaacob","doi":"10.1016/j.hybadv.2025.100595","DOIUrl":"10.1016/j.hybadv.2025.100595","url":null,"abstract":"<div><div>This study evaluated the rheological characteristics of a hybrid asphalt binder integrating sawdust, garnet waste, and palm oil fuel ash (POFA). Approximately 0 %, 3 %, 6 %, and 9 % of hybrid materials were incorporated into the unaged and rolling thin film oven (RTFO) hybrid asphalt binders were assessed. Furthermore, the central composite design (CCD) in the response surface methodology (RSM) were utilised to evaluate the effects of hybrid asphalt binder content and temperature on the rheological behaviour of the hybrid asphalt binders. Consequently, the hybrid asphalt binders showed dosage-dependent rheological behaviour, with the 6 % formulation exhibiting notably lower phase angle (δ) and complex shear modulus (G∗) than the control binder, particularly in the unaged state, while other dosages displayed more variable responses across the tested temperatures. The RTFO hybrid asphalt binders also revealed reduced stiffness across all temperatures compared to the control asphalt. Given that high correlation coefficients (R<sup>2</sup>) were demonstrated by the G∗ (<0.97) and δ (<0.93), a substantial relationship between the model values and the experimental data was identified. The optimal parameters (temperature and percentage) for the hybrid materials were also discovered to be 62.9 °C and 5.78 % using the numerical optimisation and the quadratic model. Considering that each response possessed a percentage error below 5 %, the effectiveness and the validation of the model were successfully verified in this study.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100595"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shear strengthening and rehabilitation of high-strength continuous RC beams with BFRP: A combined experimental and numerical study","authors":"Mu'tasim Abdel-Jaber , Reem AlKhawaldeh , Rawand Al-Nsour , Nasim Shatarat , Ahmed Ashteyat","doi":"10.1016/j.hybadv.2025.100592","DOIUrl":"10.1016/j.hybadv.2025.100592","url":null,"abstract":"<div><div>This study explores the use of Basalt Fiber-Reinforced Polymer (BFRP) as a retrofit and strengthening solution to improve the shear performance and durability of high-strength reinforced concrete (RC) beams. In total, seven full-scale RC beams with two-span layouts, each measuring 2 m in length, were evaluated under different test setups. One beam was left unstrengthened to act as a control, while the remaining specimens were either retrofitted or upgraded using a variety of BFRP configurations, including sheets and ropes of varying densities. Before the BFRP application, three specimens were preloaded to 70 % of their ultimate strength to mimic pre-existing structural deterioration. Post-strengthening, the beams demonstrated significant improvements in shear capacity. Specifically, externally strengthened beams showed load capacity increases ranging between 17 % and 37.4 %, whereas those that underwent rehabilitation experienced gains between 5.7 % and 19.4 %. The findings confirm the effectiveness of BFRP for both structural repair and enhancement, highlighting its role in restoring or boosting the load-bearing ability of RC members. Furthermore, the outcomes were consistent with finite element analysis and closely followed the ACI 440.2R-08 guidelines, validating the experimental results. Overall, the research identifies BFRP materials as a sustainable and efficient method for structural strengthening and rehabilitation.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2026-01-09DOI: 10.1016/j.hybadv.2026.100608
R. Kamalesh, Alan Shaji, A. Saravanan, Ragini Y P, A.S. Vickram
{"title":"Metal–organic frameworks for heavy metal remediation: Advances in sustainable adsorption mechanisms and clean water applications","authors":"R. Kamalesh, Alan Shaji, A. Saravanan, Ragini Y P, A.S. Vickram","doi":"10.1016/j.hybadv.2026.100608","DOIUrl":"10.1016/j.hybadv.2026.100608","url":null,"abstract":"<div><div>The global concern over ecological safety and public health has led to the development of a sustainable approach towards pollutant remediation. Recently, heavy metals and organic pollutants have emerged as the two major contaminants, and their remediation has attracted significant attention from researchers. Metal-Organic Frameworks (MOFs) are porous materials composed of organic linkers and metal nodes that self-assemble into crystal structures. The unique properties of MOFs include tunable porosity, large surface area, high predictability, and functional diversity for adsorption, catalysis, and pollutant degradation. One key benefit of MOFs is their selective adsorption of various pollutants, including heavy metals, organic compounds, pharmaceuticals, personal care products, and dyes. This review uniquely integrates heavy-metal sources, MOF adsorption mechanisms, and synthesis strategies into a single comprehensive framework. The main outcome of the study highlights advanced synthesis routes, including micro-wave, sonochemical, electrochemical, and mechanochemical methods, supported with research findings on adsorption performance. The study consolidates recent evidence on MOF in clean water treatment, organic pollutant degradation, and emerging fields such as drug delivery, sensing, and photocatalysis. It also emphasizes the functionalization, hybrid composites, and membrane integration of MOFs to enhance selectivity, stability, and reusability in real-world remediation scenarios. The analysis underscores MOFs’ expanding role beyond adsorption, showcasing their versatility in environmental and biomedical technologies. Additionally, it also outlines key challenges and future directions to guide the development of next-generation MOF composites for sustainable remediation.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100608"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2026-02-20DOI: 10.1016/j.hybadv.2026.100628
M.P. Mkhatshwa
{"title":"Natural convection flow of Casson hybrid nanofluid through a vertically oriented porous cone: Parametric numerical study","authors":"M.P. Mkhatshwa","doi":"10.1016/j.hybadv.2026.100628","DOIUrl":"10.1016/j.hybadv.2026.100628","url":null,"abstract":"<div><div>This paper presents the parametric and sensitivity-based numerical investigation of magnetically driven natural convective boundary layer flow of Casson hybrid nanofluid through a vertically oriented porous cone with fluctuating nanofluid features, constant wall thermal and mass fluxes, viscous and Ohmic dissipation, radiative heat flux, heat sink/source and chemical reactive species. This work is devoted to comprehending the significance of these factors on the flow fields and contours, momentum, thermal and mass transport features of hybrid nanofluids. The governing equations admit dimensionless form using similarity transformations, and the subsequent transport equations are solved via an overlapping grid multi-domain spectral discretization method. This numerical scheme enables superior accuracy in simulating the behavior of flow and transport processes. Normalized sensitivity indices are used to quantitatively evaluate how key parameters influence the behavior of the system. Graphs demonstrate that elevating values of fluctuation viscosity, permeability, magnetic field, and Casson fluid parameter diminishes flow velocity and shear stress rate. Superior thermal radiation and variable thermal conductivity enforces fluid temperature and the rate at which heat is transported, while accelerating chemical reaction rate and variable diffusivity enhances species transport rate. Hybrid nanoparticle concentration elevates the Nusselt numbers while reducing skin friction, revealing enhanced thermal transport with reduced flow resistance. Casson-hybrid nanofluid effects promote more pronounced penetration of both streamlines and isotherms, confirming enhanced convection and improved heat transport. Sensitivity analysis emphasizes that quantities of engineering interest are significantly influenced by nanoparticle volume fraction, implying that nanoparticle loading is a dominant control mechanism for transport performance in hybrid nanofluid systems.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.hybadv.2026.100603
X. Anitha Mary , G.R. Ashisha , B. Jebasingh , P. Manimegalai , C. Karthik , Ayodeji Olalekan Salau
{"title":"Development of a real-time sweat sensor using functionalized graphene oxide as an efficient electrode nanomaterial: Towards point of care sweat sensor","authors":"X. Anitha Mary , G.R. Ashisha , B. Jebasingh , P. Manimegalai , C. Karthik , Ayodeji Olalekan Salau","doi":"10.1016/j.hybadv.2026.100603","DOIUrl":"10.1016/j.hybadv.2026.100603","url":null,"abstract":"<div><div>Human sweat is an accessible biofluid that carries essential electrolytes and metabolites which reflects the physiological condition of body. Its use in routine diagnostics is limited due to the non-availability of sensing systems. In this paper, a cost effective sweat sensor employing functionalized Graphene Oxide (FGO) with tris(hydroxymethyl)amino-methane (GO-THAM) electrodes was developed. The functionalization step increases the interlayer spacing and introduces multiple hydroxyl groups, improving the interaction of the nanosheets with sodium and potassium ions. The fabricated device consists of a microfluidic channel coupled to the functionalized electrode and an ATmega328 microcontroller for real-time monitoring of ion-induced conductivity changes. The sensor was calibrated with artificial sweat solutions and further evaluated using sweat collected from volunteers during walking and after exercise. The recorded voltage outputs showed strong agreement with reference flame photometry measurements, demonstrating the reliability of the system. Because of its low cost, straightforward fabrication, and ability to detect Na<sup>+</sup> and K<sup>+</sup> concentrations in real time, the system has strong potential for athletic performance assessment and future point-of-care applications.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"12 ","pages":"Article 100603"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}