hLife Pub Date : 2025-11-01 Epub Date: 2025-06-03 DOI: 10.1016/j.hlife.2025.05.009

Wei Yang , Qi Sun , Yihao Zhang , Jingshu Yang , Feng Gao , Congchao Cheng , Yu Sun

引用次数: 0

Rational design of human CD26 receptor for a strong neutralizing ability against MjHKU4r-CoV-1 and MERS-CoV 合理设计人CD26受体，对MjHKU4r-CoV-1和MERS-CoV具有强中和能力

hLife Pub Date : 2025-11-01 Epub Date: 2025-05-19 DOI: 10.1016/j.hlife.2025.05.005

Yalei Zhang , Mingxiong Tian , Yanjun Han , Junqing Sun , Wenwei Li , Chongzhi Bai , Chao Su , Pengcheng Han

引用次数: 0

Forging trust in AI-assisted disease diagnosis 打造人工智能辅助疾病诊断的信任

hLife Pub Date : 2025-11-01 Epub Date: 2025-05-31 DOI: 10.1016/j.hlife.2025.05.011

Yangzhihao Zhang , Mengjie Fang , Xin Feng , Xu-Yao Zhang , Xuebin Xie , Di Dong

引用次数: 0

The terra incognita in microbiology for artificial intelligence and where to go next 人工智能微生物学的未知领域和下一步的发展方向

hLife Pub Date : 2025-11-01 Epub Date: 2025-06-06 DOI: 10.1016/j.hlife.2025.06.002

Siqi Guo , Jun Wang

引用次数: 0

Enabling manufacture and access to advanced therapy medicinal products in low- and middle-income countries 使低收入和中等收入国家能够生产和获得先进治疗药品

hLife Pub Date : 2025-11-01 Epub Date: 2025-07-10 DOI: 10.1016/j.hlife.2025.07.001

Antonio Carlos Campos de Carvalho , Camile Giaretta Sachetti , Marco Aurélio Krieger

引用次数: 0

Single-cell transcriptome analysis reveals mechanism of phosphodiesterase inhibitor in neonatal mouse infection-associated liver injury treatment 单细胞转录组分析揭示磷酸二酯酶抑制剂在新生小鼠感染相关肝损伤治疗中的作用机制

hLife Pub Date : 2025-11-01 Epub Date: 2025-04-14 DOI: 10.1016/j.hlife.2025.04.002

Xixi Chen , Yanhui Xu , Huifang Ren , Xiaolei Wang , Andrew M. Lew , Yuxia Zhang , Zhe Wen

{"title":"Single-cell transcriptome analysis reveals mechanism of phosphodiesterase inhibitor in neonatal mouse infection-associated liver injury treatment","authors":"Xixi Chen , Yanhui Xu , Huifang Ren , Xiaolei Wang , Andrew M. Lew , Yuxia Zhang , Zhe Wen","doi":"10.1016/j.hlife.2025.04.002","DOIUrl":"10.1016/j.hlife.2025.04.002","url":null,"abstract":"<div><div>Virus-induced neonatal liver failure remains a critical health challenge with poorly understood mechanisms. This study employed a comprehensive approach to investigate the pathological role of phosphodiesterase 4B (PDE4B) in rotavirus-associated liver injury. In this study, we utilized a mouse model of virus-induced liver injury model through the intraperitoneal injection of rhesus rotavirus (RRV) into newborn BALB/c mice, and applied dipyridamole as treatment strategy. We performed single cell sequencing and high-resolution immune landscape exploration on liver samples (<em>n</em> = 3 per group) from control (50 μL phosphate-buffered saline [PBS]), RRV-infected mice (50 μL PBS with 1.5 × 10<sup>6</sup> plaque-forming units of RRV on the first day), and dipyridamole-treated mice (RRV-injected mice with 2.5 mg/kg/day dipyridamole for 12 days). We showed that dipyridamole-mediated inhibition of phosphodiesterases (PDEs) restored the differentiation trajectory of neutrophils by suppressing their activation and promoting clearance. In addition, dipyridamole suppressed the activation of autoreactive B cells and cytotoxic lymphocytes, which collectively ameliorated liver pathology and improved neonatal survival following RRV infection. In summary, we demonstrated that inhibition of phosphodiesterase signaling alleviates liver failure in murine models of neonatal rotavirus infection, thereby revealing a candidate strategy to treat rotavirus-associated diseases in neonates.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 11","pages":"Pages 538-550"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy 肿瘤微环境中微生物群和先天免疫之间的相互作用：癌症进展和免疫治疗的新见解

hLife Pub Date : 2025-10-01 Epub Date: 2025-05-24 DOI: 10.1016/j.hlife.2025.05.008

Zhaokai Zhou , Yingying Lv , Anning Zuo , Xudong Zhu , Yudi Xu , Lulu Zuo , Hui Xu , Shutong Liu , Yuyuan Zhang , Siyuan Weng , Yuhao Ba , Peng Luo , Quan Cheng , Jiaxin Xu , Xing Zhou , Shuang Chen , Boxuan Li , Chuhan Zhang , Yukang Chen , Jinhai Deng , Xinwei Han

{"title":"Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy","authors":"Zhaokai Zhou , Yingying Lv , Anning Zuo , Xudong Zhu , Yudi Xu , Lulu Zuo , Hui Xu , Shutong Liu , Yuyuan Zhang , Siyuan Weng , Yuhao Ba , Peng Luo , Quan Cheng , Jiaxin Xu , Xing Zhou , Shuang Chen , Boxuan Li , Chuhan Zhang , Yukang Chen , Jinhai Deng , Xinwei Han","doi":"10.1016/j.hlife.2025.05.008","DOIUrl":"10.1016/j.hlife.2025.05.008","url":null,"abstract":"<div><div>Human microbiota constitute a complex and dynamic community that interacts with the innate immunity of the host at various anatomical sites, influencing both physiological and pathological states. In individuals with a genetic predisposition, disruptions to the “innate immunity‒microbiota” axis appear to rewire immune responses within the tumor microenvironment (TME), thereby driving cancer pathogenesis. This review summarizes the intricate crosstalk between the microbiota and innate immunity in both healthy and cancerous states, focusing on the modulation of immune recognition and polarization during tumor progression, including immune escape, barrier disruption, chronic inflammatory transformation, and angiogenesis in the initiation phase, as well as the regulation of local invasion, vascular invasion, and pre-metastatic ecological niche formation involved in the metastatic phase. This review also highlights recent advances and challenges in leveraging microbiota for cancer immunotherapy, covering innovations in bacteriophages, genetically engineered probiotics, and bioinformatic applications. Moreover, this review proposes potential approaches to enhance therapeutic efficacy by targeting innate immunity‒microbiota interactions. Further mechanistic insights into these interactions may pave the way for developing innovative microbiota-based cancer immunotherapies.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 10","pages":"Pages 462-493"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promise of synthetic bacteria in cancer immunotherapy: Revitalizing tumor immunity via IL-10R modulation 合成细菌在癌症免疫治疗中的应用前景：通过IL-10R调节激活肿瘤免疫

hLife Pub Date : 2025-10-01 Epub Date: 2025-06-04 DOI: 10.1016/j.hlife.2025.05.013

Jiahe Li , Allen P. Liu

引用次数: 0

Carbapenem-resistant Klebsiella pneumoniae ST11 index from a single strain enhances rapid parallel evolution during persistent infection 单一菌株耐碳青霉烯肺炎克雷伯菌ST11指数增强了持续感染期间的快速平行进化

hLife Pub Date : 2025-10-01 Epub Date: 2025-04-25 DOI: 10.1016/j.hlife.2025.04.007

Liqiang Li , Zhaofang Jiang , Xingwei Wang , Si Yang, Fei Li, Yanyu Xiao, Jiuxin Qu

引用次数: 0

Unveiling the multifaceted roles of ISG15 and ISGylation in copper metabolism and cuproptosis 揭示ISG15和isg酰化在铜代谢和铜沉积中的多方面作用

hLife Pub Date : 2025-10-01 Epub Date: 2025-05-15 DOI: 10.1016/j.hlife.2025.05.003

Junqi Xu , Qiao Zhang , Ismail Mohamed Suleiman , Jianping Xie

引用次数: 0

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