hLife最新文献_第3页

Time is now: Preparing for the next pandemic 时不我待：为下一次大流行做好准备

hLife Pub Date : 2025-03-01 DOI: 10.1016/j.hlife.2024.12.008

Jun Liu , George Fu Gao , Kwok-Yung Yuen , Lit Man Leo Poon , Nan Song

引用次数: 0

Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2 使免疫逃逸的 etesevimab 能够完全对抗 SARS-CoV-2 Omicron 亚变种，包括 KP.2

hLife Pub Date : 2025-03-01 DOI: 10.1016/j.hlife.2024.12.006

Chao Su , Juanhua He , Yufeng Xie , Yu Hu , Xin Li , Shitong Qiao , Peipei Liu , Min Huang , Rong Zhang , Liang Wang , Zhen Chang , Wenqiao Sun , Ke Xu , Jing Zhang , Longxing Cao , Pengcheng Han , Xin Zhao , Jianxun Qi , Qihui Wang , Mengsu Yang , George Fu Gao

{"title":"Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2","authors":"Chao Su , Juanhua He , Yufeng Xie , Yu Hu , Xin Li , Shitong Qiao , Peipei Liu , Min Huang , Rong Zhang , Liang Wang , Zhen Chang , Wenqiao Sun , Ke Xu , Jing Zhang , Longxing Cao , Pengcheng Han , Xin Zhao , Jianxun Qi , Qihui Wang , Mengsu Yang , George Fu Gao","doi":"10.1016/j.hlife.2024.12.006","DOIUrl":"10.1016/j.hlife.2024.12.006","url":null,"abstract":"<div><div>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving since 2019. Some monoclonal antibodies (mAbs) have been developed and widely used, such as etesevimab (CB6) developed by Eli-Lilly/Junshi. However, the mAb escaped from the variant of concern (VOC) ever since the emergence of Beta VOC, with a complete loss of efficacy against the Omicron subvariants. Here, we developed a broad-spectrum and affinity-mature antibody design (BAADesign) procedure to design CB6, enabling it to bind to the receptor-binding domains (RBDs) of multiple important Omicron subvariants, including the recent variant KP.2. Structural analysis confirmed the desired CB6-RBD interactions. Additionally, identical mutations in the complementarity determining regions (CDR)1 and CDR2 of the CB6 mutants also restored neutralizing potency for some RBD-1 group antibodies. Overall, the enhanced CB6 neutralizing capacity makes it a promising candidate against SARS-CoV-2 infection, and the BAADesign method has implications for the design of other antibodies.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 3","pages":"Pages 132-145"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H3N2 influenza virus characteristics in China (2019–2022): Genetic, antigenic, and infection dynamics during the COVID-19 pandemic 中国H3N2流感病毒特征（2019-2022年）：COVID-19大流行期间的遗传、抗原和感染动态

hLife Pub Date : 2025-03-01 DOI: 10.1016/j.hlife.2025.01.004

Jiaming Li , Yu Huan , Qianfeng Xia , Yan Li , Rahat Ullah Khan , Qingzhi Liu , Chuanran Dou , Marina Gulyaeva , Alexander Shestopalov , Ning Zhang , Xuefeng Duan , Jing Yang , Hongchun Zhang , Yuhai Bi

{"title":"H3N2 influenza virus characteristics in China (2019–2022): Genetic, antigenic, and infection dynamics during the COVID-19 pandemic","authors":"Jiaming Li , Yu Huan , Qianfeng Xia , Yan Li , Rahat Ullah Khan , Qingzhi Liu , Chuanran Dou , Marina Gulyaeva , Alexander Shestopalov , Ning Zhang , Xuefeng Duan , Jing Yang , Hongchun Zhang , Yuhai Bi","doi":"10.1016/j.hlife.2025.01.004","DOIUrl":"10.1016/j.hlife.2025.01.004","url":null,"abstract":"<div><div>Seasonal influenza activity significantly decreased in China during the coronavirus disease 2019 (COVID-19) pandemic, yet the H3N2 virus led to three epidemic waves. Understanding the characteristics of H3N2 epidemic viruses is essential for recognizing influenza during COVID-19 and for updating vaccines. In this study, we analyzed 579 respiratory samples from patients exhibiting influenza-like symptoms, collected in 2019–2022, leading to the successful sequencing of 36 complete H3N2 genomes. Genomic analysis indicated that the epidemic strains from these periods belonged to different hemagglutinin (<em>HA</em>) clades and exhibited phylogenetic divergence from the concurrently used vaccine strains. Significant antigenic differences were identified through cross-hemagglutination inhibition (HI) and cross-microneutralization (MN) assays. Furthermore, pathogenicity studies showed that representative strains replicated in Madin-Darby canine kidney‌ (MDCK) cells, with varying abilities, and all replicated more effectively at 37 °C compared to 33 °C. These strains also replicated well in the respiratory tracts of mice and guinea pigs. The findings indicate a mismatch between circulating H3N2 viruses and recommended vaccine strains, highlighting the need for improved international cooperation and epidemiological surveillance of influenza viruses post-COVID-19. Optimizing effective vaccine strain update strategy and developing a universal influenza vaccine are crucial for future preparedness.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 3","pages":"Pages 146-158"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophils: Key players in the metabolic syndrome puzzle 中性粒细胞：代谢综合征之谜中的关键角色

hLife Pub Date : 2025-03-01 DOI: 10.1016/j.hlife.2025.01.003

Hui Ping Yaw , Sapna Devi , Lai Guan Ng

{"title":"Neutrophils: Key players in the metabolic syndrome puzzle","authors":"Hui Ping Yaw , Sapna Devi , Lai Guan Ng","doi":"10.1016/j.hlife.2025.01.003","DOIUrl":"10.1016/j.hlife.2025.01.003","url":null,"abstract":"<div><div>Metabolic syndrome (MetS) is a group of metabolic abnormalities associated with an increased risk of getting type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). For many years, MetS has been viewed solely as a metabolic disease. In recent decades, MetS development has been associated with chronic inflammation related to nutrient excess, especially in the adipose tissues (AT). Metabolic stress, arising from the significant metabolic changes in MetS, is known to impact the balance of immune homeostasis. Although multiple immune cells have been investigated in this context, neutrophils, the first responder to inflammation, have only gained increased attention in recent years. Hence, this review aims to summarize the current evidence for the effects of MetS-induced systemic and AT-specific metabolic changes on neutrophils and their functions. We first provide an overview of the metabolic pathways used by neutrophils, with a specific focus on their recently discovered metabolic plasticity. This is followed by a discussion on the impact of MetS-induced alterations on the systemic metabolism and in the AT environment, how these changes may affect neutrophil effector functions, and the main mechanisms involved. Finally, we will examine the roles of neutrophils and their functions in T2DM and CVD that develop due to MetS. We will also provide perspectives on how a deeper understanding of the effects of systemic and site-specific metabolic changes in neutrophils and their effector functions could unlock the therapeutic potential of targeting neutrophils, as the arbiters of innate immunity in the context of MetS.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 3","pages":"Pages 121-131"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACSS2: Tumor-promoting lactyl-CoA synthetase that drives histone lactylation ACSS2：肿瘤促进乙酰辅酶a合成酶，驱动组蛋白乳酸化

hLife Pub Date : 2025-03-01 DOI: 10.1016/j.hlife.2024.12.007

Katherine L. Wang , Zhongsheng You

引用次数: 0

Ferritin-NP-preS1 vaccine synergizes with siRNA for sustained seroconversion against chronic hepatitis B in mice 铁蛋白np - pres1疫苗与siRNA协同作用，在小鼠体内持续进行血清转化，对抗慢性乙型肝炎

hLife Pub Date : 2025-02-18 DOI: 10.1016/j.hlife.2025.02.004

Wenjun Wang , Xiaoxiao Zhou , Tingting Guo , Qian Chai , Hongjun Wang , Mingzhao Zhu

引用次数: 0

Rethinking BCG vaccine delivery for enhanced efficacy: Are two distinct routes of BCG administration better than one? 重新思考卡介苗给药以提高疗效：两种不同的卡介苗给药途径比一种更好吗？

hLife Pub Date : 2025-02-01 DOI: 10.1016/j.hlife.2024.12.002

Raymond Moeketsi Moseki , Melissa Dalcina Chengalroyen

引用次数: 0

Forging paths together: The history of U.S.-China Track II Health Dialogue and the future of Chinese-American health communication 携手前行：中美健康对话的历史与中美健康交流的未来

hLife Pub Date : 2025-02-01 DOI: 10.1016/j.hlife.2024.12.001

Qun Yan , Mark McClellan , Gordon G Liu , Stephen Orlins , George Fu Gao

引用次数: 0

Mechanism of microglia-mediated neuroinflammation, associated cognitive dysfunction, and therapeutic updates in Alzheimer's disease 阿尔茨海默病中小胶质细胞介导的神经炎症、相关认知功能障碍和治疗进展的机制

hLife Pub Date : 2025-02-01 DOI: 10.1016/j.hlife.2024.11.006

Arpita Ghimire , Sayed Abdur Rehman , Aleena Subhani , Mansoor A Khan , Ziyaur Rahman , Mohammad Kashif Iqubal , Ashif Iqubal

{"title":"Mechanism of microglia-mediated neuroinflammation, associated cognitive dysfunction, and therapeutic updates in Alzheimer's disease","authors":"Arpita Ghimire , Sayed Abdur Rehman , Aleena Subhani , Mansoor A Khan , Ziyaur Rahman , Mohammad Kashif Iqubal , Ashif Iqubal","doi":"10.1016/j.hlife.2024.11.006","DOIUrl":"10.1016/j.hlife.2024.11.006","url":null,"abstract":"<div><div>Alzheimer's disease (AD) and associated cognitive dysfunction are major healthcare challenges globally. Various mechanisms of pathogenesis and signaling molecules have been studied for their plausible role in disease initiation and progression. Neuroinflammation has been considered a major hallmark of AD. Amyloid beta (Aβ), hyperphosphorylated tau protein, and formed neurofibrillary tangles (NFT) are positively correlated with neuroinflammation. Microglial activation was found to be a key contributor to neuroinflammation, AD pathogenesis, and progression. The mechanism of microglial activation has been studied in detail, and looking into its pivotal role in disease etiology, various drugs have been developed, and many are in the clinical phases of development. These drugs either inhibit the microglial activation or neuroinflammatory event postmicroglial activation. Considering these facts, in the present study, we herein discuss the mechanism of microglial activation and the mechanism of neuroinflammation related to microglial activation and dementia. Here we also discussed the various drugs that either act at tau protein or mitigate neuroinflammation, along with their status in clinical trials. In brief, this review provides an in-depth mechanism of microglial activation and updates on drugs that can inhibit this activation, leading to significant anti-Alzheimer effect and mitigation of cognitive dysfunction.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 2","pages":"Pages 64-81"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of cardiac tissue development by lysine lactylation 赖氨酸乳酸化对心脏组织发育的表观遗传调控

hLife Pub Date : 2025-02-01 DOI: 10.1016/j.hlife.2024.12.005

Xiaodong Luan , Runhua Du , Gengchen Su , Cong Yan , Xuelian Ren , Kaide Ju , Ye Jin , Yang An , Dan Guo , Zhuang Tian , He Huang , Shuyang Zhang

{"title":"Epigenetic regulation of cardiac tissue development by lysine lactylation","authors":"Xiaodong Luan , Runhua Du , Gengchen Su , Cong Yan , Xuelian Ren , Kaide Ju , Ye Jin , Yang An , Dan Guo , Zhuang Tian , He Huang , Shuyang Zhang","doi":"10.1016/j.hlife.2024.12.005","DOIUrl":"10.1016/j.hlife.2024.12.005","url":null,"abstract":"<div><div>Heart disease stands as the foremost global cause of mortality. In rodents, the heart possesses the remarkable ability for cardiac regeneration within the first 7 days post-birth. Furthermore, the transition to an oxygen-rich environment and altered nutrient availability trigger a profound shift in cardiac energy metabolism immediately after birth. Lactylation, which translates metabolic adjustments into enduring gene expression patterns, has been recognized for its role in this process. However, its role in heart development has remained unexplored. In this study, we conduct an integrated study combining global proteomics, lactylome, and genome-wide RNA sequencing to elucidate the role of lactylation throughout postnatal heart development. Our findings demonstrate a remarkable increase in non-histone lactylation levels as early as 1 week (1 w) to 6 weeks (6 w) postpartum and remained elevated from 6 months (6 m) onwards. However, the histone lactylation showed the opposite trend. Additionally, we propose that histone 4 lysine 12 lactylation (H4K12la) acts as a pivotal upstream regulatory element in the early postnatal mouse heart, from 1 w to 6 w postpartum. Our findings strongly suggest a significant connection between lactylation and postnatal cardiac development and highlight its involvement in gene expression regulation, thus offering potential mechanisms for targeting heart diseases.</div></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"3 2","pages":"Pages 82-97"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0