hLife最新文献

{"title":"The climate-health crisis: Innovation for adaptation","authors":"","doi":"10.1016/j.hlife.2024.04.003","DOIUrl":"10.1016/j.hlife.2024.04.003","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 7","pages":"Pages 321-324"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000282/pdfft?md5=019d5c252a804ec691cd9d6849ea5ac0&pid=1-s2.0-S2949928324000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TLR5 expression marks brain boarder associated macrophages and protects neonatal mice from bacterial meningitis","authors":"","doi":"10.1016/j.hlife.2024.04.007","DOIUrl":"10.1016/j.hlife.2024.04.007","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 7","pages":"Pages 371-376"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294992832400035X/pdfft?md5=6f38ef404e964a03aec95f384a467f67&pid=1-s2.0-S294992832400035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal microbiota transplantation in clinical practice: Present controversies and future prospects","authors":"Hongliang Tian ,&nbsp;Xinjun Wang ,&nbsp;Zhixun Fang ,&nbsp;Long Li ,&nbsp;Chunyan Wu ,&nbsp;Dexi Bi ,&nbsp;Ning Li ,&nbsp;Qiyi Chen ,&nbsp;Huanlong Qin","doi":"10.1016/j.hlife.2024.01.006","DOIUrl":"10.1016/j.hlife.2024.01.006","url":null,"abstract":"<div><p>The gut microbiota, serving as the only “organ” that humans can share, has been extensively applied in the treatment of various intestinal and extraintestinal diseases through fecal microbiota transplantation (FMT) technology. By optimizing the donor selection strategy, FMT exhibited the highest effectiveness (more than 90%) in treating acute intestinal inflammations, such as recurrent <em>Clostridium difficile</em> infection. However, the efficacy diminishes when addressing intestinal functional diseases (more than 60%), chronic intestinal inflammations or organic diseases (less than 60%), and extraintestinal diseases, particularly those lacking any gastrointestinal symptoms (less than 50%). Ongoing efforts to enhance the therapeutic response of FMT across diverse diseases represent a central focus of current clinical research. This review concentrates on donor selection, recipient management, precise donor-recipient matching, antagonistic mechanism of native bacteria to transplanted bacteria, and targeted treatment strategies for different diseases, with the aim of providing practical strategies to improve the clinical efficacy of FMT.</p></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 6","pages":"Pages 269-283"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000087/pdfft?md5=2ceb833f289cec961c3ae2a35022cdb4&pid=1-s2.0-S2949928324000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the pioneering work of anthropologist Ting-Liang Woo in the study of Chinese national physique","authors":"Ziyu Zhou ,&nbsp;Chenye Bao ,&nbsp;Yong Wang ,&nbsp;Wei Chen","doi":"10.1016/j.hlife.2024.04.002","DOIUrl":"10.1016/j.hlife.2024.04.002","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 6","pages":"Pages 263-268"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000269/pdfft?md5=d16da6612c283241c4451f686bf8122b&pid=1-s2.0-S2949928324000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau","authors":"Xiangping Li ,&nbsp;Mengge Wang ,&nbsp;Haoran Su ,&nbsp;Shuhan Duan ,&nbsp;Yuntao Sun ,&nbsp;Hongyu Chen ,&nbsp;Zhiyong Wang ,&nbsp;Qiuxia Sun ,&nbsp;Qingxin Yang ,&nbsp;Jing Chen ,&nbsp;Ting Yang ,&nbsp;Yuguo Huang ,&nbsp;Jie Zhong ,&nbsp;Xiucheng Jiang ,&nbsp;Jinyue Ma ,&nbsp;Shijia Chen ,&nbsp;Yunhui Liu ,&nbsp;Lintao Luo ,&nbsp;Xinyu Lin ,&nbsp;Shengjie Nie ,&nbsp;Guanglin He","doi":"10.1016/j.hlife.2024.04.005","DOIUrl":"10.1016/j.hlife.2024.04.005","url":null,"abstract":"<div><p>Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis of adaptive traits or complex diseases. Recent ancient genome data allow us to trace how key traits evolved in different human populations over time, connecting ancient population history with disease susceptibility in western Eurasians. To fill this gap in eastern Eurasians and provide deep insights into the evolutionary history of the population-specific genetic basis of complex biological traits, we explored the evolutionary basis of adaptive traits in one integrative modern and ancient genomic database, including 225 out of 5583 genomes first reported here. We comprehensively characterized the demographic history and biological adaptation of Han Chinese individuals on the Mongolian Plateau based on the allele frequency spectrum and haplotype-resolved fragments. We found strong genetic homogeneity among geographically different Han populations from Inner Mongolia (IMH). We reconstructed their admixture models and demographic events, revealing that IMH had a close genetic relationship with ancient millet farmers and obtained additional gene flow from Altaic-speaking populations. The enrichment of selected candidate genes suggested that essential metabolism-related genes promoted the rapid adaptation of eastern Eurasians to ancient environmental shifts and dietary changes during agricultural innovations. Evolutionary trajectory reconstruction of metabolism-related genes of methylenetetrahydrofolate reductase (<em>MTHFR</em>) and fatty acid desaturase 1 (<em>FADS1</em>) suggested that ancient dietary shifts during the Neolithic transition period promoted the differentiated metabolic rate of folate and fatty acid. We revealed the polygenicity of biological adaptation traits and the pleiotropy of adaptive genes, indicating that complex recent polygenic adaptations, genetic interactions, and genotype–phenotype correlations have contributed to the genetic architecture of complex traits in eastern Eurasians.</p></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 6","pages":"Pages 296-313"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000336/pdfft?md5=3b7d10b130d6794db4c4add576489a53&pid=1-s2.0-S2949928324000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity and clinical genomics of blaKPC-2-producing, carbapenem-resistant Pseudomonas aeruginosa","authors":"Man Huang ,&nbsp;Lizhang Liu ,&nbsp;Xiaoxia Li ,&nbsp;Yu Shi ,&nbsp;Huimin Zhang ,&nbsp;Ting Lu ,&nbsp;Youjun Feng","doi":"10.1016/j.hlife.2024.04.001","DOIUrl":"10.1016/j.hlife.2024.04.001","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 6","pages":"Pages 314-319"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000257/pdfft?md5=c3eed14be3de14f0a2f7f3dc24ae0b6d&pid=1-s2.0-S2949928324000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconciling host-microbiota metabolic incompatibility safeguards male fertility","authors":"Qing Shang ,&nbsp;Zhuoyang Li ,&nbsp;Na Yin ,&nbsp;Min Peng","doi":"10.1016/j.hlife.2024.04.006","DOIUrl":"10.1016/j.hlife.2024.04.006","url":null,"abstract":"<div><p>The symbiotic relationship between the host and microbiota is widely acknowledged as mutually beneficial. However, due to significant differences in metabolic substrates and products between prokaryotic bacteria and mammalian cells, mechanisms must exist to reconcile the metabolic incompatibility between the host and microbiota. We report that host enzymes are required to detoxify gut microbiota-derived acetate to maintain male fertility in mice. The combined deletion of acetyl-CoA synthetase short-chain family member 1 and 2 (ACSS1 and ACSS2), two enzymes consuming acetate in mammals, leads to excessive accumulation of acetate in circulation. This accumulation causes metabolic acidosis, blocking spermatogenesis and rendering male mice infertile. ACSS1/2-deficient germ cells exhibit comprehensive metabolic alterations with nicotinamide adenine dinucleotide (NAD⁺) deficiency that impairs betaine production. Supplementation with betaine restores spermatogenesis and fertility in ACSS1/2-deficient mice. Thus, the inevitable production of acetate by gut bacteria and its reproductive toxicity to the host represents an unappreciated metabolic incompatibility between the host and microbiota, which is reconciled by ACSS1/2.</p></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 6","pages":"Pages 284-295"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000348/pdfft?md5=bee3bae047fbba868d44e6bf17de35e3&pid=1-s2.0-S2949928324000348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonotic Salmonella","authors":"Linlin Huang ,&nbsp;Haiyang Zhou ,&nbsp;Jiaqi Chen ,&nbsp;Chenghao Jia ,&nbsp;Abubakar Siddique ,&nbsp;Beibei Wu ,&nbsp;Haoqiu Wang ,&nbsp;Biao Tang ,&nbsp;Fang He ,&nbsp;Guoping Zhao ,&nbsp;Min Yue","doi":"10.1016/j.hlife.2024.03.005","DOIUrl":"10.1016/j.hlife.2024.03.005","url":null,"abstract":"<div><p>Non-pharmaceutical interventions (NPIs) have been proven effective in reducing the spread of the coronavirus disease 2019 (COVID-19), but their broader impact on gastrointestinal disorders remains poorly studied. Here, we report an observational analysis and retrospective study that compares the incidence of acute diarrheal diseases in Hangzhou, Zhejiang, China, between 2019 and 2020, with an examination of the antimicrobial resistance and genetic spectrum of non-typhoidal <em>Salmonella</em> (NTS) from 2015 to 2022, before and during the COVID-19 pandemic. Our findings underscore that NPIs related to COVID-19 effectively reduced the incidence of acute diarrhea, with a substantial decrease in most enteric pathogens. Notably, NTS exhibited an unexpected surge. Further genomic investigations of NTS isolates revealed an overall reduction in antimicrobial-resistant (AMR), disinfection-tolerant, and virulent capabilities, but with marked variations detected between human and animal isolates. Additional genome-based analysis confirmed a decrease in the scale of zoonotic transmission in response to NPIs, suggesting particular NTS types may contribute to human infections <em>via</em> alternative pathways. The collective findings manifested that COVID-19-related NPIs had a mixed impact on NTS infections, which may inform AMR NTS mitigation policy.</p></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 5","pages":"Pages 246-256"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294992832400021X/pdfft?md5=ef4692c24d1eaa5a8c17e9096447be89&pid=1-s2.0-S294992832400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site","authors":"Zhao Chen ,&nbsp;Xintong Ren ,&nbsp;Yu Zhou ,&nbsp;Niu Huang","doi":"10.1016/j.hlife.2024.01.002","DOIUrl":"10.1016/j.hlife.2024.01.002","url":null,"abstract":"<div><p>G-protein coupled receptors (GPCRs) are the largest family of druggable targets. In recent years, GPCR structural biology has made great advances, revealing the three-dimensional structures of many GPCRs and their interactions with ligands, proteins, and membrane components, which also have inspired a surge of structure-based drug discovery campaigns. This article provides a comprehensive summary of the currently available structural insights into the allosteric pockets of GPCRs and their regulatory mechanisms governing GPCR conformational changes. Furthermore, this article also presents several structure-inspired studies that utilize both orthosteric and allosteric modulation to discover small molecular modulators targeting GPCRs. The article emphasizes the promising potential of drug discovery targeting GPCR allosteric sites, while acknowledging the challenges arising from the limited structural information regarding the lipids and cholesterols in the membrane. Finally, the article discusses the future prospects of using large-scale or focused compound libraries to discover novel chemotypes, as well as the application of artificial intelligence (AI) in structure-based virtual screening (SBVS) against GPCRs.</p></div>","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 5","pages":"Pages 211-226"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294992832400004X/pdfft?md5=f8438112b4a1d7b8661feb4e1f40b1ec&pid=1-s2.0-S294992832400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139537270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and immunogenicity of COVID-19 vaccine ZF2001 in Chinese aged 60 years and older","authors":"Lidong Gao ,&nbsp;Huijie Yang ,&nbsp;Peng He ,&nbsp;Shilong Yang ,&nbsp;Wanjun Li ,&nbsp;Fangjun Li ,&nbsp;Wei Xia ,&nbsp;Shangxiao Zhang ,&nbsp;Xilu Wang ,&nbsp;Lingfeng Yuan ,&nbsp;Ruyue Wang ,&nbsp;Liangliang Xiao ,&nbsp;Lianpan Dai ,&nbsp;George Fu Gao ,&nbsp;Zhongyu Hu ,&nbsp;Zaixin Zhong ,&nbsp;Fan Ding ,&nbsp;Yan Li","doi":"10.1016/j.hlife.2024.03.001","DOIUrl":"10.1016/j.hlife.2024.03.001","url":null,"abstract":"","PeriodicalId":100609,"journal":{"name":"hLife","volume":"2 5","pages":"Pages 257-261"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949928324000166/pdfft?md5=4c422165768088012a6ad5e26845cc74&pid=1-s2.0-S2949928324000166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}