Environmental Chemistry and Ecotoxicology最新文献

{"title":"Microplastics and their role in the emergence of antibiotic resistance in bacteria as a threat for the environment","authors":"Afrah Siddique ,&nbsp;Muhammad Hubab ,&nbsp;Abdul Rashid P. Rasheela ,&nbsp;Raniya Samad ,&nbsp;Mohammad Al-Ghouti ,&nbsp;Sami Sayadi ,&nbsp;Nabil Zouari","doi":"10.1016/j.enceco.2025.03.006","DOIUrl":"10.1016/j.enceco.2025.03.006","url":null,"abstract":"<div><div>Plastics and antibiotic resistance are two main global concerns, although seemingly unrelated yet interconnected threats. Microplastics (MPs) are widely present in terrestrial and marine environments that pose unique risks to living organisms. They can be absorbed by organisms, enter the food chain, accumulate pollutants on their surfaces, and contribute to antibiotic resistance (AR) in bacteria. Moreover, the World Health Organization (WHO) has declared AR a global threat, because of the increasing annual death rate caused by antibiotic-resistant bacteria (ARB). MPs due to their surface properties act as a platform for the formation of bacterial biofilms and transfer of antibiotic-resistance genes (ARGs). These polymers support bacteria in acquiring antibiotic resistance by providing a conducive environment for the horizontal gene transfer (HGT), including the transfer of ARGs. This review discusses the interplay between MPs and antibiotic resistance, by focusing briefly on interaction between MPs and ARB. Gaining insight into this interaction is crucial for developing strategies to combat the dual threats of MP pollution and the global antibiotic resistance crisis. Further studies are needed to better understand the factors impacting the interaction between ARB and MPs.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 614-622"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, trends and integrated health risk of five triazole fungicide in vegetables in Zhejiang Province (2021−2023)","authors":"Di Cai ,&nbsp;Huiyun Wang ,&nbsp;Caihao Mou ,&nbsp;Shitao Hu ,&nbsp;Zongqi Hu ,&nbsp;Yixiang Wang ,&nbsp;Tao Tang ,&nbsp;Quan Zhang","doi":"10.1016/j.enceco.2025.03.002","DOIUrl":"10.1016/j.enceco.2025.03.002","url":null,"abstract":"<div><div>Triazole fungicides (TFs) are widely used in agriculture due to their low toxicity, high efficacy, and broad-spectrum properties. Recent studies have shown that the use of TFs can be detrimental to the immune system and metabolic system of organisms, mainly by altering the composition and function of the gut microbiota of organisms. However, less attention has been paid to the residues and potential risks of TFs in vegetables compared to insecticides. In this study, 1675 vegetable samples — including beans, rhizomes, melons, bulbs, solanaceous vegetables, leafy vegetables, brassicas, and other vegetables — were collected from 2021 to 2023 to assess the integrated concentrations of five TFs (triadimefon, difenoconazole, propiconazole, myclobutanil, and tebuconazole) using the relative potency factor (RPF) method. Trend analyses were conducted using the Mann-Kendall test on the time series data. Health risks to adults and children were assessed using hazard risk index (HRI) and hazard index (HI). Results revealed that the detection rate of TFs was highest in beans (21.63 %) over the three years. The concentration of difenoconazole was notably higher, particularly in beans (10.84 μg/kg) and leafy vegetables (13.07 μg/kg). The highest integrated TF concentrations were observed in Quzhou (DCZ_RPF = 28.62 μg/kg), followed by Ningbo (DCZ_RPF = 9.22 μg/kg). Seasonally, TFs were most frequently detected in the fall (10.74 %). Tebuconazole increased significantly over the three years (S &gt; 0). Cumulative dietary risk assessments for both adults and children indicated that the health risks associated with TF exposure were low. Nevertheless, given the increasing large-scale application of TFs, continued monitoring of residue levels and comprehensive risk assessments remain essential.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 565-572"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bisphenol A and its replacement chemicals as endocrine disruptors and obesogens","authors":"Yuqi Tang ,&nbsp;Guoyi Qin ,&nbsp;Nina Qian ,&nbsp;Xiaoyun Zeng ,&nbsp;Rong Li ,&nbsp;Keng Po Lai","doi":"10.1016/j.enceco.2025.04.001","DOIUrl":"10.1016/j.enceco.2025.04.001","url":null,"abstract":"<div><div>Bisphenol A (BPA) is a common material widely used in the plastic production and processing industry. As BPA is an environmental endocrine disruptor that causes metabolic disorders, leading to the progression of diseases such as obesity, type 2 diabetes, and cardiovascular diseases, its use has been banned in many countries. Chemicals such as bisphenol S, bisphenol F (BPF), bisphenol AF, and tetramethyl BPF have been used to replace BPA. Given the similar chemical structures of BPA and its replacement chemicals, previous studies have demonstrated the potential risks of endocrine disruption and obesity. This review aims to summarize the endocrine-disrupting effects and the underlying mechanisms of BPA and its replacement chemicals based on existing experimental and epidemiological studies and to investigate BPA and its replacement chemicals linked to endocrine disruption and obesity to provide better recommendations for the safe use of BPA and its replacement chemicals.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 696-705"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fate of trace elements and emerging environmental pollutants (benzotriazoles and benzothiazoles) from a glacier-fed river in the mixing zone of an Arctic fjord system","authors":"Joséphine Amey ,&nbsp;Øyvind Mikkelsen","doi":"10.1016/j.enceco.2025.01.001","DOIUrl":"10.1016/j.enceco.2025.01.001","url":null,"abstract":"<div><div>The fate of organic and inorganic pollutants was studied in the Arctic, in the mixing zone of freshwater and seawater of a glacier-fed river and a fjord (Ny-Ålesund, Svalbard). Concentrations of trace elements and contaminants of emerging concern, benzotriazoles and benzothiazoles (BTRs and BTHs), were assessed. Metal concentrations of Al, As, Cr, Hg, Mo, Ni, Pb, Sb, Sn, V, and Zn in marine sediment were up to two or three times higher than in riverine sediment and most of them showed an increasing trend from the upper to the lower part of the river. Pb (0.058 μg/L) and Zn (0.80 μg/L) were present in levels of moderate pollution in seawater close to town, while Cu (0.11 μg/L) exceeded background levels in the same area. As (0.042 μg/L), Hg (0.004 μg/L) and Cd (0.011 μg/L) showed levels of low to moderate pollution in freshwater from the river. In seawater and river water detected BTRs and BTHs were: BTR, TTR, 2-OH-BTH, XTR, 2-Me-S-BTH, 2-M-BTH, 2-S-BTH, and 2-NH₂-BTH. Considerably high concentrations of BTR (1460 ng/L) and 2-OH-BTH (1070 ng/L) were found. Compounds present in marine and riverine sediment were BTR, 2-OH-BTH, 2-Me-S-BTH, and 2-M-BTH. Sediment appeared to be a significant sink of BTRs and BTHs with a concentration range of 1.13–32.7 ng/g. A trend of higher concentrations of trace elements in sediment (ANOVA, <em>p</em> = 0.044) and seawater (ANOVA, <em>p</em> = 0.013), as well as 2-OH-BTH in seawater (<em>t</em>-test, <em>p</em> = 0.010) was observed in the vicinity of the town, where most anthropogenic activities have taken place due to former mining operations.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 339-350"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluorinated substances in reservoir water from a metropolitan city in the Guangdong-Hong Kong-Macao Greater Bay Area, China, and their ecological risks","authors":"Yiming Ge ,&nbsp;Yi Huang ,&nbsp;Linshen Xie ,&nbsp;Chenglin Li ,&nbsp;Xiujuan Qi ,&nbsp;Pu Ye ,&nbsp;Xixiang Guo ,&nbsp;Chen Deng ,&nbsp;Rong Hu ,&nbsp;Bei Wang ,&nbsp;Jinling Wang ,&nbsp;Yihong Liu ,&nbsp;Jiayi Xu ,&nbsp;Tingting Zhu ,&nbsp;Shaoyou Lu","doi":"10.1016/j.enceco.2025.01.009","DOIUrl":"10.1016/j.enceco.2025.01.009","url":null,"abstract":"<div><div><em>Per</em>- and polyfluorinated substances (PFASs) are synthetic chemicals with thermal and chemical stability, widely used in consumer products such as food packaging, fire-fighting foams, non-stick coatings, and lubricants. Their potential threats to human health and aquatic ecosystems have prompted restrictions on their usage. However, they are still widely found in freshwater systems due to their environmental persistence. Given that reservoirs are a vital source of drinking water for coastal city residents, this study collected water samples from 35 reservoirs in SZ City and its special cooperation zone to quantify 17 PFASs. Seasonal and spatial distributions of contaminant concentrations were analyzed and ecological risks were assessed. The results showed a widespread presence of PFASs in various reservoirs, although perfluoroalkane sulfonic acids (PFSAs) were infrequently detected. The concentration of ΣPFASs in the dry season (median: 20.5 ng/L) was significantly higher than that in the wet season (6.58 ng/L), likely attributable to a dilution effect after rainfall. Pentadecafluorooctanoic acid (median: 2.76 ng/L) and perfluoro-n-butanoic acid (3.90 ng/L) dominated in the wet and dry seasons, respectively. For spatial distribution, the ΣPFASs concentration in tributaries was markedly higher than that in reservoirs during the dry seasons (median: 58.1 ng/L vs. 20.5 ng/L), probably due to the diminished wet deposition of contaminants and the reduced mobility of tributary water flow. Furthermore, the concentration of short-chain PFASs was significantly greater than that of long-chain PFASs in the dry seasons (median: 16.0 ng/L vs. 3.10 ng/L), possibly related to the widespread application of short-chain compounds. Overall, the risk to the ecosystem and humans from PFASs in reservoirs is not significant. Future regulations on fluorochemical plants may be warranted to reduce the use and discharge of PFASs. Also, subsequent studies could include a wider range of samples to better estimate the potential risk posed by PFASs with varying chain lengths and functional groups to aquatic environment.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 364-372"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics as persistent and vectors of other threats in the marine environment: Toxicological impacts, management and strategical roadmap to end plastic pollution","authors":"Sameh S. Ali ,&nbsp;Mohammed Hussein M. Alsharbaty ,&nbsp;Rania Al-Tohamy ,&nbsp;Michael Schagerl ,&nbsp;Majid Al-Zahrani ,&nbsp;Michael Kornaros ,&nbsp;Jianzhong Sun","doi":"10.1016/j.enceco.2024.12.005","DOIUrl":"10.1016/j.enceco.2024.12.005","url":null,"abstract":"<div><div>The myriad consumption of plastic regularly, environmental impact and health disquietude of humans are at high risk. Microplastics (MPs) represent a contemporary type of contamination that has permeated several environmental areas. MP pollution is already widespread in marine environments, leading to increased awareness over the past few decades. Multiple studies are being conducted to determine the source of MPs and their harmful impacts on marine life and, ultimately, human health. Thus, this paper rigorously analyzed the origin, accumulation, and detrimental impacts of MPs on the marine ecosystem. An increase in the death rate, a decrease in the rate of growth, and a reduction in the quantity of food ingested were the primary changes that occurred in marine organisms. The hydrophobic properties of MPs enable them to facilitate the formation of biofilms, which are referred to as the plastisphere. These biofilms have the capacity to transport chemicals that are frequently hazardous and may potentially infiltrate the food chain. The coronavirus 2019 (COVID-19) pandemic has significantly exacerbated the plastic and MP contamination in coastal and marine environments as a result of the improper management of personal protective equipment and explosive production. The most recent developments in environmental DNA (eDNA) are valuable tools for the detection and tracking of MP contamination in coastal and marine ecosystems. These technologies offer greater sensibility, efficacy, and involvement in the process. There are several measures and attempts that must be taken to address the MP pollution issues in the marine environment. The knowledge gained from this review will serve as a foundation for future marine MP research and management techniques.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 229-251"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous aggregation of microplastics and mineral particles in aquatic environments: Effects of surface functional groups, pH, and electrolytes","authors":"Yanhua Wang ,&nbsp;Zhengli Tang ,&nbsp;Yingnan Liu ,&nbsp;Yilin Qian ,&nbsp;Shuo Yang ,&nbsp;Anqi Wang ,&nbsp;Zhibao Dong ,&nbsp;Baoshan Xing","doi":"10.1016/j.enceco.2025.04.012","DOIUrl":"10.1016/j.enceco.2025.04.012","url":null,"abstract":"<div><div>Microplastics (MPs) aggregation critically governs their environmental transport, yet interactions with mineral surfaces remain underexplored. In this study, polyethylene (PE) MPs were employed as model particles to prepare both pristine PE and bovine serum albumin (BSA)-coated PE (B-PE). The heterogeneous aggregation of these particles with inorganic minerals (goethite, hematite, pyrite, magnetite) and clay minerals (kaolinite, montmorillonite) was systematically investigated under varying pH conditions (3.0, 6.0, 9.0) and ionic strengths (NaCl 5–300 mmol/L, CaCl₂ 1–50 mmol/L). Results demonstrated that positively charged inorganic minerals exhibited significantly stronger heterogeneous aggregation with negatively charged PE, exhibiting aggregation capacities 2.97 times higher than those of negatively charged clay minerals. The introduction of oxygen-containing functional groups such as <img>COOH and <img>OH on the B-PE surface not only enhanced electrostatic attraction but also facilitated ligand exchange and hydrogen bonding, further improving aggregation efficiency. At pH 3.0, removal efficiencies of PE and B-PE for inorganic minerals exceeded 90 %, while aggregation was nearly completely inhibited at pH 9.0. With increasing NaCl concentration, the critical coagulation concentration (CCC) of B-PE decreased by 29.6 %–42.6 % compared to pristine PE. Moreover, Ca²⁺ ions exhibited a stronger promoting effect on aggregation via cation bridging than Na⁺ ions. These findings reveal the synergistic regulatory effects of mineral type, protein coating, and environmental factors on microplastic-mineral heterogeneous aggregation, providing a theoretical foundation for predicting the transport and fate of microplastics in complex natural aquatic environments, as well as for developing biomolecule-based sustainable remediation strategies.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 848-858"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of microplastics and ciprofloxacin co-contamination on arsenic bioaccumulation and microbial dysbiosis in rice soils: Implications for multi-pollutant agroecosystem risks","authors":"Wenlong Song ,&nbsp;Xiaoxiao Zhang ,&nbsp;Bing Ma,&nbsp;Lei Zhang","doi":"10.1016/j.enceco.2025.04.011","DOIUrl":"10.1016/j.enceco.2025.04.011","url":null,"abstract":"<div><div>Soil contamination by arsenic (As), microplastics (MPs), and antibiotics poses significant risks to crop growth and food safety. However, the combined effects of MPs and antibiotics on As accumulation and microbial community structures in rice soils remain poorly understood. This study introduced polystyrene (PS), polyamide (PA), and ciprofloxacin (CIP) into soil microcosms to evaluate their individual and combined toxicological impacts on arsenate (As(V)), rice seedlings (<em>Oryza sativa</em> subsp. <em>japonica Kato</em>), and soil microbes. Both PS and CIP treatments inhibited chlorophyll production in rice while increasing plant biomass. Under combined contamination, chlorophyll content, biomass, root length, and shoot length were significantly lower than under individual treatments. Exposure to MPs and CIP also disrupted the antioxidant defense system in rice seedling leaves. Additionally, the presence of PS and PA improved soil physicochemical properties. However, the combined presence of MPs and CIP significantly reduced microbial diversity compared to individual contamination. At the phylum level, microbial composition remained consistent across treatments, whereas at the genus level, only Arthrobacter exhibited significant changes under individual treatments. In contrast, four genera were notably altered in soils co-treated with MPs and CIP. These findings highlight that the combined contamination of PS, PA, and CIP exacerbates the reduction of microbial diversity in As-contaminated soil.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 836-847"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the toxicity and potential ecological risks of various pesticides for nurses of honey bee (Apis mellifera. L)","authors":"Euijin You ,&nbsp;JooHeon Cha ,&nbsp;HeeJin Kim ,&nbsp;Young Ho Kim","doi":"10.1016/j.enceco.2025.04.008","DOIUrl":"10.1016/j.enceco.2025.04.008","url":null,"abstract":"<div><div>The honey bee (<em>Apis mellifera</em>. L) is an important pollinator worldwide, but it is facing significant population declines due to the influence of various factors, particularly the use of pesticides. Forager bees come into contact with pesticides during their foraging activity, while nurse bees are exposed to pesticides within the hive when they consume contaminated food sources. Based on established pesticide exposure routes, the present study assessed the oral toxicity and ecotoxic risks of 13 pesticides, including two organophosphates [coumaphos (COU) and fenitrothion (FEN)], two pyrethroids [τ-fluvalinate (τFLU) and cypermethrin (CYP)], four neonicotinoids [acetamiprid (ACE), imidacloprid (IMI), thiamethoxam (THIA), and flupyradifurone (FLU)], two carbamates [carbaryl (CAR) and carbofuran (CAB)], two avermectins [abamectin (ABA) and ivermectin (IVE)], and one phenyl pyrazole, fipronil (FIP) for nurse bees using the median lethal dose (LD₅₀) and hazard quotients (HQs), respectively. Based on LD₅₀ data from bioassays and previous reports, ranking pesticides by their toxicity for nurse bees resulted in the following order: FIP = THIA &gt; ABA &gt; IVE &gt; CAB &gt; IMI = FEN &gt; CAR &gt; CYP &gt; FLU &gt; ACE &gt; COU = τFLU. The HQs were calculated using the LD₅₀ and arithmetic field-detected concentration for each pesticide in bee bread and honey based on the previous studies. The HQ results indicated THIA had the highest potential risk for honey bees, followed by FIP, CAR, FLU, CYP, CAB, FEN, IMI, COU, τFLU, and ACE. Quadrant-based analysis subsequently revealed that high LD₅₀ values were not necessarily associated with high HQs for nurse honey bees. These findings suggest that differences in the residue concentration of the pesticides due to differences in their chemical properties and usages can influence their actual risk in natural systems, which is not in direct accordance with their toxicity. This study thus highlights the importance of assessing the effect of agrochemicals on honey bees in an ecological context.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 791-801"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The blockage of the electron transport chains caused by PFOA isomers induced metabolic damage of Arabidopsis leaves","authors":"Hao Wang ,&nbsp;Jianxiong Mei ,&nbsp;Zeying He ,&nbsp;Bingjie Liu ,&nbsp;Jishi Wang ,&nbsp;Yue Geng ,&nbsp;Yanwei Zhang","doi":"10.1016/j.enceco.2025.02.006","DOIUrl":"10.1016/j.enceco.2025.02.006","url":null,"abstract":"<div><div>Different metabolic damage could be caused by PFOA isomers, although the harm mechanism has not been well studied. The effects of PFOA isomers on Arabidopsis metabolism were investigated using metabolomics, proteomics and molecular docking. Compared to Pn (linear PFOA), P3 (3 - methyl - perfluoroheptanoic acid, P3MHpA) induced a greater amount of oxidative damage and more dysregulation proteins. Both PFOA isomers caused significant metabolic disorders in oxidative stress and photosynthetic dysregulation, and they happened in similar molecular components including chloroplast and thylakoids. Proteins were more readily bound by ionic PFOA, and P3 exhibited higher ability than Pn. Isomers of the ionic PFOA bound to proteins in photosynthesis, particularly the ETC proteins, leading to a blockage of the electron transport chains in the chloroplast, which induced oxidative stress and photosynthetic toxicity. This study provides a novel and important mechanism for the photosynthetic toxicity of different PFOA isomers.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 516-526"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}