Bisphenol A and its replacement chemicals as endocrine disruptors and obesogens

IF 9 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology Pub Date : 2025-01-01 DOI:10.1016/j.enceco.2025.04.001

Yuqi Tang , Guoyi Qin , Nina Qian , Xiaoyun Zeng , Rong Li , Keng Po Lai

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Abstract

Bisphenol A (BPA) is a common material widely used in the plastic production and processing industry. As BPA is an environmental endocrine disruptor that causes metabolic disorders, leading to the progression of diseases such as obesity, type 2 diabetes, and cardiovascular diseases, its use has been banned in many countries. Chemicals such as bisphenol S, bisphenol F (BPF), bisphenol AF, and tetramethyl BPF have been used to replace BPA. Given the similar chemical structures of BPA and its replacement chemicals, previous studies have demonstrated the potential risks of endocrine disruption and obesity. This review aims to summarize the endocrine-disrupting effects and the underlying mechanisms of BPA and its replacement chemicals based on existing experimental and epidemiological studies and to investigate BPA and its replacement chemicals linked to endocrine disruption and obesity to provide better recommendations for the safe use of BPA and its replacement chemicals.

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双酚A及其替代化学物质作为内分泌干扰物和致肥物质

双酚A （BPA）是一种广泛应用于塑料生产和加工行业的常见材料。BPA是一种环境内分泌干扰物，会引起代谢紊乱，导致肥胖、2型糖尿病、心血管疾病等疾病的发展，因此在许多国家已被禁止使用。双酚S、双酚F （BPF）、双酚AF和四甲基BPF等化学物质已被用来取代BPA。鉴于双酚a及其替代物的化学结构相似，先前的研究已经证明了其内分泌紊乱和肥胖的潜在风险。本文在现有实验和流行病学研究的基础上，综述了双酚a及其替代化学物质的内分泌干扰作用及其潜在机制，并探讨了双酚a及其替代化学物质与内分泌干扰和肥胖的关系，为双酚a及其替代化学物质的安全使用提供更好的建议。

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来源期刊

Environmental Chemistry and Ecotoxicology

CiteScore

15.40

自引率

0.00%

发文量