Chemical record最新文献

{"title":"Porous Framework Materials and MXenes as Biosensing Platforms for Amyloid-β Detection.","authors":"Yiqing Tan, Qingxiang Zhang, Yu Fu, Miao Zhang, Jiaying An, Xue Liu, Yujie Yu, Han Zhang, Lingge Yang, Kun Cheng, Qi Yu, Yuxin Fang, Di Zhang","doi":"10.1002/tcr.70253","DOIUrl":"https://doi.org/10.1002/tcr.70253","url":null,"abstract":"<p><p>Amyloid-β (Aβ), a 39-43-amino-acid peptide, is closely associated with the pathogenesis of Alzheimer's disease (AD) and undergoes abnormal aggregation that contributes to disease progression. Therefore, rapid and accurate Aβ detection is essential for early AD diagnosis and therapeutic monitoring. Biosensors have emerged as promising analytical tools owing to their simplicity, low cost, high sensitivity, and selectivity. In particular, metal-organic frameworks, covalent organic frameworks, hydrogen-bonded organic frameworks, and MXenes offer unique structural and functional advantages for Aβ sensing. This review summarizes recent advances in Aβ biosensors based on these materials, with emphasis on comparative analytical performance across electrochemical, optical, photoelectrochemical, and dual-mode platforms. Current challenges, including matrix interference, limited discrimination of Aβ isoforms, and biosensor miniaturization, are discussed. Future directions involving artificial intelligence and machine learning are also highlighted to advance rapid, sensitive, and accurate Aβ detection for early AD diagnosis and therapeutic monitoring.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e70253"},"PeriodicalIF":8.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-Inspired Catalytic Pathways in Green Chemistry: Recent Innovations in Waste Valorization Processes—A Review","authors":"Avvaru Praveen Kumar,&nbsp;Ramamohana Reddy Maddike,&nbsp;Venkateswarlu V,&nbsp;Dinesh Bilehal","doi":"10.1002/tcr.70197","DOIUrl":"10.1002/tcr.70197","url":null,"abstract":"<p>The importance of catalysis in the development of waste management systems in the circular economy is undeniable. This review emphasizes the emerging potential of nature-based bio-inspired catalysis to advance waste valorization. It discusses the potential of bio-inspired catalysis for waste valorization over the last 5 years. In this context, we examine the potential of four methods to utilize waste streams: enzymes, biomimetic enzyme mimics, microorganisms, and hybrid nano-bio systems. Beyond summarizing recent developments, this review provides an integrative and critical framework that connects waste-stream characteristics, catalytic platform selection, target products, and green-chemistry performance criteria. Enzymes are a unique class of catalysts that enable the degradation of plastic waste and lignocellulosic waste, and operate under mild conditions. Biomimetic catalysts such as porous coordination polymers, metal-organic frameworks, nanozymes, and others provide stability, thereby expanding the scope of catalyst use in enzymatic reactions, including CO₂ conversion, terpene epoxidation, and other reactions. Microbial and consortia systems convert complex dilute feedstocks into liquid fuels, acids, or bioplastics, whereas bioelectrochemical systems integrate waste-to-energy remediation. The greatest improvement is achieved with hybrid nano-bio catalytic systems, which provide the greatest stability for enzymes and the greatest enhancement of electrochemical processes (electron transfer) by immobilizing enzymes onto either carbon supports or photoactive supports. All of the aforementioned systems and methods restore the environment by producing useful products through the treatment, purification, and recycling of waste streams. Based on the principles of green chemistry, this review evaluates the scope and limitations and highlights key challenges to focus on the more promising advances among the methods provided. Rather than treating enzymatic, biomimetic, microbial, and hybrid nano-bio systems as isolated categories, this review compares them within a unified framework that identifies their complementary roles, trade-offs, and opportunities for integration across different waste streams and valorization targets.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Activation to Assembly: Multifunctional Reagents Enabling Step and Atom Economy in Modern Synthesis","authors":"Shovan Mondal,&nbsp;Amrit Krishna Mitra","doi":"10.1002/tcr.70188","DOIUrl":"10.1002/tcr.70188","url":null,"abstract":"<p>The strategic design of multifunctional reagents has emerged as a powerful paradigm in modern organic synthesis by integrating activation, fragment delivery, and reaction control within a single chemical entity. This review examines advances from 2005 to 2025, highlighting the evolution of multifunctional reagents from classical systems such as DMSO, DMF, dimethyl carbonate, and isocyanides to sophisticated platforms including silylated lactams, vinylene carbonates, aryldiazonium salts, <i>N</i>-alkoxy- and <i>N</i>-alkenoxypyridinium species, bifunctional polymer-supported systems, and inorganic redox mediators. The discussion is organized by reagent architecture and activation mode, covering molecular, heterogeneous, photochemical, and catalyst-programmable systems. Across cascade reactions, multicomponent processes, and late-stage functionalizations, these reagents enable compression of multistep sequences, improved chemoselectivity, and enhanced step and atom economy. Mechanistic insights from kinetic, spectroscopic, isotopic, and computational studies reveal how integrated functionalities such as internal acid or base activation, redox mediation, and proximity effects govern reactivity across radical, ionic, and photochemical pathways. Comparative analysis underscores trade-offs between efficiency, scalability, and cost, while highlighting challenges in reagent synthesis and process translation. Overall, multifunctional reagent design provides a unifying framework for sustainable and efficient molecular construction in both academic and industrial settings.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energetic 1,3,4- and 1,2,5-Oxadiazoles: Recent Update and State-of-the-Art Achievements","authors":"Ilya D. Deltsov,&nbsp;Leonid L. Fershtat","doi":"10.1002/tcr.70192","DOIUrl":"10.1002/tcr.70192","url":null,"abstract":"<p>This review describes the synthesis and physicochemical properties of high-energy-density materials (HEDMs) containing 1,2,5- or 1,3,4-oxadiazole moiety and developed in a period of 2020–2025. Several major trends in the research of these compounds are observed, based on an incorporation of linear and fused polyheterocyclic species, nitro- and nitratomethylene groups, and nitroaromatic fragments, as well as annulation of the 1,2,5-oxadiazole ring in pronounced conjugated systems, which highly contributes to thermostability and detonation performance. Overall, novel synthetic strategies along with the diversity of explosophoric structural motifs enable the design of advanced energetic materials with desirable properties and increased environmental safety.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-Dominated or Salt-Controlled? Mechanistic Insights and Design Principles for Water-in-Salt and Deep Eutectic Solvent Electrolytes in Aqueous Energy Storage","authors":"Balaraman Vedhanarayanan,&nbsp;Jagadesh Nagaraj,&nbsp;Tsung-Wu Lin,&nbsp;Hsin-Hui Shen,&nbsp;K. C. Seetha Lakshmi","doi":"10.1002/tcr.70189","DOIUrl":"10.1002/tcr.70189","url":null,"abstract":"<p>Aqueous energy storage technologies are gaining renewed attention due to their safety, low cost, and environmental compatibility. Highly concentrated electrolytes, including water-in-salt (WIS) and deep eutectic solvent (DES) systems, significantly expand the electrochemical stability window (ESW) of water, enabling higher operating voltages. However, reported improvements often conflate thermodynamic, kinetic, and interfacial effects. This review presents a mechanistic analysis of ESW expansion by distinguishing bulk solvation behavior from interfacial chemistry, ion transport limitations, and solid–electrolyte interphase formation. WIS electrolytes are predominantly salt-controlled, whereas DES systems are solvent-dominated through hydrogen-bond networks. This framework clarifies their distinct transport and stability characteristics. The review further evaluates common experimental methodologies for ESW, conductivity, and interfacial analysis. By integrating literature trends, practical performance limits are defined, and standardized evaluation protocols are proposed. Finally, actionable design principles and an experimental checklist are provided to improve reproducibility and guide the rational development of advanced aqueous energy storage systems.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Decades of Dispute: A Triptych. E. J. Corey.","authors":"Jeffrey I Seeman","doi":"10.1002/tcr.202500258","DOIUrl":"https://doi.org/10.1002/tcr.202500258","url":null,"abstract":"<p><p>In the published version of his March 2004 Priestley Medal address, E. J. Corey stated \"On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3-butadiene and 1,3,5-hexatriene/cyclohexadiene conversions that provided the basis for the further development of these ideas into what became known as the Woodward-Hoffmann rules.\" This current publication describes how Corey, based on his knowledge of the chemical literature and his own research activities, was well-positioned to conceive of a frontier molecular orbital mechanism of electrocyclic reactions. Several disclosures revealing aspects of orbital control of concerted reactions were made by Corey during a Woodward group meeting in 1961 and, according to Corey, to Roald Hoffmann in April 1964. Details, as provided by Corey, of his May 4, 1964, meeting with Woodward during which he presented Woodward with the mechanism of what was later named \"electrocyclic reactions\" will be presented. Letters and emails written by Corey to Hoffmann and interviews conducted by this author with Corey, Hoffmann, Douglas and Linda Applequist, Albert Eschenmoser, Alfred G. Hortmann, Jos Schlatmann, and others provide further information regarding Corey's intellectual property claim against Woodward and subsequent interactions with Hoffmann.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":" ","pages":"e202500258"},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geopolymers as a Sustainable Chemical Platform: From Building Materials to Advanced Functional Applications","authors":"Martina Maria Calvino,&nbsp;Lorenzo Lisuzzo,&nbsp;Giuseppe Cavallaro,&nbsp;Stefana Milioto,&nbsp;Giuseppe Lazzara","doi":"10.1002/tcr.70191","DOIUrl":"10.1002/tcr.70191","url":null,"abstract":"<p>Geopolymers are aluminosilicate inorganic polymers traditionally investigated as sustainable alternatives to ordinary cement. This review rethinks geopolymers not merely as sustainable binders but as a versatile chemical platform whose properties arise from controllable dissolution–condensation pathways, nanoscale structural disorder, and activator chemistry. We critically analyze the sustainability considering life-cycle assessments and discuss how activator production and curing conditions challenge oversimplified green claims in recent literature. The transition from bulk construction materials to nanoengineered and hybrid systems is examined, highlighting the role of nanofillers and interfacial engineering strategies. A particular focus is devoted to halloysite-based systems, tracing their evolution from early nanoarchitectural surface modification of fly ash particles to recent developments in self-assembled inorganic films with tunable morphology at a mesoscopic length scale. These systems demonstrate that geopolymerization can act as a structural converter across nano-, meso-, and macroscales, enabling applications in barrier, adsorption, CO₂ capture, and environmental remediation. We conclude by outlining design principles for future geopolymer research, emphasizing activation chemistry, structural control, and morphological programmability as key aspects in developing sustainable functional materials for advanced applications. Future efforts will need to identify sustainable activation strategies for construction applications and to develop chemically adaptable systems for high-performance functional uses.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tcr.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms","authors":"Giorgia Puleo,&nbsp;Silvia Orecchio,&nbsp;Dario Savoca,&nbsp;Claudia Pellerito,&nbsp;Vittorio Ferrara,&nbsp;Vincenzo Piscopo,&nbsp;Sebastiano Alberto Fortuna,&nbsp;Alessandra Giardina,&nbsp;Bruno Pignataro,&nbsp;Paola Costanzo,&nbsp;Floriana Campanile,&nbsp;Giuseppe Arrabito","doi":"10.1002/tcr.70186","DOIUrl":"10.1002/tcr.70186","url":null,"abstract":"<p>Antimicrobial resistance is one of the most pressing global public health threats, responsible for millions of deaths annually. To tackle this issue, additive manufacturing has been increasingly exploited to fabricate structured antimicrobial platforms with precise control over composition, geometry, and release kinetics. This review covers the most relevant approaches across different scales, from dip-pen nanolithography and inkjet printing to 3D and 4D printing, emphasizing the role of nanoscale confinement, microenvironmental control, and interfacial chemistry as key design parameters. Polymeric matrices, metal and metal oxide nanostructures, and theranostic platforms are discussed in relation to their fabrication-dependent properties, including material stability, ageing, and translational challenges. Finally, stimuli-responsive architectures, phototherapeutic strategies, and artificial intelligence-driven design are outlined as emerging tools toward next-generation antimicrobial materials.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tcr.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Z-Scheme Heterojunction for Catalytic Cancer Therapy","authors":"Shuo Wang,&nbsp;Zhengya Yue,&nbsp;Ying Tao,&nbsp;Yue Meng,&nbsp;Xiangwei Liu,&nbsp;Ruixuan Liu,&nbsp;Tiedong Sun","doi":"10.1002/tcr.70193","DOIUrl":"10.1002/tcr.70193","url":null,"abstract":"<p>Under external-field stimulation, semiconductor activation for catalytic therapy has attracted considerable attention in tumor treatment. However, achieving highly efficient catalytic reactions under limited substrate availability—particularly within the tumor microenvironment—remains the major obstacle limiting the efficacy of catalytic therapies. The construction of heterojunctions effectively suppresses rapid electron–hole recombination, thereby enhancing catalytic efficiency. Nevertheless, maintaining appropriate conduction band (CB) and valence band (VB) positions to preserve strong redox potentials represents a further challenge. To address these limitations, the Z-type heterojunction (Z-HJ) was proposed and has been widely applied in catalytic tumor therapy. This review elucidates the fundamental principles and developmental trajectory of Z-HJs in catalytic tumor therapy, emphasizing their mechanisms for enhancing therapeutic efficacy. It further explores on-demand Z-HJ design strategies that target key pathological features, including cell proliferation, apoptosis, metastasis, and immune suppression. In addition, advancements in AI-driven Z-HJ nanozyme design, theranostic integration, and multimodal synergistic treatment strategies are discussed. Finally, the review summarizes current challenges and outlines future perspectives for Z-HJ-based tumor therapy.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Cobalt-Catalyzed Difunctionalization of Alkenes and Alkynes: Recent Advances in Synthetic Applications","authors":"Ying-Chun Song,&nbsp;Hua-Zhan Ren,&nbsp;Teng-Yue Ma,&nbsp;Weihang Wang,&nbsp;Ming Hu,&nbsp;Jin-Heng Li","doi":"10.1002/tcr.70201","DOIUrl":"10.1002/tcr.70201","url":null,"abstract":"<p>Electro-organic reactions are now considered as one of the most efficient and environmentally benign methodologies to synthesize highly functionalized motifs like difunctionalized saturated and unsaturated compounds from readily available substrates. Excellent regioselectivity, functional group tolerance, and broad range of substrates are the main advantages of electrochemical difunctionalization reactions. Alkenes and alkynes readily accept radical or ionic derivatives which makes it vital precursors for the electrochemical synthesis of industrially relevant and biologically active molecules through difunctionalization. The integration of cobalt catalysis with electrochemistry not only enhances efficiency and selectivity but also provides a platform for discovering novel transformations, positioning cobalt electrosynergistic catalysis as a transformative tool for precision synthesis of functionalized alkenes and alkynes. Herein, we discuss the recent development in the difunctionalization of alkenes and alkynes via cobalt electrocatalysis.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"26 9","pages":""},"PeriodicalIF":8.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}