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EMC - Endocrinologie Pub Date : 2004-10-01 DOI: 10.1016/S1762-5653(04)00084-X
{"title":"Index des mots clés","authors":"","doi":"10.1016/S1762-5653(04)00084-X","DOIUrl":"https://doi.org/10.1016/S1762-5653(04)00084-X","url":null,"abstract":"","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 4","pages":"Pages 218-219"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1762-5653(04)00084-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91699445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochimie des hormones et leurs mécanismes d'action : récepteurs membranaires 激素的生物化学及其作用机制:膜受体
EMC - Endocrinologie Pub Date : 2004-10-01 DOI: 10.1016/j.emcend.2004.04.002
G. Assié , D. Rosenberg , E. Clauser , J. Bertherat (Praticien hospitalier et universitaire)
{"title":"Biochimie des hormones et leurs mécanismes d'action : récepteurs membranaires","authors":"G. Assié ,&nbsp;D. Rosenberg ,&nbsp;E. Clauser ,&nbsp;J. Bertherat (Praticien hospitalier et universitaire)","doi":"10.1016/j.emcend.2004.04.002","DOIUrl":"10.1016/j.emcend.2004.04.002","url":null,"abstract":"<div><p>Membrane hormone receptors are classified in three classes: G coupled receptors, tyrosine kinase receptors, and cytokine receptors. Each of these classes is characterised by structural properties shared by all constituents of the group, and specific mechanisms of signal transduction.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 4","pages":"Pages 169-199"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81750011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Métabolisme du potassium
EMC - Endocrinologie Pub Date : 2004-07-01 DOI: 10.1016/j.emcend.2004.04.001
P Houillier, A Blanchard, M Paillard
{"title":"Métabolisme du potassium","authors":"P Houillier,&nbsp;A Blanchard,&nbsp;M Paillard","doi":"10.1016/j.emcend.2004.04.001","DOIUrl":"10.1016/j.emcend.2004.04.001","url":null,"abstract":"<div><p>The intracellular content and the extracellular potassium concentration must remain within narrow limits in order to preserve many cell functions. This chapter describes the mechanisms involved in potassium transfer between extra and intracellular fluids, which are necessary for the maintenance of internal potassium balance, and renal handling of potassium, as well as the regulating factors that are involved in external potassium balance.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 3","pages":"Pages 138-157"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79576988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Faut-il revoir les indications des statines à la lumière des dernières données de la médecine fondée sur les preuves ? 他汀类药物的适应症是否应该根据最新的循证医学数据进行审查?
EMC - Endocrinologie Pub Date : 2004-07-01 DOI: 10.1016/j.emcend.2004.03.002
M Farnier
{"title":"Faut-il revoir les indications des statines à la lumière des dernières données de la médecine fondée sur les preuves ?","authors":"M Farnier","doi":"10.1016/j.emcend.2004.03.002","DOIUrl":"10.1016/j.emcend.2004.03.002","url":null,"abstract":"<div><p>The studies HPS, LIPS, PROSPER, ALLHAT and ASCOT, on cardiovascular prevention, have made available relevant complementary information on statin utilisation. In patients with a history of vascular event, and in those under primary prevention and presenting with associated risk factors, the benefit of a statin treatment is indubitable, whatever the initial level of LDL-cholesterol. These studies provide also new evidence on beneficial results of statin therapy in diabetic patients, in women, and in elderly patients with high vascular risk. In the future, statin indication in any patient should depend primarily on the degree of his vascular risk. Such new issues of the evidence-based medicine should lead soon to re-actualised therapeutic recommendations.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 3","pages":"Pages 158-162"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84607912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Épidémiologie du rachitisme carentiel 缺乏症的流行病学
EMC - Endocrinologie Pub Date : 2004-07-01 DOI: 10.1016/j.emcend.2004.03.001
E Mallet (Professeur des Universités, praticien hospitalier, chef du département de pédiatrie médicale)
{"title":"Épidémiologie du rachitisme carentiel","authors":"E Mallet (Professeur des Universités, praticien hospitalier, chef du département de pédiatrie médicale)","doi":"10.1016/j.emcend.2004.03.001","DOIUrl":"10.1016/j.emcend.2004.03.001","url":null,"abstract":"<div><p>In France, a dramatic two thirds reduction rate was observed in the incidence of nutritional rickets during the first years, with the creation of vitamin D enriched milk formula for infant feeding. However, there are number of symptomatic nutritional rickets cases among adolescents, particularly as regards skin pigmentation in girls. This suggests the use of a vitamin D supplement principally during this age period characterized by a high growth rate.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 3","pages":"Pages 163-169"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86371899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biochimie des hormones et leurs mécanismes d'action. D-Récepteurs nucléaires 激素的生物化学及其作用机制。D-Récepteurs核
EMC - Endocrinologie Pub Date : 2004-07-01 DOI: 10.1016/j.emcend.2004.03.003
J Bertherat
{"title":"Biochimie des hormones et leurs mécanismes d'action. D-Récepteurs nucléaires","authors":"J Bertherat","doi":"10.1016/j.emcend.2004.03.003","DOIUrl":"10.1016/j.emcend.2004.03.003","url":null,"abstract":"<div><p>Nuclear receptors are transcription factors that bind cell permeable hormones (steroid hormones, thyroid hormones) or non hormonal molecules (retinoic acid, vitamin D…). Orphan nuclear receptors do not have obvious naturally occurring ligand. Nuclear receptors display a modular structure with similar characteristics: transactivation domain, ligand binding domain (LBD) and DNA binding domain (DBD). The activity of nuclear receptors is regulated by coactivators and corepressors that play a major role in the control of gene expression by nuclear receptors.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 3","pages":"Pages 133-137"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91045174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hyperlipidémie des diabétiques 糖尿病患者高脂血症
EMC - Endocrinologie Pub Date : 2004-04-01 DOI: 10.1016/j.emcend.2004.02.001
B Vergès (Professeur)
{"title":"Hyperlipidémie des diabétiques","authors":"B Vergès (Professeur)","doi":"10.1016/j.emcend.2004.02.001","DOIUrl":"10.1016/j.emcend.2004.02.001","url":null,"abstract":"<div><p>Lipid abnormalities are frequent and pronounced in patients with diabetes mellitus. They are partly responsible for the increased cardiovascular risk observed in this population, particularly in type 2 diabetic subjects. Type 2 diabetic patients present both quantitative and qualitative abnormalities of lipoproteins, when type 1 diabetic patients in good (or fairly good) glycemic control have only qualitative abnormalities. Quantitative abnormalities of lipoproteins are elevated triglycerides and decreased HDL-cholesterol level. Main qualitative abnormalities are large triglyceride-rich VLDL (VLDL<sub>1</sub>), small dense triglyceride-rich LDL, increased oxidation of LDL, triglyceride-rich HDL and glycation of apolipoproteins. Both quantitative and qualitative abnormalities are atherogenic. In type 2 diabetes, insulin resistance and insulin \"relative\" failure play a crucial role in the physiopathology of lipid disorders. Treatment of diabetic hyperlipidemia, which is important to reduce cardiovascular risk, is based on diet, physical activity, glycemic control and hypolipidemic drugs (fibrates, statins). Moreover, PPARγ agonists and in development PPARα/γ agonists are promising for the treatment of diabetic hyperlipidemia.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 2","pages":"Pages 106-116"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74121429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biochimie des hormones et leurs mécanismes d'action. Méthodes de dosage, de biologie moléculaire, et pharmacologie endocrine 激素的生物化学及其作用机制。测定方法、分子生物学和内分泌药理学
EMC - Endocrinologie Pub Date : 2004-04-01 DOI: 10.1016/j.emcend.2004.01.001
G. Assié , L. Nonnenmacher , E. Clauser , J. Bertherat
{"title":"Biochimie des hormones et leurs mécanismes d'action. Méthodes de dosage, de biologie moléculaire, et pharmacologie endocrine","authors":"G. Assié ,&nbsp;L. Nonnenmacher ,&nbsp;E. Clauser ,&nbsp;J. Bertherat","doi":"10.1016/j.emcend.2004.01.001","DOIUrl":"10.1016/j.emcend.2004.01.001","url":null,"abstract":"<div><p>Biological methods currently used in endocrinology are strongly linked to clinical practice: methods based on immunoassay or molecular biology are now used on a routine basis. The understanding of the principles of these methods is crucial for valid interpretations of the results. The tools offered by the pharmacology are also very useful when used in endocrinology for the characterization of the distribution and kinetics of an hormone after its secretion in the blood stream, and the action of this hormone on its targets.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 2","pages":"Pages 93-105"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82292407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Artériopathie diabétique des membres inférieurs 下肢糖尿病性动脉疾病
EMC - Endocrinologie Pub Date : 2004-04-01 DOI: 10.1016/j.emcend.2004.01.002
A Fredenrich (Praticien hospitalier) , P.-J Bouillanne (Praticien hospitalier) , M Batt (Professeur)
{"title":"Artériopathie diabétique des membres inférieurs","authors":"A Fredenrich (Praticien hospitalier) ,&nbsp;P.-J Bouillanne (Praticien hospitalier) ,&nbsp;M Batt (Professeur)","doi":"10.1016/j.emcend.2004.01.002","DOIUrl":"10.1016/j.emcend.2004.01.002","url":null,"abstract":"<div><p>Lower limb arteriopathy is a common complication of diabetes mellitus<span>, considered as an hallmark of macroangiopathy. In addition to hyperglycemia, smoking is a potent risk factor for the development of arteriopathy. In diabetic patients, clinical signs of the disease are not specific, but arteriopathy is rarely isolated and often combined with neuropathy and infection, leading to the aspect known as the “diabetic foot”. First-line non-invasive vascular investigations are always carried out, but lower limb arteriography is often required; this procedure should be cautiously used in diabetic patients. Therapeutic management requires at first assessment and treatment of infection. Then arterial restoration can be considered, using either percutaneous angioplasty or by-pass, but amputation can occur at any step. Anyway, this disease has to be managed by a trained multidisciplinary team to provide diabetic patients with the best prognosis in order to reduce the burden of arteriopathy.</span></p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 2","pages":"Pages 117-132"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2004.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84967299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
CV2 - Editorial Board CV2 -编辑委员会
EMC - Endocrinologie Pub Date : 2004-04-01 DOI: 10.1016/S1762-5653(04)00035-8
{"title":"CV2 - Editorial Board","authors":"","doi":"10.1016/S1762-5653(04)00035-8","DOIUrl":"https://doi.org/10.1016/S1762-5653(04)00035-8","url":null,"abstract":"","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 2","pages":"Page IFC"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1762-5653(04)00035-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136554993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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