EMC - Endocrinologie最新文献_第5页

Biochimie des hormones et leurs mécanismes d’action. Généralités et synthèse des hormones polypeptidiques 激素的生物化学及其作用机制。多肽激素的一般和合成

EMC - Endocrinologie Pub Date : 2004-04-01 DOI: 10.1016/j.emcend.2004.01.003

G Abiven (Chef de clinique-assistant) , M.-L Raffin-Sanson (Praticien universitaire-praticien hospitalier) , J Bertherat (Praticien universitaire-praticien hospitalier)

引用次数: 0

Épidémiologie et physiopathologie des complications dégénératives du diabète sucré 糖尿病退行性并发症的流行病学和病理生理学

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.003

D. Raccah (Professeur des Universités, praticien hospitalier)

引用次数: 19

Éditorial

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.12.001

A Grimaldi

引用次数: 0

Transplantation pancréatique : indications, résultats et perspectives 胰腺移植:适应症、移植结果及前景

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.002

B Barrou (Professeur des Universités, Praticien hospitalier) , M.-O Bitker (Professeur des Universités, praticien hospitalier) , A Grimaldi (Professeur des Universités, praticien hospitalier) , P Debré (Professeur des Universités, praticien hospitalier) , F Richard (Professeur des Universités, praticien hospitalier)

{"title":"Transplantation pancréatique : indications, résultats et perspectives","authors":"B Barrou (Professeur des Universités, Praticien hospitalier) , M.-O Bitker (Professeur des Universités, praticien hospitalier) , A Grimaldi (Professeur des Universités, praticien hospitalier) , P Debré (Professeur des Universités, praticien hospitalier) , F Richard (Professeur des Universités, praticien hospitalier)","doi":"10.1016/j.emcend.2003.10.002","DOIUrl":"10.1016/j.emcend.2003.10.002","url":null,"abstract":"<div><p>Pancreas transplantation is now a well established treatment for type I diabetes. More than 17 000 cases have been reported to the International Pancreas Transplant Registry. One year graft survival is around 80%. The majority of the cases are combined kidney and pancreas transplants harvested from the same donor in type I diabetics with an advanced nephropathy. However, the recent progresses in the field of immunosuppression have improved the results of isolated pancreas transplants or pancreas after kidney transplants. These 2 categories are not very frequent in Europe but could be more frequently offered in light of these results. Major breakthrough have also been done in the field of islets transplantation. A multicenter trial is currently in progress to assess whether the excellent results reported by a Canadian group are reproducible or not. If yes, this technique could have a place of choice for pancreatic endocrine function replacement.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 1","pages":"Pages 43-53"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2003.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77361265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroïdites 甲状腺炎

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.005

F Duron (Professeur des Universités, praticien hospitalier) , E Dubosclard (chef de clinique-assistant) , E Ballot (Médecin attaché des Hôpitaux) , C Johanet (Maître de conférences des Universités, praticien hospitalier)

引用次数: 0

Génétique de l’obésité 肥胖的遗传学

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.004

L Pérusse (Professeur)

{"title":"Génétique de l’obésité","authors":"L Pérusse (Professeur)","doi":"10.1016/j.emcend.2003.10.004","DOIUrl":"10.1016/j.emcend.2003.10.004","url":null,"abstract":"<div><p>Obesity is a complex disease resulting from the interaction of genetic and environmental factors. Combined progress in quantitative genetics, genomics and bioinformatics have contributed to increase our knowledge of genetic and molecular bases of obesity. It is now well established that overweight and the various forms of obesity are characterized by familial resemblance. Studies have shown that the risk of obesity was 2 to 8 times higher in an individual with positive family history compared to an individual without family history and that this risk tends to be higher for severe cases of obesity. The heritability of obesity depends of the phenotype investigated and tend to be higher for phenotypes associated with fat distribution (40 % to 55 %) than for phenotypes associated with excess body mass or adiposity (5 % to 40 %). Weight gain and changes in adiposity with age are also influenced by genetic factors. The existence of monogenic forms of obesity provides an indication that obesity could result from mutations in single genes, but only 78 cases due to mutation in 7 different genes have been reported so far. The most common forms of obesity are undoubtedly caused by variations in a large number of genes. DNA sequence variations in 56 different genes have been reported to be asociated with various obesity phenotypes so far, but only 10 of these genes have been associated with obesity in at least 5 different studies. In summary, we can conclude from the evidence accumulated so far that genetic factors play a role in the etiology of obesity and that except for rare cases of severe obesity, the genes involved are genes interacting with environmental factors related to energy intake and energy expenditure to increase the risk of obesity in susceptible individuals. The identification of these susceptibility genes is the task awaiting the hunters of obesity and related co-morbidity genes in the next decade.</p></div>","PeriodicalId":100422,"journal":{"name":"EMC - Endocrinologie","volume":"1 1","pages":"Pages 67-80"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.emcend.2003.10.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82780159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Métabolisme du sélénium 硒代谢

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.001

V Ducros, A Favier

引用次数: 21

Insulinothérapie dans le diabète de type 2 2型糖尿病的胰岛素治疗

EMC - Endocrinologie Pub Date : 2004-01-01 DOI: 10.1016/j.emcend.2003.10.006

F Bosquet (Praticien hospitalier), A Hartemann-Heurtier (Praticien hospitalo-universitaire)

引用次数: 0