Decoding Infection and Transmission最新文献

{"title":"Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022","authors":"Bing Lu ,&nbsp;Wenjiao Chang ,&nbsp;Huaiwei Lu ,&nbsp;Zhengchao Nie ,&nbsp;Yongqin Wu ,&nbsp;Xiaoling Ma ,&nbsp;Yunbo Chen ,&nbsp;Xiaofang Wang ,&nbsp;Yangyan Wang ,&nbsp;Yonghong Xiao ,&nbsp;Yuanyuan Dai","doi":"10.1016/j.dcit.2025.100052","DOIUrl":"10.1016/j.dcit.2025.100052","url":null,"abstract":"<div><h3>Objective</h3><div><em>Staphylococcus aureus</em> bacteremia is a critical and pernicious infection, and in particular methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) is increasing in treatment failure. This study analyzed trends in the minimum inhibitory concentrations (MICs) of limited antimicrobials against MRSA bloodstream isolates in China; specifically, the antibiotics vancomycin, daptomycin, linezolid, and teicoplanin.</div></div><div><h3>Methods</h3><div>A total of 3901 <em>S. aureus</em> blood isolates, including 1065 MRSA isolates, were collected from ten Chinese provinces between 2017 and 2022. Broth microdilution was used to establish the MICs for the four antimicrobials. The geometric mean MICs (GM MICs), MIC50s (inhibition of 50 % of <em>S. aureus</em>), MIC90s (inhibition of 90 % of <em>S. aureus</em>), and MICs distribution were determined for each year.</div></div><div><h3>Results</h3><div>The geometric mean inhibitory concentration of vancomycin for MRSA isolates increased from 0.58 mg/L in 2018 to 1.01 mg/L by 2022; and that of linezolid decreased from 1.52 mg/L in 2017 to 0.94 mg/L in 2022. Daptomycin and teicoplanin demonstrated no clear trends. MRSA isolates with vancomycin MICs ≤0.5 mg/mL significantly decreased from 77.1 % in 2018 to 8.8 % in 2022. For linezolid, those with MICs &gt;1 and ≤ 2 mg/L also decreased from 62.8 % in 2017 to 26.1 % in 2022. The highest geometric mean MICs of daptomycin, linezolid, vancomycin, and teicoplanin were respectively seen in Yunnan (0.465 mg/L), Henan (1.368 mg/L), Gansu (0.908 mg/L), and Hubei (0.579 mg/L); whereas the lowest values were observed in Jiangxi (0.355 mg/L), Yunnan (0.896 mg/L), Yunnan (0.600 mg/L), and Henan (0.438 mg/L). MRSA isolates originating from tertiary care hospitals exhibited lower sensitivity for teicoplanin than those from non-tertiary care hospitals.</div></div><div><h3>Conclusions</h3><div>MRSA isolates from bloodstream infections in China are presently showing lower sensitivity to vancomycin and higher sensitivity to linezolid.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurring diphtheria outbreaks in Nigeria: A holistic review of challenges, knowledge and strategic recommendations for control","authors":"Adelekan Oluseyi Okunlade ,&nbsp;Ridwan Olamilekan Adesola ,&nbsp;Ibrahim Idris ,&nbsp;Foluke Olajumoke Jemilehin","doi":"10.1016/j.dcit.2025.100057","DOIUrl":"10.1016/j.dcit.2025.100057","url":null,"abstract":"<div><div>Diphtheria is a vaccine-preventable bacterial disease that has contributed to the large number of deaths in Nigeria. There have been numerous outbreaks after the COVID-19 pandemic. However, the challenges associated with this occurrence have not been well studied in Nigeria. In this study, we aimed to extensively review the challenges and knowledge gaps associated with the spread of diphtheria in Nigeria, while providing holistic approaches to tackle this menace. Several challenges have been identified contributing to the spread of diphtheria in Nigeria. These challenges were categorized into systemic, social, and environmental categories. Addressing these challenges with a holistic and multifaceted approach, as highlighted in this review, will curb the spread and eradicate diphtheria completely in Nigeria and other parts of the world.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The implications of Mpox for healthcare Providers: Understanding transmission, clinical presentation, and infection control","authors":"Promise Udohchukwu Okereke ,&nbsp;Mohamed Terra ,&nbsp;Wisdom Obumneme Okereke ,&nbsp;David Obiyenwa ,&nbsp;Collins Chidera Uche ,&nbsp;Anthony Chukwuebuka Okeke ,&nbsp;Emmanuel Onyekachukwu Okwor ,&nbsp;Oladayo Damilola Akinwale","doi":"10.1016/j.dcit.2025.100049","DOIUrl":"10.1016/j.dcit.2025.100049","url":null,"abstract":"<div><div>Mpox, formerly known as monkeypox, is a zoonotic viral disease caused by the Monkeypox virus, a member of the <em>Orthopoxvirus</em> genus. Since the 2022 global outbreak, the virus has been increasingly reported in non-endemic regions, with evidence supporting person-to-person transmission, including through sexual contact. By August 2022, the World Health Organization (WHO) declared Mpox a Public Health Emergency of International Concern (PHEIC) due to its rapid international spread. This review synthesizes the current understanding of Mpox transmission dynamics, clinical presentation, and the role of healthcare providers, including clinicians, dentists, and nurses, in its detection and control. A narrative review was conducted using scientific literature indexed in PubMed, WHO reports, and CDC guidelines from 2017 to 2024. The review highlights the need for increased awareness of atypical presentations, including oral and genital lesions, which may initially be misdiagnosed. Special emphasis is placed on the responsibilities of dental and clinical professionals in early detection, infection prevention, and patient education. As cases continue to appear globally, a comprehensive understanding of Mpox is crucial to protect both patients and healthcare workers.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosquitoes as pesticide disseminators: Advancing pyriproxyfen-based technologies for next-generation vector control","authors":"Mengyan He,&nbsp;Yuting Chen,&nbsp;Hao Yang,&nbsp;Yongjun Li","doi":"10.1016/j.dcit.2025.100059","DOIUrl":"10.1016/j.dcit.2025.100059","url":null,"abstract":"<div><div>Mosquito-borne diseases, including dengue, Zika, chikungunya, and malaria, pose significant global health challenges, exacerbated by rising insecticide resistance in key vectors like <em>Aedes</em> and <em>Anopheles</em>. Pyriproxyfen (PPF), an insect growth regulator (IGR), offers a promising alternative due to its unique mode of action, mimicking juvenile hormone to disrupt mosquito metamorphosis and reproduction at low concentrations, with minimal mammalian toxicity. This review examines PPF's role in mosquito control, focusing on its mechanisms, conventional applications, novel dissemination strategies, and challenges in the context of escalating resistance, with particular emphasis on PPF-based novel mosquito control technologies, namely the PPF-dissemination stations (PDS) and boosted sterile or incompatible insect techniques (BSIT/BIIT). These advanced technologies leverage mosquitoes to spread PPF to breeding sites (including the cryptic ones), offering targeted and cost-effective solutions. We propose that future research should prioritize the refinement of PPF delivery systems, improvement of community engagement, assessment of PPF's effects on vector competence, and establishment of international collaborative networks for PPF-resistance monitoring. This review highlights the significant value of PPF in combating mosquito-borne diseases, emphasizing the need for continued innovation to ensure its role as a valuable complement of global vector control initiatives, especially in regions prone to resistance.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of Trichosporon inkin bloodstream infection in an immunocompetent patient: Diagnostic challenges and antigenic cross-reactivity","authors":"Yongqin Wu","doi":"10.1016/j.dcit.2025.100043","DOIUrl":"10.1016/j.dcit.2025.100043","url":null,"abstract":"<div><div><em>Trichosporon inkin</em> is a rare opportunistic pathogen typically associated with superficial infections but can also cause invasive infections, particularly in immunocompromised hosts. Here, we report a rare case of <em>T. inkin</em> bloodstream infection in an immunocompetent male with a history of cerebral hemorrhage surgery. The patient presented with fever, limb twitching, and brain lesions. Blood cultures revealed fungal growth, which was initially misidentified as <em>Trichosporon ovoides</em> by mass spectrometry but was later confirmed as <em>T. inkin</em> through ITS and IGS1 sequencing. The isolate exhibited low MICs for azoles and amphotericin B but high MICs for echinocandins. Notably, the patient's serum tested positive for cryptococcal antigen and <em>Aspergillus</em> galactomannan, despite the absence of clinical signs of cryptococcosis or aspergillosis. The <em>T. inkin</em> isolate expresses cryptococcal antigen but not galactomannan cross-reactive antigens when cultured in standard media. However, it expresses galactomannan cross-reactive antigens when cultured in human whole blood. This case highlights diagnostic challenges, including antigenic cross-reactivity and misidentification, and emphasizes the role of host–pathogen interactions in antigen expression. Our findings underscore the need for improved diagnostics and cautious interpretation of fungal antigen tests. This report expands the understanding of <em>T. inkin</em> infections and provides insights into their clinical management.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO report signals tuberculosis resurgence: Addressing systemic failures and revamping control strategies","authors":"Bashar Haruna Gulumbe ,&nbsp;Abdulrakib Abdulrahim ,&nbsp;Shamsuddeen Kele Ahmad ,&nbsp;Kadai Alhaji Lawan ,&nbsp;Mohammed Bashar Danlami","doi":"10.1016/j.dcit.2025.100044","DOIUrl":"10.1016/j.dcit.2025.100044","url":null,"abstract":"<div><div>According to the World Health Organization's Global Tuberculosis Report 2024, tuberculosis (TB) has resurged as the leading cause of death from a single infectious agent, overtaking Coronavirus disease 2019 (COVID-19). With 8.2 million diagnoses and 1.25 million deaths in 2023, the highest since monitoring began in 1995, this commentary analyzes factors contributing to TB's resurgence and the limitations of current control strategies. Contributing factors include the diversion of healthcare resources during the COVID-19 pandemic, leading to diagnostic delays and treatment interruptions; the rise of multidrug-resistant TB (MDR-TB), complicated by complex treatment regimens and limited diagnostic capacity; socioeconomic barriers such as poverty and overcrowding hindering access to care; and funding shortfalls impeding program implementation and research efforts. We advocate for reevaluating TB control strategies by integrating TB services into primary healthcare, leveraging digital technologies, and investing in capacity building. Addressing drug resistance requires accelerated research, improved diagnostics, and enhanced adherence programs. Essential socioeconomic interventions include poverty alleviation, community engagement, and nutritional support. Securing sustainable funding through increased domestic investment, international cooperation, and private-sector engagement is critical. Reversing TB's resurgence requires global commitment and coordinated action. Political will, robust community involvement, and global solidarity are vital. Ending the TB epidemic is both a medical and moral imperative aligned with the United Nations Sustainable Development Goals. Immediate and decisive action is imperative to prevent further loss of life and achieve a TB-free world.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the Bite: Sensory cues, host heterogeneity, and pathogen manipulation in mosquito host-seeking behavior","authors":"Ran Zhang ,&nbsp;Rui Han ,&nbsp;Shuairu Jiao ,&nbsp;Xiuyun Wang ,&nbsp;Guizhi Xu,&nbsp;Fanghang He,&nbsp;Chengsheng Peng,&nbsp;Qilong Wu,&nbsp;Shengqun Deng","doi":"10.1016/j.dcit.2025.100055","DOIUrl":"10.1016/j.dcit.2025.100055","url":null,"abstract":"<div><div>Mosquitoes, primarily females, require blood meals for reproduction, making them prolific biters and major vectors of diseases such as malaria, dengue, Zika, and West Nile. This review synthesizes the mechanisms driving mosquito host-seeking behavior and the factors underlying heterogeneous human biting patterns. Mosquitoes locate hosts via a suite of sensory cues: long-range attraction to CO₂, followed by visual, thermal, and close-range olfactory cues. Olfaction is dominated by receptors that detect volatile organic compounds (VOCs) from human skin, sweat, and the microbiota. Host selection exhibits significant heterogeneity and is influenced by human physiological factors, including age (children/elderly individuals are often more attractive), sex (inconsistently reported), larger body size (higher metabolic output), pregnancy (increased CO₂, temperature, and VOCs), and skin/clothing color (dark colors that are more attractive). While some studies suggest blood type preferences (e.g., O for <em>Ae. albopictus</em>, B for <em>Ae. aegypti</em>), findings are inconsistent. Behavioral factors such as alcohol consumption increase attraction, whereas defensive behaviors reduce biting success. Crucially, pathogens manipulate host attractiveness: malaria (<em>Plasmodium</em>) increases the levels of aldehydes and terpenes via mechanisms involving HMBPP, and dengue/Zika increases acetophenone production via changes in the skin microbiota, increasing mosquito attraction and disease transmission. Mosquito host preference exhibits plasticity, shifting due to host availability (e.g., bird migration for West Nile vectors) or interventions (e.g., bed nets). Understanding these mechanisms (sensory cues, host factors, pathogen manipulation, and plasticity) is vital for developing targeted interventions (personal protection, odor masking, housing modifications, and microbiota management) to reduce bites and disease transmission.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mRNA vaccination facilitates the prevention and control of infectious diseases at an unprecedented speed","authors":"Jinmin Ma ,&nbsp;Meirong Li ,&nbsp;Zhihao Xie ,&nbsp;Desheng Li","doi":"10.1016/j.dcit.2025.100048","DOIUrl":"10.1016/j.dcit.2025.100048","url":null,"abstract":"<div><div>In recent years, amidst the progresses of biotechnology versus the emergence and evolution of diseases, the pursuit of mRNA (messenger RNA) vaccines has become a focal point, particularly after their revolutionary function during the COVID-19 pandemic. mRNA vaccines have assumed a pivotal role against infectious diseases, and represent an avenue of exploration that holds great promise. The merits of mRNA vaccines are manifold, and encompass rapid development, unparalleled flexibility and adaptability, the elicitation of potent immune responses, cost-effective manufacturing, and the potential for personalized medicine. The global scientific community has become inspired by the possibilities of expeditious vaccine development, resulting in an extensive tapestry of research and development. However, realizing the full potential of mRNA vaccines is not without scientific and regulatory pitfalls, and necessitates a concerted effort to surmount these challenges. Nevertheless, incremental advances bear testament to the ever-evolving landscape of mRNA vaccine advancement in the battle against COVID-19. We believe that this technology will further play a significant role in the field of infectious diseases. This article aims to describe mRNA vaccine mechanisms and their applications against infectious diseases.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythm of mosquitoes: Blood feeding and disease transmission","authors":"Chanuka Wijewardana ,&nbsp;Yunxuan Chen ,&nbsp;Yinghui Zhou ,&nbsp;Chenxuan Jiang ,&nbsp;Donghui Zhang ,&nbsp;Min Hou ,&nbsp;Zhipeng Xu ,&nbsp;Lu Chen ,&nbsp;MinJun Ji ,&nbsp;Lin Chen","doi":"10.1016/j.dcit.2025.100050","DOIUrl":"10.1016/j.dcit.2025.100050","url":null,"abstract":"<div><div>The circadian rhythm refers to the adjustment of behavioural rhythms of organisms' to the environmental cues. The rhythm adjusting and maintaining is done through an internal timekeeping mechanism. The timekeeping mechanism is governed through a series of translational transcription feedback loops that obtain the environmental cues from outside and translate them to behavioural rhythms through a series of neurotransmitters and gene transcriptions. The behavioural rhythms are essential for the animals to stay in optimal conditions. The circadian rhythm is especially important for blood-feeding arthropods, such as mosquitoes, to adjust their feeding times to the optimal time window of the day. The time window depends on host availability, evasion of predators, and other factors like humidity and temperature. This process ensures the optimum feeding and maximum efficiency in the parasite transmission. This mechanism plays an important role in the mosquito-borne disease transmission. Furthermore, due to the blood meal-induced processes such as trypsin activation and vitellogenesis, the time of blood meal might affect the mosquito's survival and reproductive health. The circadian timekeeping mechanism depends on external environmental cues. The changing of the environmental conditions due to climatic change and human intervention may alter the circadian behavioural rhythms and make erratic behaviours that are hard to predict and, in turn preventing the spread of mosquito-borne diseases. In here, we look into the circadian patterns in blood feeding in mosquitoes, the impact of environmental factors, the genetic control, and how it might contribute to the disease transmission.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype switching in hepatitis B virus as a potential risk for vertical transmission from mother-to-child was first reported","authors":"Li Zhang ,&nbsp;Guanyong Ou ,&nbsp;Yong Chen ,&nbsp;Jiumeng Min ,&nbsp;Yanjie Li ,&nbsp;Liuqing Yang ,&nbsp;Jiexiang Liu ,&nbsp;Lei Jiang ,&nbsp;Zitao Xie ,&nbsp;Jinmin Ma ,&nbsp;Yingxia Liu","doi":"10.1016/j.dcit.2025.100040","DOIUrl":"10.1016/j.dcit.2025.100040","url":null,"abstract":"<div><h3>Objective</h3><div>Hepatitis B virus (HBV) infection represents a significant global public health concern and is endemic in numerous populations. In China, mother-to-child transmission (MTCT) remains the predominant route of HBV infection. The administration of the Hepatitis B vaccine and Hepatitis B immunoglobulin (HBIG) to neonates born to mothers with chronic HBV infection constitutes the primary strategy to mitigate the risk of perinatal transmission. Nevertheless, elevated maternal viral loads are a critical risk factor for vertical transmission of HBV, even when infants are immunized at birth and treated with HBIG.</div></div><div><h3>Methods</h3><div>In this study, we enrolled 32 mother-child pairs with confirmed vertical transmission of HBV. Despite antiviral therapy administered to three pregnant women, which successfully reduced their viral loads below the threshold (HBV DNA &lt;5.3 log10 IU/mL) within 24 weeks of pregnancy, their infants still contracted HBV despite receiving immunization and HBIG at birth.</div></div><div><h3>Results</h3><div>Utilizing next-generation sequencing (NGS) and comprehensive HBV genomic analysis, we identified that 28 pairs (87.5 %) were infected with HBV genotype B2, three pairs (9.3 %) with genotype C1, and three pairs (9.3 %) exhibited genotype switching.</div></div><div><h3>Conclusion</h3><div>This study is the first to report the phenomenon of HBV genotype switching during MTCT, with the underlying mechanisms explored through the analysis of HBV quasispecies haplotypes.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}