{"title":"Decoding Infection and Transmission: Deciphering the mystery of infectious diseases from data-based research","authors":"Jun Cao, Lubin Jiang, Louis H. Miller","doi":"10.1016/j.dcit.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.03.001","url":null,"abstract":"<div><p>Infectious diseases, also known as communicable diseases, are a continuous threat to humans. Infectious disease itself is results of multifactorial effects, and a multidisciplinary research field. How to utilize multi-resource data for infectious disease prevention and control remains a great challenge in the current information age and big data era. The global output of infectious diseases research has recently poured and there is a critical need for dedicated journals to share and communicate the cutting-edge findings and latest knowledge from basic, clinical medical sciences and public health aspects at an international level. Nevertheless, there are few international peer-reviewed journals that focus on analysis, decoding and utilization of epidemiological, biological, functional and -omics data associated with infectious diseases. <em>Decoding Infection and Transmission</em>, a gold open-access, peer-reviewed journal, is therefore launched, which is dedicated to the rapid publication and global dissemination of the latest research findings about the characteristics and mechanisms of pathogenic infections and disease transmission, aims to bridge the gap between research scientists, clinical physicians, public health professionals and veterinarians working in diverse infectious diseases, and will dedicate to building an academic community of leading scientist working on infectious diseases. Welcome contributions.</p></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49727504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Roberts Padde , Qingyu Lu , Yuang Long , Donghui Zhang , Min Hou , Lu Chen , Zhipeng Xu , Lin Chen , Minjun Ji
{"title":"The impact of environmental and host factors on wolbachia density and efficacy as a biological tool","authors":"John Roberts Padde , Qingyu Lu , Yuang Long , Donghui Zhang , Min Hou , Lu Chen , Zhipeng Xu , Lin Chen , Minjun Ji","doi":"10.1016/j.dcit.2023.100006","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.100006","url":null,"abstract":"<div><p><em>Wolbachia</em>, a bacterium found naturally in some species of <em>Aedes</em> and <em>Culex</em> mosquitoes<em>,</em> has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, <em>Wolbachia</em>-mediated pathogen blockage, <em>Wolbachia</em> dynamics in field populations and vertical transmission have been reported to be density-dependent. Several factors, including host genetics, diet, temperature, and co-infections can influence <em>Wolbachia</em> titers within its host. The interplay between these factors can have significant influence on the effectiveness of <em>Wolbachia</em>-mediated pathogen blockage and cytoplasmic incompatibility. However, there is a knowledge gap regarding the regulation of <em>Wolbachia</em> density within its host, which could affect its effectiveness as a biocontrol tool. Therefore, this review aims to understand the complex tripartite association between the environment, host, and endosymbiont, and how these relationships are crucial in harnessing the full potential of <em>Wolbachia</em> as a biological tool. Further, we highlight how host, pathogen, and environmental factors influence <em>Wolbachia</em> density and how their interplay can impact CI and WMPB. We further review the strategies adopted to maintain/control <em>Wolbachia</em> densities in field populations.</p></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100006"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294992402300006X/pdfft?md5=4940ef72bb150cb61b6950d2e813a5a7&pid=1-s2.0-S294992402300006X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuanyuan Wang , Raman Thakur , Qingli Shen , Yaojuan He , Changbin Chen
{"title":"Influences of vaginal microbiota on human papillomavirus infection and host immune regulation: What we have learned?","authors":"Yuanyuan Wang , Raman Thakur , Qingli Shen , Yaojuan He , Changbin Chen","doi":"10.1016/j.dcit.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.07.001","url":null,"abstract":"<div><p>The alteration of microbiota in different host niches has been associated with numerous adverse health outcomes that affect millions of human patients annually. In last few years the interest has been increased to study the microbiota that is present in the female genital tract and may associate with various disease symptoms. Vaginal microbiota contributes to the maintenance of a healthy vaginal environment and simultaneously reduces the deleterious effect of various infectious agents. The change of vaginal microbiota has been observed using culture-independent methods such as next generation sequencing (NGS) technology, and its fluctuation was found to link with various endogenous and exogenous factors. Among them, a dynamic interplay between the vaginal microbiota and human papillomavirus (HPV) was found to be important in the acquisition and persistence of HPV and contributed to the development of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). Accumulating evidence has shown that persistent HPV infection depends upon regulation of the immune response and its associated factors such as hormones, human genetics and vaginal microbial interactions. Here, we reviewed the association of the microbiota with HPV persistence, factors in shaping the vaginal microbiota and their interplay with the regulation of immuno-regulatory molecules. The understanding of these associations could help identify important targets having impact on HPV persistence. Further, we discussed the predictive diagnostic and clinical therapeutic applications of vaginal microbiota in prevention and treatment of HPV persistence and subsequent progression of CIN and CC.</p></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49765931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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