Decoding Infection and Transmission最新文献_第4页

Observation of intestinal flora diversity with the parasites infection process in a nonlethal malaria model of BALB/c mice induced by Plasmodium yoelii 17XNL strain 约氏疟原虫17XNL诱导BALB/c小鼠非致死性疟疾模型肠道菌群多样性与寄生虫感染过程的观察

Decoding Infection and Transmission Pub Date : 2023-01-01 DOI: 10.1016/j.dcit.2023.100004

Wei Guan , Daoxiu Xu , Shuguo Yang , Yanqing Zhao , Yiting Xie , Min Lin , Yaqun Liu , Yuzhong Zheng , Jian Li

{"title":"Observation of intestinal flora diversity with the parasites infection process in a nonlethal malaria model of BALB/c mice induced by Plasmodium yoelii 17XNL strain","authors":"Wei Guan , Daoxiu Xu , Shuguo Yang , Yanqing Zhao , Yiting Xie , Min Lin , Yaqun Liu , Yuzhong Zheng , Jian Li","doi":"10.1016/j.dcit.2023.100004","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.100004","url":null,"abstract":"<div>Gut flora plays an important role in infectious diseases such as malaria, but few studies are conducted in the associated filed of murine malaria infected with Plasmodium yoelii 17XNL (Py 17XNL). In this study, the alteration of intestinal flora composition in BALB/c mice infected with Py 17XNL was detected. The kinetics of parasitemia was assessed at 1, 6, 9, 15, 25, and 28 days postinfection (dpi). The survival percentage was calculated to assess the mortality. The parasitemia reached the highest degree at 9 dpi and almost eliminated at 25 dpi. Interestingly, the morbidity was severe at 9 dpi, but it almost recovered at 28 dpi. Regarding the gut microbiota, the gut microbiota from BALB/c mice was examined by sequencing the V4 region of the 16S rRNA through the Illumina MiSeq platform. The results revealed the apparent variation of operational taxonomic unit (OTU) clustering, relative abundance of microbial composition, alpha and beta diversity among the seven groups, with an increase of the alpha diversity and a decrease of beta diversity at 9 and 15 dpi, which recovered at 28 dpi. The LEfSe analysis selected potential biomarkers at genus and species levels, such as Lactobacillus gasseri in Py9 and Py15 groups, Pseudomonas veronii in Py25 group, and Lactobacillus intestinalis and Psychrobacter in Py28 group. This study offers a new insight for investigating the effect of gut microbiota on the occurrence and development of malaria, and also provides new ideas for the treatment and prevention of malaria.</div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49765941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Infection and Transmission: Deciphering the mystery of infectious diseases from data-based research 解码感染和传播:从基于数据的研究中破译传染病的奥秘

Decoding Infection and Transmission Pub Date : 2023-01-01 DOI: 10.1016/j.dcit.2023.03.001

Jun Cao, Lubin Jiang, Louis H. Miller

{"title":"Decoding Infection and Transmission: Deciphering the mystery of infectious diseases from data-based research","authors":"Jun Cao, Lubin Jiang, Louis H. Miller","doi":"10.1016/j.dcit.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.03.001","url":null,"abstract":"<div>Infectious diseases, also known as communicable diseases, are a continuous threat to humans. Infectious disease itself is results of multifactorial effects, and a multidisciplinary research field. How to utilize multi-resource data for infectious disease prevention and control remains a great challenge in the current information age and big data era. The global output of infectious diseases research has recently poured and there is a critical need for dedicated journals to share and communicate the cutting-edge findings and latest knowledge from basic, clinical medical sciences and public health aspects at an international level. Nevertheless, there are few international peer-reviewed journals that focus on analysis, decoding and utilization of epidemiological, biological, functional and -omics data associated with infectious diseases. Decoding Infection and Transmission, a gold open-access, peer-reviewed journal, is therefore launched, which is dedicated to the rapid publication and global dissemination of the latest research findings about the characteristics and mechanisms of pathogenic infections and disease transmission, aims to bridge the gap between research scientists, clinical physicians, public health professionals and veterinarians working in diverse infectious diseases, and will dedicate to building an academic community of leading scientist working on infectious diseases. Welcome contributions.</div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49727504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The impact of environmental and host factors on wolbachia density and efficacy as a biological tool 作为一种生物工具，环境和宿主因素对沃尔巴克氏体密度和功效的影响

Decoding Infection and Transmission Pub Date : 2023-01-01 DOI: 10.1016/j.dcit.2023.100006

John Roberts Padde , Qingyu Lu , Yuang Long , Donghui Zhang , Min Hou , Lu Chen , Zhipeng Xu , Lin Chen , Minjun Ji

{"title":"The impact of environmental and host factors on wolbachia density and efficacy as a biological tool","authors":"John Roberts Padde , Qingyu Lu , Yuang Long , Donghui Zhang , Min Hou , Lu Chen , Zhipeng Xu , Lin Chen , Minjun Ji","doi":"10.1016/j.dcit.2023.100006","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.100006","url":null,"abstract":"<div>Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, Wolbachia-mediated pathogen blockage, Wolbachia dynamics in field populations and vertical transmission have been reported to be density-dependent. Several factors, including host genetics, diet, temperature, and co-infections can influence Wolbachia titers within its host. The interplay between these factors can have significant influence on the effectiveness of Wolbachia-mediated pathogen blockage and cytoplasmic incompatibility. However, there is a knowledge gap regarding the regulation of Wolbachia density within its host, which could affect its effectiveness as a biocontrol tool. Therefore, this review aims to understand the complex tripartite association between the environment, host, and endosymbiont, and how these relationships are crucial in harnessing the full potential of Wolbachia as a biological tool. Further, we highlight how host, pathogen, and environmental factors influence Wolbachia density and how their interplay can impact CI and WMPB. We further review the strategies adopted to maintain/control Wolbachia densities in field populations.</div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100006"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294992402300006X/pdfft?md5=4940ef72bb150cb61b6950d2e813a5a7&pid=1-s2.0-S294992402300006X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influences of vaginal microbiota on human papillomavirus infection and host immune regulation: What we have learned? 阴道微生物群对人乳头瘤病毒感染和宿主免疫调节的影响:我们学到了什么?

Decoding Infection and Transmission Pub Date : 2023-01-01 DOI: 10.1016/j.dcit.2023.07.001

Yuanyuan Wang , Raman Thakur , Qingli Shen , Yaojuan He , Changbin Chen

{"title":"Influences of vaginal microbiota on human papillomavirus infection and host immune regulation: What we have learned?","authors":"Yuanyuan Wang , Raman Thakur , Qingli Shen , Yaojuan He , Changbin Chen","doi":"10.1016/j.dcit.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.dcit.2023.07.001","url":null,"abstract":"<div>The alteration of microbiota in different host niches has been associated with numerous adverse health outcomes that affect millions of human patients annually. In last few years the interest has been increased to study the microbiota that is present in the female genital tract and may associate with various disease symptoms. Vaginal microbiota contributes to the maintenance of a healthy vaginal environment and simultaneously reduces the deleterious effect of various infectious agents. The change of vaginal microbiota has been observed using culture-independent methods such as next generation sequencing (NGS) technology, and its fluctuation was found to link with various endogenous and exogenous factors. Among them, a dynamic interplay between the vaginal microbiota and human papillomavirus (HPV) was found to be important in the acquisition and persistence of HPV and contributed to the development of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). Accumulating evidence has shown that persistent HPV infection depends upon regulation of the immune response and its associated factors such as hormones, human genetics and vaginal microbial interactions. Here, we reviewed the association of the microbiota with HPV persistence, factors in shaping the vaginal microbiota and their interplay with the regulation of immuno-regulatory molecules. The understanding of these associations could help identify important targets having impact on HPV persistence. Further, we discussed the predictive diagnostic and clinical therapeutic applications of vaginal microbiota in prevention and treatment of HPV persistence and subsequent progression of CIN and CC.</div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"1 ","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49765931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1