Bing Lu , Wenjiao Chang , Huaiwei Lu , Zhengchao Nie , Yongqin Wu , Xiaoling Ma , Yunbo Chen , Xiaofang Wang , Yangyan Wang , Yonghong Xiao , Yuanyuan Dai
{"title":"中国血液感染中四种药物对耐甲氧西林金黄色葡萄球菌最低抑制浓度的趋势：一项为期6年的多中心研究(2017 - 2022","authors":"Bing Lu , Wenjiao Chang , Huaiwei Lu , Zhengchao Nie , Yongqin Wu , Xiaoling Ma , Yunbo Chen , Xiaofang Wang , Yangyan Wang , Yonghong Xiao , Yuanyuan Dai","doi":"10.1016/j.dcit.2025.100052","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div><em>Staphylococcus aureus</em> bacteremia is a critical and pernicious infection, and in particular methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) is increasing in treatment failure. This study analyzed trends in the minimum inhibitory concentrations (MICs) of limited antimicrobials against MRSA bloodstream isolates in China; specifically, the antibiotics vancomycin, daptomycin, linezolid, and teicoplanin.</div></div><div><h3>Methods</h3><div>A total of 3901 <em>S. aureus</em> blood isolates, including 1065 MRSA isolates, were collected from ten Chinese provinces between 2017 and 2022. Broth microdilution was used to establish the MICs for the four antimicrobials. The geometric mean MICs (GM MICs), MIC50s (inhibition of 50 % of <em>S. aureus</em>), MIC90s (inhibition of 90 % of <em>S. aureus</em>), and MICs distribution were determined for each year.</div></div><div><h3>Results</h3><div>The geometric mean inhibitory concentration of vancomycin for MRSA isolates increased from 0.58 mg/L in 2018 to 1.01 mg/L by 2022; and that of linezolid decreased from 1.52 mg/L in 2017 to 0.94 mg/L in 2022. Daptomycin and teicoplanin demonstrated no clear trends. MRSA isolates with vancomycin MICs ≤0.5 mg/mL significantly decreased from 77.1 % in 2018 to 8.8 % in 2022. For linezolid, those with MICs >1 and ≤ 2 mg/L also decreased from 62.8 % in 2017 to 26.1 % in 2022. The highest geometric mean MICs of daptomycin, linezolid, vancomycin, and teicoplanin were respectively seen in Yunnan (0.465 mg/L), Henan (1.368 mg/L), Gansu (0.908 mg/L), and Hubei (0.579 mg/L); whereas the lowest values were observed in Jiangxi (0.355 mg/L), Yunnan (0.896 mg/L), Yunnan (0.600 mg/L), and Henan (0.438 mg/L). MRSA isolates originating from tertiary care hospitals exhibited lower sensitivity for teicoplanin than those from non-tertiary care hospitals.</div></div><div><h3>Conclusions</h3><div>MRSA isolates from bloodstream infections in China are presently showing lower sensitivity to vancomycin and higher sensitivity to linezolid.</div></div>","PeriodicalId":100358,"journal":{"name":"Decoding Infection and Transmission","volume":"3 ","pages":"Article 100052"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022\",\"authors\":\"Bing Lu , Wenjiao Chang , Huaiwei Lu , Zhengchao Nie , Yongqin Wu , Xiaoling Ma , Yunbo Chen , Xiaofang Wang , Yangyan Wang , Yonghong Xiao , Yuanyuan Dai\",\"doi\":\"10.1016/j.dcit.2025.100052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div><em>Staphylococcus aureus</em> bacteremia is a critical and pernicious infection, and in particular methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) is increasing in treatment failure. This study analyzed trends in the minimum inhibitory concentrations (MICs) of limited antimicrobials against MRSA bloodstream isolates in China; specifically, the antibiotics vancomycin, daptomycin, linezolid, and teicoplanin.</div></div><div><h3>Methods</h3><div>A total of 3901 <em>S. aureus</em> blood isolates, including 1065 MRSA isolates, were collected from ten Chinese provinces between 2017 and 2022. Broth microdilution was used to establish the MICs for the four antimicrobials. The geometric mean MICs (GM MICs), MIC50s (inhibition of 50 % of <em>S. aureus</em>), MIC90s (inhibition of 90 % of <em>S. aureus</em>), and MICs distribution were determined for each year.</div></div><div><h3>Results</h3><div>The geometric mean inhibitory concentration of vancomycin for MRSA isolates increased from 0.58 mg/L in 2018 to 1.01 mg/L by 2022; and that of linezolid decreased from 1.52 mg/L in 2017 to 0.94 mg/L in 2022. Daptomycin and teicoplanin demonstrated no clear trends. MRSA isolates with vancomycin MICs ≤0.5 mg/mL significantly decreased from 77.1 % in 2018 to 8.8 % in 2022. For linezolid, those with MICs >1 and ≤ 2 mg/L also decreased from 62.8 % in 2017 to 26.1 % in 2022. The highest geometric mean MICs of daptomycin, linezolid, vancomycin, and teicoplanin were respectively seen in Yunnan (0.465 mg/L), Henan (1.368 mg/L), Gansu (0.908 mg/L), and Hubei (0.579 mg/L); whereas the lowest values were observed in Jiangxi (0.355 mg/L), Yunnan (0.896 mg/L), Yunnan (0.600 mg/L), and Henan (0.438 mg/L). MRSA isolates originating from tertiary care hospitals exhibited lower sensitivity for teicoplanin than those from non-tertiary care hospitals.</div></div><div><h3>Conclusions</h3><div>MRSA isolates from bloodstream infections in China are presently showing lower sensitivity to vancomycin and higher sensitivity to linezolid.</div></div>\",\"PeriodicalId\":100358,\"journal\":{\"name\":\"Decoding Infection and Transmission\",\"volume\":\"3 \",\"pages\":\"Article 100052\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Decoding Infection and Transmission\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949924025000138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Decoding Infection and Transmission","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949924025000138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022
Objective
Staphylococcus aureus bacteremia is a critical and pernicious infection, and in particular methicillin-resistant Staphylococcus aureus (MRSA) is increasing in treatment failure. This study analyzed trends in the minimum inhibitory concentrations (MICs) of limited antimicrobials against MRSA bloodstream isolates in China; specifically, the antibiotics vancomycin, daptomycin, linezolid, and teicoplanin.
Methods
A total of 3901 S. aureus blood isolates, including 1065 MRSA isolates, were collected from ten Chinese provinces between 2017 and 2022. Broth microdilution was used to establish the MICs for the four antimicrobials. The geometric mean MICs (GM MICs), MIC50s (inhibition of 50 % of S. aureus), MIC90s (inhibition of 90 % of S. aureus), and MICs distribution were determined for each year.
Results
The geometric mean inhibitory concentration of vancomycin for MRSA isolates increased from 0.58 mg/L in 2018 to 1.01 mg/L by 2022; and that of linezolid decreased from 1.52 mg/L in 2017 to 0.94 mg/L in 2022. Daptomycin and teicoplanin demonstrated no clear trends. MRSA isolates with vancomycin MICs ≤0.5 mg/mL significantly decreased from 77.1 % in 2018 to 8.8 % in 2022. For linezolid, those with MICs >1 and ≤ 2 mg/L also decreased from 62.8 % in 2017 to 26.1 % in 2022. The highest geometric mean MICs of daptomycin, linezolid, vancomycin, and teicoplanin were respectively seen in Yunnan (0.465 mg/L), Henan (1.368 mg/L), Gansu (0.908 mg/L), and Hubei (0.579 mg/L); whereas the lowest values were observed in Jiangxi (0.355 mg/L), Yunnan (0.896 mg/L), Yunnan (0.600 mg/L), and Henan (0.438 mg/L). MRSA isolates originating from tertiary care hospitals exhibited lower sensitivity for teicoplanin than those from non-tertiary care hospitals.
Conclusions
MRSA isolates from bloodstream infections in China are presently showing lower sensitivity to vancomycin and higher sensitivity to linezolid.
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