Biomedical Technology最新文献

{"title":"A computational model to assess the effectiveness of adhesive materials in restoration of crown-root fractures","authors":"Amandeep Kaur ,&nbsp;Shubham Gupta ,&nbsp;Nitesh Tewari ,&nbsp;Arnab Chanda","doi":"10.1016/j.bmt.2023.09.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.09.002","url":null,"abstract":"<div><p>Fragment reattachment for crown root fractures has become a routinely employed treatment modality with the advancements in adhesive dentistry. Among the majority of documented dental trauma cases, this specific fracture type is one of the most prevalent and difficult fracture kinds. Due to its complexity, these fracture kinds are often not computationally modelled. Moreover, there is a lack of literature to understand the effect of different adhesive materials, used to re-attach this particular fracture, on traumatic injuries. In our work, 3D models of the permanent maxillary central incisor tooth were developed using cone beam computed tomography image of a patient. This model was systematically modified to represent a prominent crown root fracture and subsequently re-attached computationally using three different adhesives. A biting force and a traumatic load were applied, and the induced stresses were studied across the healthy and treated tooth models and compared for three different adhesives used for re-attachment of fractured fragments. Tooth reattached with resin adhesive performed better in all the loading conditions that were considered in the study as compared to flowable composite and resin cement.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49720774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment","authors":"Karthikeyan Elumalai ,&nbsp;Sivaneswari Srinivasan ,&nbsp;Anandakumar Shanmugam","doi":"10.1016/j.bmt.2023.09.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.09.001","url":null,"abstract":"<div><p>This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown promising results in preclinical and clinical trials. However, challenges such as limited drug loading capacity, stability issues, and potential side effects need to be addressed to enhance clinical translation. Researchers are exploring strategies to improve drug loading capacity, such as modifying nanoparticle surfaces or developing novel drug encapsulation techniques. By increasing drug loading, the therapeutic efficacy of these systems can be significantly enhanced. Stability issues also pose a hurdle in clinical translation. To overcome stability issues, researchers are investigating methods to enhance the stability of nanoparticles, such as using protective coatings or optimising the formulation. Additionally, efforts are being made to minimise potential side effects by carefully selecting biocompatible materials for nanoparticle synthesis and conducting rigorous toxicity studies before moving forward with clinical trials.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 109-122"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach for assessing osteoporosis utilizing DXA, HU and VBQ","authors":"Wei Xu ,&nbsp;Yifan Li ,&nbsp;Xiangyang Zhang ,&nbsp;Liwei Chen ,&nbsp;Silian Wang ,&nbsp;Yi Wang ,&nbsp;Wenjun Liu ,&nbsp;Ruijun Xu ,&nbsp;Xiaojian Ye ,&nbsp;Chi Zhang ,&nbsp;Zhikun Li","doi":"10.1016/j.bmt.2023.08.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.08.001","url":null,"abstract":"<div><h3>Objective</h3><p>To precisely assess preoperative osteoporosis in patients, a more precise method for evaluating osteoporosis is being developed to better guide the use of bone cement reinforced screws.</p></div><div><h3>Method</h3><p>The retrospective analysis was conducted on patients who underwent posterior lumbar decompression and fusion internal fixation at Shanghai Tongren Hospital.The general information, bone mineral density assessment data, Fracture risk prediction rate(WHO Fracture Risk Assessment Tool (FRAX)), and whether to use cement reinforced screws were collected. Definition of combination method: T value ​&lt; ​−2.5 or HU value ​&lt; ​110 or VBQ &gt;3.5.The diagnostic rates of osteoporosis were compared between dual energy x-ray absorptiometry(DXA), Hounsfield Units(HU), Vertebral Bone Quality (VBQ), National Bone Health Alliance(NBHA), and combination methods, and the correlation between different methods was analyzed. Binary logistic regression was used to analyze the significant influencing factors of the use of cement-reinforced screws.</p></div><div><h3>Result</h3><p>A total of 178 patients were enrolled in the study, aged 65.73 ​± ​14.43 years, 121 female, 57 male, Body Mass Index(BMI) was 22.88 ​± ​3.52, 57 (32.0%) used cement reinforced screws, and 14 (7.9%) had previous fracture history.The diagnostic rates of osteoporosis by DXA, HU, VBQ, NBHA and combination method were 22.5% (40/178), 47.2% (84/178), 56.2% (100/178), 64.0% (114/178) and 75.8% (135/178), respectively.HU, VBQ, NBHA, and combination methods were significantly different from DXA in the diagnosis rate of osteoporosis (P ​&lt; ​0.001). Binary Logistics regression showed that age, T value, HU value, and VBQ value significantly influenced bone cement screw use, and the odds ratio of VBQ was 4.315. The prediction accuracy of the regression equation was 90.4%, the area under the receiver operator characteristic(ROC) curve was 0.974, and the Youden index was 0.830.</p></div><div><h3>Conclusion</h3><p>Currently, the DXA method widely used for diagnosing osteoporosis yields false negative results and there are significant discrepancies among different diagnostic methods. The combined approach exhibits a higher detection rate (75.8%). Age, T value, HU value, and VBQ value significantly influence the use of cement screws with a regression equation accuracy of 90.4%. Cement-reinforced screws are recommended when osteoporosis is determined by a combination method.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 102-108"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49731542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations of robotics and laparoscopy in minimally invasive hepatectomy","authors":"Jinglin Wang ,&nbsp;Yuyan Chen ,&nbsp;Senzhe Xia,&nbsp;Xueqian Qin,&nbsp;Shujun Liu,&nbsp;Haozhen Ren","doi":"10.1016/j.bmt.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.001","url":null,"abstract":"<div><p>The concept of minimally invasive liver surgery has been widely accepted due to the advantages of fast recovery. Robotic hepatectomy is different from laparoscopic hepatectomy due to its fixed joint instruments, operation mode and magnification. This manuscript aims to compare the safety and efficacy of robotic and laparoscopic hepatectomy in the treatment of liver diseases. In this manuscript, we retrospectively studied 246 patients (143 with robotic hepatectomy and 103 with laparoscopic hepatectomy). The clinical basic information, operation time, intraoperative bleeding, conversion to laparotomy, postoperative hospital stay, anal exhaust time, postoperative eating time, ambulation time, and postoperative hematological indicators were analyzed. Robotic hepatectomy has certain advantages in shortening the length of hospital stay (4.9 ​± ​1.3 VS 6.8 ​± ​2.2 days, P ​&lt; ​0.001) and reducing intraoperative bleeding (174.8 ​± ​142.7 VS 341.2 ​± ​187.3 ​ml, P ​&lt; ​0.001) compared with laparoscopic hepatectomy. It is demonstrated that robotic hepatectomy is an outstanding surgical strategy for clinical application.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 11-17"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in Fenton and Fenton-like reaction mediated nanoparticle in cancer therapy","authors":"Huijie Han ,&nbsp;Jiachen Li ,&nbsp;Hélder A. Santos","doi":"10.1016/j.bmt.2022.12.004","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.004","url":null,"abstract":"<div><p>Fenton and Fenton like reaction have been well clarified as efficient reactive oxygen species (ROS) sources in tumor, and have been widely developed into a cancer treatment method. Meanwhile, transition metal-based nanomaterials with Fenton or Fenton like reaction characteristics also have been well explored as therapeutic agents for the cancer therapy, mainly in chemo-dynamic and ferroptosis induced cancer therapy. Herein,to summarize recent advances in Fenton and Fenton like reaction mediated nanoparticles for cancer therapy, in this minireview, we first introduced the mechanisms of Fenton and Fenton like reaction and two therapeutic methods based on Fenton and Fenton like reaction, and then we introduced the well-designed nanoparticles with Fenton reaction or Fenton-like reaction characteristics for the cancer therapies. Finally its challenges and perspectives are discussed.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 40-51"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KRT17 serves as an oncogene biomarker of poor survival in patients with hepatocellular carcinoma","authors":"Jing-Lin Wang ,&nbsp;Lu Zhang ,&nbsp;Chen-Zhuo Xu ,&nbsp;Xue-Qian Qin ,&nbsp;Shu-Jun Liu ,&nbsp;Bao-Jie Wen ,&nbsp;Hao-Zhen Ren","doi":"10.1016/j.bmt.2022.12.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.002","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is the second leading cause of cancer death from worldwide. Thus, it is imperative to clarify valuable diagnostic and prognostic biomarkers for early-stage HCC. The expression of Keratin 17 (KRT17) has been reported to be associated with certain cancer types previously. However, its role in the development of HCC has not been fully clarified. Here, we assessed the expression of KRT17 in the cancer genome atlas liver hepatocellular carcinoma (TCGA LIHC) database and in 44 pairs of samples collected from patients with HCC. In addition, Kaplan-Meir curves were used to assess the prognostic relevance of KRT17. The essential cancer- and KRT17-related biological processes were defined through gene set enrichment analysis (GSEA). Finally, the functional association between KRT17 expression and tumor cell proliferation/survival was evaluated and the signaling pathways associated with KRT17 expression in HCC were identified. Overall, we found that increased KRT17 levels were associated with lower survival, more aggressive disease, and altered immune cell infiltration in HCC patients. KRT17 may potentially act as a prognostic biomarker in HCC.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 18-25"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery","authors":"Ruoyu Cheng ,&nbsp;Shiqi Wang ,&nbsp;Hélder A. Santos","doi":"10.1016/j.bmt.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.01.001","url":null,"abstract":"<div><p>In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-loaded nanoparticle systems arrive at the target cells, they must be successfully internalized into the cells, followed by the endosome escape, to release the payload in the cytoplasm. This is crucial so that the payloads are not degraded in the endosome (around pH 6.8–6.0) or lysosome (around pH 4.5). Considering the acid environment of the endosome, several studies have shown the design of different acid-labile nanoparticle delivery systems attempting to achieve endosome escape by, for example, endosomal rupture, membrane destabilization, and membrane fusion. In this mini-review, we summarize current designs in acid-labile chemical bonds for endosome escape of nanosystems. First, we briefly introduce the structural design of acid-labile nanoparticles and their endosomal escape mechanisms. Then, we review recent research work on the topic, highlighting how the nanoparticle designs can be used in endosome escape for different biomedical applications. Finally, we discuss the challenges and future perspectives in this field.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 52-58"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ignored roles of gases in digestive diseases","authors":"Cheng Zhao ,&nbsp;Rui Liu ,&nbsp;Yujia Zhou ,&nbsp;Ruhua Zheng ,&nbsp;Yonghua Shen ,&nbsp;Baojie Wen ,&nbsp;Bin Zhang ,&nbsp;Junyi Che","doi":"10.1016/j.bmt.2022.11.014","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.014","url":null,"abstract":"<div><p>Complexities of the intestine have brought enormous controversy and discussions to the research on the digestive diseases. The neglected gas environment is crucial in shaping the dynamic intestinal microenvironment. Many gases are involved in the biological activities within the intestinal anaerobic environment, including oxygen, hydrogen, carbon monoxide, ammonia, methane, hydrogen sulfide, carbon dioxide, and nitrogen. These gases participate in the regulation of systemic inflammation and metabolism via different pathways, thereby alleviating or promoting the development of intestinal disease. Meanwhile, the constitution and changes of gases reflect the intestinal environment, which could be utilized to monitor the variation in local metabolism and imply the progress of digestive disorders. However, individual gas has intrinsic functions in maintaining a healthy intestinal microenvironment or causing digestive diseases, and the underlying mechanisms are still unclear. Therefore, exploring the profile of gases in the digestive tract and their extraordinary impact on the intestinal microenvironment will be of great value in understanding the interplay between intestinal health and diseases. By reviewing the research progress of gases in the digestive tract, we anticipate that a better understanding of the roles of gases would promote the research and application transformation in this field as well as the diagnostics and treatment of clinical diseases.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance in oral delivery of living material","authors":"Hua Liu ,&nbsp;Yanmiao Fan ,&nbsp;Jie Zhong ,&nbsp;Michael Malkoch ,&nbsp;Zhengwei Cai ,&nbsp;Zhengting Wang","doi":"10.1016/j.bmt.2022.12.003","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.003","url":null,"abstract":"<div><p>Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activity to acquire stable and ideal therapeutic efficacy remain challenging. Living material is the smart integration of the flexibly programmable functionality of biomaterial and the autonomous environmental responsiveness of living elements, heralding a new era of biotherapeutics in addressing human health concerns. Here, our review aims at presenting an overview of the status of the oral delivery of living material from a biological, technical, and practical perspective, describing the clinical significance and potential, the current technological development and dilemma, as well as the prospect.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 26-39"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49702785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia","authors":"Chengxin Luan,&nbsp;Haixia Wang,&nbsp;Junjie Zhou,&nbsp;Zhangbiao Long,&nbsp;Xin Chen,&nbsp;Xiaowen Chen,&nbsp;Jing Ni,&nbsp;Zhengqi Huang,&nbsp;Ruixiang Xia,&nbsp;Jian Ge","doi":"10.1016/j.bmt.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.01.002","url":null,"abstract":"<div><h3>Background</h3><p>Tocilizumab is a well-practiced strategy to manage cytokine release syndrome (CRS) after chimeric antigen receptor T cell (CAR-T) therapy. However, varied efficiency in CRS mitigation by tocilizumab has been reported to highlight affecting variables such as tumor types and timing of the administration.</p></div><div><h3>Objective</h3><p>The objective of this study is to identify different curative effect between diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) by early use of tocilizumab for prophylaxis and treatment of CRS.</p></div><div><h3>Methods</h3><p>By retrospectively summarizing our institution's experience with a CAR-T clinical trial targeting CD19, 11 cases were analyzed: 5 DLBCL, and 6 ALL. The two groups were compared with patient characteristics, CRS information and clinical outcomes. 3 patients were pretreated with tocilizumab for prophylaxis and the rest were treated with tocilizumab at CRS diagnosis.</p></div><div><h3>Results</h3><p>CRS occurred in 81.8% of patients (9/11), grade 3 or higher occurred in 55.6% of the CRS patients (5/9). The two group were similar in patient characteristics, CAR-T and CRS profile. However, tocilizumab produced much better efficacy against CRS in DLBCL group compared with ALL group (80% versus 16.7%, P ​= ​0.08).</p></div><div><h3>Conclusions</h3><p>Despite the statistical was non-significant, possibly due to small case pool and bias was unavoidable, our analysis suggested that early use of tocilizumab was more effective for DLBCL than ALL in the prophylaxis and treatment of CRS. A treatment algorithm for management of CRS with regard to DLBCL and ALL is proposed, which may extend to other local or systemic malignancies and warrant further investigation.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}