Biomedical Technology最新文献_第4页

Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia 早期使用tocilizumab预防和治疗嵌合抗原受体T细胞(CAR-T)治疗弥漫性大b细胞淋巴瘤的疗效优于急性淋巴细胞白血病

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2023.01.002

Chengxin Luan, Haixia Wang, Junjie Zhou, Zhangbiao Long, Xin Chen, Xiaowen Chen, Jing Ni, Zhengqi Huang, Ruixiang Xia, Jian Ge

{"title":"Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia","authors":"Chengxin Luan, Haixia Wang, Junjie Zhou, Zhangbiao Long, Xin Chen, Xiaowen Chen, Jing Ni, Zhengqi Huang, Ruixiang Xia, Jian Ge","doi":"10.1016/j.bmt.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.01.002","url":null,"abstract":"<div><h3>Background</h3><p>Tocilizumab is a well-practiced strategy to manage cytokine release syndrome (CRS) after chimeric antigen receptor T cell (CAR-T) therapy. However, varied efficiency in CRS mitigation by tocilizumab has been reported to highlight affecting variables such as tumor types and timing of the administration.</p></div><div><h3>Objective</h3><p>The objective of this study is to identify different curative effect between diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) by early use of tocilizumab for prophylaxis and treatment of CRS.</p></div><div><h3>Methods</h3><p>By retrospectively summarizing our institution's experience with a CAR-T clinical trial targeting CD19, 11 cases were analyzed: 5 DLBCL, and 6 ALL. The two groups were compared with patient characteristics, CRS information and clinical outcomes. 3 patients were pretreated with tocilizumab for prophylaxis and the rest were treated with tocilizumab at CRS diagnosis.</p></div><div><h3>Results</h3><p>CRS occurred in 81.8% of patients (9/11), grade 3 or higher occurred in 55.6% of the CRS patients (5/9). The two group were similar in patient characteristics, CAR-T and CRS profile. However, tocilizumab produced much better efficacy against CRS in DLBCL group compared with ALL group (80% versus 16.7%, P = 0.08).</p></div><div><h3>Conclusions</h3><p>Despite the statistical was non-significant, possibly due to small case pool and bias was unavoidable, our analysis suggested that early use of tocilizumab was more effective for DLBCL than ALL in the prophylaxis and treatment of CRS. A treatment algorithm for management of CRS with regard to DLBCL and ALL is proposed, which may extend to other local or systemic malignancies and warrant further investigation.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys 庆大霉素聚多巴胺诱导镁合金钙磷膜的骨再生及抗菌性能

Biomedical Technology Pub Date : 2023-07-20 DOI: 10.1016/j.bmt.2023.06.002

Xuecheng Shen , Zhenbao Zhang , Chuxian Cheng , Chang Liu , Nan Ma , Danfang Sun , Dan Li , Chengyue Wang

{"title":"Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys","authors":"Xuecheng Shen , Zhenbao Zhang , Chuxian Cheng , Chang Liu , Nan Ma , Danfang Sun , Dan Li , Chengyue Wang","doi":"10.1016/j.bmt.2023.06.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.06.002","url":null,"abstract":"<div><p>Improving the corrosion resistance, osteogenic activity, and antimicrobial capacity of the magnesium-based implant is considered the key to promoting their large-scale clinical application. In this study, we reported a novel calcium-phosphorus coating induced by gentamicin (G)-loaded polydopamine for the surface treatment of the magnesium alloy. According to material characterization, immersion tests, and electrochemical analysis, the composite coating has a dense structure and a high crystallinity for greater corrosion resistance. Meanwhile, drug release and antimicrobial experiments demonstrated that the magnesium matrix loaded with gentamicin showed strong inhibition of <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>, and the calcium-phosphorus coating further prolonged the release profile of G, which would contribute to the long-term bactericidal activity of the magnesium implants. In addition, the coating significantly promoted the adhesion, proliferation, and osteogenic differentiation ability of MC3T3-E1. The results of <em>in vivo</em> experiments confirmed that magnesium alloys with composite coatings significantly promoted bone regeneration under infected conditions. This study provides a promising strategy for the development of multifunctional magnesium-based implants with good corrosion resistance, and antibacterial and osteogenic capabilities.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 87-101"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring mitochondrial DNA content as a novel biomarker to improve embryo implantation potential: A review 探索线粒体DNA含量作为一种新的生物标志物，以提高胚胎着床潜力:综述

Biomedical Technology Pub Date : 2023-07-06 DOI: 10.1016/j.bmt.2023.06.001

Devon Dickson , Tao Tao , Wensheng Qin

{"title":"Exploring mitochondrial DNA content as a novel biomarker to improve embryo implantation potential: A review","authors":"Devon Dickson , Tao Tao , Wensheng Qin","doi":"10.1016/j.bmt.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.06.001","url":null,"abstract":"<div><p>According to the society of assisted reproductive technologies (SART), the top fertility clinics in North America have reported overall pregnancy rates of up to 50% in good prognosis patients. Although new techniques in advanced reproductive technologies have begun to emerge in the twenty-first century, including time-lapse monitoring of embryo development, analysis of metabolites in embryo culture media, and the use of artificial intelligence in morphometric embryo grading, currently chromosomal status obtained via pre-implantation genetic testing for aneuploidy (PGT-A) appears to be the most definitive in evaluating embryonic potential. Yet still, in most clinics, approximately 30% of euploid or chromosomally normal embryos fail to achieve a viable pregnancy resulting in stress and anxiety for patients, repeat cycles, and increased cost of treatment. Recent literature suggests that blastocysts with an increased mitochondrial DNA (mtDNA) ratio have greatly reduced implantation potential, however, there exists controversial studies which do not report a relationship. This review summarizes the current literature on utilizing mitochondrial DNA as a possible biomarker for embryo implantation, highlights the reasons for inconsistencies in some studies and suggests possible improvements to the study design of future mtDNA ratio research.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 82-86"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Functional hydrogels for treatment of dental caries 治疗龋齿的功能性水凝胶

Biomedical Technology Pub Date : 2023-06-15 DOI: 10.1016/j.bmt.2023.05.002

Chuanhui Song , Rui Liu , Bin Kong , Zhuxiao Gu , Guopu Chen

引用次数: 0

Multiscale polymeric fibers for drug delivery and tissue engineering 用于药物输送和组织工程的多尺度聚合物纤维

Biomedical Technology Pub Date : 2023-06-07 DOI: 10.1016/j.bmt.2023.05.001

Junnan Mu , Danni Luo , Wei Li , Yaping Ding

{"title":"Multiscale polymeric fibers for drug delivery and tissue engineering","authors":"Junnan Mu , Danni Luo , Wei Li , Yaping Ding","doi":"10.1016/j.bmt.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.05.001","url":null,"abstract":"<div><p>Owing to their superior capacity for building structures, polymeric fibers with diameters varying from a few nanometers to hundreds of microns have been explored in biomedical applications as drug carriers or tissue engineering scaffolds. Depending on the source materials, fabrication techniques, and post-treatments, both the fiber diameter and surface morphology, as well as mechanical features and the cell-fiber structure interactions can be thoroughly tuned. Although most techniques could produce fibers within a wide range of sizes, each type may have superior advantages in a certain range, which may highly relate to target biomedical fields. Therefore, to properly choose the optimal technique for specific fibers, a comprehensive review of the current fiber-producing techniques is indispensable. In the current review, several main fiber-producing techniques are summarized, compared, and discussed in detail regarding their dominant fiber size ranges, which were classified as nano (<1000 nm), micro (1 μm−100 μm) and macro (>100 μm). The principals, main parameters, and corresponding applications for each technique are reviewed, and the challenges and future perspectives are proposed. We believe this review is highly informative for novice researchers in this field.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 60-72"},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49715721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tailoring micro/nano-materials with special wettability for biomedical devices 为生物医学设备定制具有特殊润湿性的微/纳米材料

Biomedical Technology Pub Date : 2023-06-01 DOI: 10.1016/j.bmt.2022.11.005

Shuangshuang Miao , Xinyue Cao , Minhui Lu , Xiangdong Liu

{"title":"Tailoring micro/nano-materials with special wettability for biomedical devices","authors":"Shuangshuang Miao , Xinyue Cao , Minhui Lu , Xiangdong Liu","doi":"10.1016/j.bmt.2022.11.005","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.005","url":null,"abstract":"<div><p>Wettability, as a fundamental property of interface materials, is becoming increasingly prominent in frontier research areas, such as water harvesting, microfluidics, biomedicine, sensors, decontamination, wearables, and micro-electromechanical systems. Taking advantage of biological paradigm inspirations and manufacturing technology advancements, diverse wettability materials with precisely customized micro/nano-structures have been developed. As a result of these achievements, wettability materials have significant technical ramifications in sectors spanning from academics to industry, agriculture, and biomedical engineering. Practical applications of wettability-customized materials in medical device domains have drawn significant scientific interest in recent decades due to the increased emphasis on healthcare. In this review, recent advances of wettability-customized micro/nano-materials for biomedical devices are presented. After briefly introducing the natural wettable/non-wettable phenomena, the fabrication strategies and novel processing techniques are discussed. The study emphasizes the application progress of biomedical devices with customized wettability. The future challenges and opportunities of wettability-customized micro/nano-materials are also provided.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"2 ","pages":"Pages 15-30"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Fabricated technology of biomedical micro-nano hydrogel 生物医用微纳水凝胶制备技术

Biomedical Technology Pub Date : 2023-06-01 DOI: 10.1016/j.bmt.2022.11.012

Shu Yang , Fan Wang , Huijie Han , Hélder A. Santos , Yu Zhang , Hongbo Zhang , Jie Wei , Zhengwei Cai

{"title":"Fabricated technology of biomedical micro-nano hydrogel","authors":"Shu Yang , Fan Wang , Huijie Han , Hélder A. Santos , Yu Zhang , Hongbo Zhang , Jie Wei , Zhengwei Cai","doi":"10.1016/j.bmt.2022.11.012","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.012","url":null,"abstract":"<div><p>Micro-nano hydrogel is a novel functional material that has attracted extensive attention in various fields. Due to the size of micron and nano level, high water content and high specific surface area, the micro-nano hydrogels can achieve minimally invasive repair and are considered as promising agents in tissue repair engineering. In this review, we summarize the design and development of micro-nano hydrogels for biomedical applications, first introduce biopolymers for the synthesis of hydrogels, then introduce the preparation technologies of microgels and nanogels respectively, and systematically summarize the application characteristics and forms of different preparation technologies. Finally, the latest application progresses of microgels in local drug delivery, bone tissue repair, soft tissue repair and immunomodulation are introduced in detail, as well as the latest application progress of nanohydrogels in cartilage repair, antibacterial, antitumor/cancer nerve repair and prevention and diagnosis of diseases, and the key research directions of micro-nano hydrogel preparation technologies in the future are clarified.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"2 ","pages":"Pages 31-48"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Self-healing hydrogels based on the Knoevenagel condensation reaction for wound healing 基于Knoevenagel缩合反应的伤口愈合自愈水凝胶

Biomedical Technology Pub Date : 2023-06-01 DOI: 10.1016/j.bmt.2022.11.008

Xiaoya Ding , Yunru Yu , Yan Zu

引用次数: 3

Nanocarriers for platinum drug delivery 铂药物递送的纳米载体

Biomedical Technology Pub Date : 2023-06-01 DOI: 10.1016/j.bmt.2022.11.011

Qingfei Zhang, Gaizhen Kuang, Lexiang Zhang, Yujuan Zhu

引用次数: 8

Advances in the delivery systems for oral antibiotics 口服抗生素给药系统研究进展

Biomedical Technology Pub Date : 2023-06-01 DOI: 10.1016/j.bmt.2022.11.010

Li Wang , Lu Fan , Kexin Yi , Yuanyuan Jiang , Anne M. Filppula , Hongbo Zhang

{"title":"Advances in the delivery systems for oral antibiotics","authors":"Li Wang , Lu Fan , Kexin Yi , Yuanyuan Jiang , Anne M. Filppula , Hongbo Zhang","doi":"10.1016/j.bmt.2022.11.010","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.010","url":null,"abstract":"<div><p>Oral antibiotics have served as a primary strategy for bacterial infection. However, the increasingly prominent issues including antibiotics resistance and intestinal dysbiosis sounded the alarm to this traditional administration strategy. Herein, we summarize the state-of-the-art advances in the delivery of oral antibiotics. In this review, the emergency of bacterial infection and the effect of excessive antibiotics are discussed at first. Then, current attempts to prevent microflorae from resistance and dysbiosis are briefly enumerated, including oral co-administration systems (like protectors, adsorbents, activity enhancers, etc.) and nanoparticle-based delivery systems. Moreover, we also briefly introduce the development of mimetic antibiotics based on metal particles and highlight a novel micelle nanoparticle system, which possesses a positive charge and glucosylated surface to achieve targeted treatment. We strongly believe such an ingenious design could be applied in more scenarios for oral antibiotics delivery. Ultimately, we also put forward a concise summary and perspective of this field.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"2 ","pages":"Pages 49-57"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1