Biomedical Technology最新文献_第4页

Investigations of robotics and laparoscopy in minimally invasive hepatectomy 机器人技术和腹腔镜技术在微创肝切除术中的应用研究

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2022.12.001

Jinglin Wang , Yuyan Chen , Senzhe Xia, Xueqian Qin, Shujun Liu, Haozhen Ren

{"title":"Investigations of robotics and laparoscopy in minimally invasive hepatectomy","authors":"Jinglin Wang , Yuyan Chen , Senzhe Xia, Xueqian Qin, Shujun Liu, Haozhen Ren","doi":"10.1016/j.bmt.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.001","url":null,"abstract":"<div><p>The concept of minimally invasive liver surgery has been widely accepted due to the advantages of fast recovery. Robotic hepatectomy is different from laparoscopic hepatectomy due to its fixed joint instruments, operation mode and magnification. This manuscript aims to compare the safety and efficacy of robotic and laparoscopic hepatectomy in the treatment of liver diseases. In this manuscript, we retrospectively studied 246 patients (143 with robotic hepatectomy and 103 with laparoscopic hepatectomy). The clinical basic information, operation time, intraoperative bleeding, conversion to laparotomy, postoperative hospital stay, anal exhaust time, postoperative eating time, ambulation time, and postoperative hematological indicators were analyzed. Robotic hepatectomy has certain advantages in shortening the length of hospital stay (4.9 ± 1.3 VS 6.8 ± 2.2 days, P < 0.001) and reducing intraoperative bleeding (174.8 ± 142.7 VS 341.2 ± 187.3 ml, P < 0.001) compared with laparoscopic hepatectomy. It is demonstrated that robotic hepatectomy is an outstanding surgical strategy for clinical application.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 11-17"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in Fenton and Fenton-like reaction mediated nanoparticle in cancer therapy 芬顿和类芬顿反应介导的纳米粒子在癌症治疗中的最新进展

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2022.12.004

Huijie Han , Jiachen Li , Hélder A. Santos

引用次数: 6

KRT17 serves as an oncogene biomarker of poor survival in patients with hepatocellular carcinoma KRT17是肝细胞癌患者生存率低的癌基因生物标志物

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2022.12.002

Jing-Lin Wang , Lu Zhang , Chen-Zhuo Xu , Xue-Qian Qin , Shu-Jun Liu , Bao-Jie Wen , Hao-Zhen Ren

{"title":"KRT17 serves as an oncogene biomarker of poor survival in patients with hepatocellular carcinoma","authors":"Jing-Lin Wang , Lu Zhang , Chen-Zhuo Xu , Xue-Qian Qin , Shu-Jun Liu , Bao-Jie Wen , Hao-Zhen Ren","doi":"10.1016/j.bmt.2022.12.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.12.002","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is the second leading cause of cancer death from worldwide. Thus, it is imperative to clarify valuable diagnostic and prognostic biomarkers for early-stage HCC. The expression of Keratin 17 (KRT17) has been reported to be associated with certain cancer types previously. However, its role in the development of HCC has not been fully clarified. Here, we assessed the expression of KRT17 in the cancer genome atlas liver hepatocellular carcinoma (TCGA LIHC) database and in 44 pairs of samples collected from patients with HCC. In addition, Kaplan-Meir curves were used to assess the prognostic relevance of KRT17. The essential cancer- and KRT17-related biological processes were defined through gene set enrichment analysis (GSEA). Finally, the functional association between KRT17 expression and tumor cell proliferation/survival was evaluated and the signaling pathways associated with KRT17 expression in HCC were identified. Overall, we found that increased KRT17 levels were associated with lower survival, more aggressive disease, and altered immune cell infiltration in HCC patients. KRT17 may potentially act as a prognostic biomarker in HCC.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 18-25"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery 基于酸不稳定化学键的纳米粒子用于内体逃逸和细胞内递送

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2023.01.001

Ruoyu Cheng , Shiqi Wang , Hélder A. Santos

{"title":"Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery","authors":"Ruoyu Cheng , Shiqi Wang , Hélder A. Santos","doi":"10.1016/j.bmt.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.01.001","url":null,"abstract":"<div><p>In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-loaded nanoparticle systems arrive at the target cells, they must be successfully internalized into the cells, followed by the endosome escape, to release the payload in the cytoplasm. This is crucial so that the payloads are not degraded in the endosome (around pH 6.8–6.0) or lysosome (around pH 4.5). Considering the acid environment of the endosome, several studies have shown the design of different acid-labile nanoparticle delivery systems attempting to achieve endosome escape by, for example, endosomal rupture, membrane destabilization, and membrane fusion. In this mini-review, we summarize current designs in acid-labile chemical bonds for endosome escape of nanosystems. First, we briefly introduce the structural design of acid-labile nanoparticles and their endosomal escape mechanisms. Then, we review recent research work on the topic, highlighting how the nanoparticle designs can be used in endosome escape for different biomedical applications. Finally, we discuss the challenges and future perspectives in this field.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 52-58"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ignored roles of gases in digestive diseases 忽略了气体在消化系统疾病中的作用

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2022.11.014

Cheng Zhao , Rui Liu , Yujia Zhou , Ruhua Zheng , Yonghua Shen , Baojie Wen , Bin Zhang , Junyi Che

{"title":"Ignored roles of gases in digestive diseases","authors":"Cheng Zhao , Rui Liu , Yujia Zhou , Ruhua Zheng , Yonghua Shen , Baojie Wen , Bin Zhang , Junyi Che","doi":"10.1016/j.bmt.2022.11.014","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.014","url":null,"abstract":"<div><p>Complexities of the intestine have brought enormous controversy and discussions to the research on the digestive diseases. The neglected gas environment is crucial in shaping the dynamic intestinal microenvironment. Many gases are involved in the biological activities within the intestinal anaerobic environment, including oxygen, hydrogen, carbon monoxide, ammonia, methane, hydrogen sulfide, carbon dioxide, and nitrogen. These gases participate in the regulation of systemic inflammation and metabolism via different pathways, thereby alleviating or promoting the development of intestinal disease. Meanwhile, the constitution and changes of gases reflect the intestinal environment, which could be utilized to monitor the variation in local metabolism and imply the progress of digestive disorders. However, individual gas has intrinsic functions in maintaining a healthy intestinal microenvironment or causing digestive diseases, and the underlying mechanisms are still unclear. Therefore, exploring the profile of gases in the digestive tract and their extraordinary impact on the intestinal microenvironment will be of great value in understanding the interplay between intestinal health and diseases. By reviewing the research progress of gases in the digestive tract, we anticipate that a better understanding of the roles of gases would promote the research and application transformation in this field as well as the diagnostics and treatment of clinical diseases.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advance in oral delivery of living material 活体材料口服递送技术的进展

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2022.12.003

Hua Liu , Yanmiao Fan , Jie Zhong , Michael Malkoch , Zhengwei Cai , Zhengting Wang

引用次数: 3

Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia 早期使用tocilizumab预防和治疗嵌合抗原受体T细胞(CAR-T)治疗弥漫性大b细胞淋巴瘤的疗效优于急性淋巴细胞白血病

Biomedical Technology Pub Date : 2023-09-01 DOI: 10.1016/j.bmt.2023.01.002

Chengxin Luan, Haixia Wang, Junjie Zhou, Zhangbiao Long, Xin Chen, Xiaowen Chen, Jing Ni, Zhengqi Huang, Ruixiang Xia, Jian Ge

{"title":"Improved efficacy with early tocilizumab in the prophylaxis and treatment of cytokine release syndrome of chimeric antigen receptor T cell (CAR-T) therapy for diffuse large B-cell lymphoma than acute lymphoblastic leukemia","authors":"Chengxin Luan, Haixia Wang, Junjie Zhou, Zhangbiao Long, Xin Chen, Xiaowen Chen, Jing Ni, Zhengqi Huang, Ruixiang Xia, Jian Ge","doi":"10.1016/j.bmt.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.01.002","url":null,"abstract":"<div><h3>Background</h3><p>Tocilizumab is a well-practiced strategy to manage cytokine release syndrome (CRS) after chimeric antigen receptor T cell (CAR-T) therapy. However, varied efficiency in CRS mitigation by tocilizumab has been reported to highlight affecting variables such as tumor types and timing of the administration.</p></div><div><h3>Objective</h3><p>The objective of this study is to identify different curative effect between diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) by early use of tocilizumab for prophylaxis and treatment of CRS.</p></div><div><h3>Methods</h3><p>By retrospectively summarizing our institution's experience with a CAR-T clinical trial targeting CD19, 11 cases were analyzed: 5 DLBCL, and 6 ALL. The two groups were compared with patient characteristics, CRS information and clinical outcomes. 3 patients were pretreated with tocilizumab for prophylaxis and the rest were treated with tocilizumab at CRS diagnosis.</p></div><div><h3>Results</h3><p>CRS occurred in 81.8% of patients (9/11), grade 3 or higher occurred in 55.6% of the CRS patients (5/9). The two group were similar in patient characteristics, CAR-T and CRS profile. However, tocilizumab produced much better efficacy against CRS in DLBCL group compared with ALL group (80% versus 16.7%, P = 0.08).</p></div><div><h3>Conclusions</h3><p>Despite the statistical was non-significant, possibly due to small case pool and bias was unavoidable, our analysis suggested that early use of tocilizumab was more effective for DLBCL than ALL in the prophylaxis and treatment of CRS. A treatment algorithm for management of CRS with regard to DLBCL and ALL is proposed, which may extend to other local or systemic malignancies and warrant further investigation.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"3 ","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49732715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys 庆大霉素聚多巴胺诱导镁合金钙磷膜的骨再生及抗菌性能

Biomedical Technology Pub Date : 2023-07-20 DOI: 10.1016/j.bmt.2023.06.002

Xuecheng Shen , Zhenbao Zhang , Chuxian Cheng , Chang Liu , Nan Ma , Danfang Sun , Dan Li , Chengyue Wang

{"title":"Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys","authors":"Xuecheng Shen , Zhenbao Zhang , Chuxian Cheng , Chang Liu , Nan Ma , Danfang Sun , Dan Li , Chengyue Wang","doi":"10.1016/j.bmt.2023.06.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.06.002","url":null,"abstract":"<div><p>Improving the corrosion resistance, osteogenic activity, and antimicrobial capacity of the magnesium-based implant is considered the key to promoting their large-scale clinical application. In this study, we reported a novel calcium-phosphorus coating induced by gentamicin (G)-loaded polydopamine for the surface treatment of the magnesium alloy. According to material characterization, immersion tests, and electrochemical analysis, the composite coating has a dense structure and a high crystallinity for greater corrosion resistance. Meanwhile, drug release and antimicrobial experiments demonstrated that the magnesium matrix loaded with gentamicin showed strong inhibition of <em>Escherichia coli</em> and <em>Staphylococcus aureus</em>, and the calcium-phosphorus coating further prolonged the release profile of G, which would contribute to the long-term bactericidal activity of the magnesium implants. In addition, the coating significantly promoted the adhesion, proliferation, and osteogenic differentiation ability of MC3T3-E1. The results of <em>in vivo</em> experiments confirmed that magnesium alloys with composite coatings significantly promoted bone regeneration under infected conditions. This study provides a promising strategy for the development of multifunctional magnesium-based implants with good corrosion resistance, and antibacterial and osteogenic capabilities.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 87-101"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring mitochondrial DNA content as a novel biomarker to improve embryo implantation potential: A review 探索线粒体DNA含量作为一种新的生物标志物，以提高胚胎着床潜力:综述

Biomedical Technology Pub Date : 2023-07-06 DOI: 10.1016/j.bmt.2023.06.001

Devon Dickson , Tao Tao , Wensheng Qin

{"title":"Exploring mitochondrial DNA content as a novel biomarker to improve embryo implantation potential: A review","authors":"Devon Dickson , Tao Tao , Wensheng Qin","doi":"10.1016/j.bmt.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.06.001","url":null,"abstract":"<div><p>According to the society of assisted reproductive technologies (SART), the top fertility clinics in North America have reported overall pregnancy rates of up to 50% in good prognosis patients. Although new techniques in advanced reproductive technologies have begun to emerge in the twenty-first century, including time-lapse monitoring of embryo development, analysis of metabolites in embryo culture media, and the use of artificial intelligence in morphometric embryo grading, currently chromosomal status obtained via pre-implantation genetic testing for aneuploidy (PGT-A) appears to be the most definitive in evaluating embryonic potential. Yet still, in most clinics, approximately 30% of euploid or chromosomally normal embryos fail to achieve a viable pregnancy resulting in stress and anxiety for patients, repeat cycles, and increased cost of treatment. Recent literature suggests that blastocysts with an increased mitochondrial DNA (mtDNA) ratio have greatly reduced implantation potential, however, there exists controversial studies which do not report a relationship. This review summarizes the current literature on utilizing mitochondrial DNA as a possible biomarker for embryo implantation, highlights the reasons for inconsistencies in some studies and suggests possible improvements to the study design of future mtDNA ratio research.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"5 ","pages":"Pages 82-86"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Functional hydrogels for treatment of dental caries 治疗龋齿的功能性水凝胶

Biomedical Technology Pub Date : 2023-06-15 DOI: 10.1016/j.bmt.2023.05.002

Chuanhui Song , Rui Liu , Bin Kong , Zhuxiao Gu , Guopu Chen

引用次数: 0