Biomedical Technology最新文献

{"title":"Proteomic insights into myopia development: Differential protein expression and the role of calcium signaling in form deprivation myopia in Guinea pigs","authors":"Rongbin Liang ,&nbsp;Tao Li ,&nbsp;Wenqing Shi ,&nbsp;Hui Gao ,&nbsp;Bei Ai ,&nbsp;Bing Li ,&nbsp;Xiaodong Zhou","doi":"10.1016/j.bmt.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2024.06.001","url":null,"abstract":"<div><p>This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of myopia. The myopia model in guinea pigs was successfully established by covering one eye of the guinea pigs with a latex bead sac for 4 weeks. This study used 4D data-independent acquisition proteomics technology to analyze vitreous body samples from both the FDM group and the control group. The goal of the proteomics analysis was to identify differences in protein expression within the vitreous body of FDM guinea pigs. Myopia was successfully induced in the FDM group after 4 weeks of modeling. A total of 6298 proteins were identified, among which 348 were differentially expressed proteins (DEPs), with 81 upregulated and 267 downregulated. These DEPs were subjected to in-depth bioinformatics analyses, including Gene Ontology, the Eukaryotic Orthologous Groups, and the Kyoto Encyclopedia of Genes and Genomes. These analyses revealed significant involvement in cellular processes, metabolic pathways, biological regulation, cytoskeletal organization, and cell movement. Our results indicate that calcium signaling plays a critical role in mediating eye changes associated with form deprivation, which may bear similarities to mechanisms observed in neurodegenerative diseases. A total of 348 DEPs related to the development and progression of myopia were identified. These changes involve key biological processes, including protein degradation, cell adhesion, and transport, especially alterations in calcium signaling pathways. Stromal interaction molecule 1 (STIM1) is an important biological marker of FDM, which was confirmed by Western blot, immunohistochemistry and ELISA. Our study found clear differences in the expression of proteins in the vitreous during the development of myopic guinea pigs, especially those related to calcium signaling pathway. Our study offers new insights into the pathogenesis of myopia, particularly changes related to protein metabolism pathways.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"7 ","pages":"Pages 15-24"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X24000126/pdfft?md5=c7b83f5cf95221d34931ea50c1ab4a18&pid=1-s2.0-S2949723X24000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials for cardiovascular diseases","authors":"Yongqi Huang ,&nbsp;Ziqi Ding","doi":"10.1016/j.bmt.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2024.05.001","url":null,"abstract":"<div><p>Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing a formidable health challenge. Extensive efforts have been dedicated to combating this disease, including the development of innovative biomaterials for blood vessel stents, drug delivery and imaging diagnosis. These advancements have substantially addressed issues such as patient rejection and blood contamination. In this review, we begin by outlining the prevalence and various forms of CVD. Subsequently, we delve into advanced biomaterials—including synthetic biomaterials, natural biomaterials, and hybrid biomaterials—and medical instruments used in the treatment or alleviation of CVD, discussing their advantages and limitations. Finally, we offer insights into future prospects and strategies for refining these technologies and instruments moving forward.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"7 ","pages":"Pages 1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X24000114/pdfft?md5=cb5784637ec851af912f15042bb6e167&pid=1-s2.0-S2949723X24000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Declaration of Competing Interest statements in previously published articles","authors":"","doi":"10.1016/j.bmt.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2024.04.001","url":null,"abstract":"","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 91-92"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X24000023/pdfft?md5=8230957c0b6cf2e210228a9aa1877084&pid=1-s2.0-S2949723X24000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A computational model to assess the effectiveness of adhesive materials in restoration of crown-root fractures” [Biomed. Technol. 6 (2024) 1-8]","authors":"Amandeep Kaur ,&nbsp;Shubham Gupta ,&nbsp;Nitesh Tewari ,&nbsp;Arnab Chanda","doi":"10.1016/j.bmt.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2024.03.001","url":null,"abstract":"","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Page 90"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X24000011/pdfft?md5=8841db78a0faa73d458151ab891957fe&pid=1-s2.0-S2949723X24000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140343751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyaryletherketones: Properties and applications in modern medicine","authors":"Gregory Sacks ,&nbsp;Veer Shah ,&nbsp;Lilian Yao ,&nbsp;Catherine Yan ,&nbsp;Darshi Shah ,&nbsp;Lorely Limeta ,&nbsp;Vincent DeStefano","doi":"10.1016/j.bmt.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.11.002","url":null,"abstract":"<div><p>Polyaryletherketones (PAEKs) are a family of durable, multifunctional, thermoplastic biopolymers. This article first provides necessary context and thorough information regarding the mechanical, physical, chemical, crystalline, and shape memory properties of PAEKs as well as critical details regarding manufacturing. Additionally, it provides an update on the clinical and biomedical uses of PAEKs by summarizing the most recent and groundbreaking applications of these thermopolymers. PAEKs have been used clinically in fields including orthopedics, craniofacial and cardiothoracic surgery, as well as cardiovascular and dental medicine. Other applications include tissue engineering, post-surgical antibiotic delivery, antimicrobial applications, anti-cancer drug delivery, and 3D printing. Of importance, PAEKs have comparable mechanical strength and elastic modulus to human bone, which enable PAEKs to serve as a viable alternative to metal-based implants. Given their remarkable properties, and ability to be specifically and rapidly manufactured through 3D printing, PAEKs will continue to be a subject of biomedical research and serve a vital role in medical applications.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 75-89"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000673/pdfft?md5=741112a94bdd8f8660046b21062d8865&pid=1-s2.0-S2949723X23000673-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139399084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on selenium nanoparticles and their biomedical applications","authors":"K.K. Karthik ,&nbsp;Binoy Varghese Cheriyan ,&nbsp;S. Rajeshkumar ,&nbsp;Meenaloshini Gopalakrishnan","doi":"10.1016/j.bmt.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.12.001","url":null,"abstract":"<div><p>Nanotechnology has enormous promise for a wide range of applications in biology. Nanoparticles (NPs) have the benefit of improving bioactivity, decreasing toxicity, allowing for precision targeting, and modulating the release profile of encapsulated compounds. Nanomaterials' unique qualities, such as their tiny size, biocompatibility, and ability to cross cell membranes for drug administration, make them useful in a variety of biological applications. Selenium (Se), a critical trace element, stands out among these nanoparticles due to its specific bioactivities in nano forms. Selenium is incorporated into Selenoproteins such as selenocysteine (Sec), which play an important role in maintaining physiological redox balance via oxidoreductase activity, a critical enzymatic process. In the field of medication delivery, selenium-based devices have been designed to transport pharmaceuticals to specific locations. Selenium nanoparticles (SeNPs) appear to be a suitable platform for delivering medications to their desired sites. Selenium's medicinal potential has been thoroughly investigated, including its efficacy against various cancer cells, microbial pathogens, viral infections, neuroprotective properties, diabetic control, oxidative stress, and inflammation-mediated illnesses such as rheumatoid arthritis. Notably, due to selenium's extraordinary involvement in immune system regulation, SeNPs have an edge over other nanoparticles. SeNPs phytosynthesis offers an appealing alternative to standard physical and chemical processes, featuring biocompatibility and environmental friendliness. This paper gives an overview of SeNPs' biological uses and emphasizes recent advances in the field.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 61-74"},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000764/pdfft?md5=a445391da4c23dcea4c119151b5d864c&pid=1-s2.0-S2949723X23000764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of gas molecules in cancer therapy","authors":"Danna Liang ,&nbsp;Qingfei Zhang ,&nbsp;Xiang Chen ,&nbsp;Jianhua Lu ,&nbsp;Xian Shen ,&nbsp;Weijian Sun","doi":"10.1016/j.bmt.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.11.001","url":null,"abstract":"<div><p>Gas therapy is currently popular in cancer treatment because of its controllability, effectiveness, and biosafety, as well as the fast development of carriers for gas delivery. Here, we introduce the various gas molecules with exact anticancer effects, including nitric oxide (NO), carbon monoxide (CO), oxygen (O₂), hydrogen (H₂), etc., and their anticancer mechanisms. Besides, recent advances in stimuli-responsive delivery systems for gas therapy are summarized. In terms of the various stimulation methods, the design of delivery systems for gases is introduced. In addition, the strategies of gas therapy combined with other therapeutic modalities, including chemotherapy, radiotherapy (RT), photodynamic therapy (PDT), photothermal therapy (PTT), etc., are described. Finally, the current challenges and prospects of delivery platforms for gases, and the future development and clinical translational value of gas therapy are also discussed.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 46-60"},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000661/pdfft?md5=82a54cc81d7777d450c9d5f129f934b9&pid=1-s2.0-S2949723X23000661-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138557479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired hierarchical particles for bioassays","authors":"Ning Li ,&nbsp;Hanxu Chen ,&nbsp;Dongyu Xu ,&nbsp;Yuanjin Zhao","doi":"10.1016/j.bmt.2023.09.003","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.09.003","url":null,"abstract":"<div><p>Bioassay technology has been proved important in the field of environmental monitoring, disease diagnosis and clinical treatment. At present, diverse bioassay technologies have achieved reliability, rapid responsiveness, convenient operation, along with high sensitivity, and specificity. Among them, micro-nano structure particles-based bioassay will inevitably play an important role for future development. Especially, compared with typical solid, porous or hollow particles, hierarchical particles are featured with hierarchical configurations and considerable surface area, and thus have gained extensive research interest as ideal scaffolds for biological, medical and catalytic applications in biomedicine. In this review, we present the recent advances in bio-inspired hierarchical particles. After introducing a variety of hierarchical particles and their synthesis methods, we focus on their applications in multiple biological detections of different targets such as proteins, DNA, RNA, exosomes and cells. In addition, the highlighted applications of hierarchical particles in bioassays for clinical diagnosis are also summarized and prospected.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 17-25"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000557/pdfft?md5=209b9046b798cf66e21ce001ba543aca&pid=1-s2.0-S2949723X23000557-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92073831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitolisant nanofibers: A promising frontier in drug delivery for narcolepsy - Formulation, optimisation, and characterization insights","authors":"J. Nandhini ,&nbsp;E. Karthikeyan ,&nbsp;C. Jegatheshwaran ,&nbsp;K. Vignesh ,&nbsp;G. Muthuboopathi ,&nbsp;S. Rajeshkumar","doi":"10.1016/j.bmt.2023.10.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.10.002","url":null,"abstract":"<div><p>The study focuses on developing a new way to deliver the narcolepsy medication pitolisant. Electrospinning was used to make polyvinyl alcohol (PVA) and hyperbranched polyglycerol (HPG) polymers into pitolisant nanofibers (PT-NF). A design expert created the best formulation to optimise the process variables like applied voltage, distance, and feed rate. The nanofibers were characterised using scanning electron microscopy, X-ray diffraction, FT-IR, entrapment efficiency, and in-vitro drug release studies. Results showed that the optimal PT-NF formulation had an average diameter of 172 ​nm with an entrapment efficacy of 95 ​% and 92 ​% drug release within 45 ​min. HPG polymer was included in the optimised formulation, whose average fibre diameter was 118 ​nm with 98 ​% entrapment efficacy and 98 ​± ​2 ​% drug release within 30 ​min. These findings strongly suggest that PT nanofibers hold substantial promise as a viable alternative to conventional solid dosage forms for brain-targeted administration, especially when administered via a transdermal patch to a patient during sleep.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 9-16"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000570/pdfft?md5=fa1c5c35b3b72e011ee68bcd166f5ffc&pid=1-s2.0-S2949723X23000570-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92046601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials for wound healing: Current status and futuristic frontier","authors":"J. Nandhini ,&nbsp;E. Karthikeyan ,&nbsp;S. Rajeshkumar","doi":"10.1016/j.bmt.2023.10.001","DOIUrl":"https://doi.org/10.1016/j.bmt.2023.10.001","url":null,"abstract":"<div><p>Wound healing is a complex process that involves a variety of physical, chemical, and biological processes. Because of their remarkable characteristics and capabilities, nanomaterials have recently emerged as potential therapeutic agents for wound healing. Many different nanomaterial-based wound-healing treatments have been created and put into widespread use. In this review, we compile the most recent research on cutting-edge nanomaterials for wound healing, including both organic and inorganic nanomaterials. We highlight prospective approaches for developing nanomaterial-based wound healing therapy procedures and talk about the benefits and limitations of these treatments. Future prospects for wound healing therapies based on nanomaterials are discussed, including the need to address toxicity concerns, the scalability of production, and the long-term stability of nanomaterials. The safety and effectiveness of nanomaterials depend on further investigation into their design, interactions with biological systems, and the results of rigorous preclinical and clinical trials. There is great potential for a dramatic improvement in patient outcomes with the introduction of nanomaterial-based wound healing therapies.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"6 ","pages":"Pages 26-45"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949723X23000569/pdfft?md5=c7e7bfb4a63f383dc74e52635f35aea9&pid=1-s2.0-S2949723X23000569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92066691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}