Jianghe Zhang , Yan Yan , Jun Wan , Yiming Zhang , Junli Zhou
{"title":"Gαi1 activation induced by short-term hypoxia promotes epidermal cell migration in wound healing through the Akt-mTOR pathway","authors":"Jianghe Zhang , Yan Yan , Jun Wan , Yiming Zhang , Junli Zhou","doi":"10.1016/j.bmt.2025.100072","DOIUrl":"10.1016/j.bmt.2025.100072","url":null,"abstract":"<div><div>Hypoxia is commonly observed in the wound microenvironment; however, the specific mechanism by which it affects epidermal cell migration remains unclear. This study aimed to examine the impact of hypoxia on epidermal cell migration and explore the underlying mechanisms involved. The impact of hypoxia (1 % oxygen) on the migration of an immortal keratinocyte cell line, HaCaT, was evaluated using a scratch assay and live cell imaging system. The activation of Gαi1 in HaCaT cells following hypoxia treatment was detected by immunoprecipitation. Possible biological mechanisms were explored through gene microarray assays and bioinformatics methods. Furthermore, the effect of Gαi1 loss-of-function on wound healing was investigated using a rat wound model. Short-term hypoxia significantly enhances HaCaT cell migration and Gαi activation, also observed in rat wound tissue. However, the migration difference between hypoxic and normoxic conditions is negligible after Gαi1 knockdown, highlighting Gαi1's role. Bioinformatics analysis points to the PI3K-Akt pathway as a key mediator, which is confirmed by Akt inhibitor experiments. Additionally, Gαi1 promotes cell migration via the PI3K/Akt/mTORC pathway under hypoxia, and Gαi1 knockdown in rats results in slower wound healing and reduced re-epithelialization. Short-term hypoxia promotes epidermal cell migration through the activation of the Akt-mTOR pathway by Gαi1. Defects in Gαi1 lead to impaired re-epithelialization and delayed wound healing in rats.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"10 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingyue Liu , Yu Chen , Yu Zhang , Pengzhen Zhuang , Juan Wang
{"title":"Breathable functional aerogel dressings facilitate the healing of diabetic wounds","authors":"Mingyue Liu , Yu Chen , Yu Zhang , Pengzhen Zhuang , Juan Wang","doi":"10.1016/j.bmt.2025.100071","DOIUrl":"10.1016/j.bmt.2025.100071","url":null,"abstract":"<div><div>Due to the complexity of the microenvironment and healing process of diabetic wounds, developing wound dressings that offer good biocompatibility, breathability, and promote vascular regeneration is essential but remains a significant challenge. In this study, we prepared loose and porous aerogel wound dressings using electrospinning and freeze-drying methods with natural polymer compounds: gelatin, polylactic acid, and magnesium oxide nanoparticles (MgO) as raw materials. MgO serves as a functional modification component that regulates the wound microenvironment and promotes vascular regeneration by releasing bioactive ions, thereby facilitating wound healing. Additionally, this scaffold provides excellent breathability and exudate management due to its loose porous structure. These advantages enable the aerogel scaffold to effectively promote collagen deposition and neovascularization, accelerating the healing of diabetic infected wounds.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Bai , Jine Wang , Ruhui Yan , Yuxian Zhao , Shuang Han , Zhichao Zhang , Yuewu Zhao
{"title":"Progress of metal-organic frameworks in improving the effect of sonodynamic therapy","authors":"Yu Bai , Jine Wang , Ruhui Yan , Yuxian Zhao , Shuang Han , Zhichao Zhang , Yuewu Zhao","doi":"10.1016/j.bmt.2025.100070","DOIUrl":"10.1016/j.bmt.2025.100070","url":null,"abstract":"<div><div>Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field. Based on the research progress of SDT, this paper reviews the latest situation of metal-organic frameworks (MOF) based sonosensitizer in recent years, and introduces the preparation methods and related properties of MOF materials. By describing the many in-depth observations and understandings of MOF-assisted SDT strategies in anticancer applications, we aim to highlight the advantages and improvements of MOF-enhanced SDT and synergistic therapy. The methods to improve the effect of SDT were discussed by exploring the measures of combining hypoxia activating drugs, improving hypoxia microenvironment, accelerating glutathione consumption, and enhancing cavitation effect. Based on the extensive application of MOF materials in SDT and the related technical challenges, this review hopes to bring some enlightenment to improve the therapeutic effect of cancer and promote the development of nanomedicine.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Sun , Hao Liang , Qianwen Mu , Chengchao Chu , Gang Liu , Chao Liu
{"title":"Virus-inspired biogenic delivery system for advancing cancer therapy","authors":"Di Sun , Hao Liang , Qianwen Mu , Chengchao Chu , Gang Liu , Chao Liu","doi":"10.1016/j.bmt.2025.100069","DOIUrl":"10.1016/j.bmt.2025.100069","url":null,"abstract":"<div><div>Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of viruses are regarded as innovative nanoplatforms used to deliver drug compounds to related sites and target cells in organisms. Among them, the components comprised of virus-like particles (VLPs) derive from the proteins or peptides of the viruses; the glycoproteins on their surface exert significant function as specific targeting. Types of assembled glycoproteins and encapsulated drug molecules confer the complexity and varieties of structure, function, and treatment of VLPs. VLPs lack viral virulence, resulting from a viral genetic material deficiency. In vaccine research, Virus-mimic nanovesicles have been effectively verified against cancer via the immunogenicity and the pharmacological effect of drug molecules delivered to mediate an immune response in the body. This review summarizes the research status of virus-inspired drug delivery platforms for cancer therapy utilization.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiwen Xu , Miaojie Fang , Zilong Li , Yucheng Xue , Kelei Wang , Feng Lin , Ning Zhang
{"title":"Embracing the future: The application of regenerative biomaterials in the spinal disorders","authors":"Yiwen Xu , Miaojie Fang , Zilong Li , Yucheng Xue , Kelei Wang , Feng Lin , Ning Zhang","doi":"10.1016/j.bmt.2024.100068","DOIUrl":"10.1016/j.bmt.2024.100068","url":null,"abstract":"<div><div>Spinal disorders, particularly disc degeneration, vertebral fractures, and loss of spinal stability, have become a major health problem affecting quality of life worldwide. Although conventional treatments such as surgery and conservative therapy provide some relief, these methods often fail to fully address the underlying problems of spinal disorders. In recent years, the application of regenerative biomaterials has provided new ideas and solutions for the repair and regeneration of spinal disorders. This paper provides a systematic review of the application of regenerative biomaterials in the treatment of spinal disorders, including natural materials, synthetic materials and composites. In addition, this paper describes several advanced tissue engineering fabrication techniques, such as 3D printing and bioprinting, which enable regenerative biomaterials to be applied more precisely in the treatment of spinal disorders. This paper also explores the role of regenerative biomaterials in spinal disorders. The aim of this paper is to provide references and new insights for future exploration of the application of regenerative biomaterials in spinal disorders, and to promote research and clinical practice in related fields, with a view to achieving more effective and safer therapeutic strategies for spinal disorders.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developing biotechnologies in organoids for liver cancer","authors":"Yingzhe Hu , Zheng Peng , Mengdi Qiu , Lingling Xue , Haozhen Ren , Xingyu Wu , Xinhua Zhu , Yitao Ding","doi":"10.1016/j.bmt.2024.100067","DOIUrl":"10.1016/j.bmt.2024.100067","url":null,"abstract":"<div><div>Organoids, three-dimensional cellular constructs, have revolutionized in vitro culture by replicating the histological and physiological functions of organs, offering a model that closely mimics physiological conditions. Liver cancer presents a significant challenge due to its heterogeneity and the influence of the liver's microenvironment on therapeutic responses. Organoid technology addresses this complexity by simulating the tumor microenvironment in vitro, capturing the heterogeneity of liver cancer, and facilitating personalized treatment approaches. This study explores the integration of organoids in liver cancer research, focusing on genetic and phenotypic fidelity, disease modeling, and drug screening. We discuss the latest advancements in biotechnology, including CRISPR/Cas9, 3D bioprinting, and microfluidics, and their role in personalized medicine. Despite challenges in scalability and variability, organoids offer a promising avenue for liver cancer research and precision oncology, with the potential to transform our understanding and treatment of this disease.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir S. Komlev , Vladislav A. Parfenov , Pavel A. Karalkin , Stanislav V. Petrov , Frederico D.A.S. Pereira , Elizaveta V. Koudan , Aleksandr A. Levin , Margarita A. Golberg , Alexander Yu. Fedotov , Igor V. Smirnov , Andrey D. Kaprin , Natalia S. Sergeeva , Irina K. Sviridova , Valentina A. Kirsanova , Suraja A. Akhmedova , Georgy V. Mamin , Marat R. Gafurov , Alexey N. Gurin , Yusef D. Khesuani , Yury M. Urlichich
{"title":"Space manufacturing of a bone tissue destined for patients on Earth?","authors":"Vladimir S. Komlev , Vladislav A. Parfenov , Pavel A. Karalkin , Stanislav V. Petrov , Frederico D.A.S. Pereira , Elizaveta V. Koudan , Aleksandr A. Levin , Margarita A. Golberg , Alexander Yu. Fedotov , Igor V. Smirnov , Andrey D. Kaprin , Natalia S. Sergeeva , Irina K. Sviridova , Valentina A. Kirsanova , Suraja A. Akhmedova , Georgy V. Mamin , Marat R. Gafurov , Alexey N. Gurin , Yusef D. Khesuani , Yury M. Urlichich","doi":"10.1016/j.bmt.2024.10.004","DOIUrl":"10.1016/j.bmt.2024.10.004","url":null,"abstract":"<div><div>Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that is not possible anywhere else. Tissue engineering in outer space, where state of the gravity can be ‘turned off’ or ‘turned on’ in the case of application of centrifuges, is a new research field with high-value goals. The microgravity conditions allow to design novel biomaterials that cannot be produced on Earth but benefit the Earth civilisation. Developing and manufacturing a biomaterial to address a space-based challenge may lead to novel biomaterials that will find important applications in medicine on Earth and/or for long-duration space missions. Today, there are only a handful of emerging biomaterials that have been tested in space, none of which have been used for their eventual function. This paper presents advances in space technology <em>via</em> 3D magnetic assembly: the development of synthetic bone graft constructs aboard the International Space Station during expeditions 60/61 with clear evidence of the materials' functioning in preclinical (animal) tests on Earth. The results indicate high osteoconductivity and ultimately a good rate of tissue formation by the bone grafts prepared in space.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenhan Li , Quanchi Chen , Yanyu Ma , Haiwen Su , Haoyu Ren , Huan Wang
{"title":"Antibacterial hydrogels for bacteria-infected wound treatment","authors":"Wenhan Li , Quanchi Chen , Yanyu Ma , Haiwen Su , Haoyu Ren , Huan Wang","doi":"10.1016/j.bmt.2024.11.001","DOIUrl":"10.1016/j.bmt.2024.11.001","url":null,"abstract":"<div><div>Bacteria-infected wounds are enormous clinical obstacles and cause huge burdens to patients and society. Recently, many biomaterials are designed to treat bacterial infected wounds. Among various biomaterials, antibacterial hydrogels are one of the most recommended groups due to their ability to load antibacterial drugs and cover wounds while maintaining a moist environment. In this review, we present the progress in antibacterial hydrogels for bacteria-infected wound treatment. We first summarize the pathophysiology of bacteria-infected wounds, which demonstrates the clinical manifestations and offers clinical therapy projects. Afterwards, we describe the different morphologies of antibacterial hydrogels. Then, we focus on the various practical applications and therapeutic effects of antibacterial hydrogels. At last, the recent problems and outlook of antibacterial hydrogels for bacteria-infected wound healing are summarized. We hope this review can inspire the development of bacteria-infected wound treatment and the related biomedical fields.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongze Chang, Feng Cai, Xiaohu Li, Ang Li, Yan Zhang, Xiaolong Yang, Xiaodong Liu
{"title":"Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration","authors":"Hongze Chang, Feng Cai, Xiaohu Li, Ang Li, Yan Zhang, Xiaolong Yang, Xiaodong Liu","doi":"10.1016/j.bmt.2024.09.002","DOIUrl":"10.1016/j.bmt.2024.09.002","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IDD) is the leading cause of low-back pain, which brings huge threaten to patients' life and workability. However, IDD's pathophysiology is still a puzzle, thus conventional conservative therapy leads to little success. Among all advanced therapies, the rising gene therapy might be the most promising, which combats diseases by the long-term expression of therapeutic proteins, silencing pathological genes, or editing genes. Since circular RNA (circRNA) is a critical regulator in nucleus pulposus cells' proliferation, apoptosis and extracellular matrix metabolism, making it an important research object for IDD repair. To target the pathogenic gene, silencing gene medicines carried by biomaterials have produced interesting breakthroughs in the safe, manageable, and effective administration. In this review, we took an insight into circRNA-related properties and biological processes, so as to inspire IDD treatment. At the same time, we focused on the circRNA related therapies for the treatment of IDDs by using biomaterial-based delivery systems. To note, we also discussed the perspectives of biomaterial-delivered gene therapies as effective means from the frontier needs in biomedicines, to facilitate the rapid development of biomaterial-based delivery systems.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wanqing Weng , Li Wang , Lu Fan , Xiaoya Ding , Xiaocheng Wang
{"title":"Ordered micro-nano structured biomaterials for wound healing","authors":"Wanqing Weng , Li Wang , Lu Fan , Xiaoya Ding , Xiaocheng Wang","doi":"10.1016/j.bmt.2024.09.001","DOIUrl":"10.1016/j.bmt.2024.09.001","url":null,"abstract":"<div><div>The complexity of wound healing, influenced by both external factors and internal pathological mechanisms, presents a significant challenge in clinical treatment. However, strategically designed micro-nano structured scaffolds show great potential in enhancing wound healing. This article reviews groundbreaking research on ordered micro-nano structures for wound repair and tissue regeneration, highlighting their crucial roles in regulating cell behavior, promoting cell differentiation, balancing the immune microenvironment, and providing antibacterial properties. Subsequently, we provide a detailed overview of advanced technologies used to fabricate these precision structures, including template replication, electrospinning, microfluidics, and 3D printing. Finally, we discuss the challenges and future directions for developing finely structured materials, considering both the current achievements and existing limitations.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"8 ","pages":"Pages 104-114"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
