Biomedical Technology最新文献

Virus-inspired biogenic delivery system for advancing cancer therapy

Biomedical Technology Pub Date : 2025-02-08 DOI: 10.1016/j.bmt.2025.100069

Di Sun , Hao Liang , Qianwen Mu , Chengchao Chu , Gang Liu , Chao Liu

引用次数: 0

Embracing the future: The application of regenerative biomaterials in the spinal disorders

Biomedical Technology Pub Date : 2024-12-25 DOI: 10.1016/j.bmt.2024.100068

Yiwen Xu , Miaojie Fang , Zilong Li , Yucheng Xue , Kelei Wang , Feng Lin , Ning Zhang

{"title":"Embracing the future: The application of regenerative biomaterials in the spinal disorders","authors":"Yiwen Xu , Miaojie Fang , Zilong Li , Yucheng Xue , Kelei Wang , Feng Lin , Ning Zhang","doi":"10.1016/j.bmt.2024.100068","DOIUrl":"10.1016/j.bmt.2024.100068","url":null,"abstract":"<div><div>Spinal disorders, particularly disc degeneration, vertebral fractures, and loss of spinal stability, have become a major health problem affecting quality of life worldwide. Although conventional treatments such as surgery and conservative therapy provide some relief, these methods often fail to fully address the underlying problems of spinal disorders. In recent years, the application of regenerative biomaterials has provided new ideas and solutions for the repair and regeneration of spinal disorders. This paper provides a systematic review of the application of regenerative biomaterials in the treatment of spinal disorders, including natural materials, synthetic materials and composites. In addition, this paper describes several advanced tissue engineering fabrication techniques, such as 3D printing and bioprinting, which enable regenerative biomaterials to be applied more precisely in the treatment of spinal disorders. This paper also explores the role of regenerative biomaterials in spinal disorders. The aim of this paper is to provide references and new insights for future exploration of the application of regenerative biomaterials in spinal disorders, and to promote research and clinical practice in related fields, with a view to achieving more effective and safer therapeutic strategies for spinal disorders.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing biotechnologies in organoids for liver cancer 开发治疗肝癌的有机体生物技术

Biomedical Technology Pub Date : 2024-11-26 DOI: 10.1016/j.bmt.2024.100067

Yingzhe Hu , Zheng Peng , Mengdi Qiu , Lingling Xue , Haozhen Ren , Xingyu Wu , Xinhua Zhu , Yitao Ding

{"title":"Developing biotechnologies in organoids for liver cancer","authors":"Yingzhe Hu , Zheng Peng , Mengdi Qiu , Lingling Xue , Haozhen Ren , Xingyu Wu , Xinhua Zhu , Yitao Ding","doi":"10.1016/j.bmt.2024.100067","DOIUrl":"10.1016/j.bmt.2024.100067","url":null,"abstract":"<div><div>Organoids, three-dimensional cellular constructs, have revolutionized in vitro culture by replicating the histological and physiological functions of organs, offering a model that closely mimics physiological conditions. Liver cancer presents a significant challenge due to its heterogeneity and the influence of the liver's microenvironment on therapeutic responses. Organoid technology addresses this complexity by simulating the tumor microenvironment in vitro, capturing the heterogeneity of liver cancer, and facilitating personalized treatment approaches. This study explores the integration of organoids in liver cancer research, focusing on genetic and phenotypic fidelity, disease modeling, and drug screening. We discuss the latest advancements in biotechnology, including CRISPR/Cas9, 3D bioprinting, and microfluidics, and their role in personalized medicine. Despite challenges in scalability and variability, organoids offer a promising avenue for liver cancer research and precision oncology, with the potential to transform our understanding and treatment of this disease.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Space manufacturing of a bone tissue destined for patients on Earth? 在太空中为地球上的病人制造骨组织？

Biomedical Technology Pub Date : 2024-11-26 DOI: 10.1016/j.bmt.2024.10.004

Vladimir S. Komlev , Vladislav A. Parfenov , Pavel A. Karalkin , Stanislav V. Petrov , Frederico D.A.S. Pereira , Elizaveta V. Koudan , Aleksandr A. Levin , Margarita A. Golberg , Alexander Yu. Fedotov , Igor V. Smirnov , Andrey D. Kaprin , Natalia S. Sergeeva , Irina K. Sviridova , Valentina A. Kirsanova , Suraja A. Akhmedova , Georgy V. Mamin , Marat R. Gafurov , Alexey N. Gurin , Yusef D. Khesuani , Yury M. Urlichich

{"title":"Space manufacturing of a bone tissue destined for patients on Earth?","authors":"Vladimir S. Komlev , Vladislav A. Parfenov , Pavel A. Karalkin , Stanislav V. Petrov , Frederico D.A.S. Pereira , Elizaveta V. Koudan , Aleksandr A. Levin , Margarita A. Golberg , Alexander Yu. Fedotov , Igor V. Smirnov , Andrey D. Kaprin , Natalia S. Sergeeva , Irina K. Sviridova , Valentina A. Kirsanova , Suraja A. Akhmedova , Georgy V. Mamin , Marat R. Gafurov , Alexey N. Gurin , Yusef D. Khesuani , Yury M. Urlichich","doi":"10.1016/j.bmt.2024.10.004","DOIUrl":"10.1016/j.bmt.2024.10.004","url":null,"abstract":"<div><div>Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that is not possible anywhere else. Tissue engineering in outer space, where state of the gravity can be ‘turned off’ or ‘turned on’ in the case of application of centrifuges, is a new research field with high-value goals. The microgravity conditions allow to design novel biomaterials that cannot be produced on Earth but benefit the Earth civilisation. Developing and manufacturing a biomaterial to address a space-based challenge may lead to novel biomaterials that will find important applications in medicine on Earth and/or for long-duration space missions. Today, there are only a handful of emerging biomaterials that have been tested in space, none of which have been used for their eventual function. This paper presents advances in space technology <em>via</em> 3D magnetic assembly: the development of synthetic bone graft constructs aboard the International Space Station during expeditions 60/61 with clear evidence of the materials' functioning in preclinical (animal) tests on Earth. The results indicate high osteoconductivity and ultimately a good rate of tissue formation by the bone grafts prepared in space.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial hydrogels for bacteria-infected wound treatment 用于治疗细菌感染伤口的抗菌水凝胶

Biomedical Technology Pub Date : 2024-11-21 DOI: 10.1016/j.bmt.2024.11.001

Wenhan Li , Quanchi Chen , Yanyu Ma , Haiwen Su , Haoyu Ren , Huan Wang

引用次数: 0

Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration 修复椎间盘变性的基于生物材料的环状 RNA 治疗策略

Biomedical Technology Pub Date : 2024-11-21 DOI: 10.1016/j.bmt.2024.09.002

Hongze Chang, Feng Cai, Xiaohu Li, Ang Li, Yan Zhang, Xiaolong Yang, Xiaodong Liu

{"title":"Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration","authors":"Hongze Chang, Feng Cai, Xiaohu Li, Ang Li, Yan Zhang, Xiaolong Yang, Xiaodong Liu","doi":"10.1016/j.bmt.2024.09.002","DOIUrl":"10.1016/j.bmt.2024.09.002","url":null,"abstract":"<div><div>Intervertebral disc degeneration (IDD) is the leading cause of low-back pain, which brings huge threaten to patients' life and workability. However, IDD's pathophysiology is still a puzzle, thus conventional conservative therapy leads to little success. Among all advanced therapies, the rising gene therapy might be the most promising, which combats diseases by the long-term expression of therapeutic proteins, silencing pathological genes, or editing genes. Since circular RNA (circRNA) is a critical regulator in nucleus pulposus cells' proliferation, apoptosis and extracellular matrix metabolism, making it an important research object for IDD repair. To target the pathogenic gene, silencing gene medicines carried by biomaterials have produced interesting breakthroughs in the safe, manageable, and effective administration. In this review, we took an insight into circRNA-related properties and biological processes, so as to inspire IDD treatment. At the same time, we focused on the circRNA related therapies for the treatment of IDDs by using biomaterial-based delivery systems. To note, we also discussed the perspectives of biomaterial-delivered gene therapies as effective means from the frontier needs in biomedicines, to facilitate the rapid development of biomaterial-based delivery systems.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"9 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ordered micro-nano structured biomaterials for wound healing 用于伤口愈合的有序微纳结构生物材料

Biomedical Technology Pub Date : 2024-11-13 DOI: 10.1016/j.bmt.2024.09.001

Wanqing Weng , Li Wang , Lu Fan , Xiaoya Ding , Xiaocheng Wang

引用次数: 0

HMS-TENet: A hierarchical multi-scale topological enhanced network based on EEG and EOG for driver vigilance estimation HMS-TENet：基于脑电图和眼电图的分层多尺度拓扑增强网络，用于驾驶员警惕性估计

Biomedical Technology Pub Date : 2024-10-28 DOI: 10.1016/j.bmt.2024.10.003

Meng Tang , Pengrui Li , Haokai Zhang , Liu Deng , Shihong Liu , Qingyuan Zheng , Hongli Chang , Changming Zhao , Manqing Wang , Guilai Zuo , Dongrui Gao

{"title":"HMS-TENet: A hierarchical multi-scale topological enhanced network based on EEG and EOG for driver vigilance estimation","authors":"Meng Tang , Pengrui Li , Haokai Zhang , Liu Deng , Shihong Liu , Qingyuan Zheng , Hongli Chang , Changming Zhao , Manqing Wang , Guilai Zuo , Dongrui Gao","doi":"10.1016/j.bmt.2024.10.003","DOIUrl":"10.1016/j.bmt.2024.10.003","url":null,"abstract":"<div><div>Driving vigilance estimation is an important task for traffic safety. Nowadays, electroencephalography (EEG) and electrooculography (EOG) have made some achievements in vigilance estimation, but there are still some challenges: 1) The traditional approachs with direct multimodal fusion may face the problems of information redundancy and data dimensionality mismatch; 2) Capture key discriminative features during multimodal fusion without losing specific patterns to each modality. In order to solve the above problems, this paper proposes a approach with fusion of EEG and EOG features in split bands, which not only preserves the information about brain activities in different bands of EEG, but also effectively integrates the relevant information of EOG. On this basis, we further propose a hierarchical multi-scale topological enhanced network (HMS-TENet). This network first introduces a pyramid pooling structure (PPS) to capture contextual relationships from different discriminative perspectives. And then we design a selective convolutional structure (SCS) for adaptive sense-field selection, which enables us to mine the desired discriminative information in small-size features. In addition, we design a topology self-aware attention to enhance the learning of representations of complex topological relationships among EEG channels. Finally, the output of the model can be selected for both regression and classification tasks, providing higher flexibility and adaptability. We demonstrate the robustness, generalizability, and utility of the proposed method based on intra-subject and cross-subject experiments on the SEED-VIG public dataset. Codes are available at <span><span>https://github.com/tangmeng28/HMS-TENet</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"8 ","pages":"Pages 92-103"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D2 receptor antagonist raclopride regulates glutamatergic neuronal activity in the pedunculopontine nucleus in a rat model of Parkinson's disease 在帕金森病大鼠模型中，D2 受体拮抗剂拉克必利可调节足底核的谷氨酸能神经元活动

Biomedical Technology Pub Date : 2024-10-25 DOI: 10.1016/j.bmt.2024.10.002

Hongli Chang , Bo Liu , Hongguang Chang , Na Li , Min Xu , Guilai Zuo , Wubing He , Xuenan Wang

{"title":"D2 receptor antagonist raclopride regulates glutamatergic neuronal activity in the pedunculopontine nucleus in a rat model of Parkinson's disease","authors":"Hongli Chang , Bo Liu , Hongguang Chang , Na Li , Min Xu , Guilai Zuo , Wubing He , Xuenan Wang","doi":"10.1016/j.bmt.2024.10.002","DOIUrl":"10.1016/j.bmt.2024.10.002","url":null,"abstract":"<div><div>Parkinson disease (PD) is defined by the loss of dopamine (DA). Changes in the pedunculopontine nucleus (PPN), particularly in local field potential (LFP), can be attributed to deficits in DA and DA receptor expression levels. PPN is a heterogeneous nucleus consisting of cholinergic, γ-aminobutyric acid (GABAergic), and glutamatergic neurons. However, it is unclear whether low levels of DA receptors affect the activity of different PPN neuron types. We record the neuronal activity of PPN by administering the selective dopamine D1 and D2 receptor antagonists, SCH23390 and Raclopride, respectively. This study discover that the firing rates of glutamatergic neurons could be normalized, and their firing patterns were more consistent in lesioned rats treated with raclopride. Raclopride administration could correct the increased coherence and phase locking between glutamatergic spikes and beta-band oscillatory activity in lesioned rats. Raclopride administration correct the increased coherence and phase locking between glutamatergic spikes and beta-band oscillatory activity in lesioned rats.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"8 ","pages":"Pages 81-91"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma 用于皮肤鳞状细胞癌术后伤口愈合的电纺丝药物负载聚己内酯/聚己内酯-明胶多功能双层纳米纤维复合支架

Biomedical Technology Pub Date : 2024-10-09 DOI: 10.1016/j.bmt.2024.10.001

Yongteng Song , Qingxi Hu , Suihong Liu , Guotai Yao , Haiguang Zhang

{"title":"Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma","authors":"Yongteng Song , Qingxi Hu , Suihong Liu , Guotai Yao , Haiguang Zhang","doi":"10.1016/j.bmt.2024.10.001","DOIUrl":"10.1016/j.bmt.2024.10.001","url":null,"abstract":"<div><div>Cutaneous squamous cell carcinoma (cSCC) tumor resection surgery poses challenges due to incomplete cancer cell removal, which increases the risk of local recurrence and micrometastasis, while large-scale surgical wounds are susceptible to severe infections. Therefore, a drug-loaded multi-functional bilayer nanofibers skin scaffold was fabricated for postoperative wound care of cSCC. Briefly, the antibacterial drug enrofloxacin (ENR) was loaded into polycaprolactone (PCL) nanofibers using electrospinning to form an antibacterial nanofiber membrane (PCL-ENR) as the outer layer of scaffold. The anticancer drug bleomycin (BLM) was loaded into PCL/Gelatin (Gel) nanofibers via electrospinning to form an anticancer nanofiber membrane (PG-BLM) as the inner layer of scaffold. ENR and BLM were successfully loaded into the scaffold. The scaffold had excellent physicochemical properties, with the outer layer exhibiting hydrophobicity and excellent antibacterial activity, and the inner layer showing hydrophilicity and outstanding anticancer activity. The elongation at break and tensile modulus of the scaffold were 26.35 ± 1.61 % and 15.25 ± 1.56 MPa, respectively. <em>In vitro</em> and <em>in vivo</em> experiments suggested that the scaffold not only has good biocompatibility to promote wound healing but also could inhibit the proliferation of A431 cells, which has great potential clinical application in postoperative wound care of cSCC.</div></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"8 ","pages":"Pages 65-80"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0