{"title":"Scenario-oriented nanopesticides: Shaping nanopesticides for future agriculture","authors":"Wenjie Shangguan , Huiping Chen , Pengyue Zhao, Chong Cao, Manli Yu, Qiliang Huang, Lidong Cao","doi":"10.1016/j.aac.2024.07.002","DOIUrl":"10.1016/j.aac.2024.07.002","url":null,"abstract":"<div><div>Nanopesticides, as a promising technology, bring scientific and technological impetus to sustainable development and green revolution of agriculture. The excellent physicochemical properties, beneficial biological effects, and functional potential of nanopesticides have significantly contributed to improving utilization rates of pesticides, enhancing pest and disease management, and alleviating stresses. However, agricultural production and plant cultivation are diverse, leading to a wide range of application scenarios for pesticides. These application scenarios put forward more precise requirements and numerous innovative opportunities for the development of nanopesticides. Scenario-oriented nanopesticides are customized for various application scenarios and methods, aligning with the principles of economical, efficient, and sustainable future agriculture. This article outlines the development status of nanopesticides and then reviews the research progress of scenario-oriented nanopesticides, encompassing nine major application scenarios. Finally, the development priorities and prospects of scenario-oriented nanopesticides are summarized, offering innovative concepts for advancement of nanopesticides.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 265-278"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-07-01DOI: 10.1016/j.aac.2024.07.001
Roghayeh Rezaeimalidareh, Mohammad Ahmadi, S. Shahidi, Sahar Aghamirzaei
{"title":"Evaluation of mold, yeast and phage contamination of yogurt collected from North of Iran, measurement of their potent natamycin preservative","authors":"Roghayeh Rezaeimalidareh, Mohammad Ahmadi, S. Shahidi, Sahar Aghamirzaei","doi":"10.1016/j.aac.2024.07.001","DOIUrl":"https://doi.org/10.1016/j.aac.2024.07.001","url":null,"abstract":"","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Practical method for the large-scale synthesis of 4′-chloro-2-nitrobiphenyl: A key intermediate of Boscalid","authors":"You Chen, Tong Meng, Rui Guo, Zhaoru Liu, Sixuan Meng, Jian Chen, Guang-Ao Yu","doi":"10.1016/j.aac.2024.06.002","DOIUrl":"10.1016/j.aac.2024.06.002","url":null,"abstract":"<div><p>Boscalid is a pesticide with the advantages of broad spectrum bactericidal activity, high efficiency, low toxicity, and no cross-resistance with other fungicides currently available on the market. Herein, we report the synthesis of 4′-chloro-2-nitrobiphenyl, a key intermediate of Boscalid using a palladium-catalyzed Suzuki-Miyaura cross-coupling employing the 2-aryl-substituted indenyl phosphine ligand. 4′-Chloro-2-nitrobiphenyl was prepared in 94 % yield on a 100 g scale. This method allows for the industrial production of alimide and active substances bearing a biphenyl moiety.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 3","pages":"Pages 256-260"},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000510/pdfft?md5=a57c823472b60ff6759e6d92612aca17&pid=1-s2.0-S2773237124000510-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AI-driven drug discovery from natural products","authors":"Feng-Lei Duan , Chun-Bao Duan , Hui-Lin Xu , Xin-Ying Zhao , Otgonpurev Sukhbaatar , Jie Gao , Ming-Zhi Zhang , Wei-Hua Zhang , Yu-Cheng Gu","doi":"10.1016/j.aac.2024.06.003","DOIUrl":"10.1016/j.aac.2024.06.003","url":null,"abstract":"<div><p>The latest review published in <em>Nature Reviews Drug Discovery</em> by Michael W. Mullowney and co-authors focuses on the use of artificial intelligence techniques, specifically machine learning, in natural product drug discovery. The authors discussed various applications of AI in this field, such as genome and metabolome mining, structural characterization of natural products, and predicting targets and biological activities of these compounds. They also highlighted the challenges associated with creating and managing large datasets for training algorithms, as well as strategies to address these obstacles. Additionally, the authors examine common pitfalls in algorithm training and offer suggestions for avoiding them.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 3","pages":"Pages 185-187"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000522/pdfft?md5=2dd2ba82adcf65a6ea25064ea9146daa&pid=1-s2.0-S2773237124000522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-06-12DOI: 10.1016/j.aac.2024.06.001
Li He , Yifan Zhou , Qin Mo , Yanna Huang , Xueming Tang
{"title":"Spray-induced gene silencing in phytopathogen: Mechanisms, applications, and progress","authors":"Li He , Yifan Zhou , Qin Mo , Yanna Huang , Xueming Tang","doi":"10.1016/j.aac.2024.06.001","DOIUrl":"10.1016/j.aac.2024.06.001","url":null,"abstract":"<div><div>Phytopathogens can continuously cause serious losses worldwide to crop, fruit, and vegetable yields. The excessive use of conventional fungicides in pathogen management has raised severe environmental and health side effects and induced fungicide-resistant pathogen strains. RNA-based spray-induced gene silencing (SIGS) has emerged as an ecologically sustainable pathogen control approach. Here, we introduce the SIGS mechanism in plant pathogens, summarize the application of SIGS in controlling plant pathogens, and highlight the major considerations of SIGS. In addition, we propose the future perspectives of SIGS in crop protection and disease management.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 289-297"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-05-31DOI: 10.1016/j.aac.2024.05.001
Zhaochen Wu , Ziqi Liu , Zhihong Hu , Tingting Wang , Lijie Teng , Tan Dai , Pengfei Liu , Jianjun Hao , Xili Liu
{"title":"Utilizing metabolomic approach to study the mode of action of fungicides and corresponding resistance in plant pathogens","authors":"Zhaochen Wu , Ziqi Liu , Zhihong Hu , Tingting Wang , Lijie Teng , Tan Dai , Pengfei Liu , Jianjun Hao , Xili Liu","doi":"10.1016/j.aac.2024.05.001","DOIUrl":"10.1016/j.aac.2024.05.001","url":null,"abstract":"<div><p>Fungicides are an indispensable tool in plant disease control. Various modes of action (MOAs) have been identified in different fungicides to suppress plant pathogens. The combined use of fungicides with distinct MOAs has been recommended to prevent the development of pathogen resistance. In studying MOAs, metabolomics has been proven to be a robust and high-throughput method. Because metabolites are unique and distinct depending on the biological activities of an organism, MOAs can be identified and classified by establishing metabolic fingerprinting and metabolic profiles. Similarly, if fungicide resistance is developed in a pathogen, the metabolome will change, which can be identified. In this review, we have discussed the principles and advanced applications of metabolomics in the study of MOAs and resistance mechanisms of fungicides, and the potential of metabolic data in understanding the interaction between fungicides and pathogens. Challenges are also discussed in the application of metabolomics, improvement of the study on the mechanism of fungicides in their functions against pathogens and advancing the development of novel fungicides.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 3","pages":"Pages 197-205"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000492/pdfft?md5=358ec1c09071e8212f6f45edbba29929&pid=1-s2.0-S2773237124000492-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-05-01DOI: 10.1016/j.aac.2024.04.003
{"title":"TIR domain protein-mediated phase separation activates plant immunity","authors":"","doi":"10.1016/j.aac.2024.04.003","DOIUrl":"10.1016/j.aac.2024.04.003","url":null,"abstract":"<div><p>We spotlight recent findings from a Nature paper unveiling captivating insights into how substrates such as NAD+ and ATP stimulate the condensation of TIR domain proteins. This process culminates in the formation of a quaternary structural pattern akin to the catalytic arrangement observed in conventional TNL proteins. Consequently, this mechanism enables the production of pivotal signaling molecules crucial for fortifying plant immunity. Expanding on these revelations, we propose the prospect of creating modulatory compounds capable of initiating the phase separation of TIR domain proteins as an innovative approach to enhance plant immunity against pathogenic challenges.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 3","pages":"Pages 183-184"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000467/pdfft?md5=d8b82182ba57c5a5c1f146bbbfdaae98&pid=1-s2.0-S2773237124000467-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-04-24DOI: 10.1016/j.aac.2024.04.002
Caiyue Liu , Yuelan Yin , Hao Liu , Longfei Yang , Minghui Chen , Ting Ma , Guoqiang Zhang , Chunjuan Wang , Sifeng Zhao , Xiaoqiang Han
{"title":"Design, synthesis, and insecticidal activity of novel terpenoid ester compounds containing bicyclo[2.2.1] heptane against Aphis gossypii Glover","authors":"Caiyue Liu , Yuelan Yin , Hao Liu , Longfei Yang , Minghui Chen , Ting Ma , Guoqiang Zhang , Chunjuan Wang , Sifeng Zhao , Xiaoqiang Han","doi":"10.1016/j.aac.2024.04.002","DOIUrl":"10.1016/j.aac.2024.04.002","url":null,"abstract":"<div><p>To discover novel and efficient compounds against <em>Aphis gossypii</em> Glover, a series of novel terpene ester derivatives containing the structure of bicyclo[2.2.1]heptane were designed and synthesized using tschimganin as the lead compound. Bioactivity assays showed that most tschimganin analogs exhibited moderate to outstanding insecticidal activity against <em>A</em>. <em>gossypii</em>. In particular, compound <strong>56</strong> (LC<sub>50</sub> = 0.28 μg mL<sup>−1</sup>), identified as (1<em>S</em>,2<em>S</em>,4<em>R</em>)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl nicotinate, exhibited the best activity, which was significantly superior to that of imidacloprid (LC<sub>50</sub> = 0.54 μg mL<sup>−1</sup>) and sulfoxaflor (LC<sub>50</sub> = 0.70 μg mL<sup>−1</sup>). The precise and dependable 3D-QSAR model suggests a promising direction for further design of more active tschimganin-based insecticides. Metabolomics showed that compound <strong>56</strong> disrupted detoxification, amino acid biosynthesis, and energy metabolism and may affect the central nervous system of <em>A. gossypii</em>. The results of this study indicated that tschimganin analogs are a potential new class of green insecticides that can be used for the integrated management of <em>A. gossypii</em>.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 2","pages":"Pages 171-181"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000327/pdfft?md5=3f863eb162810587c73f1644fd0fac89&pid=1-s2.0-S2773237124000327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reducing pesticide use: Synthesis and application of ROS-SPC as an efficient nanocarrier and scavenger of reactive oxygen species in plants","authors":"Tian-shi Jiang , Su-zhen Qi , Chang-heng Zhu , Han-qing Zhao , Liu-sheng Duan","doi":"10.1016/j.aac.2024.03.001","DOIUrl":"10.1016/j.aac.2024.03.001","url":null,"abstract":"<div><p>There is an increasing need to reduce the use of pesticides to reduce their potential threat to food/environmental safety. At the same time, an increase in reactive oxygen species (ROS) induced by abiotic stresses in plants can lead to an increase in ROS in the plant and affect yield. In this paper, ROS-SPC was synthesised by two reactions and used as an efficient pesticide nanocarrier/adjuvant and scavenger of reactive oxygen species (ROS) in plants. By hydrophobic interaction, ROS-SPC spontaneously conjugated to fluazinam with a pesticide loading capacity (PLC) of 15.1 %. After fluazinam was conjugated to ROS-SPC, the particle size of fluazinam was reduced from 64.70 nm reduced to 19.82 nm, and the contact angle of pesticide droplets on plant leaves was significantly reduced from 59.44° to 26.76°. ROS-SPC as a carrier was tested to inhibit phytopathogenic fungi by 200 % more than conventional delivery methods. In addition, we also learned that ROS-SPC with endocytosis capability can indeed remove reactive oxygen species from plants. Tests using HUVEC cells showed that ROS-SPC has low cytotoxicity within a reasonable range of applications, and ROS-SPC was tested to have low toxicity to pollinating bees.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 2","pages":"Pages 162-170"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000297/pdfft?md5=71581b4d44320b2bd4c7d6e33de037be&pid=1-s2.0-S2773237124000297-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140766677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced AgrochemPub Date : 2024-04-17DOI: 10.1016/j.aac.2024.04.001
Dongmei Chen, Tianhui Liao, Wenjun Ye, Zhichao Jin, Shichao Ren
{"title":"Research progress on the synthesis of phenylurea derived plant growth regulators","authors":"Dongmei Chen, Tianhui Liao, Wenjun Ye, Zhichao Jin, Shichao Ren","doi":"10.1016/j.aac.2024.04.001","DOIUrl":"10.1016/j.aac.2024.04.001","url":null,"abstract":"<div><p>Plant growth regulators (PGRs) are chemical substances that imitate the functions of phytohormones to enhance the crop yield and the harvest process. Phenylurea-derived plant growth regulators are known for their excellent efficacy in promoting fruit growth, particularly in kiwifruit, grapes, and melons. Phenylurea derivatives represent one class of the highly efficient and versatile PGRs. Specifically, forchlorfenuron (CPPU, <em>N</em>-(2-chloro-4-pyridinyl)-<em>N′</em>-phenylurea) exhibits similar growth-regulating efficacy to cytokinins and has a significant impact on the plant growth and the crop yield. As a result, there is growing interest in exploring the incorporation of various phenylurea moieties into agrochemicals to enhance their regulatory properties on crops. This review aims to provide a comprehensive overview on representative synthetic approaches for phenylurea derived PGRs. Additionally, we provide our perspective on the future development in this active research field.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 2","pages":"Pages 143-150"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000315/pdfft?md5=e555c0162c31724d5f4b279c20f8d8fd&pid=1-s2.0-S2773237124000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140773581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}