Advanced Agrochem最新文献

Design, synthesis, and evaluation of biological activity of camphor-based oxo-phenylacetamide ester compounds 樟脑基氧苯乙酰胺酯类化合物的设计、合成及生物活性评价

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-03-10 DOI: 10.1016/j.aac.2026.03.001

Hao Liu, Yuelan Yin, Juncheng Yan, Yuting Yang, Siying Ye, Ting Ma, Chunjuan Wang, Sifeng Zhao, Guoqiang Zhang, Xiaoqiang Han

{"title":"Design, synthesis, and evaluation of biological activity of camphor-based oxo-phenylacetamide ester compounds","authors":"Hao Liu, Yuelan Yin, Juncheng Yan, Yuting Yang, Siying Ye, Ting Ma, Chunjuan Wang, Sifeng Zhao, Guoqiang Zhang, Xiaoqiang Han","doi":"10.1016/j.aac.2026.03.001","DOIUrl":"10.1016/j.aac.2026.03.001","url":null,"abstract":"<div><div>This study presents the design, synthesis, and biological evaluation of a novel series of amide derivatives based on the fenchol/bornyl scaffold. Systematic screening of biological activity revealed that 3y exhibited significant antifungal activity against both <em>Fusarium oxysporum</em> and <em>Fusarium graminearum</em>, with half-maximal inhibitory concentration (EC<sub>50</sub>) values of 15.732 mg/L and 19.348 mg/L, respectively. Transcriptomic analysis coupled with molecular docking studies demonstrated that <strong>3y</strong> specifically targets ERG13, a key enzyme in ergosterol biosynthesis. This action effectively disrupts fungal cell membrane integrity, induces oxidative stress, and ultimately inhibits hyphal growth and spore germination. Furthermore, density functional theory calculations provided detailed insights into the high-affinity binding mechanism between the compound and its target protein, revealing the molecular basis of its efficacy. This study presents a novel molecular template and design strategy for the development of highly selective, low-risk ergosterol synthesis inhibitors.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 364-376"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A fluorescent sensor for non-enzymatic detection of glufosinate ammonium 一种非酶检测草甘膦铵的荧光传感器

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-01-05 DOI: 10.1016/j.aac.2026.01.001

Binjie Zhang, Shijun Chen, Xianzhe Yu, Qiye Liu, Cailing Fan, Chunmei Chen, Weijie Chi, Chaoyuan Zeng

{"title":"A fluorescent sensor for non-enzymatic detection of glufosinate ammonium","authors":"Binjie Zhang, Shijun Chen, Xianzhe Yu, Qiye Liu, Cailing Fan, Chunmei Chen, Weijie Chi, Chaoyuan Zeng","doi":"10.1016/j.aac.2026.01.001","DOIUrl":"10.1016/j.aac.2026.01.001","url":null,"abstract":"<div><div>Glufosinate ammonium (GLA) ranks as the second most widely used herbicide worldwide and plays a vital role in modern agriculture. However, excessive or improper application of GLA has resulted in substantial environmental residues, raising concerns about potential risks to human health. Rapid detection of GLA is essential to mitigate the environmental, ecological, and food safety impacts caused by its residues. In this study, a fluorescent probe (<em>R</em>)-<strong>3</strong> was successfully developed for the detection of GLA. (<em>R</em>)-<strong>3</strong> exhibited high selectivity for GLA over 11 other common pesticides. Upon excitation at 425 nm, it produces intense absorption at 575 nm accompanied by bright yellow fluorescence emission. The probe achieved a low detection limit of 507.3 nM and a distinct colorimetric response. Furthermore, test strips based on (<em>R</em>)-<strong>3</strong> were fabricated and applied to the detection of GLA in real weed and soil samples. A smartphone-based detection platform was also developed, highlighting its considerable potential for rapid pesticide monitoring and food safety applications.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 288-297"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing herbicide safeners: Integrating structure-guided design, pathway mechanism elucidation, and smart delivery 推进除草剂安全剂：整合结构导向设计、途径机制阐明和智能交付

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-05-20 DOI: 10.1016/j.aac.2026.05.001

Xile Deng, Yudan Wu, Lianyang Bai

引用次数: 0

Advances in electrochemical sensing for plant health monitoring 电化学传感技术在植物健康监测中的研究进展

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-05-22 DOI: 10.1016/j.aac.2026.05.002

Jingyi Zhang, Haifei Wan, Miao Xu, Wenling Gu, Chengzhou Zhu

{"title":"Advances in electrochemical sensing for plant health monitoring","authors":"Jingyi Zhang, Haifei Wan, Miao Xu, Wenling Gu, Chengzhou Zhu","doi":"10.1016/j.aac.2026.05.002","DOIUrl":"10.1016/j.aac.2026.05.002","url":null,"abstract":"<div><div>Plant health monitoring is becoming increasingly important for food security, precision agriculture and smart farming under the combined pressures of climate change, pathogen infection, pest infestation and multiple environmental stresses. Since plant health is fundamentally governed by dynamic molecular changes rather than visible symptoms alone, analytical strategies capable of capturing early, localized and continuous physiological information are urgently needed. Electrochemical sensing has emerged as a particularly attractive approach owing to its high sensitivity, low sample demand, facile miniaturization and compatibility with in situ and real-time analysis. In this review, we summarize recent advances in electrochemical sensing for plant health monitoring. First, we discuss major classes of plant health-related molecules and the analytical characteristics that make electrochemical monitoring especially suitable for these targets. Then, we classify recent electrochemical strategies into two major categories: ex situ electrochemical sensing of plant health-related molecules and in situ continuous monitoring of living plants. Particular emphasis is placed on direct electrochemical sensing, recognition-coupled transduction and implantable, microneedle and wearable platforms. Finally, we outline future priorities spanning rational interface and materials design, multiplexed and multimodal sensing, AI-enabled data analytics and integrated system development. Electrochemical technologies are thus advancing from molecular-level analytical tools toward integrated platforms capable of decoding plant health from dynamic, multiscale information, with growing significance for both plant science and smart agriculture.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 267-278"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and mechanism evaluation of a novel molluscicide targeting three parasitic disease intermediate hosts 一种针对三种寄生虫病中间宿主的新型杀螺剂的研制及作用机理评价

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-01-17 DOI: 10.1016/j.aac.2026.01.003

Lanyun Zhang, Jingwei Huang, Jinping Huang, Shangjie Pu, Jun Yin, Ying Zhou

{"title":"Development and mechanism evaluation of a novel molluscicide targeting three parasitic disease intermediate hosts","authors":"Lanyun Zhang, Jingwei Huang, Jinping Huang, Shangjie Pu, Jun Yin, Ying Zhou","doi":"10.1016/j.aac.2026.01.003","DOIUrl":"10.1016/j.aac.2026.01.003","url":null,"abstract":"<div><div><em>Pomacea canaliculata</em>, <em>Oncomelania hupensis</em>, and <em>Parafossarulus striatulus</em> are gastropod species present to varying extents across the Yunnan Province. These snails are important intermediate hosts for parasites and pose a considerable economic and public health concern. In this study, 43 novel pyridylurea derivatives were synthesized, characterized, and evaluated for molluscicidal efficacy. The most active compound, 1-(3-bromophenyl)-3-(5-methoxypyridin-3-yl) urea (compound O-1), exhibited significant molluscicidal activity with lethal concentration 50 % (LC<sub>50</sub>) values of 0.15 mg/L (<em>O. hupensis</em>), 0.49 mg/L (<em>P. striatulus</em>), and 1.84 mg/L (<em>P. canaliculata</em>). Compound O-1 exhibited remarkable molluscicidal activity for <em>O. hupensis</em>, which was significantly superior to that of niclosamide (LC<sub>50</sub> = 0.40 mg/L). Preliminary investigations were conducted to determine the molecular mechanism of molluscicidal action of O-1 in the three types of snails. After treatment with O-1, the activity of the enzymes nitric oxide synthase and acetylcholinesterase in snails increased significantly, disrupting neurotransmitter conduction and energy metabolism. O-1 also inhibited phosphofructokinase, which was likely to impede glycolysis in the three types of snails. Our findings reveal that O-1 may interfere with immune regulation in snails, representing a universally applicable molluscicidal mechanism. Moreover, O-1 shows potential as a molluscicide with broad applications to control the intermediate hosts of parasites.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 298-305"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-encapsulation of pyraclostrobin within mesoporous silica mitigates toxicity in zebrafish (Danio rerio) 介孔二氧化硅内吡咯菌酯的纳米包封减轻斑马鱼的毒性（Danio rerio）

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-02-05 DOI: 10.1016/j.aac.2026.02.002

Xuanli Chang, Chang Yu, Jiaqing Li, Kang Ouyang, Tingwei Cai, Jiayin Wang, Danming Zhao, Mengying Gong, Hongju Ma, Hu Wan, Jianhong Li, Dan Wang, Jianfeng Chen, Shun He

{"title":"Nano-encapsulation of pyraclostrobin within mesoporous silica mitigates toxicity in zebrafish (Danio rerio)","authors":"Xuanli Chang, Chang Yu, Jiaqing Li, Kang Ouyang, Tingwei Cai, Jiayin Wang, Danming Zhao, Mengying Gong, Hongju Ma, Hu Wan, Jianhong Li, Dan Wang, Jianfeng Chen, Shun He","doi":"10.1016/j.aac.2026.02.002","DOIUrl":"10.1016/j.aac.2026.02.002","url":null,"abstract":"<div><div>Pyraclostrobin, a widely used broad-spectrum fungicide, poses significant ecological risks to aquatic ecosystems due to its high toxicity to non-target organisms, limiting its application in paddy fields. To address these challenges, this study developed a nano-controlled release system of pyraclostrobin encapsulated within pectin-coated mesoporous silica nanoparticles (Pyr@MSN-Pec). The novel formulation exhibited sustained-release properties, significantly enhanced antifungal activity against <em>Magnaporthe oryzae</em> (EC<sub>50</sub> = 0.007 mg/L compared to 0.021 mg/L for conventional pyraclostrobin), and substantially reduced acute toxicity to zebrafish (LC<sub>50</sub> increased from 0.046 mg/L to 0.314 mg/L). Furthermore, zebrafish embryos exposed to Pyr@MSN-Pec exhibited lower incidences of developmental abnormalities, impaired autonomous movement, and oxidative stress responses compared with those exposed to free pyraclostrobin. These findings highlight the potential of Pyr@MSN-Pec to enable safer and more effective fungicide applications in rice cultivation, supporting the development of more sustainable pest management strategies.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 313-323"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, biological activity, and acaricidal mechanism of chiral 2,4-diphenyloxazolines 手性2,4-二苯基氯恶唑啉的合成、生物活性及杀螨机理

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-02-04 DOI: 10.1016/j.aac.2026.02.003

Xiwei Xun, Yuhao Tan, Jiarui Tian, Peilin Guo, Dong Wang, Fengshou Dong, Peng Wei, Hongjian Song, Yuxiu Liu, Qingmin Wang

{"title":"Synthesis, biological activity, and acaricidal mechanism of chiral 2,4-diphenyloxazolines","authors":"Xiwei Xun, Yuhao Tan, Jiarui Tian, Peilin Guo, Dong Wang, Fengshou Dong, Peng Wei, Hongjian Song, Yuxiu Liu, Qingmin Wang","doi":"10.1016/j.aac.2026.02.003","DOIUrl":"10.1016/j.aac.2026.02.003","url":null,"abstract":"<div><div>In addition to differences in effects on the target organism, chiral compounds also have different environmental behavior and even mechanisms of action in their two enantiomers. Examining the differences between these enantiomers facilitates the full evaluation and identification of potential pesticide candidates. In this work, we used a unique chiral synthesis approach to produce the enantiomers of many highly active acaricidal 2,4-diphenyloxazolines. We also looked at differences in acaricidal activity, the activity of certain compounds against non-target organisms, and used molecular docking modeling, enzyme activity testing, and resistance mite acaricidal activity testing to confirm that their acaricidal mechanism of action was the same as that of the commercial acaricide etoxazole. This study not only gives crucial data for the development of new chiral acaricides but also provides theoretical support for the future design and synthesis of oxazoline-based acaricides and chitin synthase 1 inhibitors.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 324-332"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding spatiotemporal dynamics of phytohormones under stress: From subcellular visualization to wearable sensing 解码压力下植物激素的时空动态：从亚细胞可视化到可穿戴传感

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-06-23 DOI: 10.1016/j.aac.2026.06.008

Yaming Liu, Xue Wang, Hao Wang, Ying Xu, Anjing Liao, Rasha H. Ahmed, Abdallah S. Ali, Hossam S. El-Beltagi, Yangyang Gao, Jian Wu

引用次数: 0

Discovery of novel plant immune-priming compounds through WRKY45 promoter-based chemical screening 通过基于WRKY45启动子的化学筛选发现新的植物免疫启动化合物

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-02-05 DOI: 10.1016/j.aac.2026.02.005

Yao Sun, Ruiming Zhang, Yanan He, Yaping Li, Yongbin Peng, Chongke Zheng, Lixia Xie, Conghui Jiang, Jinjun Zhou, Guanhua Zhou, Wei Sun, Guo-Bang Li, Qiaoxia Zhao, Haitao Yu, Shunbin Wang, Chang-Jie Jiang, Xianzhi Xie

{"title":"Discovery of novel plant immune-priming compounds through WRKY45 promoter-based chemical screening","authors":"Yao Sun, Ruiming Zhang, Yanan He, Yaping Li, Yongbin Peng, Chongke Zheng, Lixia Xie, Conghui Jiang, Jinjun Zhou, Guanhua Zhou, Wei Sun, Guo-Bang Li, Qiaoxia Zhao, Haitao Yu, Shunbin Wang, Chang-Jie Jiang, Xianzhi Xie","doi":"10.1016/j.aac.2026.02.005","DOIUrl":"10.1016/j.aac.2026.02.005","url":null,"abstract":"<div><div>Plant activators enhance disease resistance by priming host immunity, offering a sustainable alternative or complement to conventional pesticides. To advance this field, we established a high-throughput screening platform based on activation of the rice <em>WRKY45</em> promoter, a central regulator of disease resistance. From a library of 80,232 compounds, we identified five novel plant immune-priming compounds (PIPC1–5) that significantly enhanced resistance to rice blast caused by <em>Magnaporthe oryzae</em> following seed or foliar application. These PIPCs showed no direct antifungal activity, indicating that they act through activation of host defense responses. The PIPCs also conferred broad-spectrum resistance to rice bacterial blight (<em>Xanthomonas oryzae pv. oryzae</em>), rice false smut (<em>Ustilaginoidea virens</em>), pepper spotted wilt (tomato spotted wilt virus), and downy mildew of Chinese cabbage (<em>Hyaloperonospora brassicae</em>). Notably, PIPCs lack the thiazole ring characteristic of classical salicylic acid (SA) pathway activators such as probenazole and benzothiadiazole, representing a novel chemical scaffold. Mechanistically, the PIPCs primed rice seedlings to establish immune memory by acting either upstream or downstream of SA synthesis, thereby accelerating defense gene induction upon subsequent pathogen challenge. These findings expand the repertoire of immune-priming agents for managing diverse and evolving crop pathogens.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 349-363"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isosteric ring exchange: Design and synthesis of phenylpyrazole derivatives with insecticidal activity 等构环交换：具有杀虫活性的苯吡唑衍生物的设计与合成

IF 9.2

Advanced Agrochem Pub Date : 2026-09-01 Epub Date: 2026-02-02 DOI: 10.1016/j.aac.2026.02.001

Yong-chao Gao, He Hong, Liping Du, Yongtao Cui, Zheng Sun, Guangkai Yao, Hanhong Xu

{"title":"Isosteric ring exchange: Design and synthesis of phenylpyrazole derivatives with insecticidal activity","authors":"Yong-chao Gao, He Hong, Liping Du, Yongtao Cui, Zheng Sun, Guangkai Yao, Hanhong Xu","doi":"10.1016/j.aac.2026.02.001","DOIUrl":"10.1016/j.aac.2026.02.001","url":null,"abstract":"<div><div>The development of novel phenylpyrazole insecticides is essential for managing pest resistance. Nicofluprole, a phenylpyrazole insecticide, serves as a valuable lead compound for structural optimization due to its insecticidal activity. In this study, a series of phenylpyrazole derivatives was designed and synthesized <em>via</em> an isosteric ring exchange strategy, in which the 2-chloropyridine ring of nicofluprole was replaced with substituted phenyl rings. The corresponding compounds exhibited good insecticidal activity against <em>Plutella xylostella</em>, and compounds <strong>9q</strong> and <strong>9r</strong> showed LC<sub>50</sub> values of 0.49 and 0.20 mg/L, respectively. Structure-activity relationship (SAR) analysis indicated that electron-withdrawing substituents on the phenyl ring were associated with enhanced insecticidal activity. Density functional theory (DFT) calculations and molecular docking studies were conducted to investigate the electronic properties and potential binding modes of representative compounds. The results provide mechanistic insight into how ring replacement and phenyl substitution modulate insecticidal activity within the phenylpyrazole scaffold.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"5 3","pages":"Pages 306-312"},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0