Advanced Agrochem最新文献

Discovery of 4-Hydroxyphenylpyruvate dioxygenase inhibitors with novel pharmacophores 发现具有新药理作用的 4-羟基苯基丙酮酸二氧酶抑制剂

Advanced Agrochem Pub Date : 2024-09-19 DOI: 10.1016/j.aac.2024.09.004

Tai-Li Yang , Jin Dong , Xin-Long Wang , Jiangqing Dong , Hong-Yan Lin

{"title":"Discovery of 4-Hydroxyphenylpyruvate dioxygenase inhibitors with novel pharmacophores","authors":"Tai-Li Yang , Jin Dong , Xin-Long Wang , Jiangqing Dong , Hong-Yan Lin","doi":"10.1016/j.aac.2024.09.004","DOIUrl":"10.1016/j.aac.2024.09.004","url":null,"abstract":"<div><div>4-Hydroxyphenylpyruvate dioxygenase (HPPD) is pivotal in tyrosine metabolism and essential for plant survival. Its inhibition leads to leaf bleaching and plant death. While current HPPD inhibitors are effective, they pose phytotoxicity risks and may contribute to herbicide resistance. Here, we investigated the inhibitory potential of sethoxydim and atovaquone, which traditionally target acetyl-CoA carboxylase and the cytochrome <em>bc</em>1 complex, respectively. Both atovaquone and the degradation product of sethoxydim exhibited moderate HPPD inhibitory activity. But the mechanism by which sethoxydim inhibited HPPD remained unclear. Therefore, we embarked on an investigation into the crystal structure of the complex, with the aim of elucidating its precise binding mode. Our findings revealed that sethoxydim degrades in solution, producing dealkoxy sethoxydim as the active component in HPPD inhibition. Structural analysis elucidated the binding modes of atovaquone and dealkoxy sethoxydim with HPPD. These binding motifs represent novel pharmacophores and offer promising leads for developing HPPD inhibitors with improved pesticidal profiles.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 344-350"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis and bioactivity of cyclic dinucleotides against Lepidoptera insects 针对鳞翅目昆虫的环状二核苷酸的设计、合成和生物活性

Advanced Agrochem Pub Date : 2024-09-04 DOI: 10.1016/j.aac.2024.09.002

Zhiqiang Xie , Sijing An , Dejun Ma , Zhen Xi

{"title":"Design, synthesis and bioactivity of cyclic dinucleotides against Lepidoptera insects","authors":"Zhiqiang Xie , Sijing An , Dejun Ma , Zhen Xi","doi":"10.1016/j.aac.2024.09.002","DOIUrl":"10.1016/j.aac.2024.09.002","url":null,"abstract":"<div><div>Cyclic dinucleotides (CDNs) play important physiological roles in bacteria, mammals and insects as a novel class of signaling molecules. However, the application of CDNs in agricultural pest control has not been reported yet. To explore the potential bioactivity of CDNs on agricultural pests, we synthesized ten kinds of CDNs containing adenine and guanine bases with different internucleotide linkages (3′,3′; 2′,3′; 2′,2′). The target CDNs were used to determine the antifeedant and insecticidal activity against common Lepidoptera pests including <em>S. frugiperda, M. separata,</em> and <em>H. armigera</em>. The bioassay tests indicated that 3′,3′-<em>c</em>-di-AMP showed the highest antifeedant activity (EC<sub>50</sub> = 0.59 mg/L) against <em>M. separata</em> larvae among all the tested CDNs. Regarding insecticidal activity, 2′,3′-<em>c</em>-di-AMP showed higher insecticidal activity against <em>M. separata</em> larvae with LC<sub>50</sub> of 55.4 mg/L. RNA-seq further revealed that 3′,3′-<em>c</em>-di-AMP and 2′,3′-<em>c</em>-di-AMP exhibited a significant effect on the growth and development process of insects. More importantly, the bioactivity of 3′,3′-<em>c</em>-di-AMP was also closely correlated with the stimulation of insect immune inflammation. These results indicated that cyclic dinucleotides can affect the normal physiological process of insects, providing a new direction for managing pests.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 337-343"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nature: Zinc-mediated regulation of nitrogen fixation through transcription factor filamentation in legumes 自然豆科植物中锌通过转录因子丝状化调控固氮作用

Advanced Agrochem Pub Date : 2024-08-02 DOI: 10.1016/j.aac.2024.07.008

Le Yu, Ying Zhou

引用次数: 0

Antimicrobial metabolites produced by the plant growth-promoting rhizobacteria (PGPR): Bacillus and Pseudomonas 植物生长促进根瘤菌（PGPR）产生的抗菌代谢物：芽孢杆菌和假单胞菌

Advanced Agrochem Pub Date : 2024-07-25 DOI: 10.1016/j.aac.2024.07.007

Yiheng Wang, Yongfu Pei , Xin Wang , Xiongfeng Dai, Manlu Zhu

{"title":"Antimicrobial metabolites produced by the plant growth-promoting rhizobacteria (PGPR): Bacillus and Pseudomonas","authors":"Yiheng Wang, Yongfu Pei , Xin Wang , Xiongfeng Dai, Manlu Zhu","doi":"10.1016/j.aac.2024.07.007","DOIUrl":"10.1016/j.aac.2024.07.007","url":null,"abstract":"<div><p>Plant growth-promoting rhizobacteria (PGPR) such as <em>Bacillus</em> and <em>Pseudomonas</em> have drawn broad attention and interest due to their agricultural benefits. One of the major benefits of PGPR lies at their biocontrol capabilities against various plant pathogens. The biocontrol capability of PGPR is closely related to its capability of producing various kinds of antimicrobial substances. Major antimicrobial secondary metabolites secreted by PGPR include non-ribosomal lipopeptides (NRLPs), polyketides, ribosomal peptides, phenazines, pyrrolnitrins, <em>etc</em>. This review focuses on the major antimicrobial secondary metabolites produced by <em>Bacillus</em> and <em>Pseudomonas</em> including their classifications, structures, mechanisms of action and genetic regulations. We have also discussed their applications in plant biocontrol and provided insights into future development of improved biocontrol strains using synthetic biology approaches.</p></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 3","pages":"Pages 206-221"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773237124000583/pdfft?md5=c1df4bed0939dbcac0be8a5537d9d581&pid=1-s2.0-S2773237124000583-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Agrochem Pub Date : 2024-07-24 DOI: 10.1016/j.aac.2024.07.006

Agus Wedi Pratama, Bambang Piluharto, Nurul Widiastuti, Melbi Mahardika

引用次数: 0

Ethylene and jasmonate as stimulants of latex yield in rubber trees (Hevea brasiliensis): Molecular and physiological mechanisms. A systematic approximation review 乙烯和茉莉酸作为橡胶树（Hevea brasiliensis）乳胶产量的促进剂：分子和生理机制。系统近似综述。

Advanced Agrochem Pub Date : 2024-07-17 DOI: 10.1016/j.aac.2024.07.003

Nixon Florez-Velasco , Vanessa Florez Ramos , Stanislav Magnitskiy , Helber Balaguera-López

{"title":"Ethylene and jasmonate as stimulants of latex yield in rubber trees (Hevea brasiliensis): Molecular and physiological mechanisms. A systematic approximation review","authors":"Nixon Florez-Velasco , Vanessa Florez Ramos , Stanislav Magnitskiy , Helber Balaguera-López","doi":"10.1016/j.aac.2024.07.003","DOIUrl":"10.1016/j.aac.2024.07.003","url":null,"abstract":"<div><div>The rubber tree <em>Hevea brasiliensis</em> (Willd. Ex Adr. De Juss.) Müell Arg.] is an important source of latex for the production natural rubber. Natural rubber is an important biopolymer used in various industries, but aspects related to hormonal regulation in biosynthesis are still unknown, which would allow optimizing its production. We review the molecular and physiological mechanisms of increases latex regeneration and flow by the stimulation of rubber trees with exogenous applications of ethylene and jasmonate. We found that the increase in latex regeneration by ethylene is due to the increase in gene level expression and enzymatic activity of key photosynthesis and glycolysis enzymes for the generation of precursors in the first phase of rubber biosynthesis. Latex flow is supported by up-regulated genes in sucrose metabolism such as invertases, induction of sucrose transporters (SUT), and aquaporins (PIP) to maintain flow and turgor pressure in laticifers. Meanwhile, the increase in latex yield mediated by jasmonate may be due to the induction of laticifer differentiation in the long term and in the short term be mediated by the induction of small rubber particles (SRPP) as non-enzymatic cofactors in the production of latex. This information contributes to the knowledge of latex biosynthesis, which allows for a greater support for the exogenous application of jasmonates and ethylene to regulate its production.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 279-288"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scenario-oriented nanopesticides: Shaping nanopesticides for future agriculture 以情景为导向的纳米农药：为未来农业打造纳米农药

Advanced Agrochem Pub Date : 2024-07-16 DOI: 10.1016/j.aac.2024.07.002

Wenjie Shangguan , Huiping Chen , Pengyue Zhao, Chong Cao, Manli Yu, Qiliang Huang, Lidong Cao

{"title":"Scenario-oriented nanopesticides: Shaping nanopesticides for future agriculture","authors":"Wenjie Shangguan , Huiping Chen , Pengyue Zhao, Chong Cao, Manli Yu, Qiliang Huang, Lidong Cao","doi":"10.1016/j.aac.2024.07.002","DOIUrl":"10.1016/j.aac.2024.07.002","url":null,"abstract":"<div><div>Nanopesticides, as a promising technology, bring scientific and technological impetus to sustainable development and green revolution of agriculture. The excellent physicochemical properties, beneficial biological effects, and functional potential of nanopesticides have significantly contributed to improving utilization rates of pesticides, enhancing pest and disease management, and alleviating stresses. However, agricultural production and plant cultivation are diverse, leading to a wide range of application scenarios for pesticides. These application scenarios put forward more precise requirements and numerous innovative opportunities for the development of nanopesticides. Scenario-oriented nanopesticides are customized for various application scenarios and methods, aligning with the principles of economical, efficient, and sustainable future agriculture. This article outlines the development status of nanopesticides and then reviews the research progress of scenario-oriented nanopesticides, encompassing nine major application scenarios. Finally, the development priorities and prospects of scenario-oriented nanopesticides are summarized, offering innovative concepts for advancement of nanopesticides.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"3 4","pages":"Pages 265-278"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mold, yeast and phage contamination of yogurt collected from North of Iran, measurement of their potent natamycin preservative 评估从伊朗北部采集的酸奶中的霉菌、酵母菌和噬菌体污染情况，测定其有效的纳他霉素防腐剂

Advanced Agrochem Pub Date : 2024-07-01 DOI: 10.1016/j.aac.2024.07.001

Roghayeh Rezaeimalidareh, Mohammad Ahmadi, S. Shahidi, Sahar Aghamirzaei

引用次数: 0

Practical method for the large-scale synthesis of 4′-chloro-2-nitrobiphenyl: A key intermediate of Boscalid 大规模合成 4′-氯-2-硝基联苯的实用方法：Boscalid 的关键中间体

Advanced Agrochem Pub Date : 2024-06-29 DOI: 10.1016/j.aac.2024.06.002

You Chen, Tong Meng, Rui Guo, Zhaoru Liu, Sixuan Meng, Jian Chen, Guang-Ao Yu

引用次数: 0

AI-driven drug discovery from natural products 人工智能驱动的天然产品药物研发

Advanced Agrochem Pub Date : 2024-06-25 DOI: 10.1016/j.aac.2024.06.003

Feng-Lei Duan , Chun-Bao Duan , Hui-Lin Xu , Xin-Ying Zhao , Otgonpurev Sukhbaatar , Jie Gao , Ming-Zhi Zhang , Wei-Hua Zhang , Yu-Cheng Gu

引用次数: 0