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Toxicological response and bioaccumulation of strontium in Triticum durum (Nachit) and Triticum aestivum (Ibtissam)
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.08.001
Ayyoub Ammar , Zineb El Mouridi , Asmae Nouira , Said Boughribil
{"title":"Toxicological response and bioaccumulation of strontium in Triticum durum (Nachit) and Triticum aestivum (Ibtissam)","authors":"Ayyoub Ammar ,&nbsp;Zineb El Mouridi ,&nbsp;Asmae Nouira ,&nbsp;Said Boughribil","doi":"10.1016/j.aac.2024.08.001","DOIUrl":"10.1016/j.aac.2024.08.001","url":null,"abstract":"<div><div>The present study examines the toxicological effects and bioaccumulation of strontium (Sr<sup>2+</sup>) in two Moroccan wheat species, <em>Triticum durum</em> (Nachit) and <em>Triticum aestivum</em> (Ibtissam). Germination rates and seedling growth parameters were evaluated under Sr<sup>2+</sup> concentrations of 0, 10, 100, and 1000 mM. Results revealed a significant decline in germination rates as Sr<sup>2+</sup> concentrations increased, with <em>T. aestivum</em> showing higher sensitivity compared to <em>T. durum</em>. Low Sr<sup>2+</sup> concentrations (10 mM) initially promoted stem growth in <em>T. aestivum</em>, but growth declined sharply at higher concentrations. Both species sustained growth at moderate Sr<sup>2+</sup> concentrations (100 mM), but experienced a substantial reduction at 1000 mM, with <em>T. durum</em> demonstrating slightly better tolerance. Elevated Sr<sup>2+</sup> concentrations notably affected root length and stem branching, indicating severe phytotoxic effects. Enzyme activity assays showed that at low Sr<sup>2+</sup> concentration (10 mM), GST, CAT, POD, and SOD activities were similar to the control. At moderate concentrations (100 mM), GST and POD activities increased, suggesting enhanced detoxification. At high concentrations (1000 mM), all enzyme activities were significantly elevated, reflecting a robust antioxidative defense mechanism. This study provides valuable insights into the toxicological impacts and physiological responses of these wheat species to Sr<sup>2+</sup> stress.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 49-58"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for previous published articles
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.11.004
{"title":"Erratum for previous published articles","authors":"","doi":"10.1016/j.aac.2024.11.004","DOIUrl":"10.1016/j.aac.2024.11.004","url":null,"abstract":"","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Page 97"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key players in plant defense: How scaffold protein GAME15 orchestrates the biosynthesis of steroidal defense metabolite
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.11.008
Shengmei Kang , Feng Wang
{"title":"Key players in plant defense: How scaffold protein GAME15 orchestrates the biosynthesis of steroidal defense metabolite","authors":"Shengmei Kang ,&nbsp;Feng Wang","doi":"10.1016/j.aac.2024.11.008","DOIUrl":"10.1016/j.aac.2024.11.008","url":null,"abstract":"<div><div>GAME15, a scaffold protein, orchestrates the biosynthesis of steroidal glycoalkaloids (a class of compounds with known defensive properties) and steroidal saponins (which contribute to plant defense) in <em>Solanaceae</em> plants, essential for their defense mechanisms. By assembling key enzymes at the endoplasmic reticulum, GAME15 ensures efficient metabolite production, preventing toxic intermediate diffusion. This breakthrough in plant defense biosynthesis opens opportunities for metabolic engineering, enabling the production of valuable metabolites in non-native hosts and offering potential strategies for crop protection, reducing the need for chemical pesticides.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 10-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell: Dual-functional ABCH transporter lit the light for pesticide discovery
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2025.01.005
Jiangqing Dong
{"title":"Cell: Dual-functional ABCH transporter lit the light for pesticide discovery","authors":"Jiangqing Dong","doi":"10.1016/j.aac.2025.01.005","DOIUrl":"10.1016/j.aac.2025.01.005","url":null,"abstract":"<div><div>Pesticides play a pivotal role in modern agriculture. However, the pesticide industry faces significant challenges closely linked to major global concerns such as pesticide resistance, environmental pollution, food safety, and crop yields. Developing safe, efficient, and environmentally friendly pesticides has become a key challenge for the industry. Recently, Qing Yang and colleagues unveiled the mode of action of a dual-functional protein, the ABCH transporter, which plays essential roles in lipid transport to construct the lipid barrier of insect cuticles and in pesticide detoxification within insects. Since ABCH transporters are critical for all insects but absent in mammals and plants, this elegant and exciting work provides a highly promising target for developing safe, low-resistance pesticides. Here, we highlight the groundbreaking discoveries made by Qing Yang's team in unraveling the intricate mechanisms of the ABCH transporter.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 8-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The isolation, identification and efficacy of Bacillus velezensis XF-8 in tomato bacterial wilt control
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.08.002
Jiawei Xu , Jiatong Jiang , Zhiye Song , Junhuang Hong , Tongchao Zhao , Kaiwen Wu , Xueping Guo , Zhi Chen , Xiong Guan , Xiaohong Pan
{"title":"The isolation, identification and efficacy of Bacillus velezensis XF-8 in tomato bacterial wilt control","authors":"Jiawei Xu ,&nbsp;Jiatong Jiang ,&nbsp;Zhiye Song ,&nbsp;Junhuang Hong ,&nbsp;Tongchao Zhao ,&nbsp;Kaiwen Wu ,&nbsp;Xueping Guo ,&nbsp;Zhi Chen ,&nbsp;Xiong Guan ,&nbsp;Xiaohong Pan","doi":"10.1016/j.aac.2024.08.002","DOIUrl":"10.1016/j.aac.2024.08.002","url":null,"abstract":"<div><div>Tomato bacterial wilt is an important disease caused by <em>Ralstonia solanacearum</em>, which is harmful to the development of tomato industry and seriously affects the yield and quality of tomato. In this study, the strain XF-8 with antagonism against <em>R</em>. <em>solanacearum</em> was isolated from soil and identified as <em>Bacillus velezensis</em>, and its control effect on tomato bacterial wilt was better than that of kasugamycin. The disease index of tomato plants treated with XF-8 was significantly reduced (<em>P</em> &lt; 0.05) in the pot experiment, and the control effect was 74.25 %, which was higher than 45.11 % of kasugamycin treatment group. The antibacterial activity of lipopeptide extract from the fermentation supernatant of strain XF-8 was further verified, and then the inhibitory rate of the substance at the concentration of 1 mg/mL was as high as 96.20 %. The microscopic investigations indicated that the surface of <em>R</em>. <em>solanacearum</em> was wrinkled and deformed after treating with lipopeptide extract, and most of the bacteria were dead and rupture of the cell membrane, which leading to the cell death. Meanwhile, the active oxygen was produced and the lipopeptide extract could also significantly induced DNA injuries of <em>R</em>. <em>solanacearum</em>. All these results confirmed that the isolated strain <em>B. velezensis</em> exhibited excellent effect of preventing and controlling the tomato bacterial wilt. Moreover, XF-8 strain has high inhibitory effect on 10 types of pathogenic fungi, which shows broad-spectrum bacteriostasis. This study provides a theoretical basis and strain resources for the development and application of biopesticides, and broadened the potential biocontrol value of <em>B</em>. <em>velezensis</em>.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 59-69"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery of NH4+‒N and PO43-‒P is Promoted by competitive interactions between M. aeruginosa and MgCO3
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.09.001
Lihong Qin , Jianbo Cao , Dengyue Zheng , Guimin Tian , Chunli Chen
{"title":"Recovery of NH4+‒N and PO43-‒P is Promoted by competitive interactions between M. aeruginosa and MgCO3","authors":"Lihong Qin ,&nbsp;Jianbo Cao ,&nbsp;Dengyue Zheng ,&nbsp;Guimin Tian ,&nbsp;Chunli Chen","doi":"10.1016/j.aac.2024.09.001","DOIUrl":"10.1016/j.aac.2024.09.001","url":null,"abstract":"<div><div>Here we report that the presence of MgCO<sub>3</sub> stimulates the extracellular polymeric substance (EPS) secretion of <em>Microcystis Aeruginosa</em> (<em>M</em>. <em>Aeruginosa</em>). This stimulation led to a significant reduction in the total concentration of NH<sub>4</sub><sup>+</sup>‒N by more than 86%, and effective recovery of PO<sub>4</sub><sup>3-</sup>‒P within three days from concentrated wastewater (WW), although the secreted EPS inhibited the conversion of MgCO<sub>3</sub> to specific crystal forms (MgNH<sub>4</sub>PO<sub>4</sub>.6H<sub>2</sub>O or MgHPO<sub>4</sub>.7H<sub>2</sub>O). Moreover, with an increase in PO<sub>4</sub><sup>3−</sup> concentration in WW, these crystals appeared, thus the removal of NH<sub>4</sub><sup>+</sup>‒N and PO<sub>4</sub><sup>3-</sup>‒P nutrients can be attributed to the combined effect of <em>M. Aeruginosa</em> and MgCO<sub>3</sub>. We used Surface-Enhanced Raman Spectroscopy (SERS) combined with X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (FESEM-EDS), and X-ray Photoelectron Spectroscopy (XPS) to investigate the mechanism for competitive interactions between <em>M. Aeruginosa</em> and MgCO<sub>3</sub> in removing NH<sub>4</sub><sup>+</sup>‒N and PO<sub>4</sub><sup>3-</sup>‒P. We identified that the bound EPS accumulated amorphous Mg–P–O dense particles on <em>M. Aeruginosa</em>, while soluble EPS, containing –COOH groups of humic-like substances decreased the pH of the solution and coordinated with Mg<sup>2+</sup> ions. Therefore, both secreted bound and soluble EPS play a vital role in hindering the transformation of Mg<sup>2+</sup> ions or MgCO<sub>3</sub> to MgNH<sub>4</sub>PO<sub>4</sub>.6H<sub>2</sub>O or MgHPO<sub>4</sub>.7H<sub>2</sub>O crystals within WW, and they enhanced <em>M. Aeruginosa</em> 's ability in absorbing nutrients of NH<sub>4</sub><sup>+</sup>‒N and PO<sub>4</sub><sup>3-</sup>‒P. This mechanism plays a crucial role in the efficient recovery of NH<sub>4</sub><sup>+</sup>‒N and PO<sub>4</sub><sup>3-</sup>‒P from concentrated wastewater sources such as aerobically or anaerobically digested effluent from various sources like agriculture, livestock, and domestic wastewaters.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 70-77"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plants self-synthesize “agrochemical” to fight pests and diseases
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.11.002
Xue Yin, Yahui Li
{"title":"Plants self-synthesize “agrochemical” to fight pests and diseases","authors":"Xue Yin,&nbsp;Yahui Li","doi":"10.1016/j.aac.2024.11.002","DOIUrl":"10.1016/j.aac.2024.11.002","url":null,"abstract":"<div><div>In this article, we present recent findings from a Nature Chemical Biology paper that elucidate the mechanism of crucial biosynthetic steps involved in the synthesis of steroidal glycoalkaloids (SGAs), an important defense substance in a variety of <em>Solanum</em> plants. The enzyme GAME12, identified in <em>Solanum lycopersicum</em>, has evolved from the ancestral GABA enzyme through gene duplication events. Notably, GAME12 has acquired a neofunctional capability, undergoing modifications in both active site specificity and subcellular localization. This shift allows for a transition from its foundational role in core metabolism to its involvement in specialized metabolic pathways. The distinctive function of transamination enables the incorporation of nitrogen atoms into the backbones of steroidal specialized metabolites during the later stages of SGA biosynthesis, resulting in the production of nitrogen-containing antinutrients. This research underscores the significance of hijacking shunt enzymes from core metabolic pathways to facilitate the biosynthesis of nitrogen-containing steroidal glycoalkaloids, thereby enhancing the defensive mechanisms of <em>Solanum</em> species against pests and diseases.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 5-7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of novel pyridine-based agrochemicals: A review
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.10.002
Vladimir V. Zakharychev , Andrey M. Martsynkevich
{"title":"Development of novel pyridine-based agrochemicals: A review","authors":"Vladimir V. Zakharychev ,&nbsp;Andrey M. Martsynkevich","doi":"10.1016/j.aac.2024.10.002","DOIUrl":"10.1016/j.aac.2024.10.002","url":null,"abstract":"<div><div>Pyridine-based agrochemical products have become the most commercially successful in the 21st century. About half of the agrochemicals with pyridine scaffold were released, registered or invented only in the current millennium. Some of them have a unique structure and previously unknown modes of action. The literature provides examples of the use of the pyridine ring in pesticides for reducing the dosage of the active ingredient, hence to take care of the environment due to their increased efficacy, overcoming the pest resistance, and also makes it possible to create patentable structures by dodging the parent patent, which sometimes leads to a change in the spectrum of activity of the compounds. The newest 13 substances registered by the ISO from January 2021 to June 2024, and not reviewed previously are considered.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 30-48"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migrated silicon dioxide nanoparticles activates the rice immunity for systemic resistance against two pathogens
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.11.001
Nawei Tan , Wei Yuan , Yi Xu , Jingyue Wang , Bin Yuan , Heqiang Huo , Wenxiu Qiu , Ying Zhou
{"title":"Migrated silicon dioxide nanoparticles activates the rice immunity for systemic resistance against two pathogens","authors":"Nawei Tan ,&nbsp;Wei Yuan ,&nbsp;Yi Xu ,&nbsp;Jingyue Wang ,&nbsp;Bin Yuan ,&nbsp;Heqiang Huo ,&nbsp;Wenxiu Qiu ,&nbsp;Ying Zhou","doi":"10.1016/j.aac.2024.11.001","DOIUrl":"10.1016/j.aac.2024.11.001","url":null,"abstract":"<div><div>Rice, the world's primary staple food, is under severe threat from several devastating diseases. To sustainably management rice diseases, developing safe, environmentally friendly alternatives urgently need to be developed. In this study, we synthesized two silicon dioxide nanoparticles, spherical mesoporous silica nanoparticles (MSNs) and virus-like mesoporous silica nanoparticles (VMSNs), and we performed a resistance assay on rice for two major diseases, bacterial blight caused by <em>Xanthomonas oryzae</em> pv. <em>oryzae</em> and sheath blight caused by <em>Rhizoctonia solani</em>. Compared to the control, the two nanoparticle treatments increased rice resistance, with VMSNs exhibiting the highest efficacy in controlling these two diseases, causing a shorter lesion length than those plants treated by MSNs. Coincidentally, the foliar application of VMSNs activates a higher expression level of several pathogenesis-related (<em>PR</em>) genes compared to those of MSNs and SiO<sub>2</sub> treatment. By using fluorescein isothiocyanate (FITC)-labeled VMSNs (VMSNs-FITC) to soak the top expanded leaf tips or roots, we observed that the fluorescence of the nanoparticles firstly accumulated at the local site of the top leaves or roots, rapidly migrated to the hypocotyl of rice, and then redistributed sequentially from the bottom leaves to the upper leaves. Furthermore, the foliar or root application of VMSNs-FITC could trigger the local and systemic resistance to PXO99. Notably, no significant toxicity was observed on plants and mice after excessive foliar treatment or feeding tests, respectively. Overall, our research revealed that VMSNs are an effective, systemic, and safe nano-pesticides for controlling rice diseases. Boosting the immune responses may be associated with the transporting of nanoparticles.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 78-89"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments in the synthesis of pharmacological alkyl phosphonates 药用烷基膦酸盐合成的最新进展
Advanced Agrochem Pub Date : 2025-03-01 DOI: 10.1016/j.aac.2024.07.005
Chenglong Xuan , Zhimin Zhu , Ziyang Li , Chao Shu
{"title":"Recent developments in the synthesis of pharmacological alkyl phosphonates","authors":"Chenglong Xuan ,&nbsp;Zhimin Zhu ,&nbsp;Ziyang Li ,&nbsp;Chao Shu","doi":"10.1016/j.aac.2024.07.005","DOIUrl":"10.1016/j.aac.2024.07.005","url":null,"abstract":"<div><div>Organophosphate analogues are commonly occurring structural features that are widely present in numerous natural substances, biologically active molecules and modern pharmaceutical compounds. The development of efficient strategies for the preparation of these analogues is still attractive but challenging in organophosphorus chemistry. In order to fill this gap, different new routes have been discovered including direct phosphonylation of alkyl radicals, indirect Arbuzov phosphonylation of alkyl radicals and nucleopilic phosphonylation of phosphorus. In this short review, we have attempted to summarize these recent developments for the synthesis of alkyl phosphonates in order to facilitate the development of green pharmacological alkyl phosphonates by emphasizing their variety of products, specificity and relevance, and providing the underlying mechanistic rationale whenever it is possible. We aim to provide readers with a comprehensive understanding of the current state of this field and contribute to future research.</div></div>","PeriodicalId":100027,"journal":{"name":"Advanced Agrochem","volume":"4 1","pages":"Pages 13-29"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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