IF 1.4 4区化学

Chimia Pub Date : 2026-03-25 DOI: 10.2533/chimia.2026.138

Joanna Bonnici, Christopher J Schofield, Akane Kawamura

引用次数: 0

Editorial. 社论。

IF 1.6 4区化学

Chimia Pub Date : 2026-03-25 DOI: 10.2533/chimia.2026.105

Claudia Höbartner, Uwe Grether

引用次数: 0

Nanopore Studies of DNA Damage and G-quadruplex Folding in the Human Telomere Sequence. 人类端粒序列中DNA损伤和g -四重折叠的纳米孔研究。

IF 1.4 4区化学

Chimia Pub Date : 2026-03-25 DOI: 10.2533/chimia.2026.120

Aaron M Fleming, Cynthia J Burrows

{"title":"Nanopore Studies of DNA Damage and G-quadruplex Folding in the Human Telomere Sequence.","authors":"Aaron M Fleming, Cynthia J Burrows","doi":"10.2533/chimia.2026.120","DOIUrl":"10.2533/chimia.2026.120","url":null,"abstract":"The bacterial pore-forming toxin α-hemolysin has dimensions appropriate for capture and translocation of DNA strands in a single-molecule electrophoresis experiment. We used the nanopore's properties to study G-quadruplex unfolding in the human telomere repeat sequence with and without the presence of DNA lesions introduced into either the GGG tracks of a potential G-quadruplex (via oxidation) or the TTA loops (via photodimerization). Different topological folds of the G-quadruplex could be distinguished by either their current-time signatures or by their unfolding rates when a dA25 tail was added. Another more compact four-stranded structure, the i-motif, was also studied and found to be exceptionally well folded and stable inside the nanopore cavity. Comparisons are made between early studies with a home-built nanopore device vs. the currently available instrument from Oxford Nanopore Technologies (ONT), showing that we approach, but do not yet achieve, single-molecule sequencing of DNA damage sites in human telomere repeats. These studies aid in our understanding of the structure and dynamics of non-canonically folded DNA, its behaviour in crowded environments that mimic intracellular conditions, and the ability to use nanopore sequencing to identify DNA damage sites in this oxidation-prone segment of the genome.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"80 3","pages":"120-124"},"PeriodicalIF":1.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemistry of Combustion-generated Nanoparticles and their Transformation in Particle Filters. 燃烧生成纳米颗粒的化学性质及其在颗粒过滤器中的转化。

IF 1.4 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.51

Norbert Heeb, Joachim Mohn, Adrian Wichser, Markus Zennegg, Kerstin Zeyer

引用次数: 0

Airborne Ultrafine Particles: Real-life Exposure Patterns, Epidemiological Evidence and Regulatory Responses in Switzerland and Beyond. 空气中的超细颗粒：现实生活中的暴露模式，流行病学证据和瑞士及其他地区的监管反应。

IF 1.4 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.64

Marloes Eeftens, Eric P Twomey, Fiona Streit, Martin Röösli

引用次数: 0

Swiss Made Measurement Techniques for Carbonaceous Aerosols. 瑞士制造的碳质气溶胶测量技术。

IF 1.6 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.21

Alejandro Keller, Heinz Burtscher, Ernest Weingartner

{"title":"Swiss Made Measurement Techniques for Carbonaceous Aerosols.","authors":"Alejandro Keller, Heinz Burtscher, Ernest Weingartner","doi":"10.2533/chimia.2026.21","DOIUrl":"https://doi.org/10.2533/chimia.2026.21","url":null,"abstract":"Carbonaceous aerosols (CA) represent a chemically and physically diverse class of airborne particles. Their relevance for climate and health is significant, but poorly understood. Conventional metrics, such as particulate matter (PM10 or PM2.5), are insufficient to capture their impact. More specific indicators, such as elemental and organic carbon (EC and OC) and equivalent black carbon (eBC), often suffer from methodological artefacts, limited compatibility, and insufficient time resolution. In this work, we present an overview of the techniques and measurement systems developed by members of our group at FHNW for improved in situ quantification and characterization of CA. Photoemission-based sensors provide a real-time signal that serves as a proxy for particle-bound polycyclic aromatic hydrocarbons (PAHs), which include well known carcinogenic substances. Photothermal methods, such as photothermal interferometry (PTI) and photoacoustic spectroscopy (PAS), are used for direct observation of light absorption - an optical property directly linked to climate effects - without artefacts inherent to filter-based measurements. The fast thermal carbon totalizator (FATCAT) provides robust, unattended measurement of total carbon with high time resolution and generates fast-thermograms that reveal volatility and refractivity. Collectively, these methods address key limitations of current CA monitoring and support the long-term goal of integrating relevant metrics into air quality monitoring and climate observation networks.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"80 1-2","pages":"21-28"},"PeriodicalIF":1.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial. 社论。

IF 1.6 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.5

Loretta Müller, Heinz Burtscher, Norbert Heeb

引用次数: 0

Aviation Particulate Matter Emissions Research in Switzerland: History and Milestones to Date. 瑞士航空微粒物质排放研究：历史和至今的里程碑。

IF 1.6 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.36

Jacinta Edebeli, Lukas Durdina, Benjamin T Brem, Theo Rindlisbacher

引用次数: 0

Retrospective on the Introduction of Particle Filters to Eliminate Emissions of Nanoparticles from Engine Exhaust Gas. 微粒过滤器的引入以消除发动机废气中的纳米颗粒排放的回顾。

IF 1.6 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.41

Andreas Mayer, Max Wyser, Jan Czerwinski, Thomas Lutz, Friedrich Legerer, François Jaussi, Norbert Heeb

{"title":"Retrospective on the Introduction of Particle Filters to Eliminate Emissions of Nanoparticles from Engine Exhaust Gas.","authors":"Andreas Mayer, Max Wyser, Jan Czerwinski, Thomas Lutz, Friedrich Legerer, François Jaussi, Norbert Heeb","doi":"10.2533/chimia.2026.41","DOIUrl":"https://doi.org/10.2533/chimia.2026.41","url":null,"abstract":"The particle filter for most diesels and some petrol categories is now state of the art. The worldwide population is estimated to be >250 million vehicles with filters. The nanoparticle concentration in ambient air is thus reduced in Switzerland to one third of the status of 2005 and worldwide premature deaths by traffic related ambient air is reduced by >2 million cases annually. This success story started in 1995 when SUVA, the Swiss occupation health authority, had to guarantee safety and health in the world's largest railway transalpine tunnelling system, NEAT, scheduled to be built from the year 2000. The solution was VERT certified diesel particle filters (DPFs) on all engines without any exceptions. Transfer to other applications and other countries, however, had to overcome serious resistance of industry and politics which delayed the process remarkably until filters became mandatory by the EU-legislation 2011. The decisive element was the introduction of the particle number (PN) limit for solid particles of sizes 10-500 nm in place of particulate matter (PM) mass in 1995. Many vehicles are still waiting for filters worldwide and the effect of this highly effective and cost-efficient tool on health and global warming could be more than tripled.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"80 1-2","pages":"41-50"},"PeriodicalIF":1.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction in Nanoparticle Physics with a Focus on Combustion-derived Particles. 纳米粒子物理学介绍，重点是燃烧衍生的粒子。

IF 1.6 4区化学

Chimia Pub Date : 2026-02-25 DOI: 10.2533/chimia.2026.8

Heinz Burtscher

引用次数: 0

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