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Solvent Selection for Circular Designs - Bridging Process Needs and Sustainability Goals. 循环设计的溶剂选择-衔接工艺需求和可持续性目标。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.606
Michael U Luescher, Alessia Valotta, Julien Haber, Fabrice Gallou
{"title":"Solvent Selection for Circular Designs - Bridging Process Needs and Sustainability Goals.","authors":"Michael U Luescher, Alessia Valotta, Julien Haber, Fabrice Gallou","doi":"10.2533/chimia.2025.606","DOIUrl":"10.2533/chimia.2025.606","url":null,"abstract":"<p><p>Pharmaceutical industries play a crucial role in enhancing global health outcomes; however, like many other sectors, they also encounter significant environmental challenges. The extraction of raw materials and the manufacture of active pharmaceutical ingredients (APIs) result in considerable waste production, substantial resource consumption, and environmental pollution. Transitioning from traditional linear economic models to circular processes presents an opportunity for more sustainable pharmaceutical operations that benefit both communities and the environment. The circular economy framework - grounded in resource efficiency, waste minimization, and material regeneration - offers a path towards comprehensive sustainability in pharmaceutical practices. This is particularly relevant in the area of solvent usage, which accounts for over half the input mass and associated waste in most processes. This article examines the application of circular economy principles to solvent selection within process design, highlighting its significance as a central component of sustainable pharmaceutical development.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"606-613"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride. 以Isatin衍生物和甘氨酸酯盐酸盐为原料，可见光诱导一锅法合成螺环丙基氧吲哚。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.639
Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen
{"title":"Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride.","authors":"Subhankar Bera, Tejas Prabakar, Khushi Verma, Subhabrata Sen","doi":"10.2533/chimia.2025.639","DOIUrl":"https://doi.org/10.2533/chimia.2025.639","url":null,"abstract":"<p><p>An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin derivatives) to afford diastereomeric mixtures of spirocyclopropyl oxoindoles in toluene at room temperature is presented. Spirocyclopropyl oxoindoles are interesting building blocks prevalent in many active pharmaceutical ingredients and in natural products. This protocol is devoid of any metal catalysts or bases.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"639-643"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing the Production of Therapeutic Bacteriophages Through Quality by Design: A Case Study on Pseudomonas Aeruginosa. 通过质量设计优化治疗性噬菌体的生产——以铜绿假单胞菌为例。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.644
Carmen Jungo, Samuel Garcia, Jean-François Brunet, Grégory Resch
{"title":"Optimizing the Production of Therapeutic Bacteriophages Through Quality by Design: A Case Study on <i>Pseudomonas Aeruginosa</i>.","authors":"Carmen Jungo, Samuel Garcia, Jean-François Brunet, Grégory Resch","doi":"10.2533/chimia.2025.644","DOIUrl":"10.2533/chimia.2025.644","url":null,"abstract":"<p><p>A Failure Modes and Effects Analysis (FMEA) risk assessment was conducted to evaluate and document the criticality of process parameters and material attributes involved in a Pseudomonas aeruginosa phage production process. This assessment was carried out following the principles of Quality by Design (QbD) as outlined by the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use. By systematically identifying and controlling critical factors, this approach contributes to the development of a more robust and reproducible phage production process, ultimately enhancing process efficiency and product quality.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"644-649"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalization of Quinones by Green Methods. 醌类化合物的绿色官能化。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.630
Sarban Kumar Yadav, Bhawana Nagar, Basab Bijayi Dhar
{"title":"Functionalization of Quinones by Green Methods.","authors":"Sarban Kumar Yadav, Bhawana Nagar, Basab Bijayi Dhar","doi":"10.2533/chimia.2025.630","DOIUrl":"https://doi.org/10.2533/chimia.2025.630","url":null,"abstract":"<p><p>Quinone motifs play a crucial role in a wide range of living organisms, including bacteria, fungi, higher plants, and some animals. They are also present in numerous natural pigments. This review summarizes recent advances in the direct functionalization of quinones using green methods. Green synthesis of quinones employs environmentally sustainable strategies such as solvent-free microwave-assisted techniques, photoredox catalysis, and electrochemical oxidation, etc. These approaches aim to minimize hazardous waste generation and energy consumption, offering a cleaner alternative to conventional synthetic methods.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"630-638"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging Innovation and Efficiency: The Promises and Challenges of Self-Driving Labs as Sustainable Drivers for Chemistry. 桥接创新与效率：自动驾驶实验室作为化学可持续驱动力的承诺与挑战。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.600
Florian A Formica, Edlyn Wu, Lucien Brey, Daniel Pacheco Gutiérrez, Riccardo Barbano, Hermann Tribukait, José Miguel Hernández-Lobato, Paco Laveille, Loïc M Roch
{"title":"Bridging Innovation and Efficiency: The Promises and Challenges of Self-Driving Labs as Sustainable Drivers for Chemistry.","authors":"Florian A Formica, Edlyn Wu, Lucien Brey, Daniel Pacheco Gutiérrez, Riccardo Barbano, Hermann Tribukait, José Miguel Hernández-Lobato, Paco Laveille, Loïc M Roch","doi":"10.2533/chimia.2025.600","DOIUrl":"https://doi.org/10.2533/chimia.2025.600","url":null,"abstract":"<p><p>Self-driving laboratories (SDLs) are reshaping scientific discovery by combining robotics, artificial intelligence (AI), and data science to automate the full Design-Make-Test-Analyze (DMTA) cycle. This review highlights how SDLs address the inefficiencies of traditional trial-and-error methods through intelligent, autonomous experimentation. We explore key advances in AI, automation, and data infrastructure, as well as the remaining technical challenges. Applications across organic synthesis, materials science, and biotechnology (e.g. such as catalytic reaction optimization, solid-state synthesis, and protein engineering) demonstrate their transformative potential. A recurring theme is the role of SDLs in promoting sustainability by miniaturizing reactions and maximizing sample efficiency through AI and machine learning. Finally, we discuss the requirements for broader adoption, including robust hardware, interoperable software, and high-quality datasets, positioning SDLs as essential tools for next-generation sustainable research.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"600-605"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis of Stereodefined Tri- and Tetrasubstituted Alkenes via 100% Atomeconomic and Regio-, and Stereoselective Halo-chalcogenation and Sulfonylation of Alkynes. 100%原子经济性、区域选择性和立体选择性卤代和磺化合成立体三取代和四取代烯烃的绿色合成。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.622
Appanapalli N V Satyanarayana, Tanmay Chatterjee
{"title":"Green Synthesis of Stereodefined Tri- and Tetrasubstituted Alkenes <i>via</i> 100% Atomeconomic and Regio-, and Stereoselective Halo-chalcogenation and Sulfonylation of Alkynes.","authors":"Appanapalli N V Satyanarayana, Tanmay Chatterjee","doi":"10.2533/chimia.2025.622","DOIUrl":"https://doi.org/10.2533/chimia.2025.622","url":null,"abstract":"<p><p>Achieving 100% atom economy in an organic transformation is a challenging task but it is always desirable in the context of green chemistry. Difunctionalization of alkynes using a bifunctional reagent is a useful strategy to achieve 100% atom economy, however, the challenge is to control the regio- and stereoselectivity of the reaction. In this article, we discuss the recent advances in developing 100% atom economic, highly regio- and stereoselective halo-chalcogenation and chlorosulfonylation strategies with alkynes for the green and sustainable synthesis of stereodefined tri- or tetrasubstituted alkenes, and its application in accessing valuable molecules including a marketed drug in a green and sustainable manner. The green chemistry metrics are presented to highlight the greenness of some of these protocols.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"622-629"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial. 社论。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.597
Ludovic Gremaud, Fabrice Gallou
{"title":"Editorial.","authors":"Ludovic Gremaud, Fabrice Gallou","doi":"10.2533/chimia.2025.597","DOIUrl":"https://doi.org/10.2533/chimia.2025.597","url":null,"abstract":"","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"597"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanochemical Degradation of Active Pharmaceutical Ingredients (APIs): A Simple Tool for the Prediction of Drug Stability. 有效药物成分（api）的机械化学降解：预测药物稳定性的简单工具。
IF 1.6 4区 化学
Chimia Pub Date : 2025-09-10 DOI: 10.2533/chimia.2025.614
Ulrike Holzgrabe, Helmut Buschmann, Norbert Handler, Mostafa M Amer, Renè Hommelsheim, Torsten Beweries, Carsten Bolm
{"title":"Mechanochemical Degradation of Active Pharmaceutical Ingredients (APIs): A Simple Tool for the Prediction of Drug Stability.","authors":"Ulrike Holzgrabe, Helmut Buschmann, Norbert Handler, Mostafa M Amer, Renè Hommelsheim, Torsten Beweries, Carsten Bolm","doi":"10.2533/chimia.2025.614","DOIUrl":"10.2533/chimia.2025.614","url":null,"abstract":"<p><p>Knowledge of the potential degradation products of active pharmaceutical ingredients (APIs) is of major interest for the development and approval of new drugs. Therefore, methodologies for the time-efficient and precise prediction of degradation products and pathways are of great importance. Traditional degradation assessments typically involve solution-based forced degradations under acidic, basic, thermal, or photolytic conditions. However, such conditions often fail to accurately replicate degradation pathways relevant to solid-state formulations. A promising addition to the established solvent-based approaches are forced degradation processes in the solid-state using mechanochemistry. The newly developed methodologies enable a time-efficient and accurate simulation of degradation pathways under mild reaction conditions in the solid-state. Herein, the general principles of forced mechanochemical degradations will be discussed on the basis of published case studies involving marketed drugs.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 9","pages":"614-621"},"PeriodicalIF":1.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fascinating Ambimobile Aryldiones in Crop Protection: Managing Grass Weeds and Harmful Sucking Insects. 迷人的芳香二酮在作物保护：管理杂草和有害的吸吮昆虫。
IF 1.6 4区 化学
Chimia Pub Date : 2025-08-20 DOI: 10.2533/chimia.2025.499
Michel Muehlebach
{"title":"Fascinating Ambimobile Aryldiones in Crop Protection: Managing Grass Weeds and Harmful Sucking Insects.","authors":"Michel Muehlebach","doi":"10.2533/chimia.2025.499","DOIUrl":"https://doi.org/10.2533/chimia.2025.499","url":null,"abstract":"<p><p>This review examines the innovation journeys, developments, and properties of two ambimobile crop protection compounds containing a 2-aryl-1,3-dione pharmacophoric motif: pinoxaden for post-emergence broad-spectrum grass weed control in cereals, and spiropidion for protecting multiple crops against damaging and difficult to control piercing and sucking pests. Both active ingredients function as propesticides, hydrolyzing in planta to release their bioactive aryldione forms, which inhibit acetyl-CoA carboxylase and disrupt fatty acid metabolism. As weak acids with specific physicochemical properties, these aryl cyclic diones demonstrate ambimobility in plants, enabling them to access both long-distance translocation pathways in plant vasculature, xylem, and phloem. This systemic translocation is crucial for both herbicidal and insecticidal applications.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 7-8","pages":"499-508"},"PeriodicalIF":1.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced Wastewater Treatment by Ozonation for Abatement of Micropollutants from Municipal Wastewater Effluents. 臭氧氧化深度处理城市污水中微污染物的研究。
IF 1.6 4区 化学
Chimia Pub Date : 2025-08-20 DOI: 10.2533/chimia.2025.491
Urs Von Gunten, Christa S McArdell, Christian Abegglen, Marc Böhler, Juliane Hollender, Adriano Joss, Hansruedi Siegrist
{"title":"Advanced Wastewater Treatment by Ozonation for Abatement of Micropollutants from Municipal Wastewater Effluents.","authors":"Urs Von Gunten, Christa S McArdell, Christian Abegglen, Marc Böhler, Juliane Hollender, Adriano Joss, Hansruedi Siegrist","doi":"10.2533/chimia.2025.491","DOIUrl":"https://doi.org/10.2533/chimia.2025.491","url":null,"abstract":"<p><p>Municipal wastewater treatment plants are important contributors to the discharge of micropollutants to the aquatic environment. Therefore, in Switzerland it has been decided to treat the water at these point sources to reduce the discharge of micropollutants from municipal wastewater effluents. A team of scientists at Eawag has evaluated treatment options, which need to be readily available, easily applicable, and cheap. Based on a rigorous assessment, activated carbon-based processes and ozonation were selected. In this paper the focus is on ozonation, and the different aspects of its application are discussed, including kinetics and mechanisms for ozone reactions with micropollutants and matrix components, formation, and fate of transformation products in biological post-filtration and toxicological aspects. Finally, upgrading of ozonation is described including outreach of this approach to other countries.</p>","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 7-8","pages":"491-498"},"PeriodicalIF":1.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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