Chimia最新文献_第2页

Portable and Handheld Raman Instruments Open a Multitude of Applications.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.46

Christoph Jansen

{"title":"Portable and Handheld Raman Instruments Open a Multitude of Applications.","authors":"Christoph Jansen","doi":"10.2533/chimia.2025.46","DOIUrl":"https://doi.org/10.2533/chimia.2025.46","url":null,"abstract":"Fundamental science can sometimes take a long time until it is useful for practical applications, as was the case for Raman spectroscopy. For a long time, it lacked powerful excitation sources and sensitive detectors. However as technology evolved, the number of exciting applications has boomed. Modern Raman spectroscopy has significant advantages, especially in sample preparation. Handheld Raman devices can be very compact and therefore be easily taken to the sample instead of bringing the sample to the lab. Non-destructive measurements obviously are important in gemmology and mineralogy, even in space. In the field of archaeology, pigments in precious ancient paintings, scrolls or books can be identified. This application is also used to identify fraud and falsification and in studies from a medical school they have reported that Raman spectroscopy can be applied to distinguish cancerous tissue from healthy tissue. Due to the mobility and ruggedness of the handheld hardware, Raman spectroscopy can be used for police, firefighters, and military applications for identification of explosives and illicit drugs or warfare substances. With SERS (Surface Enhanced Raman Spectroscopy), Raman spectroscopy can even be used for trace analysis. The SERS effect enhances the sensitivity of the Raman signal by a factor of up to 107. This enables, for example, measuring pesticide residuals on fruit or vegetable surfaces for food safety. It can also be used to identify traces of drugs, e.g. in urine. However, one of the most common Raman-applications is the identity check or verification of incoming goods (RMID) in the pharma industries, directly in the warehouse. Users appreciate the ease of use and the ruggedness of the Raman hardware.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 1-2","pages":"46-51"},"PeriodicalIF":1.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Paper Diagnostics: A Brief History and Future Perspectives.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.29

Nathan Khosla, Andrew DeMello, Daniel Richards

{"title":"On Paper Diagnostics: A Brief History and Future Perspectives.","authors":"Nathan Khosla, Andrew DeMello, Daniel Richards","doi":"10.2533/chimia.2025.29","DOIUrl":"https://doi.org/10.2533/chimia.2025.29","url":null,"abstract":"For centuries, diagnostic technologies have played a key role in medicine. Effective diagnostics can help clinicians identify the presence and extent of disease in their patients, as well as their general health. Precipitated by advances in biochemistry, chemistry, and engineering, the 20th and 21st centuries have witnessed rapid advancement in diagnostic technologies. However, these improvements have brought increased complexity and a corresponding move towards more centralized and specialized laboratories. This has led to significant healthcare disparities between high- and low/middle-income regions. However, with the introduction of paper-based diagnostics this paradigm has begun to shift, with new assay formats designed for point-of-care (PoC) or at-home use. By leveraging innovations from multiple fields, these paper-based tests can translate complex assay procedures into easy-to-use, single-step tests for the end user. In this review, we summarize the interdisciplinary beginnings of paper-based diagnostics, detailing their development through market introduction and commercial successes, and discuss the current state-of-the-art. Finally, we highlight areas for improvement and propose pathways that could enable increasingly complex chemistries to be performed on simple paper-based devices.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 1-2","pages":"29-35"},"PeriodicalIF":1.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extending Resonant Inelastic X-ray Scattering to Extreme Ultraviolet.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.25

Samuel Menzi, Fabio La Mattina, Francesco Barbato, Yunieski Arbelo Pena, Sven Augustin, Gregor Knopp, Marcello Coreno, Stefano Orlando, Monica De Simone, Paolo Miotti, Fabio Frassetto, Luca Poletto, Davide Bleiner, Claudio Cirelli

引用次数: 0

Life Detection Beyond Earth: Laser-Based Mass Spectrometry for Organics Detection on Solar System Objects.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.70

Andreas Riedo, Nikita J Boeren, Peter Keresztes Schmidt, Marek Tulej, Peter Wurz

{"title":"Life Detection Beyond Earth: Laser-Based Mass Spectrometry for Organics Detection on Solar System Objects.","authors":"Andreas Riedo, Nikita J Boeren, Peter Keresztes Schmidt, Marek Tulej, Peter Wurz","doi":"10.2533/chimia.2025.70","DOIUrl":"https://doi.org/10.2533/chimia.2025.70","url":null,"abstract":"The detection and identification of the building blocks of life, from amino acids to more complex molecules such as certain lipids, is a crucial but highly challenging task for current and future space exploration missions in our Solar System. To date, Gas Chromatography Mass Spectrometry has been the main technology applied. Although it has shown excellent performance in laboratory research, it has not yet been able to provide a conclusive answer regarding the presence or absence of a signature of life, extinct or extant, in space exploration. In this contribution we present the current measurement capabilities of our space prototype laser-based mass spectrometer for organics detection. The developed mass spectrometer currently allows the detection and identification of small organic molecules, such as amino acids and nucleobases, at sample concentrations at the level of femtomole mm-2, using the same measurement protocol. The latter is highly relevant to space exploration, since with the instrumentation in use so far only one class of organics can be measured with one instrument configuration.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 1-2","pages":"70-76"},"PeriodicalIF":1.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Potential of Browser- Based Scientific Data Analysis: A 20-Year Journey of Expertise.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.66

Luc Patiny

引用次数: 0

The openBIS Digital Platform for Instrumentation and Data Workflow in the Analytical Laboratory.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.36

Yousuf Hemani, Kilian Koch, Oscar Mendo-Diaz, Anusch Bachhofner, Simone Baffelli, Davide Bleiner

{"title":"The openBIS Digital Platform for Instrumentation and Data Workflow in the Analytical Laboratory.","authors":"Yousuf Hemani, Kilian Koch, Oscar Mendo-Diaz, Anusch Bachhofner, Simone Baffelli, Davide Bleiner","doi":"10.2533/chimia.2025.36","DOIUrl":"https://doi.org/10.2533/chimia.2025.36","url":null,"abstract":"The management of scientific data plays a key role in all research areas and has increased in importance. Providing researchers with customizable data management tools is crucial for effectively managing data according to the FAIR principles. These principles have been defined by Wilkinson et al. in 2016, which describe how scientific data should be managed.[1] To support the specific needs of researchers at Empa, openBIS[2] was chosen as a FAIR compliant data management platform. OpenBIS is an Electronic Laboratory Notebook (ELN) and Laboratory Information Management System (LIMS) developed at ETH. The commissioning of this platform for the case of an analytical chemistry lab presented multiple challenges. In this paper, solutions to adapt openBIS as a digital platform to integrate the laboratory data workflow in chemical analysis and for spectroscopy instruments are presented. Two laboratory projects as case studies are described, consisting of a data pipeline and a complex dashboard for data collection, visualization and interaction. These examples show a successful integration of the data management platform in accordance with the FAIR data guidelines along with maximizing efficiency for laboratory personnel.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 1-2","pages":"36-45"},"PeriodicalIF":1.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Nanoscale Chemical Analysis using Tip-Enhanced Raman Spectroscopy.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.52

Siiri Bienz, Chengcheng Xu, Yuanzhi Xia, Anushree Dutta, Renato Zenobi, Naresh Kumar

{"title":"Advancements in Nanoscale Chemical Analysis using Tip-Enhanced Raman Spectroscopy.","authors":"Siiri Bienz, Chengcheng Xu, Yuanzhi Xia, Anushree Dutta, Renato Zenobi, Naresh Kumar","doi":"10.2533/chimia.2025.52","DOIUrl":"https://doi.org/10.2533/chimia.2025.52","url":null,"abstract":"Tip-enhanced Raman spectroscopy (TERS) has established itself as a powerful tool in nanoscale chemical analysis, providing unprecedented spatial resolution with high molecular sensitivity and chemical specificity. TERS employs localized surface plasmon resonance at the apex of a sharp scanning probe microscopy tip to overcome the diffraction limit inherent in conventional Raman spectroscopy, achieving spatial resolutions down to the nanometer scale. In this article, we highlight major advancements in TERS over the past five years from our laboratory at ETH Zurich in the following key areas: heterogeneous catalysis, photovoltaic materials, biological membranes, and on-surface molecular assembly. Our recent studies demonstrate the unique capabilities of TERS for in situmonitoring of catalytic reactions, nanoscale mapping of phase behavior in biomembranes, and precise characterization of photovoltaic interfaces. Through these applications, we highlight the potential of TERS for addressing critical challenges across the chemical, biological, and materials sciences. This review serves as a guide for researchers aiming to harness TERS for label-free, non-destructive nanoanalysis to advance understanding of complex molecular materials and processes through ultrahigh sensitivity, specificity, and spatial resolution.","PeriodicalId":9957,"journal":{"name":"Chimia","volume":"79 1-2","pages":"52-59"},"PeriodicalIF":1.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miniaturization of MALDI Mass Spectrometers with the Technological Breakthrough of the Digital Ion Trap: Peptide and Protein Analysis in MS¹, MS^2, and MS³. 利用数字离子阱的技术突破实现 MALDI 质谱仪的微型化：MS1、MS2 和 MS3 中的肽和蛋白质分析。

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.12

Andreas Baumeister, Lyna Sellami, Shuichi Nakaya

引用次数: 0

Aerolysin Nanopores for Single-Molecule Analysis.

IF 1.1 4区化学

Chimia Pub Date : 2025-02-26 DOI: 10.2533/chimia.2025.18

Yun Zhang, Chan Cao

引用次数: 0

Mössbauer Spectroscopy as a Valuable Analysis Technique in Biomedical Research.