Chinese Herbal Medicines最新文献

{"title":"Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review","authors":"Lanying Zhang ,&nbsp;Xinrui Wang ,&nbsp;Jingze Zhang ,&nbsp;Dailin Liu ,&nbsp;Gang Bai","doi":"10.1016/j.chmed.2024.01.005","DOIUrl":"10.1016/j.chmed.2024.01.005","url":null,"abstract":"<div><p><em>Platycodonis Radix</em> (Jiegeng in Chinese) is a well-known traditional Chinese medicine used for both medicinal and culinary purposes. Its historical use as an antitussive and expectorant has been extensively documented. Researchers, to date, have identified 219 chemical constituents in <em>Platycodon grandiflorum</em> (Jacq.) A. DC, encompassing 89 saponins, 11 flavonoids, 21 polysaccharides, 14 phenolic acids, six polyacetylenes, five sterols, 34 fatty acids, 17 amino acids, and 22 trace elements. Jiegeng exhibits diverse pharmacological effects, including antitussive and anti-phlegm properties, anti-cancer activity, anti-inflammatory effects, immune regulation, antioxidant properties, anti-obesity, and antidiabetic effects. Additionally, Jiegeng shows potential in protecting the heart and liver. Beyond its medicinal benefits, Jiegeng is highly esteemed in culinary applications, and its global demand is on the rise. Its utilization has expanded beyond medicine and food to encompass daily necessities, cosmetics, agricultural supplies, and other fields. Currently, there are 18 272 patents related to <em>P. grandiflorum.</em> This comprehensive review summarizes the latest research published over the past 20 years, providing a robust foundation for further exploration of the medicinal and health benefits of <em>P. grandiflorum</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 327-343"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000406/pdfft?md5=81b1a4c46c1b7409e6f2332dc91f8e8b&pid=1-s2.0-S1674638424000406-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair","authors":"Junjie Li ,&nbsp;Ming Dong ,&nbsp;Qing Yao ,&nbsp;Xu Dong ,&nbsp;Yuanyuan Chen ,&nbsp;Jincai Wen ,&nbsp;Yingjie Xu ,&nbsp;Zhixin Wu ,&nbsp;Xiaomei Zhao ,&nbsp;Ye Xiu ,&nbsp;Xiaoyan Zhan ,&nbsp;Zhaofang Bai ,&nbsp;Xiaohe Xiao","doi":"10.1016/j.chmed.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.04.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;Acute lung injury (ALI) is characterized by inflammation and currently lacks an efficacious pharmacological intervention. The medicine combination of &lt;em&gt;Lonicerae Japonicae Flos&lt;/em&gt; (LJF) and &lt;em&gt;Forsythiae Fructus&lt;/em&gt; (FF) demonstrates combined properties in its anti-infective, anti-inflammatory, and therapeutic effects, particularly in alleviating respiratory symptoms. In previous studies, Chinese medicine has shown promising efficacy in lipopolysaccharides (LPS)-induced ALI. However, there have been no reports of LJF and FF pairing for lung injury. The aim of this study is to compare the efficacy of herb pair &lt;em&gt;Lonicerae Japonicae Flos&lt;/em&gt;-&lt;em&gt;Forsythiae Fructus&lt;/em&gt; (LF) with LJF or FF alone in the treatment of ALI, and to explore whether LJF and FF have a combined effect in the treatment of lung injury, along with the underlying mechanism involved.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;A total of 36 mice were divided into six groups (control, model, LJF, FF, LF, dexamethasone) based on the treatments they received after undergoing sham-operation/LPS tracheal instillation. H&amp;E staining and pulmonary edema indexes were used to evaluate lung injury severity. Alveolar exudate cells (AECs) were counted based on cell count in bronchoalveolar lavage fluid (BALF), and neutrophil percentage in BALF was measured using flow cytometry. Myeloperoxidase (MPO) activity in BALF was measured using enzyme-linked immunosorbent assay (ELISA), while the production of IL-1β, TNF-α, and IL-6 in the lung and secretion level of them in BALF were detected by quantitative polymerase chain reaction (qPCR) and ELISA. The effect of LJF, FF, and LF on the expression of Caspase-1 and IL-1β proteins in bone marrow derived macrophages (BMDMs) supernatant was assessed using Western blot method under various inflammasome activation conditions. In addition, the concentration of IL-1β and changes in lactatedehydrogenase (LDH) release levels in BMDMs supernatant after LJF, FF, and LF administration, respectively, were measured using ELISA. Furthermore, the effects of LJF, FF and LF on STING and IRF3 phosphorylation in BMDMs were detected by Western blot, and the mRNA changes of IFN-β, TNF-α, IL-6 and CXCL10 in BMDMs were detected by qPCR.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;LF significantly attenuated the damage to alveolar structures, pulmonary hemorrhage, and infiltration of inflammatory cells induced by LPS. This was evidenced by a decrease in lung index score and wet/dry weight ratio. Treatment with LF significantly reduced the total number of neutrophil infiltration by 75% as well as MPO activity by 88%. The efficacy of LF in reducing inflammatory factors IL-1β, TNF-α, and IL-6 in the lungs surpasses that of LJF or FF, approaching the effectiveness of dexamethasone. In BMDMs, the co-administration of 0.2 mg/mL of LJF and FF demonstrated superior inhibitory effects on the expression of nigericin-stimulated Caspase-1 and IL-1β, as well as the releas","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 3","pages":"Pages 422-434"},"PeriodicalIF":4.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S167463842400039X/pdfft?md5=991836f0d90df0541e74f54a21582387&pid=1-s2.0-S167463842400039X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China","authors":"Chunyan Guo ,&nbsp;Lingfei Wang ,&nbsp;Namuhan Chen ,&nbsp;Mingxu Zhang ,&nbsp;Junying Jia ,&nbsp;Lijuan Lv ,&nbsp;Minhui Li","doi":"10.1016/j.chmed.2023.04.002","DOIUrl":"10.1016/j.chmed.2023.04.002","url":null,"abstract":"<div><p>Traditional Chinese herbal medicines not only cure human diseases, but also play an important role as insecticides. Compared with conventional chemical agents, traditional Chinese herbal medicines are characterized by low toxicity, low residues, and being eco-friendly, and they have become a research hotspot. Traditional Chinese herbal medicines have tremendous flexibility and indefinite potential. Therefore, this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia, China, including their traditional uses, secondary metabolites, biological activities, action mechanisms, application methods, and development status. In addition, the most relevant issues involved in the development of traditional Chinese herbal medicines was discussed. We believe that traditional Chinese herbal medicines can be better implemented and developed; such that its other advantages, such as an insect repellent, can be promoted. Moreover, this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia, China.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 248-262"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S167463842300076X/pdfft?md5=54e01ba5fc1c8fc0a0d426ce0a67c9d1&pid=1-s2.0-S167463842300076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49275715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development","authors":"Liping Gong ,&nbsp;Hang Du ,&nbsp;Xin Guo ,&nbsp;Jianchao Li ,&nbsp;Xiaomin Zhu ,&nbsp;Xianhui Shen ,&nbsp;Zhiyan Huang ,&nbsp;Kaiyi Wu ,&nbsp;Guimin Zhang ,&nbsp;Rong Sun","doi":"10.1016/j.chmed.2023.05.006","DOIUrl":"10.1016/j.chmed.2023.05.006","url":null,"abstract":"<div><p>Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera. Its pathogenesis is conductive dysfunction of large intestine. Based on the theory, Shouhui Tongbian Capsule (SHTB) is composed of eight traditional Chinese medicines, including <em>Polygoni multiflori Radix</em> (Heshouwu in Chinese), <em>Aloe</em> (Luhui in Chinese), <em>Cassiae Semen</em> (Juemingzi in Chinese), <em>Ginseng Radix</em> et <em>Rhizoma</em> (Renshen in Chinese), <em>Lycii Fructus</em> (Gouqizi in Chinese), <em>Asini Corii Colla</em> (Ejiao in Chinese), <em>Aurantii Fructus Immaturus</em> (Zhishi in Chinese), and <em>Atractylodis Macrocephalae Rhizoma</em> (Baizhu in Chinese), which could help to release excessive turbid, and nourishing <em>yin</em> and supplementing <em>qi</em> in the treatment. This study has been carried out to review the latest advances of SHTB in the treatment of constipation. The results showed that significant effect of SHTB was found in the treatment of constipation, such as functional constipation, and constipation associated with tumor chemotherapy, colitis, type 2 diabetes and chronic cardiac failure. Besides, obvious adverse reactions were not observed. SHTB could effectively treat five types of constipation, provide direction for the future exploration of SHTB in the treatment of other types of constipation.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 239-247"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423001016/pdfft?md5=c9267d87e671fb0e3527725e7a8dd717&pid=1-s2.0-S1674638423001016-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New indole derivatives from endophytic fungus Colletotruchum sp. HK-08 originated from leaves of Nerium indicum","authors":"Huiqin Chen ,&nbsp;Hao Zheng ,&nbsp;Caihong Cai ,&nbsp;Hao Wang ,&nbsp;Cuijuan Gai ,&nbsp;Zhiqiong Tan ,&nbsp;Haofu Dai ,&nbsp;Wenli Mei","doi":"10.1016/j.chmed.2023.07.004","DOIUrl":"10.1016/j.chmed.2023.07.004","url":null,"abstract":"<div><h3>Objective</h3><p>To study secondary metabolites from endophytic fungus <em>Colletotruchum</em> sp. HK-08 originated from the leaves of <em>Nerium indicum</em>.</p></div><div><h3>Methods</h3><p>The compounds were isolated by various column chromatographic techniques, and their structures were elucidated by spectroscopic techniques [high resolution electrospray ionization mass spectroscopy (HRESIMS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance spectroscopy (NMR)], as well as comparison with literature data. The Ellman method was used to determine the acetylcholinesterase (AChE) inhibitory activity.</p></div><div><h3>Results</h3><p>Four indole derivatives were identified from <em>Colletotruchum</em> sp. HK-08, including 6<em>′-</em>hydroxymonaspiloindole (<strong>1</strong>), 2-(2-oxoindolin-3-yl)ethyl 2-(4-hydroxyphenyl) acetate (<strong>2</strong>), 2-(2-oxoindolin-3-yl)ethyl 2-(2-hydroxyphenyl)acetate (<strong>3</strong>), and monaspiloindole (<strong>4</strong>). Compound <strong>4</strong> presented weak AChE inhibitory activity with IC₅₀ value of (69.30 ± 6.27) μmol/L [tacrine as the positive control, with IC₅₀ value of (0.61 ± 0.07) μmol/L].</p></div><div><h3>Conclusion</h3><p>Compounds <strong>1–3</strong> were new compounds, and compound <strong>4</strong> had weak AChE inhibitory activity.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 235-238"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000054/pdfft?md5=3293dee1afdfcb765876b62d62f1c458&pid=1-s2.0-S1674638424000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of endophytic fungi in medicinal plant abiotic stress response and TCM quality development","authors":"Jiahao Zhang ,&nbsp;Jiemiao Lu ,&nbsp;Yichun Zhu ,&nbsp;Xiaoxia Shen ,&nbsp;Bo Zhu ,&nbsp;Luping Qin","doi":"10.1016/j.chmed.2023.02.006","DOIUrl":"10.1016/j.chmed.2023.02.006","url":null,"abstract":"<div><p>Medicinal plants, as medicinal materials and important drug components, have been used in traditional and folk medicine for ages. However, being sessile organisms, they are seriously affected by extreme environmental conditions and abiotic stresses such as salt, heavy metal, temperature, and water stresses. Medicinal plants usually produce specific secondary metabolites to survive such stresses, and these metabolites can often be used for treating human diseases. Recently, medicinal plants have been found to partner with endophytic fungi to form a long-term, stable, and win–win symbiotic relationship. Endophytic fungi can promote secondary metabolite accumulation in medicinal plants. The close relationship can improve host plant resistance to the abiotic stresses of soil salinity, drought, and extreme temperatures. Their symbiosis also sheds light on plant growth and active compound production. Here, we show that endophytic fungi can improve the host medicinal plant resistance to abiotic stress by regulating active compounds, reducing oxidative stress, and regulating the cell ion balance. We also identify the deficiencies and burning issues of available studies and present promising research topics for the future. This review provides guidance for endophytic fungi research to improve the ability of medicinal plants to resist abiotic stress. It also suggests ideas and methods for active compound accumulation in medicinal plants and medicinal material development during the response to abiotic stress.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 204-213"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000710/pdfft?md5=14b53ca680149d54acbcdf98f5332863&pid=1-s2.0-S1674638423000710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47973055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines","authors":"Yue Ouyang ,&nbsp;Qiqing Cheng ,&nbsp;Chunsong Cheng ,&nbsp;Ziyu Tang ,&nbsp;Yufeng Huang ,&nbsp;Eyu Tan ,&nbsp;Shaofeng Ma ,&nbsp;Xinheng Lin ,&nbsp;Ying Xie ,&nbsp;Hua Zhou","doi":"10.1016/j.chmed.2022.12.004","DOIUrl":"10.1016/j.chmed.2022.12.004","url":null,"abstract":"<div><p>Microbial resource influences the life activities of medicinal plants from several perspectives. Endophytes, rhizosphere microorganisms, and other environmental microorganisms play essential roles in medicinal plant growth and development, plant yield, and clinical efficacy. The microbiota can influence the biosynthesis of active compounds in medicinal plants by stimulating specific metabolic pathways. They induce host plants to improve their resistance to environmental stresses by accumulating secondary metabolites. Microorganisms can interact with their host plants to produce long-term, targeted selection results and improve their ability to adapt to the environment. Due to the interdependence and interaction between microorganisms and medicinal plants, Chinese herbal medicines (CHMs) quality is closely related to the associated microorganisms. This review summarizes the relationship between medicinal plants and their associated microorganisms, including their species, distribution, life activities, and metabolites. Microorganisms can aid in quality control, improve the efficacy of medicinal plants, and provide markers for identifying the origin and storage time of CHMs. Therefore, a comprehensive understanding of the relationship between microorganisms and medicinal plants will help to control the quality of CHMs from different perspectives.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 190-203"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000060/pdfft?md5=2537272de6b17f8e0511aff527932011&pid=1-s2.0-S1674638423000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41271564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective and challenges of mycorrhizal symbiosis in orchid medicinal plants","authors":"Chunyan Leng,&nbsp;Mengyan Hou,&nbsp;Yongmei Xing,&nbsp;Juan Chen","doi":"10.1016/j.chmed.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.chmed.2024.03.001","url":null,"abstract":"<div><p>The family Orchidaceae is of the most diverse taxon in the plant kingdom, and most of its members are highly valuable herbal medicines. Orchids have a unique mycorrhizal symbiotic relationship with specific fungi for carbohydrate and nutrient supplies in their whole lifecycle. The large-scale cultivation of the medicinal plant <em>Gastodia elata</em> is a successful example of using mycorrhizal symbiotic technology. In this review, we adopted <em>G. elata</em> and <em>Dendrobium officinale</em> as examples to describe the characteristics of orchid mycorrhiza and mycorrhizal benefits for host plants’ growth and health (e.g. biotic and abiotic stress and secondary metabolite accumulation). The challenges in applying mycorrhizal technology to the cultivation of orchid medicinal plants in the future were also discussed. This review aims to serve as a theoretical guide for the cultivation of mycorrhizal technology in medicinal orchid plants.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 172-179"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638424000133/pdfft?md5=1cc06da6f5ba4728bbb6777687d09e30&pid=1-s2.0-S1674638424000133-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new tetracyclic triterpenoid from endophytic fungus Fusarium sporotrichioides","authors":"Yajing Wang,&nbsp;Chunyue Liu,&nbsp;Yihui Yang,&nbsp;Chang Li,&nbsp;Yuehu Pei","doi":"10.1016/j.chmed.2022.10.007","DOIUrl":"10.1016/j.chmed.2022.10.007","url":null,"abstract":"<div><h3>Objective</h3><p>To isolate bioactive compounds from the endophytic fungus <em>Fusarium sporotrichioides</em> isolated from <em>Rauwolfia yunnanensis</em>, and investigate their pharmacological activities.</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated and purified by combining with ODS column chromatography, silica gel column chromatography and by performing semipreparative HPLC. Their structures were established on the basis of 1D NMR (¹H-NMR and ¹³C-NMR) and 2D NMR (¹H–¹H COSY, HSQC, HMBC and NOESY), as well as HRESIMS and comparison with literature data. In addition, the absolute configuration of compound <strong>1</strong> was determined by calculated ECD data.</p></div><div><h3>Results</h3><p>One previously undescribed tetracyclic triterpenoid derivative, named as integracide L (<strong>1</strong>), 12<em>α</em>-acetoxy-4,4-dimethyl-24-methylene-5<em>α</em>-cholesta-8,14-diene-2<em>α</em>,3<em>β</em>,11<em>β</em>-triol (<strong>2</strong>), 12<em>α</em>-acetoxy-4,4-dimethyl-24-methylene-5<em>α</em>-cholesta-8-momoene-2<em>α</em>,3<em>β</em>,11<em>β</em>-triol (<strong>3</strong>), 12<em>α</em>-acetoxy-4,4-dimethyl-24-methylene-5<em>α</em>-cholesta-8,14-diene-3<em>β</em>,11<em>β</em>-triol (<strong>4</strong>), and 12<em>α</em>-acetoxy-4,4-dimethyl-24-methylene-5<em>α</em>-cholesta-8-momoene-3<em>β</em>,11<em>β</em>-triol (<strong>5</strong>) were isolated from <em>F. sporotrichioide</em>. Moreover, compound <strong>1</strong> was rare tetracyclic triterpenoid with single methyl replacement at C-4 position.</p></div><div><h3>Conclusion</h3><p>Compound <strong>1</strong> was a new tetracyclic triterpenoid isolated from the endophytic fungus <em>F. sporotrichioides.</em> In addition, compound <strong>2</strong> could inhibit the growth of three different human cancer cells significantly. Compounds <strong>3</strong> and <strong>5</strong> were found to possess better cytotoxic activities on HepG-2 cells than the other compounds, with IC₅₀ values of (2.8 ± 0.1) and (6.3 ± 0.3) μmol/L respectively.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 231-234"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000497/pdfft?md5=c01ee69ebdd540fb5907795d661bfd93&pid=1-s2.0-S1674638423000497-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46201506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase","authors":"Chuan Tang,&nbsp;Rui Gao,&nbsp;Xiaoyuan Tang,&nbsp;Yu Zhang,&nbsp;Weixing Feng,&nbsp;Baomin Feng,&nbsp;Xuan Lu","doi":"10.1016/j.chmed.2022.12.009","DOIUrl":"10.1016/j.chmed.2022.12.009","url":null,"abstract":"<div><h3>Objective</h3><p>To study the compounds isolated from <em>Penicillium</em> HDS-Z-1E, an endophytic fungal strain isolated from <em>Taxus cuspidata</em> and their activation effect of catalase (CAT).</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated from <em>Penicillium</em> HDS-Z-1E, by using silica gel, Sephadex LH-20 and HPLC. The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including ¹H-NMR, ¹³C-NMR, HMBC and HSQC. Their activation sites of catalase have been investigated by molecular docking.</p></div><div><h3>Results</h3><p>Five metabolites, compounds (<strong>1</strong>–<strong>5</strong>) were isolated from <em>Penicillium</em> HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2<em>H</em>-pyran-2-one (<strong>1</strong>), 4-hydroxymethyl-5, 6-dihydro-pyran-2-one (<strong>2</strong>), 5, 6-dihydro-2-oxo-2<em>H</em>-pyran-4-carboxylic (<strong>3</strong>), <em>N</em>-acetyl-hydrazinobenzoic acid (<strong>4</strong>), and methyl 2-(2, 5-dihydroxyphenyl) acetate (<strong>5</strong>).</p></div><div><h3>Conclusion</h3><p>Compound <strong>3</strong> is a new compound. Compounds <strong>3</strong> and <strong>4</strong> may have potential activators of catalase, providing a theoretical basis for the development of CAT activators.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 2","pages":"Pages 227-230"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1674638423000515/pdfft?md5=33e6a3b81bc02850668e73681a37affc&pid=1-s2.0-S1674638423000515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48207504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}