Chinese Herbal Medicines最新文献

{"title":"Compound Danshen Dripping Pills combined with isosorbide mononitrate for angina pectoris: A systematic review and a Meta-analysis","authors":"Ru Wang,&nbsp;Jing Hu,&nbsp;Yuanyuan Li,&nbsp;Hong Yin","doi":"10.1016/j.chmed.2023.12.005","DOIUrl":"10.1016/j.chmed.2023.12.005","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of Compound Danshen Dripping Pills (CDDP) combined with isosorbide mononitrate (ISMN) versus ISMN alone for treating angina pectoris in patients.</div></div><div><h3>Methods</h3><div>The PubMed, Web of Science, Cochrane Library, Embase China National Knowledge Infrastructure, China Biomedical Literature Service System, Chinese Medical Journal Database, and Wan Fang MED databases were searched from inception to November 2022. Randomized controlled trials (RCTs) and cohort studies were included. The primary outcomes were angina symptom and electrocardiography (ECG) efficacy, angina symptom efficacy, and ECG efficacy. The protocol was registered with PROSPERO No. CRD42022314774.</div></div><div><h3>Results</h3><div>Our study included 7 245 patients with angina (59 RCTs, 11 cohort studies). When ISMN was combined with CDDP, the efficacy of angina symptom and ECG [odds ratio (OR) = 4.824, 95% confidence interval (CI) = 3.636–6.401, <em>P</em> = 0.000], the efficacy of angina symptom (OR = 4.347, 95% CI = 3.635–5.198, <em>P</em> = 0.000), the efficacy of ECG (OR = 3.364, 95% CI = 2.767–4.089, <em>P</em> = 0.000) were better than that of patients treated with ISMN alone. CDDP combined with ISMN was superior to ISMN alone in reducing triglyceride (TG) [mean difference (MD) =  −35.176, 95% CI =  −37.439 to −32.912, <em>P</em> = 0.000], total cholesterol (TC) (MD =  −24.296, 95% CI =  −26.429 to −22.163, <em>P</em> = 0.000), the duration of angina attack (MD =  −1.991, 95% CI =  −2.349 to −1.633, <em>P</em> = 0.000), and the frequency of angina attack [standardized MD (SMD) =  −2.840, 95% CI =  −3.416 to −2.265, <em>P</em> = 0.000]. There was no increase in adverse events between CDDP combined with ISMN and ISMN alone (OR = 0.513, 95% CI = 0.421–0.626, <em>P</em> = 0.000).</div></div><div><h3>Conclusion</h3><div>CDDP combined with ISMN improved treatment efficacy and was well tolerated. Therefore, this combination could be used as an alternative treatment. However, clinical and patient conditions should be considered.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 622-637"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on chemical diversity of saponins in Panax ginseng","authors":"Xiaoyu Geng ,&nbsp;Jia Wang ,&nbsp;Yuwei Liu ,&nbsp;Linxuan Liu ,&nbsp;Xuekun Liu ,&nbsp;Yan Zhao ,&nbsp;Cuizhu Wang ,&nbsp;Jinping Liu","doi":"10.1016/j.chmed.2024.08.005","DOIUrl":"10.1016/j.chmed.2024.08.005","url":null,"abstract":"<div><div>Saponins, the major bioactive components of <em>Panax ginseng</em> C. A. Mey., are gradually emerging as research hotspots owing to the possession of various pharmacological activities. This review updates the ginsenosides list from <em>P. ginseng</em> and the steam-processed ginseng (red ginseng and black ginseng) up to 271 by June of 2024, encompassing 243 saponins from different parts of <em>P. ginseng</em> (roots, stems, leaves, flowers, berries, and seeds), 103 from red ginseng, and 65 from black ginseng, respectively. Among 271 saponins, there are a total of 249 (<strong>1</strong>–<strong>249</strong>) dammarane type (with <strong><em>a</em></strong>–<strong><em>z</em></strong> subtypes) tetracyclic triterpene saponins reported from each part of <em>P. ginseng</em> and steam-processed ginseng, two (<strong>250</strong>–<strong>251</strong>) lanostane type tetracyclic triterpene saponins identified from red ginseng, 18 (<strong>252</strong>–<strong>269</strong>) oleanane type pentacyclic triterpenoid saponins discovered from each part of <em>P. ginseng</em> and steam-processed ginseng, and two (<strong>270</strong>–<strong>271</strong>) ursane type pentacyclic triterpenoid saponins reported from red ginseng. Overall, this review expounds on the chemical diversity of ginsenosides in various aspects, such as chemical structure, spatial distribution and subtype comparison, processed products, and transformation. This facilitates more in-depth research on ginsenosides and contributes to the future development of ginseng.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 529-547"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of steaming process on rare saponins and efficacy of Panax ginseng, Panax notoginseng and Panax quinquefolium","authors":"Wenjie Zhao ,&nbsp;Linlin Han ,&nbsp;Tao Li,&nbsp;Jungjoon Lee,&nbsp;Yuqing Zhao","doi":"10.1016/j.chmed.2024.07.003","DOIUrl":"10.1016/j.chmed.2024.07.003","url":null,"abstract":"<div><div>The steamed <em>Panax ginseng</em> C. A. Mey., <em>Panax notoginseng</em> (Burk.) F. H. Chen, and <em>Panax quinquefolium</em> L. not only facilitate storage, but also increase the content of rare saponins and enhance their clinical application value. The traditional steaming process has high energy consumption, low efficiency, and lacks standardized operating procedures and unified standards. This paper retrieves the research literature on the steaming process parameters, rare saponin increments, and efficacy enhancement results of ginseng plants. By summarizing the effects of different steaming processes on rare saponins and pharmacodynamics in <em>P. ginseng</em>, <em>P. notoginseng</em> and <em>P. quinquefolium</em>, we explored new steaming methods and established a new quality evaluation system to provide guarantee for the effectiveness and safety of clinical medication and provide scientific basis for its rational use.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 521-528"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of constipation with Aloe and its compatibility prescriptions","authors":"Xianhui Shen ,&nbsp;Liping Gong ,&nbsp;Rongrong Li ,&nbsp;Nana Huang ,&nbsp;Huijie Zhang ,&nbsp;Siyi Chen ,&nbsp;Ying Liu ,&nbsp;Rong Sun","doi":"10.1016/j.chmed.2024.07.005","DOIUrl":"10.1016/j.chmed.2024.07.005","url":null,"abstract":"<div><div>Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory. The pathogenesis of constipation is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang, with the syndrome being asthenia in origin and asthenia in superficiality. <em>Aloe</em> is a traditional Chinese medicine with cold properties and a bitter taste, and one of the most commonly used herbs for constipation. Based on <em>Aloe</em> and its monomer components, combined with the existing compatibility studies of <em>Aloe</em> and several Chinese patent drugs represented by <em>Aloe</em>, this paper comprehensively and systematically introduced the research progress of <em>Aloe</em> and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations, providing theoretical basis and medication guidance for the clinical rational application of <em>Aloe</em> and its prescriptions in the treatment of constipation. At the same time, it also provides the direction for future research on the mechanism of <em>Aloe</em> in the treatment of constipation.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 561-571"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology for traditional Chinese medicine in era of artificial intelligence","authors":"Weibo Zhao,&nbsp;Boyang Wang,&nbsp;Shao Li","doi":"10.1016/j.chmed.2024.08.004","DOIUrl":"10.1016/j.chmed.2024.08.004","url":null,"abstract":"<div><h3>Abstract</h3><div>Traditional Chinese Medicine Network Pharmacology (TCM-NP) is an interdisciplinary discipline that integrates information science, systems biology, network science and pharmacology, providing a systematic research methodology for TCM studies. With the development of artificial intelligence (AI) and multi-omics technologies, TCM-NP has entered a new era and can incorporate multimodal and high-dimensional data in the context of big data to enhance both theoretical foundations and technical capabilities. Despite its advancement, TCM-NP still faces challenges, particularly in ensuring the quality of data and research, as well as achieving more profound scientific discoveries. The field needs further innovation to obtain more precise and biomedically meaningful results. Overall research progress in TCM-NP depends on developing more accurate algorithms together with utilizing higher-quality and larger-scale data. This paper gives a perspective on the trends and characteristics of TCM-NP development and application in the era of AI.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 558-560"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating tradition and innovation: Health industry opportunities for ginseng with foods and medicines","authors":"Wei Li","doi":"10.1016/j.chmed.2024.09.007","DOIUrl":"10.1016/j.chmed.2024.09.007","url":null,"abstract":"","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 487-488"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui Granules","authors":"Qi Wang ,&nbsp;Yingxia Zhao ,&nbsp;Xuemei Qin ,&nbsp;Junsheng Tian","doi":"10.1016/j.chmed.2023.12.003","DOIUrl":"10.1016/j.chmed.2023.12.003","url":null,"abstract":"<div><h3>Objective</h3><div>To decipher the antidepression effect of Chaigui Granules (CGKL) from the relationship between depression and microbial molecules based on multi-omics.</div></div><div><h3>Methods</h3><div>Male SD rats were subjected to chronic unpredictable mild stress (CUMS) for seven weeks. The antidepressants CGKL extract and CGKL were administered for the following four weeks. The behavior test and the content of monoamine neurotransmitters were used to evaluate the efficacy of CGKL. The 16S rRNA sequencing, LC-MS technology and molecular biological techniques were used to explore the pharmacological mechanism of CGKL.</div></div><div><h3>Results</h3><div>CGKL treatment obviously alleviated the depressive behavioral indicators and regulated the content of monoamine neurotransmitters, and presented dose-dependent manner. CGKL could also improve the arginine metabolism disorder of gut microbiota in the jejunum. Meanwhile, the contents of arginine and its metabolites in the serum and hippocampus were regulated to normal levels. Further investigation indicated that the expression of related rate-limiting enzyme genes and proteins in the hippocampus was validated by qRT-PCR and Western blotting. The results showed that the gut microbiota, metabolites, and genes or proteins of rate-limiting enzymes involved in the arginine pathway were significantly regulated by CGKL.</div></div><div><h3>Conclusion</h3><div>The present study demonstrates that CGKL might exert antidepressant effects through regulating arginine metabolism, and its mechanism may be related to modulating the gut microbiota and related metabolic enzyme.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 612-621"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology","authors":"Yishu Liu ,&nbsp;Xue Li ,&nbsp;Chao Chen ,&nbsp;Nan Ding ,&nbsp;Shiyu Ma ,&nbsp;Ming Yang","doi":"10.1016/j.chmed.2023.09.008","DOIUrl":"10.1016/j.chmed.2023.09.008","url":null,"abstract":"<div><div>Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within the realm of traditional Chinese medicine (TCM), network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas. It facilitates the identification of potential active ingredients within these formulas, providing a comprehensive understanding of their holistic and systematic nature, which aligns with the holistic principles inherent in TCM theory. TCM formulas exhibit complexity due to their multi-component characteristic, involving diverse targets and pathways. Consequently, investigating their material basis and mechanisms becomes challenging. Network pharmacology has emerged as a valuable approach in TCM formula research, leveraging its holistic and systematic advantages. The manuscript aims to provide an overview of the application of network pharmacology in studying TCM formula compatibility rules and explore future research directions. Specifically, we focus on how network pharmacology aids in interpreting TCM pharmacological theories and understanding formula compositions. Additionally, we elucidate the process of utilizing network pharmacology to identify active ingredients within TCM formulas. These findings not only offer novel research models and perspectives for integrating network pharmacology with TCM theory but also present new methodologies for investigating TCM formula compatibility. All in all, network pharmacology has become an indispensable and crucial tool in advancing TCM formula research.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 572-588"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms","authors":"Yueqin Song ,&nbsp;Chen Chen ,&nbsp;Wei Li","doi":"10.1016/j.chmed.2024.09.006","DOIUrl":"10.1016/j.chmed.2024.09.006","url":null,"abstract":"<div><div>Cardiovascular and cerebrovascular diseases (CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the improvement of economic level and the change of human lifestyle, the prevalence of CCVDs continues to increase. <em>Ginseng</em> (<em>Panax ginseng</em> C. A. Mey.) was widely used in traditional diseases due to its supposed tonic properties. Ginsenoside Rb₁ (G-Rb₁) is the most abundant active ingredient with multiple pharmacological effects extracted from <em>ginseng</em>, which has been shown to have potential benefits on the cardiovascular system through a variety of mechanisms, including anti-oxidation, anti-inflammatory, regulation of vasodilation, reduction of platelet adhesion, influence of calcium ion channels, improvement of lipid distribution, involving in glucose metabolism and controlling blood sugar. This review reviewed the protective effects of G-Rb₁ on CCVDs and its potential mechanisms, such as atherosclerosis (AS), hypertension, coronary heart disease (CHD), ischemic stroke (IS) and periocular microvascular retinopathy. Finally, we reviewed and reported the results of <em>in vivo</em> and <em>in vitro</em> experiments using G-Rb₁ to improve CCVDs, highlighted its efficacy, safety, and limitations.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 489-504"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA metabarcoding uncovers fungal communities in Zingiberis Rhizoma","authors":"Chune Fan,&nbsp;Yanan Xu,&nbsp;Yufeng Li,&nbsp;Meihua Yang,&nbsp;Jianping Han,&nbsp;Xiaohui Pang","doi":"10.1016/j.chmed.2023.12.001","DOIUrl":"10.1016/j.chmed.2023.12.001","url":null,"abstract":"<div><h3>Objective</h3><div><em>Zingiberis Rhizoma</em> (ZR, Ganjiang in Chinese), also known as dried ginger, is a popular spice and medicinal herb that has been used for several thousand years. However, ZR is easily contaminated by fungi and mycotoxin under suitable conditions, and might be hazardous to the health and safety of consumers, thus concerns about the herb’s safety have been raised. The aim of this study was to investigate the fungal community and the effects of collection areas and processing methods on the fungal community in ZR.</div></div><div><h3>Methods</h3><div>A total of 18 ZR samples were collected from four provinces of China, and the samples were divided into four groups based on collecting sites. Meanwhile, the samples collected in Sichuan Province, China were divided into three groups based on the processing methods. We employed the Illumina MiSeq PE300 platform and targeted the internal transcribed spacer 2 (ITS2) sequences to investigate fungal contamination in ZR samples, and the difference in fungal community among the groups of different collection sites and processing methods.</div></div><div><h3>Results</h3><div>All 18 samples were contaminated with fungi. Ascomycota was the dominant phyla, accounting for 34.46%−100% of the fungal reads. At the genus level, <em>Candida</em>, <em>Diutina</em>, and <em>Aspergillus</em> were the most dominant genera, with relative abundances of 0–98.37%, 0–99.82%, and 0–79.08%, respectively. Meanwhile, four potential toxigenic fungi and seven human pathogens were found. Furthermore, differences in the community composition of ZR samples from four collecting sites and three processing methods were observed.</div></div><div><h3>Conclusion</h3><div>DNA metabarcoding provides a novel insight into fungal community diversity in ZR samples, providing references to ensure the sustainable utilization and quality research of ZR.</div></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"16 4","pages":"Pages 679-685"},"PeriodicalIF":4.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}