{"title":"Wie Chemie missbraucht werden kann: Illegale Drogen","authors":"Dieter Wöhrle","doi":"10.1002/ciuz.70026","DOIUrl":"https://doi.org/10.1002/ciuz.70026","url":null,"abstract":"<div>\u0000 \u0000 <p>The number of users of illegal drugs, which lead to serious psychological and physical damage, is alarmingly high. The high demand has created an illegal underground economy. This justifies dealing with these psychotropic substances. After a brief outlook on the history of biogenic drugs, the legal regulations concerning drugs and the manifold psychotropic effects are discussed. The article focuses on the preparation or production and effects of biogenic (cannabis/marijuana/hashish, cocaine, morphine/opium), semi-synthetic (heroin, LSD) and fully synthetic (cannabinoids, opioids, phenylalkylamines, cathinones, tryptamines, benzodiazepines, arylcyclohexylamines, GHB/GBL, alkylnitrite) drugs. Increasingly, however, previously unknown i.e. new drugs, known as designer drugs, are entering the illicit drug market.</p>\u0000 </div>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 2","pages":"70-86"},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sind Metalloxid-Cluster molekulare Modelle von Metalloxiden?","authors":"Ulrich Schubert","doi":"10.1002/ciuz.70036","DOIUrl":"https://doi.org/10.1002/ciuz.70036","url":null,"abstract":"<div>\u0000 \u0000 <p>When metal oxides are synthesized from molecular precursors, metal oxide clusters are obtained under certain reaction conditions. They can either be stabilized by negative surface charges (M–O<sup>−</sup> groups) or (mostly organic) ligands. Comparison of the structures shows that oxo clusters are no molecular models for metal oxides. The coordination polyhedra of the metals are interconnected in various ways, but different to the corresponding metal oxides. This results very frequently in very complex structures. Many clusters are modularly structured, which means they can be notionally disassembled in smaller building blocks.</p>\u0000 </div>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 2","pages":"62-69"},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147682892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inhalt: Chemie in unserer Zeit 2/2026","authors":"","doi":"10.1002/ciuz.70054","DOIUrl":"https://doi.org/10.1002/ciuz.70054","url":null,"abstract":"","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 2","pages":"54-55"},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wirkstoffreich aber unterschätzt: Heimische Amphibien als Quelle bioaktiver Peptide","authors":"Marie-T. Hopp","doi":"10.1002/ciuz.70025","DOIUrl":"https://doi.org/10.1002/ciuz.70025","url":null,"abstract":"<div>\u0000 \u0000 <p>Peptides perform a variety of biological functions in nature, ranging from immune defence to signal transduction. Their therapeutic potential is increasingly bringing them to the forefront of biomedical research. Peptides from animal sources in particular are considered promising starting points for novel drug candidates. Until now, the focus has been primarily on exotic animals such as tropical frogs. However, it is becoming increasingly apparent that native amphibians could also be a previously overlooked but very rich source of bioactive peptides. Native species such as the grass frog, midwife toad and fire salamander produce skin secretions with antimicrobial, antiinflammatory, antitumour and/or wound-healing properties. Modified variants are even undergoing preclinical and clinical research. Nevertheless, some native species have not yet been analyzed for bioactive peptides in their skin secretions. Current and prospective studies will provide insights into this area and pave the way for new potential peptide therapeutics based on the biochemical resources of our native amphibians.</p>\u0000 </div>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 2","pages":"88-93"},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rätsel: Das beliebteste aller Gifte?","authors":"Deike Hatscher","doi":"10.1002/ciuz.70048","DOIUrl":"10.1002/ciuz.70048","url":null,"abstract":"<p>Wissen Sie, welcher qualitative chemische Nachweis direkt nach der Veröffentlichung blitzschnell in der internationalen, forensischen Fachwelt die Runde machte und auch in Agatha Christie's “Der Unfall” erwähnt wird?</p>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147683829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inhalt: Chemie in unserer Zeit 1/2026","authors":"","doi":"10.1002/ciuz.70033","DOIUrl":"https://doi.org/10.1002/ciuz.70033","url":null,"abstract":"","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146176277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rätsel: Was verzögert die Vergiftung?","authors":"Deike Hatscher","doi":"10.1002/ciuz.70027","DOIUrl":"https://doi.org/10.1002/ciuz.70027","url":null,"abstract":"<p>Wissen Sie, welche Eigenschaft Agatha Christie für ihr Erstlingswerk verwendete? Dessen quantitative Beschreibung spielt vor allem in der (wässrigen) Elektrochemie eine wichtige Rolle, so dass es nicht verwundert, dass die Herren Arrhenius, van't Hoff, Ostwald und Nernst damit in Verbindung gebracht werden.</p>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146162349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Markus Emden, Yasmin Delic, Hannes Fischer, Elias Hoffmann
{"title":"Versuche aus dem Küchenschrank: Wenn der Bengalo nicht mit reindarf","authors":"Markus Emden, Yasmin Delic, Hannes Fischer, Elias Hoffmann","doi":"10.1002/ciuz.70028","DOIUrl":"https://doi.org/10.1002/ciuz.70028","url":null,"abstract":"<p>Anliegen der in loser Folge erscheinenden Versuche ist es, Impulse für chemische Versuche zu geben, die mit haushaltsüblichen Gegenständen durchgeführt werden können. Die Versuche sind explizit nicht als Experimente im fachdidaktischen bzw. wissenschaftstheoretischen Sinn konzipiert, sondern sollen unter anderem durch Erzeugung einfacher naturwissenschaftlicher Phänomene eine positive Haltung gegenüber der Chemie wecken. Lehrpersonen öffnen sie Möglichkeiten, grundlegende chemische Zusammenhänge ohne teure Spezialchemikalien im Alltag aufzuzeigen. Nicht zuletzt sollen sie dazu anregen, unsere nächste Nähe stärker bezüglich ihrer chemischen Funktionen zu hinterfragen. Denn Chemie wirkt schließlich überall.</p>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 1","pages":"50-51"},"PeriodicalIF":0.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metalle für das Gehirn","authors":"","doi":"10.1002/ciuz.70035","DOIUrl":"https://doi.org/10.1002/ciuz.70035","url":null,"abstract":"<p><b>(Schwer-) Metalle und Gehirn gehen gar nicht? Denkste!</b></p><p>Obwohl wir erst am Anfang des Verständnisses der Rolle von Metallen im ZNS stehen, ergeben sich erste Teile eines zusammenhängenden Bildes. Die Biometalle Kupfer, Mangan, Eisen und Zink sind von zentraler Bedeutung in der Signalweiterleitung und somit einer gesunden Gehirnfunktion. Bricht ihre Homöostase zusammen, hat dies entsprechend dramatische Folgen, denn eine gestörte Metallionenhomöostase hat einen enormen Einfluss nicht nur auf unsere physische, sondern auch psychische Gesundheit. Wollen wir neurodegenerative Erkrankungen ursächlich behandeln, so sollten wir uns bei der Forschung nicht nur auf (im chemischen Sinne) organische Wirkmechanismen und nicht-körpereigene Metalle wie Aluminium konzentrieren, sondern verstärkt auf unsere körpereigenen (Schwer-)Metalle, die ganz natürlich in unserem Gehirn vorkommen, nur im Falle von Erkrankung offenbar leider nicht immer da, wo sie eigentlich sein sollten.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ciuz.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146162486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"(Schwer-) Metalle und Gehirn gehen gar nicht? Denkste!","authors":"Sabine Becker","doi":"10.1002/ciuz.70021","DOIUrl":"https://doi.org/10.1002/ciuz.70021","url":null,"abstract":"<div>\u0000 \u0000 <p>Although we are only beginning to understand the role of metals in the CNS, the first pieces of a coherent picture are emerging. The biominerals copper, manganese, iron, and zinc are of central importance in signal transmission and thus, in a healthy brain function. A breakdown of their homeostasis has dramatic consequences as a disturbed metal ion homeostasis has an enormous impact not only on our physical but also on our mental health. If we want to treat neurodegenerative diseases at their root cause, our research should not only focus on (in the chemical sense) organic mechanisms of action and non-endogenous metals such as aluminum, but also increasingly on our body's own (heavy) metals, which occur naturally in our brain but, unfortunately, are not always present where they should be in the event of disease.</p>\u0000 </div>","PeriodicalId":9911,"journal":{"name":"Chemie in Unserer Zeit","volume":"60 1","pages":"10-23"},"PeriodicalIF":0.6,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}