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A simple approach to produce 34 mM hydrogen peroxide utilizing carbon nitride photocatalysts 利用氮化碳光催化剂生产 34 mM 过氧化氢的简单方法
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-30 DOI: 10.1093/chemle/upae175
Hiroshi Kominami, Ryuki Yamashita, Xiangru Liu, Atsuhiro Tanaka
{"title":"A simple approach to produce 34 mM hydrogen peroxide utilizing carbon nitride photocatalysts","authors":"Hiroshi Kominami, Ryuki Yamashita, Xiangru Liu, Atsuhiro Tanaka","doi":"10.1093/chemle/upae175","DOIUrl":"https://doi.org/10.1093/chemle/upae175","url":null,"abstract":"The production of hydrogen peroxide (H2O2) by photocatalytic reduction of oxygen (O2) has attracted considerable attention as a more efficient and cleaner method than traditional methods for synthesizing H2O2. Carbon nitride (C3N4) is a suitable photocatalyst for H2O2 production under solar light due to its band gap. The objective of this study was to achieve rapid production and high concentration of H2O2 over a C3N4 photocatalyst through the strategy of increasing the H2O2 production rate and decreasing the H2O2 decomposition rate. The results showed that 34 mM H2O2 was produced by photocatalytic reactions in an alcohol at slightly elevated temperatures under visible light irradiation. To gain a deeper understanding of the rapid production and high concentration of H2O2, various parameters were investigated.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical permeability assays of hydrolyzed acetylsalicylic acid (aspirin) in engineered gut models 水解乙酰水杨酸（阿司匹林）在工程肠道模型中的电化学渗透性测定
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-30 DOI: 10.1093/chemle/upae174
Chisato Ito, Kosuke Ino, Yoshinobu Utagawa, Kazuyuki Iwase, Yasuhiko Shinoda, Hiroya Abe, Hitoshi Shiku
{"title":"Electrochemical permeability assays of hydrolyzed acetylsalicylic acid (aspirin) in engineered gut models","authors":"Chisato Ito, Kosuke Ino, Yoshinobu Utagawa, Kazuyuki Iwase, Yasuhiko Shinoda, Hiroya Abe, Hitoshi Shiku","doi":"10.1093/chemle/upae174","DOIUrl":"https://doi.org/10.1093/chemle/upae174","url":null,"abstract":"This study presents an electrochemical permeability assay for drugs using an engineered gut model. Caco-2 cells (human colorectal adenocarcinoma cell line) were cultured on porous membranes for 21 days. Acetylsalicylic acid (aspirin), after hydrolysis, was introduced from either the apical or basal sides and incubated for 2 h. The solution from the acceptor side was collected, and cyclic voltammetry was conducted to measure the hydrolyzed acetylsalicylic acid. This electrochemical approach holds promise for drug screening applications in engineered gut models.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"34 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward accelerated discovery of solid catalysts using extrapolative machine learning approach 利用外推式机器学习方法加速发现固体催化剂
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-29 DOI: 10.1093/chemle/upae163
Takashi Toyao
{"title":"Toward accelerated discovery of solid catalysts using extrapolative machine learning approach","authors":"Takashi Toyao","doi":"10.1093/chemle/upae163","DOIUrl":"https://doi.org/10.1093/chemle/upae163","url":null,"abstract":"Designing novel catalysts is pivotal for overcoming numerous energy and environmental challenges. Although data science approaches, particularly machine learning (ML) approaches, hold promise for accelerating catalyst development, discovering truly novel catalysts through ML remains rare. This is largely due to the perceived inability of the ML models to extrapolate and identify exceptional materials. In this Review, I present our approach taken to tackle this limitation. Specifically, we employed an advanced ML methodology that could make extrapolative predictions. This approach led to the discovery of multielemental solid catalysts for CO2 hydrogenation to CO. The results not only demonstrate the immense potential of ML in catalysis research but also set a new standard for the rapid development of high-performance catalysts.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"2 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indole–thiazolidinedione–triazole hybrids: synthesis, molecular docking, absorption, distribution, metabolism and excretion (ADME) profiling, and biological evaluation as α-amylase inhibitors 吲哚-噻唑烷二酮-三唑混合物：合成、分子对接、吸收、分布、代谢和排泄（ADME）分析，以及作为α-淀粉酶抑制剂的生物学评价
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-27 DOI: 10.1093/chemle/upae162
Monil P Dholariya, Anilkumar S Patel
{"title":"Indole–thiazolidinedione–triazole hybrids: synthesis, molecular docking, absorption, distribution, metabolism and excretion (ADME) profiling, and biological evaluation as α-amylase inhibitors","authors":"Monil P Dholariya, Anilkumar S Patel","doi":"10.1093/chemle/upae162","DOIUrl":"https://doi.org/10.1093/chemle/upae162","url":null,"abstract":"A novel series of hybrid indole–thiazolidinedione–triazole derivatives (6a-l) were synthesized and assessed for their in vitro inhibitory activity against porcine pancreatic α-amylase. The synthetic procedure consists of 3 steps. A crucial step in this process involves the generation of novel target molecules using a Cu(I)-catalyzed azide–alkyne cycloaddition reaction. The α-amylase inhibition IC50 value of the targeted compounds ranged from 0.51 ± 0.02 to 7.99 ± 0.28 μM as compared with 0.68 ± 0.02 μM with acarbose as the standard drug. Using the Autodock technique, all the derivatives 6a-l were subjected to molecular docking investigations against porcine pancreatic α-amylase (PDB ID: 1OSE). Moreover, it was discovered that the docked compounds had excellent binding affinities that ranged from −10.1 to −10.8 kcal/mol as compared with the standard −7.9 kcal/mol. Additionally, a comprehensive analysis of the physicochemical and pharmacokinetic properties associated with absorption, distribution, metabolism and excretion (ADME) was conducted for all the synthesized compounds.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"408 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of Ionic Liquids as a Desiccant for the Liquid Desiccant Type Air-Conditioning System 离子液体作为液体干燥剂型空调系统干燥剂的设计
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-26 DOI: 10.1093/chemle/upae172
Toshiyuki Itoh, Hyung J Kim
{"title":"Design of Ionic Liquids as a Desiccant for the Liquid Desiccant Type Air-Conditioning System","authors":"Toshiyuki Itoh, Hyung J Kim","doi":"10.1093/chemle/upae172","DOIUrl":"https://doi.org/10.1093/chemle/upae172","url":null,"abstract":"Recently, liquid desiccant air conditioners (LDACs) have gained rapidly growing interest as an important candidate for an energy-efficient air conditioner. By enabling moisture absorption from the air, ionic liquids (ILs) can serve as a novel desiccant source for LDACs. For insights into the design and optimization of ILs to this end, we herein present a survey of studies on dehumidification and other relevant properties of ILs and offer some molecular perspective on their feasibility as a desiccant.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"71 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological effect of TiO2 nanoparticles in TiO2/g-C3N4 heterojunctions on photocatalytic dye degradation TiO2/g-C3N4 异质结中 TiO2 纳米粒子的形态对光催化降解染料的影响
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-26 DOI: 10.1093/chemle/upae171
Zijian Deng, Ryota Osuga, Masaki Matsubara, Kiyoshi Kanie, Atsushi Muramatsu
{"title":"Morphological effect of TiO2 nanoparticles in TiO2/g-C3N4 heterojunctions on photocatalytic dye degradation","authors":"Zijian Deng, Ryota Osuga, Masaki Matsubara, Kiyoshi Kanie, Atsushi Muramatsu","doi":"10.1093/chemle/upae171","DOIUrl":"https://doi.org/10.1093/chemle/upae171","url":null,"abstract":"The effects of TiO2 nanoparticle (NP) morphology on the photocatalytic activity of physically assembled TiO2 NP/g-C3N4 heterojunctions (TCNPHY) was investigated. Spherical, spindle and cubic TiO2 NPs were synthesized and separately supported on g-C3N4 nanosheets to form physically assembled TCNPHY catalysts. The photocatalytic activity for methylene blue (MB) degradation observed for TCNPHY with the cubic TiO2 NPs supported higher light absorption and a lower recombination rate; therefore, this was an adequate catalyst for the construction of catalytically active heterojunctions. The cubic-TiO2 TCNPHY exhibited a degradation rate that was 2.2 times higher than that for the g-C3N4 nanosheets alone.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"73 1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fluorescent complex with PNAs modified by boronic acid and its ligand detects target RNA in cells 由硼酸修饰的 PNA 及其配体组成的荧光复合物可检测细胞中的目标 RNA
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-24 DOI: 10.1093/chemle/upae169
Koki Ishii, Yoshihide Hattori, Hajime Shigeto, Shohei Yamamura, Mizuki Kitamatsu
{"title":"A fluorescent complex with PNAs modified by boronic acid and its ligand detects target RNA in cells","authors":"Koki Ishii, Yoshihide Hattori, Hajime Shigeto, Shohei Yamamura, Mizuki Kitamatsu","doi":"10.1093/chemle/upae169","DOIUrl":"https://doi.org/10.1093/chemle/upae169","url":null,"abstract":"We have developed peptide nucleic acids (PNAs) modified with boronic acid (Boa) and its ligand 2-(pyridin-2-yl)phenol (Pyp) as a probe for fluorescence detection of a target nucleic acid. Boa and Pyp successfully showed fluorescence by complexing via hybridization with PNA and the target. This fluorescent PNA probe also successfully responded to the target RNA in cells.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"14 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photo-cross-linking reactions in RNA–DNA heteroduplexes using photoreactive DNA incorporated with diazirine and aryl azide warheads 使用含有重氮和芳基叠氮弹头的光活性 DNA 在 RNA-DNA 异质双链中进行光交联反应
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-24 DOI: 10.1093/chemle/upae152
Kazuya Matsuo, Machiko Kitamura, Kentaro Kobata, Daiki Unita, Tomonori Waku, Akio Kobori
{"title":"Photo-cross-linking reactions in RNA–DNA heteroduplexes using photoreactive DNA incorporated with diazirine and aryl azide warheads","authors":"Kazuya Matsuo, Machiko Kitamura, Kentaro Kobata, Daiki Unita, Tomonori Waku, Akio Kobori","doi":"10.1093/chemle/upae152","DOIUrl":"https://doi.org/10.1093/chemle/upae152","url":null,"abstract":"Utilizing photoreactive oligodeoxyribonucleotides (ODNs) presents a promising avenue for significantly enhancing antisense effects with high spatiotemporal resolution. This enhancement arises from the increased stability of RNA–DNA heteroduplexes achieved through photo-cross-linking with complementary RNAs upon light illumination. In this study, we propose a post-introduction approach for preparing ODNs incorporating diazirine and aryl azide warheads, employing 2′-amino-2′-deoxyuridine. We investigate the photo-cross-linking efficiencies, rates, and nucleobase preferences of these photoreactive ODNs when paired with their complementary RNAs.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"35 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isochalcogenourea-Catalyzed Asymmetric (4+2)-Heterocycloadditions of Allenoates 异氰脲催化的烯酸盐不对称 (4+2)- 异环加成反应
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-24 DOI: 10.1093/chemle/upae168
Mario Waser
{"title":"Isochalcogenourea-Catalyzed Asymmetric (4+2)-Heterocycloadditions of Allenoates","authors":"Mario Waser","doi":"10.1093/chemle/upae168","DOIUrl":"https://doi.org/10.1093/chemle/upae168","url":null,"abstract":"Allenoates are versatile reagents that can be used for numerous (formal) cycloaddition reactions under (chiral) Lewis base catalysis. Most commonly, the catalysts of choice are phosphines, amines, and N-heterocyclic carbenes. We have recently established the use of readily available chiral isochalcogenoureas as catalysts for asymmetric (4+2)-heterocycloadditions of allenoates with various vinylogous acceptors. This represents a complementary approach for allenoate activation and gives access to various highly functionalized chiral dihydropyrans with good to excellent enantioselectivities and diastereoselectivities.","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"11 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum chemical analysis and biochemical evaluation of the inhibitory activity of puerarin on CYP1B1 enzyme 葛根素对 CYP1B1 酶抑制活性的量子化学分析和生物化学评价
IF 1.6 4区 化学
Chemistry Letters Pub Date : 2024-08-24 DOI: 10.1093/chemle/upae160
Xue Li, Jinyue Lu, Lianrong Yang, Yuan Tian, Liwei Jia, Xin Meng
{"title":"Quantum chemical analysis and biochemical evaluation of the inhibitory activity of puerarin on CYP1B1 enzyme","authors":"Xue Li, Jinyue Lu, Lianrong Yang, Yuan Tian, Liwei Jia, Xin Meng","doi":"10.1093/chemle/upae160","DOIUrl":"https://doi.org/10.1093/chemle/upae160","url":null,"abstract":"The inhibitory activity of puerarin on the CYP1B1 enzyme was evaluated by the 7-ethoxyresorufin O-dealkylation method. At the same time, the density functional theory algorithm, molecular docking, and molecular dynamics simulations were used to verify the stability of the puerarin–CYP1B1 complex. It has been found that puerarin is a potent uncompetitive inhibitor of CYP1B1 (IC50: 1.06 ± 0.15 μM).","PeriodicalId":9862,"journal":{"name":"Chemistry Letters","volume":"62 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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