Cell Regeneration最新文献_第7页

Macrophages in tissue repair and regeneration: insights from zebrafish. 组织修复和再生中的巨噬细胞：斑马鱼的启示。

Cell Regeneration Pub Date : 2024-06-11 DOI: 10.1186/s13619-024-00195-w

Changlong Zhao, Zhiyong Yang, Yunbo Li, Zilong Wen

{"title":"Macrophages in tissue repair and regeneration: insights from zebrafish.","authors":"Changlong Zhao, Zhiyong Yang, Yunbo Li, Zilong Wen","doi":"10.1186/s13619-024-00195-w","DOIUrl":"10.1186/s13619-024-00195-w","url":null,"abstract":"Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury. However, due to their complex compositional heterogeneity and functional plasticity, deciphering the nature of different macrophage subpopulations and unraveling their dynamics and precise roles during the repair process have been challenging. With its distinct advantages, zebrafish (Danio rerio) has emerged as an invaluable model for studying macrophage development and functions, especially in tissue repair and regeneration, providing valuable insights into our understanding of macrophage biology in health and diseases. In this review, we present the current knowledge and challenges associated with the role of macrophages in tissue repair and regeneration, highlighting the significant contributions made by zebrafish studies. We discuss the unique advantages of the zebrafish model, including its genetic tools, imaging techniques, and regenerative capacities, which have greatly facilitated the investigation of macrophages in these processes. Additionally, we outline the potential of zebrafish research in addressing the remaining challenges and advancing our understanding of the intricate interplay between macrophages and tissue repair and regeneration.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases. TGF-β 信号串在细胞功能、免疫和疾病中的作用研究取得新进展。

Cell Regeneration Pub Date : 2024-05-23 DOI: 10.1186/s13619-024-00194-x

Shuchen Gu, Rik Derynck, Ye-Guang Chen, Xin-Hua Feng

引用次数: 0

Forkhead box O proteins: steering the course of stem cell fate. 叉头盒 O 蛋白：引导干细胞命运的进程。

Cell Regeneration Pub Date : 2024-03-11 DOI: 10.1186/s13619-024-00190-1

Mengdi Cheng, Yujie Nie, Min Song, Fulin Chen, Yuan Yu

{"title":"Forkhead box O proteins: steering the course of stem cell fate.","authors":"Mengdi Cheng, Yujie Nie, Min Song, Fulin Chen, Yuan Yu","doi":"10.1186/s13619-024-00190-1","DOIUrl":"10.1186/s13619-024-00190-1","url":null,"abstract":"Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately balanced between maintaining their pluripotency and differentiating as needed. Disruptions in this balance can lead to a spectrum of diseases, underscoring the importance of unraveling the complex molecular mechanisms that govern stem cell fate. Forkhead box O (FOXO) proteins, a family of transcription factors, are at the heart of this intricate regulation, influencing a myriad of cellular processes such as survival, metabolism, and DNA repair. Their multifaceted role in steering the destiny of stem cells is evident, as they wield influence over self-renewal, quiescence, and lineage-specific differentiation in both embryonic and adult stem cells. This review delves into the structural and regulatory intricacies of FOXO transcription factors, shedding light on their pivotal roles in shaping the fate of stem cells. By providing insights into the specific functions of FOXO in determining stem cell fate, this review aims to pave the way for targeted interventions that could modulate stem cell behavior and potentially revolutionize the treatment and prevention of diseases.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Models for calcific aortic valve disease in vivo and in vitro. 钙化性主动脉瓣疾病的体内和体外模型。

Cell Regeneration Pub Date : 2024-03-01 DOI: 10.1186/s13619-024-00189-8

Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai

引用次数: 0

Asymmetric division of stem cells and its cancer relevance. 干细胞的非对称分裂及其与癌症的关系

Cell Regeneration Pub Date : 2024-02-27 DOI: 10.1186/s13619-024-00188-9

Shanshan Chao, Huiwen Yan, Pengcheng Bu

引用次数: 0

Reevaluating Golgi fragmentation and its implications in wound repair. 重新评估高尔基体碎片及其在伤口修复中的意义

Cell Regeneration Pub Date : 2024-02-13 DOI: 10.1186/s13619-024-00187-w

Chandra Sugiarto Wijaya, Suhong Xu

引用次数: 0

Correction: RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss. 更正：RhoA/Rock 激活是在衰老相关骨质流失中使 Wnt/β-catenin 信号失活的一种新机制。

Cell Regeneration Pub Date : 2024-02-10 DOI: 10.1186/s13619-023-00185-4

Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng, Ximei Wu

引用次数: 0

Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation. 线粒体与细胞核之间的通讯通过多种途径调节心肌细胞的增殖。

IF 4

Cell Regeneration Pub Date : 2024-01-31 DOI: 10.1186/s13619-024-00186-x

Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei

{"title":"Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation.","authors":"Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei","doi":"10.1186/s13619-024-00186-x","DOIUrl":"10.1186/s13619-024-00186-x","url":null,"abstract":"The regenerative capacity of the adult mammalian heart remains a formidable challenge in biological research. Despite extensive investigations into the loss of regenerative potential during evolution and development, unlocking the mechanisms governing cardiomyocyte proliferation remains elusive. Two recent groundbreaking studies have provided fresh perspectives on mitochondrial-to-nuclear communication, shedding light on novel factors that regulate cardiomyocyte proliferation. The studies identified two mitochondrial processes, fatty acid oxidation and protein translation, as key players in restricting cardiomyocyte proliferation. Inhibition of these processes led to increased cell cycle activity in cardiomyocytes, mediated by reduction in H3k4me3 levels through accumulated α-ketoglutarate (αKG), and activation of the mitochondrial unfolded protein response (UPRmt), respectively. In this research highlight, we discuss the novel insights into mitochondrial-to-nuclear communication presented in these studies, the broad implications in cardiomyocyte biology and cardiovascular diseases, as well as the intriguing scientific questions inspired by the studies that may facilitate future investigations into the detailed molecular mechanisms of cardiomyocyte metabolism, proliferation, and mitochondrial-to-nuclear communications.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"2"},"PeriodicalIF":4.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future of low back pain: unravelling IVD components and MSCs' potential. 腰背痛的未来：了解 IVD 成分和间充质干细胞的潜力。

IF 4

Cell Regeneration Pub Date : 2024-01-16 DOI: 10.1186/s13619-023-00184-5

Raquel Leão Monteiro

{"title":"Future of low back pain: unravelling IVD components and MSCs' potential.","authors":"Raquel Leão Monteiro","doi":"10.1186/s13619-023-00184-5","DOIUrl":"10.1186/s13619-023-00184-5","url":null,"abstract":"Low back pain (LBP) mainly emerges from intervertebral disc (IVD) degeneration. However, the failing mechanism of IVD ́s components, like the annulus fibrosus (AF) and nucleus pulposus (NP), leading to IVD degeneration/herniation is still poorly understood. Moreover, the specific role of cellular populations and molecular pathways involved in the inflammatory process associated with IVD herniation remains to be highlighted. The limited knowledge of inflammation associated with the initial steps of herniation and the lack of suitable models to mimic human IVD ́s complexity are some of the reasons for that. It has become essential to enhance the knowledge of cellular and molecular key players for AF and NP cells during inflammatory-driven degeneration. Due to unique properties of immunomodulation and pluripotency, mesenchymal stem cells (MSCs) have attained diverse recognition in this field of bone and cartilage regeneration. MSCs therapy has been particularly valuable in facilitating repair of damaged tissues and may benefit in mitigating inflammation' degenerative events. Therefore, this review article conducts comprehensive research to further understand the intertwine between the mechanisms of action of IVD components and therapeutic potential of MSCs, exploring their characteristics, how to optimize their use and establish them safely in distinct settings for LPB treatment.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"1"},"PeriodicalIF":4.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity. mTORC1信号激活的敏感性使组织具有再生能力。

Cell Regeneration Pub Date : 2023-12-07 DOI: 10.1186/s13619-023-00183-6

Hanyu Dou, Jianzhou Li, Taomin Huang, Xiaolei Ding

引用次数: 0