干细胞的非对称分裂及其与癌症的关系

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2024-02-27 DOI:10.1186/s13619-024-00188-9

Shanshan Chao, Huiwen Yan, Pengcheng Bu

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引用次数: 0

摘要

不对称分裂是产生细胞多样性和维持干细胞群体的基本过程。在不对称分裂过程中，蛋白质、细胞器甚至核糖核酸在两个子细胞之间的分布不均，决定了它们不同的细胞命运。协调这一过程的机制极其复杂。不对称分裂的失调有可能引发癌症进展。癌症干细胞尤其会进行不对称分裂，从而导致瘤内异质性，这也是导致治疗无效的原因之一。在这篇综述中，我们将深入研究支配不对称分裂的细胞和分子机制，并探讨其与肿瘤发生的相关性。

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Asymmetric division of stem cells and its cancer relevance.

Asymmetric division is a fundamental process for generating cell diversity and maintaining the stem cell population. During asymmetric division, proteins, organelles, and even RNA are distributed unequally between the two daughter cells, determining their distinct cell fates. The mechanisms orchestrating this process are extremely complex. Dysregulation of asymmetric division can potentially trigger cancer progression. Cancer stem cells, in particular, undergo asymmetric division, leading to intra-tumoral heterogeneity, which contributes to treatment refractoriness. In this review, we delve into the cellular and molecular mechanisms that govern asymmetric division and explore its relevance to tumorigenesis.

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine