Cell Regeneration最新文献_第6页

Models for calcific aortic valve disease in vivo and in vitro. 钙化性主动脉瓣疾病的体内和体外模型。

Cell Regeneration Pub Date : 2024-03-01 DOI: 10.1186/s13619-024-00189-8

Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai

引用次数: 0

Asymmetric division of stem cells and its cancer relevance. 干细胞的非对称分裂及其与癌症的关系

Cell Regeneration Pub Date : 2024-02-27 DOI: 10.1186/s13619-024-00188-9

Shanshan Chao, Huiwen Yan, Pengcheng Bu

引用次数: 0

Reevaluating Golgi fragmentation and its implications in wound repair. 重新评估高尔基体碎片及其在伤口修复中的意义

Cell Regeneration Pub Date : 2024-02-13 DOI: 10.1186/s13619-024-00187-w

Chandra Sugiarto Wijaya, Suhong Xu

引用次数: 0

Correction: RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss. 更正：RhoA/Rock 激活是在衰老相关骨质流失中使 Wnt/β-catenin 信号失活的一种新机制。

Cell Regeneration Pub Date : 2024-02-10 DOI: 10.1186/s13619-023-00185-4

Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng, Ximei Wu

引用次数: 0

Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation. 线粒体与细胞核之间的通讯通过多种途径调节心肌细胞的增殖。

IF 4

Cell Regeneration Pub Date : 2024-01-31 DOI: 10.1186/s13619-024-00186-x

Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei

{"title":"Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation.","authors":"Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei","doi":"10.1186/s13619-024-00186-x","DOIUrl":"10.1186/s13619-024-00186-x","url":null,"abstract":"The regenerative capacity of the adult mammalian heart remains a formidable challenge in biological research. Despite extensive investigations into the loss of regenerative potential during evolution and development, unlocking the mechanisms governing cardiomyocyte proliferation remains elusive. Two recent groundbreaking studies have provided fresh perspectives on mitochondrial-to-nuclear communication, shedding light on novel factors that regulate cardiomyocyte proliferation. The studies identified two mitochondrial processes, fatty acid oxidation and protein translation, as key players in restricting cardiomyocyte proliferation. Inhibition of these processes led to increased cell cycle activity in cardiomyocytes, mediated by reduction in H3k4me3 levels through accumulated α-ketoglutarate (αKG), and activation of the mitochondrial unfolded protein response (UPRmt), respectively. In this research highlight, we discuss the novel insights into mitochondrial-to-nuclear communication presented in these studies, the broad implications in cardiomyocyte biology and cardiovascular diseases, as well as the intriguing scientific questions inspired by the studies that may facilitate future investigations into the detailed molecular mechanisms of cardiomyocyte metabolism, proliferation, and mitochondrial-to-nuclear communications.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"2"},"PeriodicalIF":4.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Future of low back pain: unravelling IVD components and MSCs' potential. 腰背痛的未来：了解 IVD 成分和间充质干细胞的潜力。

IF 4

Cell Regeneration Pub Date : 2024-01-16 DOI: 10.1186/s13619-023-00184-5

Raquel Leão Monteiro

{"title":"Future of low back pain: unravelling IVD components and MSCs' potential.","authors":"Raquel Leão Monteiro","doi":"10.1186/s13619-023-00184-5","DOIUrl":"10.1186/s13619-023-00184-5","url":null,"abstract":"Low back pain (LBP) mainly emerges from intervertebral disc (IVD) degeneration. However, the failing mechanism of IVD ́s components, like the annulus fibrosus (AF) and nucleus pulposus (NP), leading to IVD degeneration/herniation is still poorly understood. Moreover, the specific role of cellular populations and molecular pathways involved in the inflammatory process associated with IVD herniation remains to be highlighted. The limited knowledge of inflammation associated with the initial steps of herniation and the lack of suitable models to mimic human IVD ́s complexity are some of the reasons for that. It has become essential to enhance the knowledge of cellular and molecular key players for AF and NP cells during inflammatory-driven degeneration. Due to unique properties of immunomodulation and pluripotency, mesenchymal stem cells (MSCs) have attained diverse recognition in this field of bone and cartilage regeneration. MSCs therapy has been particularly valuable in facilitating repair of damaged tissues and may benefit in mitigating inflammation' degenerative events. Therefore, this review article conducts comprehensive research to further understand the intertwine between the mechanisms of action of IVD components and therapeutic potential of MSCs, exploring their characteristics, how to optimize their use and establish them safely in distinct settings for LPB treatment.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"1"},"PeriodicalIF":4.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity. mTORC1信号激活的敏感性使组织具有再生能力。

Cell Regeneration Pub Date : 2023-12-07 DOI: 10.1186/s13619-023-00183-6

Hanyu Dou, Jianzhou Li, Taomin Huang, Xiaolei Ding

引用次数: 0

BMP signaling in cancer stemness and differentiation. BMP信号在肿瘤发生和分化中的作用。

Cell Regeneration Pub Date : 2023-12-05 DOI: 10.1186/s13619-023-00181-8

Wei Zhou, Kun Yan, Qiaoran Xi

{"title":"BMP signaling in cancer stemness and differentiation.","authors":"Wei Zhou, Kun Yan, Qiaoran Xi","doi":"10.1186/s13619-023-00181-8","DOIUrl":"10.1186/s13619-023-00181-8","url":null,"abstract":"The BMP (Bone morphogenetic protein) signaling pathway plays a central role in metazoan biology, intricately shaping embryonic development, maintaining tissue homeostasis, and influencing disease progression. In the context of cancer, BMP signaling exhibits context-dependent dynamics, spanning from tumor suppression to promotion. Cancer stem cells (CSCs), a modest subset of neoplastic cells with stem-like attributes, exert substantial influence by steering tumor growth, orchestrating therapy resistance, and contributing to relapse. A comprehensive grasp of the intricate interplay between CSCs and their microenvironment is pivotal for effective therapeutic strategies. Among the web of signaling pathways orchestrating cellular dynamics within CSCs, BMP signaling emerges as a vital conductor, overseeing CSC self-renewal, differentiation dynamics, and the intricate symphony within the tumor microenvironment. Moreover, BMP signaling's influence in cancer extends beyond CSCs, intricately regulating cellular migration, invasion, and metastasis. This multifaceted role underscores the imperative of comprehending BMP signaling's contributions to cancer, serving as the foundation for crafting precise therapies to navigate multifaceted challenges posed not only by CSCs but also by various dimensions of cancer progression. This article succinctly encapsulates the diverse roles of the BMP signaling pathway across different cancers, spanning glioblastoma multiforme (GBM), diffuse intrinsic pontine glioma (DIPG), colorectal cancer, acute myeloid leukemia (AML), lung cancer, prostate cancer, and osteosarcoma. It underscores the necessity of unraveling underlying mechanisms and molecular interactions. By delving into the intricate tapestry of BMP signaling's engagement in cancers, researchers pave the way for meticulously tailored therapies, adroitly leveraging its dualistic aspects-whether as a suppressor or promoter-to effectively counter the relentless march of tumor progression.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"12 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis 利用干细胞和系谱重编程技术治疗心脏纤维化

Cell Regeneration Pub Date : 2023-12-01 DOI: 10.1186/s13619-023-00182-7

Ni Zeng, Wei Tang, Yanghong Wu, Hang Fan, Shuanglun Xie, Nan Cao

引用次数: 0

ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances. ERK信号波通过体壁肌肉引导涡虫全身长距离再生。

Cell Regeneration Pub Date : 2023-11-08 DOI: 10.1186/s13619-023-00180-9

Chenglu Xiao, Jing-Wei Xiong

引用次数: 0