Chromatin remodeling in tissue stem cell fate determination.

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2024-09-30 DOI:10.1186/s13619-024-00203-z

Xinyang Li, Gaoxiang Zhu, Bing Zhao

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Abstract

Tissue stem cells (TSCs), which reside in specialized tissues, constitute the major cell sources for tissue homeostasis and regeneration, and the contribution of transcriptional or epigenetic regulation of distinct biological processes in TSCs has been discussed in the past few decades. Meanwhile, ATP-dependent chromatin remodelers use the energy from ATP hydrolysis to remodel nucleosomes, thereby affecting chromatin dynamics and the regulation of gene expression programs in each cell type. However, the role of chromatin remodelers in tissue stem cell fate determination is less well understood. In this review, we systematically discuss recent advances in epigenetic control by chromatin remodelers of hematopoietic stem cells, intestinal epithelial stem cells, neural stem cells, and skin stem cells in their fate determination and highlight the importance of their essential role in tissue homeostasis, development, and regeneration. Moreover, the exploration of the molecular and cellular mechanisms of TSCs is crucial for advancing our understanding of tissue maintenance and for the discovery of novel therapeutic targets.

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组织干细胞命运决定过程中的染色质重塑

组织干细胞（TSCs）存在于特异性组织中，是组织稳态和再生的主要细胞来源，过去几十年来，人们一直在讨论组织干细胞转录或表观遗传调控对不同生物过程的贡献。与此同时，依赖 ATP 的染色质重塑者利用 ATP 水解产生的能量重塑核小体，从而影响染色质动态和各细胞类型中基因表达程序的调控。然而，染色质重塑者在组织干细胞命运决定中的作用还不太清楚。在这篇综述中，我们系统讨论了染色质重塑因子对造血干细胞、肠上皮干细胞、神经干细胞和皮肤干细胞命运决定的表观遗传调控的最新进展，并强调了它们在组织稳态、发育和再生中的重要作用。此外，对TSCs的分子和细胞机制的探索对于促进我们对组织维持的理解和发现新的治疗靶点至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine