Cellular and molecular biology最新文献

{"title":"Evaluation of blood components and their association with Interleukin-18 in chronic myeloid leukemia.","authors":"Noor Abd Al-Zahra Ali, Hind Mohameed Hadi, Omar Ahmed Khorsheed, Ali Hassanen Ali, Naam Ali Hamza, Assel Abdulsattar Hussein","doi":"10.14715/cmb/2025.71.4.10","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.10","url":null,"abstract":"<p><p>This study investigated the association between Chronic Myeloid Leukemia (CML), Interleukin-18 (IL-18), and blood components. A case-control, multi-center trial was conducted from November 12, 2023, to August 8, 2024, including 134 CML patients and 44 healthy controls. Results indicated a statistically significant difference between the control group and CML patients in IL-18 levels, platelet count (PLT), and white blood cell count (WBC) (p = 0.048, 0.033, and 0.029, respectively). A significant age difference was also observed between the control group and patients (p = 0.0441). Furthermore, there was a highly significant difference in age distribution (>40, 40-60, <60 years) between the two groups (p = 0.0001). Significant differences were also found in PDW, RBC, MCHC, RDW-CV, MCH, HCT, and PCT levels (p = 0.0001). MPV and RDW-SD also showed significant differences between groups (p = 0.0006 and 0.0498, respectively). Finally, a significant difference was observed in age distribution (less than 40, 40-60, and more than 60 years) between the two groups (p=0.048). These findings suggest that IL-18 and specific blood components may play a role in the pathogenesis of CML.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"78-87"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional modulation of skin cells using liganded immodulin peptides.","authors":"Desmond D Mascarenhas, Bhaumik Patel, Puja Ravikumar, Edward Amento, Ajay Bhargava","doi":"10.14715/cmb/2025.71.3.15","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.15","url":null,"abstract":"<p><p>Immodulins are synthetic peptides that efficiently utilize iron-mediated cellular uptake, importin-mediated nuclear translocation and binding to retinoid X receptor to mediate transcriptional effects. The possible use of side-chain derivatized immodulins (SCDI) as tunable therapeutic agents is explored in this work. Rat biodistribution studies show that, when applied transdermally to rats using a nanoemulsion, immodulin peptides rapidly partition to skin tissue resulting in a 9X enrichment in skin relative to plasma, even at skin locations distant from the site of application. We show that optimized side-chain derivatization of immodulins with selected ligands of RXR heterodimeric partners can stimulate by one to three orders of magnitude: [a] CD169+CCL22+ macrophage differentiation (RARα/β ligand); [b] IL-19, IL-22 and IL-24 production by HaCaT keratinocytes (RARγ agonist); and [c] FGF7/KGF-1, TGFβ and COL1A1 by dermal fibroblasts (partial PPARγ ligand); all p<0.01. Differentiated CD169+ macrophages, in turn, drive the conversion of FoxP3 CD4+Tcells into iTregs (>4-fold, p<0.01) while reducing IL-17 levels >4-fold (p<0.01). In addition, myoblast differentiation is stimulated >10X by a PPARα ligand (p<0.01). These processes resemble key features of paracrine circuitry in skin known to be involved in wound healing. Versatile SCDI scaffolds hold promise for the rapid and inexpensive development of safe, targeted, self-administered therapeutic agents for skin.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"124-133"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of some thiazolidine 4-one derivatives derived from Schiff bases, and evaluation of their antibacterial and antifungal activity.","authors":"Diana AbdAlkreem Al-Rifaie, Zainab Hashim Mohammad Mohammed, Rabeah T Mahmood, Malath Khalaf Rasheed, Ahmad Yaseen Taha, Othman Rashid Al Samarrai","doi":"10.14715/cmb/2025.71.3.9","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.9","url":null,"abstract":"<p><p>Schiff bases compounds were synthesized by reaction of the Benzidine with different aldehydes and ketones by using microwave method to obtain compounds (N1-N5). Thiazolidine 4-one compounds were prepared by the cyclization of Schiff bases with thioglycolic acid to obtain thiazolidine 4-one compounds (N6-N10). The prepared compounds were characterized by physical methods, through melting points and color, as well as by spectroscopic methods such as FT-IR and 1H-NMR. The purity of the prepared compounds was evaluated using TLC. The bioactivity of these compounds was tested on the growth of one type of a fungus of the yeast variety Candida was studied and type of bacterial isolates of Bacillus pumilus and the standard fungicide (Nystatin) of the fungus was used and the standard antibiotic (neomycin sulfate) of bacteria and the results indicate that the synthesized compounds have the ability to inhibit the fungus and bacteria used by using different concentrations. Molecular docking studies were conducted to examine how some of the synthesized compounds bind to the putative target, Protein structures i.e. HER2 (PDB ID: 1N8Z), Carcinoembryonic antigen (PDB ID; 2VER), BRCA1 (PDB ID 4OFB), BRCA2 (PDB ID 1MJE).</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"66-75"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antagonistic effects of PU.1 on Gfi-1B-induced erythroid colony formation in human cord blood cells.","authors":"Noriyoshi Manabe, Takuya Sakurai, Fumiko Kihara-Negishi, Yosuke Nakazawa, Toshiyuki Yamada, Atsushi Iwama, Tsuneyuki Oikawa","doi":"10.14715/cmb/2025.71.3.6","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.6","url":null,"abstract":"<p><p>Gfi-1B is a hematopoietic transcription factor essential for growth and differentiation of the erythroid/megakaryocytic lineages, and PU.1 is a master regulator for myeloid development. Herein, we demonstrate that PU.1 interacted with Gfi-1B in vivo by immunoprecipitation assay. GST pull-down assays showed that the binding sites were located in the Ets domain of PU.1 and the zinc finger domain of Gfi-1B. Luciferase reporter assays revealed that PU.1 and Gfi-1B antagonized each other's transcriptional activity in a dose-dependent manner. The transduction of Gfi-1B alone in human cord blood progenitor cells strongly enhanced erythroid colony formation. However, the transduction of PU.1 along with Gfi-1B in the progenitors significantly inhibited erythroid colony formation. Co-expression of Gfi-1B with a mutant PU.1, which bound to Gfi-1B but not to GATA1, another erythroid master regulator, also inhibited Gfi-1B-induced erythroid colony formation. Our results suggest that the function of Gfi-1B in the growth and differentiation of erythroid cells is antagonized by the expression of PU.1.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"48-56"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants of HOTAIR (rs920778) and miR-3117 (rs7512692) influence susceptibility to colorectal cancer in a Mexican population.","authors":"Yuri Giovanna Vanessa Trujillo-Fernández, Dalia Elizabeth Rodríguez-Torres, Cesar de Jesús Tovar-Jácome, Patricio Barros-Núñez, Miriam Yadira Godínez-Rodríguez, Perla Janeth Pérez-Bojórquez, Luis Alberto Flores-Martínez, Tomas Daniel Pineda-Razo, María Eugenia Marín-Contreras, Aldo Antonio Alcaraz-Wong, Ignacio Mariscal-Ramirez, Mónica Alejandra Rosales-Reynoso","doi":"10.14715/cmb/2025.71.3.4","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.4","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is the most prevalent type of gastrointestinal cancer. Genetic, epigenetic, and lifestyle factors have been implicated in the development of CRC. Non-coding RNAs such as HOX transcript antisense RNA (HOTAIR) and miR-3117 have been associated with cell proliferation, progression, invasion, and metastasis, as well as poor survival in several cancer types. This study examines the potential association between the HOTAIR (rs920778 T>C) and miR-3117 (rs7512692 C>T and rs4655646 G>A) variants and the clinicopathological features of CRC in Mexican patients. The study included genomic DNA of peripheral blood samples from 557 individuals (296 CRC patients and 261 controls). The variants were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The association was calculated using the odds ratio (OR) test. P-values were adjusted using the Bonferroni test (0.016). Individuals carrying the T/C and C/C genotypes for the HOTAIR rs920778 variant exhibited a higher susceptibility to CRC (OR=1.73, 95% CI: 1.15-2.58, P=0.009 and OR=2.78, 95% CI: 1.74-4.45, P=0.001, respectively). Male patients older than 50 years and carrying the C/C genotype demonstrated an increased susceptibility to developing CRC (OR=2.77, 95% CI: 1.63-4.70, P=0.001). Additionally, C/C genotype carriers exhibited an association with the advanced TNM stage. Furthermore, for the rs7512692 variant of the miR-3117 gene, patients carrying the C/T genotype exhibited increased susceptibility to developing CRC (OR=1.92, 95% CI: 1.35-2.74, P=0.001). Male patients over 50 years of age and carrying the C/T genotype demonstrated increased susceptibility for early TNM stages and tumor location in the colon. The results obtained suggest that the HOTAIR rs920778 and miR-3117 rs7512692 variants play a significant role in colorectal cancer risk.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"31-41"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic spectrums of Mucopolysaccharidosis type IV in Duhok city, Kurdistan region, Iraq.","authors":"Azad A Haleem","doi":"10.14715/cmb/2025.71.3.5","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.5","url":null,"abstract":"<p><p>Mucopolysaccharidosis type IV also known as Morquio syndrome is a rare autosomal recessive lysosomal storage disorder due to deficiency of either N-acetyl-galactosamine-6-sulfatase (type A) or deficiency of beta-galactosidase (type B) which results in damages of bones, cartilages, eye corneas, skin and connective tissue. The objective of this study was to explore the relationship between specific gene mutations (c.860C>T, c.421T>A, c.1196delA) and clinical manifestations in patients with mucopolysaccharidosis type IV (MPS IV. The study was conducted at Heevi Tertiary Hospital in Duhok, Iraqi Kurdistan, till the period of September 2024, it involved 10 patients with confirmed MPS IV. Data on demographics, family history, consanguinity, skeletal, intelligence, and genetic mutations were collected. Results showed that mean age at diagnosis of 7.94 years, with females predominating. Consanguinity and family history were common. Short stature, macrocephaly, fatigue, generalized pain, and various skeletal abnormalities such as dysostosis multiplex and others. Hip dysplasia was present in 50% of patients, while intelligence was normal in most. The most frequent genetic mutation was c.860C>T, followed by c.421T>A and c.1196delA. Biochemical and hematological parameters were within normal ranges, but growth retardation was evident. Geographic clustering of mutations was noted, with c.860C>T prevalent in Zakho and c.1196delA exclusive to Akre. In conclusion, the study highlights the severe phenotypic expression associated with these mutations and underscores the influence of consanguinity and regional genetic predispositions. These findings emphasize the need for targeted genetic counseling and population screening programs in high-risk areas.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"42-47"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals, bioactive compounds, and antimicrobial activities of Ocimum basilicum, Teucrium polium, Cleome amblyocarpa, and Caralluma arabica extracts: a comparative Omani study.","authors":"Juma Al-Mutaani, Lazhar Zourgui, Nabiha Missaoui","doi":"10.14715/cmb/2025.71.3.16","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.16","url":null,"abstract":"<p><p> The study aims to identify and quantify the phytochemical components of Ocimum basilicum, Teucrium polium, Cleome amblyocarpa, and Caralluma arabica extracts and to evaluate the antimicrobial activities of these Omani plants. The total phenolic content, flavonoid content, and tannin levels were quantified in both water and absolute ethanol extracts. The bioactive compounds present in the aerial parts of these plants were identified and characterized using liquid chromatography coupled with electrospray ionization mass. The antimicrobial properties were explored via the agar diffusion approach. The absolute ethanol extracts demonstrated higher phytochemical content compared to the water extracts for all plants. Ocimum basilicum revealed the highest quantities of total phenolic acids and flavonoids, followed by Teucrium polium, Cleome amblyocarpa, and Caralluma arabica. Quinic acid was detected in substantial quantities across all extracts, while three flavonoid compounds-1,3-di-O-caffeoylquinic acid, acacetin, and naringenin-were identified in all extracts, albeit in varying concentrations. Furthermore, the ethanolic extracts exhibited potent antimicrobial activity on the tested bacterial and fungal species. Staphylococcus aureus showed the highest sensitivity to Caralluma arabica extracts (22±0.1 mm). Staphylococcus aureus and Escherichia coli were the most vulnerable strains to Ocimum basilicum extracts (21±0.2 mm and 20±0.2 mm, respectively). Ocimum basilicum extracts demonstrated the best minimum inhibitory concentration (MIC: 1.28 mg/ml against Staphylococcus aureus and Salmonella enteritidis) and minimum bactericidal concentration (33.5 mg/ml against Salmonella enteritidis). Additionally, the Teucrium polium extract exhibited the lowest MIC (3.25 mg/ml) and minimum fungicidal concentration (17.28 mg/ml) against Fusarium spp. In conclusion, the aerial parts of Ocimum basilicum and Teucrium polium were rich in bioactive compounds, exhibited strong antimicrobial activity, and hold great potential for ethnomedicinal applications, warranting further investigation.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"134-145"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-infiltrating CD20+ B lymphocyte: evaluation and association with clinical and pathological characteristics in oral squamous cell carcinoma.","authors":"Ahlam T Bdaiwi, Aseel M Yousif, Ban F Al Drobie, Suhair W Abbood Al-Osaighari","doi":"10.14715/cmb/2025.71.3.13","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.13","url":null,"abstract":"<p><p>B lymphocyte cells have received considerable attention in recent studies regarding their role in tumor immunity. Tumor Infiltrating B cells (TIBs) are the name that describes the B lymphocyte cells that infiltrate a tumor tissue. Different cellular components interplay in the environment of tumor and modulate the response of antitumor immune dynamically.   A Dual role for TIBs is detected in tumor immunity regulation instead of just tumor promotion or inhibition. The present study was performed to evaluate the tumor-infiltrating B lymphocyte and the clinical outcome. Immunohistochemical analysis of B Lymphocytes in stromal/intratumoral regions was performed in 40 OSCC specimens by using CD20 antibodies. Expression of the markers and their relationship with clinicopathological parameters was evaluated by using of Independent t-test and Analysis of Variance (ANOVA) (two-tailed). Data analysis demonstrates a significant association of stromal and intratumoral CD20+ B lymphocyte infiltration with well-differentiated lesions (P < 0.05) and stage I cases (P>0.05). In addition to a significant correlation of stromal infiltration of CD20+B lymphocytes with lymph node metastasis (P=0.01). The results suggest that CD20+ B lymphocytes play an important role in OSCC, where higher infiltration of CD20+ B cells in stromal regions, particularly in cases with lymph node involvement, may be used as a prognostic indicator and may aid in determining whether the use of B lymphocyte as therapeutic targets in OSCC.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"110-116"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNAs upregulated in insulin resistance are downregulated by metformin in a liver cell line.","authors":"Vianet Argelia Tello-Flores, Yesica Eulogio-Metodio, Marco Antonio Ramírez-Vargas, Carlos Aldair Luciano-Villa, Miguel Cruz, Jaime Héctor Gómez-Zamudio, Mónica Ramírez, Luz Del Carmen Alarcón-Romero, José Ángel Cahua-Pablo, Eugenia Flores-Alfaro","doi":"10.14715/cmb/2025.71.3.7","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.7","url":null,"abstract":"<p><p>Insulin resistance (IR) is a key contributor to the development of metabolic diseases, and metformin has been shown to help mitigate IR. Long non-coding RNAs (lncRNAs) are emerging as important regulators in metabolic disorders. This study aimed to investigate the differential expression of lncRNAs in IR and assess the impact of metformin on these lncRNAs. Using the Huh7 cell line to model IR (Huh7-IR), we treated the cells with metformin (Huh7-IR+Metf). Microarray analysis, followed by bioinformatic analysis in RStudio, identified 127 downregulated and 109 upregulated lncRNAs, among which 60 showed reduced expression following metformin treatment in Huh7-IR cells. Notably, the upregulated lncRNAs HOX transcript antisense RNA (HOTAIR), long intergenic non-protein coding RNA, muscle differentiation 1 (LINCMD1) and Prader-Willi region non-protein coding RNA 2 (PWRN2) were found to be associated with genes involved in the insulin signaling pathway. These three lncRNAs were further validated using real-time RT-PCR. This study highlights the differential expression of lncRNAs in IR and their modulation by metformin. Specifically, metformin restores the expression of lncRNAs that were deregulated in IR, including HOTAIR, LINCMD1, and PWRN2, likely through the regulation of critical biological processes and signaling pathways associated with IR. In conclusion, our findings demonstrate that metformin modulates the expression of key lncRNAs, including HOTAIR, LINCMD1, and PWRN2, which are deregulated in insulin resistance. This regulation likely occurs through the modulation of critical signaling pathways, such as NFκB and AMPK, suggesting that targeting lncRNAs could offer new therapeutic avenues for managing IR and related metabolic disorders.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"57-65"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing hygiene and microbial aspect of paper recycling: a sustainable approach for environmental conservation.","authors":"Ahmed Bahram Wlia, Soma Majedi","doi":"10.14715/cmb/2025.71.3.18","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.3.18","url":null,"abstract":"<p><p>This study explores microbial dynamics in paper recycling, emphasizing the significance of sustainable practices for environmental preservation. Samples were collected from various urban waste sources in Erbil city, Kurdistan Region, Iraq, including materials such as pizza boxes, cigarette packets, and coffee cups. Pure bacterial colonies were isolated using standard methods, and their morphological and physiological traits were characterized through biochemical tests. Identification of bacterial species followed established protocols. The study identified diverse bacterial species associated with paper waste, highlighting potential hygiene concerns in the recycling process. The findings of this study contribute to understanding the microbial ecology associated with paper waste and recycling processes. By optimizing hygiene measures and gaining insights into the microbial communities present, this research underscores the importance of sustainable practices in paper recycling to mitigate environmental impacts and promote a healthier ecosystem. Policies for future waste management and reduction of environmental risks have been proposed.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 3","pages":"151-157"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}