Cellular and molecular biology最新文献

{"title":"Metagenomic analysis microbial biodiversity of Trojena' the Mountains of Neom.","authors":"Amenah S Alotaib, Waqas Anwar, Hanin Qasem Albalawi, Hind Saleem Albalawi, Mona Abdulhadi Alshehri, Fatimah Mohammed Al-Atawi, Ibrahim T Al Joundi, Abdulrahman Y Al Samini, Rashed Z Alqarni, Nawaf E Alzahrani, Meshal A Huraysi","doi":"10.14715/cmb/2025.71.4.13","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.13","url":null,"abstract":"<p><p>About 80% of the biosphere is constantly exposed to temperatures below 5 °C in cold environments. Microorganisms in cold environments can grow and decompose various organic compounds at sub-zero temperatures despite exposure to conditions that are harmful to their survival, such as sub-zero temperatures and low nutrient and water availability. The present study was designed to investigate metagenomic insights into the microbial diversity in (Al-Lawz Mountains / Trojena Mountains) Saudi Arabia. Metagenomic data sets are obtained by high-throughput sequencing of environmental soil samples and provide an aggregation of all the conceptually genetic materials of the intended area of this project. This study easily overcomes the bottlenecks associated with conventional molecular methods of retrieving genetic information and the unscientific shortage of microbial biodiversity research at Tabuk. High throughput bioinformatic analysis has been highlighted as the accurate exploration of the abundance and diversity of bacterial communities. Environmental DNA can be sequenced to identify the recent presence, relative abundance & distribution of a prokaryotic species or whole communities of bacteria. A total of 333 bacterial metagenomes were sequenced over two seasons, fall and winter. The 16S rRNA genes were quantified during this period. The most significant species regarding the relative abundance and diversity were in the location of sample1 by, Klebsiella michiganensis (251), stenotrophomonass maltophilia (110), Escherichia coli USML2 (88), Zhongshania aliphaticivorans (40), Acidibrevibacterium fodinaquatile (12) Calothrix spp. & Nibribacter ruber (10) Bacillus spp (10) respectively. On the other hand, the lowest abundances were in sample 4 location with Pseudomonas fluorescens (5) and Corynebacterium glutamicum (3) with (NA) species. This means these were unidentified yet. All these species have a growing demand for microbial biodiversity evaluations, given the pronounced impact of climate change in this region (Al-Lawz Mountains/Trojena Mountain). Benthic microbial communities are to be considered, given they have a potential role in CO2 and nitrogen fixation, which is related to plant growth-promoting properties. They can resist salinity, radiation, low-temperature adaptation, and biocontrol properties. Thus, eDNA cold-mountain biodiversity is a fraction of the time it costs to conduct conventional ecological monitoring.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"100-110"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of naphthalene acetic acid on aborted okra production, antioxidants, minerals, phenol, flavonoid, and carotenoid content applied to flower ovary stigma.","authors":"Abu Bakar Mohammad Sharif Hossain, Mekhled M Alenazi, Danial Kahrizi","doi":"10.14715/cmb/2025.71.4.2","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.2","url":null,"abstract":"<p><p>The experiment was carried out to investigate the effect of different concentrations of NAA (naphthalene acetic acid) on the seedless (aborted) okra production, vitamin C, carotenoids, flavonoids, antioxidants (DPPH), phenolic, and mineral content. The micro-syringe injection in flower stigma was an innovative application method used in this experiment, rather than spray, which was a common and traditional method. The flower stigma injection method was applied on the flower stigma after the anthesis of the flower of the okra plant using NAA at different concentrations. In Experiment 1: The lowest concentration (25 mg/l) of NAA greatly increased the pod setting compared to the higher concentrations and control. NAA application at 25 and 50 mg/l concentrations induced higher values of pod length, diameter, size, weight, ascorbic acid, and soluble solid content over the control. The chlorophyll content in leaves was affected significantly by different concentrations of NAA. It was found that 25 and 50 mg/l concentrations of NAA significantly increased chlorophyll content, fiber, moisture, flavonoid, carotenoid, antioxidant (DPPH), minerals, and phenolic content compared to the other concentrations and control. In addition to that, control and 25 mg/l concentrations of NAA increased the production of healthy seeds compared to the 50 and 100 mg/l. Moreover, 50 and 100mg/l of concentrations showed higher aborted seed (seedless) than the other concentration and control. In Experiment 2:  In the second year, the residual effects of aborted seed (seedless) were found to have a decreasing trend of most of the parameters like pod weight, size, aborted okra percent, leaf chlorophyll, antioxidant (DPPH), and Vitamin C. But, NAA concentrations showed better residual effects in the second year in comparison to the control. Therefore, it seemed that 25 mg/l was the best concentration for pod growth and development, and 100 mg/l was the best for seedless okra production in the first and second years.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"15-21"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of candidate biomarkers and pathways associated with vedolizumab response in T cell populations of IBD patients by WGCNA.","authors":"Abdelkader Oumeddour","doi":"10.14715/cmb/2025.71.4.8","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.8","url":null,"abstract":"<p><p>Vedolizumab is a monoclonal IgG1 antibody that prevents T cells from migrating to the gut mucosa. The purpose of this study was to identify key genes with promising therapeutic targets, and molecular pathways associated with vedolizumab response. Gene expression profiles of the GSE234736 dataset were downloaded from the Gene Expression Omnibus (GEO). A co-expression network was constructed, and significant modules were identified using the weighted gene co-expression network analysis (WGCNA) package. Next, functional enrichment analysis was performed using the R package clusterProfiler to explore gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Then, protein-protein interaction (PPI) was constructed by using the function \"exportNetworkToCytoscape\" and visualized by Cytoscape software. There were three modules correlated with vedolizumab response: black (r=0.41; P<4e-05), magenta (r=0.3; P<0.004), and blue (cor = -0.29, P< 0.004). Genes in selected modules were mainly enriched in lymphocyte differentiation, cytoplasmic translation, and rRNA metabolic processes, respectively. KEGG pathway analysis showed that these genes were particularly enriched in Human T-cell leukemia virus 1 infection and protein processing in the endoplasmic reticulum. Furthermore, six selected hub genes were detected in each module by overlapping PPI and WGCNA networks. Finally, GO enrichment re-analysis of selected hub genes revealed 11 hub genes that were significantly enriched in the positive regulation of intracellular protein transport and regulation of alternative mRNA splicing. This study identified hub target genes and functional pathways that may provide new insights into responsiveness to vedolizumab, a targeted therapy for IBD.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"60-66"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC-MS analysis of volatile components in different populations of Ophiocordyceps sinensis.","authors":"Zhou Jinna, Tahir Khan, Xia Haiwen, Liu Jinlin, Wang Zhenji","doi":"10.14715/cmb/2025.71.4.16","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.16","url":null,"abstract":"<p><p>Cordyceps, a genus of ascomycete fungi, are renowned for their medicinal and functional food applications, and are attributed to bioactive compounds such as nucleosides, lipids, saccharides, and amino acids. Among its species, Ophiocordyceps sinensis has significant pharmacological value, impacting multiple organ systems and exhibiting antioxidant and antitumor properties. Although natural populations are limited, artificial cultivation has provided a sustainable source of medicinal products. This study investigated the volatile components of O. sinensis mycelia from five regions, Tibet, Yunnan, Sichuan, Gansu, and Qinghai, using gas chromatography-mass spectrometry (GC-MS) combined with multivariate statistical analysis. Fifty volatile substances were identified, including hydrocarbons, acids, esters, alcohols, phenols, aldehydes, and ketones, with hydrocarbons being the most abundant (60%). Cluster analysis highlighted significant differences in the volatile profiles between populations, with 12 common compounds identified across all regions. Population-specific variations in volatile classes, such as hydrocarbons, acids, and alcohols, were observed, suggesting a composite odor profile for O. sinensis rather than a single characteristic scent. This study provides insights into the chemical diversity of volatile components in O. sinensis, emphasizing the influence of climatic factors and advancing their potential applications in medicinal and functional products.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"128-135"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New strategies for treating Sjogren's syndrome.","authors":"Alexander V Blagov, Vasily V Kashtalap, Ksenia O Lapshina, Amina E Karimova, Alikhan Z Asoyan, Alexander Orekhov","doi":"10.14715/cmb/2025.71.4.14","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.14","url":null,"abstract":"<p><p>Sjögren's syndrome (SS) is a complex autoimmune disorder characterized by dryness, fatigue, and systemic involvement, with current treatments largely limited to symptom management. This review explores promising new therapeutic strategies targeting specific molecular pathways implicated in SS pathogenesis, including the roles of B cells, T cells, dendritic cells, cytokines, and neuroendocrine factors. We examine recent advances in drug development and clinical trials focusing on novel biological agents that modulate these pathways, potentially offering a more targeted and effective approach to SS treatment. Ultimately, this review aims to provide an overview of these emerging therapies and their potential to improve outcomes for patients with SS.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"111-119"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of stemness between dermal papilla cells and human dermal stem/progenitor cells.","authors":"Joong Hyun Shim","doi":"10.14715/cmb/2025.71.4.6","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.6","url":null,"abstract":"<p><p>Adult stem cells (ASCs) have great applicative potential in tissue regeneration. Comparative analyses of ASCs derived from various niches are essential for comprehending the unique traits of each population and evaluating their potential for therapeutic use. In this study, the proliferation ability, stem cell marker expressions, and differentiation potential of skin-derived ASCs were compared between hair follicle dermal papilla cells (HFDPCs) and human dermal stem/progenitor cells (hDSPCs). The cell division capacity of hDSPCs was significantly increased compared with HFDPCs, and the differentiation capacity into adipocytes, chondrocytes, and osteoblasts was significantly increased in hDSPCs. On the contrary, HFDPCs showed significantly increased expression of dermal papilla-related markers (SOX2, S100β, CORIN and Snai2) compared with hDSPCs. To analyze why these two types of ASCs have different properties, I analyzed intracellular signaling by protein kinase assay. Protein kinase assays showed that the phosphorylation of ERK1/2, c-JUN, CREB, YES, and GSK3α/β is significantly changed in HFDPCs and hDSPCs compared with dermal fibroblasts. HFDPCs have increased expression of markers related to hair regeneration compared with hDSPCs, on the other hand, hDSPCs are more multipotent than HFDPCs. The five above-mentioned phosphorylated signaling proteins (ERK1/2, c-JUN, CREB, YES, and GSK3α/β) are responsible for the characterization of HFDPCs and hDSPCs. The different characteristics of each skin-derived ASC might be a major factor influencing their effective use for tissue regeneration and therapeutics.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"42-49"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of di(2-ethylhexyl) phthalate on dysregulation of testosterone production via alteration of aromatase expression.","authors":"Min Ju Park, Seung Ju Lee, Yong Joo Park, Eunsoo Yoo, Hye Kyung Kim, Min Hi Park","doi":"10.14715/cmb/2025.71.4.4","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.4","url":null,"abstract":"<p><p>Di(2-ethylhexyl) phthalate (DEHP), an endocrine-disrupting chemicals (EDCs), is commonly used as a plasticizer to improve the flexibility and durability of plastics. On a daily basis, we are exposed to varying amounts of this compound. Several studies have demonstrated that exposure to DEHP and its metabolite, mono(2-ethylhexyl) phthalate (MEHP), leads to testosterone deficiency (TD) in both humans and animals. However, the precise mechanism that causes DEHP-induced TD is still not completely understood. This study aims to determine the effects of DEHP on testosterone levels and elucidate the underlying mechanisms. C57BL/6 mice and Leydig cells were exposed to various doses of DEHP (0, 0.5, and 5 mg/kg/day) for 9 weeks and MEHP (0, 0.05, 0.5, and 5 μM) for 24 hours, respectively. Both in vivo and in vitro results indicated significant reductions in testosterone levels due to DEHP and MEHP. Additionally, DEHP and MEHP increased the expression of aromatase, a gene that converts testosterone to estradiol and induced an increase in the expression of inflammatory cytokines such as IL-6, IL-1β, and TNF-α. Moreover, DEHP activated NF-κB, a key transcription factor regulating numerous genes associated with inflammation. These results suggest that sustained exposure to DEHP increases inflammatory factors, which may elevate aromatase activity and result in decreased testosterone levels in the body. Furthermore, this study provides a basis for discussing the potential correlation between persistent DEHP exposure and TD characterized by low testosterone levels in the body.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"30-35"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of lysosomal dysfunction on cytoplasmic vacuolation and amyloid-beta 40 (Aß40) level in human brain endothelial cells (HBEC-5i).","authors":"Nor Azma Hannah Mazlan, Mohd Hamzah Mohd Nasir, Farah Wahida Ibrahim, Asmah Hamid, Iffah Nadiah Laili, Nurul Farhana Jufri","doi":"10.14715/cmb/2025.71.4.5","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.5","url":null,"abstract":"<p><p>Lysosomes are an important intracellular organelle that regulates cellular degradation. Dysfunctional lysosomes disrupt this process, leading to the accumulation of toxic proteins that are meant to be degraded inside the cell, leading to cellular stress and potential toxicity. One of the proteins is beta-amyloid which is associated with conditions like cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). To identify its effects on the vascular compartment, the current study explored lysosomal dysfunction's impact on cytosolic vacuole formation and amyloid beta 40 (Aß40) levels in human brain endothelial cells (HBEC-5i). Cells treated with the lysosomotropic compound chloroquine (70.5 µM) exhibited morphological changes, including prominent cytosolic vacuole formation. The vacuole density was recorded at 11.86 ± 1.907 vacuoles per cell (p < 0.05), and its diameter was significantly increased (3.76 ± 0.182 µm, p < 0.05) compared to the negative control group. However, the average cell size remained unchanged despite the vacuole formation in CQ-treated cells. ELISA tests on lysate and supernatant revealed no significant differences between treatment and control groups in intracellular and extracellular Aß40 levels. This suggested that while lysosomal dysfunction induced cytosolic vacuole changes, it did not significantly alter Aß40 levels. Further research is needed to elucidate the pathways involved in Aß40.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"36-41"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution and genetic diversity of TYLCV in Saudi Arabia.","authors":"Zafar Iqbal","doi":"10.14715/cmb/2025.71.4.7","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.7","url":null,"abstract":"<p><p>This study investigated the genetic diversity, phylogeny, and evolutionary dynamics of Tomato yellow leaf curl virus (TYLCV) across seven regions in Saudi Arabia. Analyzing 28 full-length TYLCV genomes, phylogenetic analysis revealed two distinct clades: one predominantly comprised of isolates from the Ahsa (Eastern province) region and the other encompassing isolates from Northern and Western regions. The Ahsa region exhibited significantly higher TYLCV prevalence and genetic diversity, harboring the most divergent isolates with high haplotype (Hd = 1.00) and nucleotide (π = 0.079) diversity. Conversely, regions like Jeddah and Hadasham showed lower diversity, suggesting less or stable viral populations. Genetic diversity analyses revealed high variation in coding regions like CP and Rep, which are under strong selective pressures and prone to recombination. Conversely, V2 displayed lower diversity, indicating purifying selection. Selection pressure analysis using dN/dS ratios indicated diversifying selection in C4 (2.20) and Rep (1.28). Single Likelihood Ancestor Counting identified one positively selected site in Rep. In contrast, Fast Unconstrained Bayesian AppRoximation identified multiple sites in C4 (8), TrAP (7), REn (6), and V2 (1), suggesting roles in host adaptation and immune evasion. A total of 32 credible recombination events, predominantly in Ahsa isolates, were identified using RDP and confirmed by GARD analysis. These events, involving both inter- and intraspecies recombination, play a crucial role in enhancing TYLCV genetic diversity and adaptability. The conservation of motifs in V2 and C4 indicated their essential roles in TYLCV function. In contrast, variations in ORFs like CP, Rep, TrAP, and REn among specific isolates may promote viral diversity and adaptation. This study demonstrates the crucial role of geographic and genetic factors, with Ahsa as a key hub for TYLCV diversity, in driving viral evolution and diversification. The findings emphasize the need to monitor regions with high viral diversity, like Ahsa, and develop strategies to manage TYLCV's swift spread.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"50-59"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis-associated microRNAs: Systematic review.","authors":"Maria Del Carmen Candia Plata, Juan Manuel Martínez Soto, Jeanette Guadalupe Arredondo Damián, Astrid Nallely Ramírez Romero Ramírez Romero, Lucía Guadalupe Villegas Coronado, Jesús Adriana Soto Guzmán, Luis Fernando López Soto, Ana Lourdes Mata Pineda, Gerardo Álvarez Hernández, José Manuel Galván Moroyoqui","doi":"10.14715/cmb/2025.71.4.1","DOIUrl":"https://doi.org/10.14715/cmb/2025.71.4.1","url":null,"abstract":"<p><p>Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, has emerged as a critical process in various diseases. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, are increasingly recognized as key modulators of ferroptosis pathways. This systematic review aims to provide a comprehensive overview of the current knowledge regarding miRNAs implicated in ferroptosis across a spectrum of diseases. We conducted a systematic search of EMBL-EBI, PubMed, Scopus, and Web of Science databases to identify relevant studies published up to October 31, 2022. Our search strategy identified 127 articles encompassing 107 distinct miRNAs that influence ferroptosis. This review synthesizes the findings of these studies, highlighting the specific miRNAs that act as either inhibitors or inducers of ferroptosis in different disease contexts, including various cancers (e.g., lung, breast, colorectal) and degenerative conditions (e.g., acute renal failure, diabetic retinopathy). We discuss the molecular mechanisms by which these miRNAs regulate ferroptosis, often by targeting key genes involved in iron metabolism, lipid peroxidation, and antioxidant defense. Furthermore, we explore the potential of these miRNAs to serve as diagnostic biomarkers and therapeutic targets in ferroptosis-related disorders, offering insights into novel strategies for disease management.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"71 4","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}