Chemical Senses最新文献_第9页

Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders. 概念验证：SCENTinel 1.1 可快速分辨与 COVID-19 相关的嗅觉障碍。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad002

Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O'Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma

{"title":"Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders.","authors":"Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O'Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma","doi":"10.1093/chemse/bjad002","DOIUrl":"10.1093/chemse/bjad002","url":null,"abstract":"It is estimated that 20%-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of this study was to provide a proof-of-concept that SCENTinel 1.1, a rapid, inexpensive, population-wide olfactory test, can discriminate between anosmia (total smell loss), hyposmia (reduced sense of smell), parosmia (distorted odor perception), and phantosmia (odor sensation without a source). Participants were mailed a SCENTinel 1.1 test, which measures odor detection, intensity, identification, and pleasantness, using one of 4 possible odors. Those who completed the test (N = 287) were divided into groups based on their self-reported olfactory function: quantitative olfactory disorder only (anosmia or hyposmia, N = 135), qualitative olfactory disorder only (parosmia and/or phantosmia; N = 86), and normosmia (normal sense of smell; N = 66). SCENTinel 1.1 accurately discriminates quantitative olfactory disorders, qualitative olfactory disorders, and normosmia groups. When olfactory disorders were assessed individually, SCENTinel 1.1 discriminates between hyposmia, parosmia, and anosmia. Participants with parosmia rated common odors less pleasant than those without parosmia. We provide proof-of-concept that SCENTinel 1.1, a rapid smell test, can discriminate quantitative and qualitative olfactory disorders, and is the only direct test to rapidly discriminate parosmia.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"48 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9143203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks. 人类嗅觉受体OR5AN1的遗传变异与麝香的感知有关。

IF 2.8 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjac037

Narumi Sato-Akuhara, Casey Trimmer, Andreas Keller, Yoshihito Niimura, Mika Shirasu, Joel D Mainland, Kazushige Touhara

{"title":"Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks.","authors":"Narumi Sato-Akuhara, Casey Trimmer, Andreas Keller, Yoshihito Niimura, Mika Shirasu, Joel D Mainland, Kazushige Touhara","doi":"10.1093/chemse/bjac037","DOIUrl":"10.1093/chemse/bjac037","url":null,"abstract":"Humans have significant individual variations in odor perception, derived from their experience or sometimes from differences in the olfactory receptor (OR) gene repertoire. In several cases, the genetic variation of a single OR affects the perception of its cognate odor ligand. Musks are widely used for fragrance and are known to demonstrate specific anosmia. It, however, remains to be elucidated whether the OR polymorphism contributes to individual variations in musk odor perception. Previous studies reported that responses of the human musk receptor OR5AN1 to a variety of musks in vitro correlated well with perceptual sensitivity to those odors in humans and that the mouse ortholog, Olfr1440 (MOR215-1), plays a critical role in muscone perception. Here, we took advantage of genetic variation in OR5AN1 to examine how changes in receptor sensitivity are associated with human musk perception. We investigated the functional differences between OR5AN1 variants in an in vitro assay and measured both perceived intensity and detection threshold in human subjects with different OR5AN1 genotypes. Human subjects homozygous for the more sensitive L289F allele had a lower detection threshold for muscone and found macrocyclic musks to be more intense than subjects homozygous for the reference allele. These results demonstrate that the genetic variation in OR5AN1 contributes to perceptual differences for some musks. In addition, we found that the more functional variant of OR5A1, a receptor involved in β-ionone perception, is associated with the less functional variant of OR5AN1, suggesting that the perceived intensities of macrocyclic musks and β-ionone are inversely correlated.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"48 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9511019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liking of salt is associated with depression, anxiety, and stress. 喜盐与抑郁、焦虑和压力有关。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad038

Celeste Ferraris, Christopher J Scarlett, Tamara Bucher, Emma L Beckett

{"title":"Liking of salt is associated with depression, anxiety, and stress.","authors":"Celeste Ferraris, Christopher J Scarlett, Tamara Bucher, Emma L Beckett","doi":"10.1093/chemse/bjad038","DOIUrl":"10.1093/chemse/bjad038","url":null,"abstract":"Early research has shown variations in salt taste qualities in depression, anxiety, and stress. These studies evaluated changes to salt taste intensity and liking (pleasantness) of salt solutions but not of salty foods. Therefore, an Australian population survey (n = 424) was conducted where participants rated recalled intensity and liking of salt index foods and completed the Depression, Anxiety, and Stress Scale (DASS-21) to measure these states. Standard least squares regression (post hoc Tukey's HSD) compared means between groups, and nominal logistic regression assessed differences in distributions between categories. Higher salt liking was found in participants with DASS-21 scores indicative of severe depression (68.3 vs. 60.0, P = 0.005) and severe anxiety (68.4 vs. 60.0, P = 0.001) in comparison to those with normal scores, in all models. Higher salt liking was found in participants with DASS-21 scores indicative of moderate stress (67.7 vs. 60.2, P = 0.009) in the unadjusted model only. Higher salt liking was found in females with DASS-21 scores indicative of anxiety and stress, and in males with indicative depression and anxiety. No relationships between salt taste intensity ratings and the mood states were found. Results indicate that liking salty foods is positively correlated with depression, anxiety, and stress scores. Further research on the relationships between salt liking and intake of salt and salty foods, and the biological mechanisms of these mood states are needed to direct the application of findings toward potential new risk assessment measures, dietary interventions, or therapeutics.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of taste sentinels, T1R, T2R, and PLCβ2, on the passageway for olfactory signals in zebrafish. 味觉哨兵T1R、T2R和PLCß2在斑马鱼嗅觉信号通路上的表达。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad040

Günes Birdal, Percival P D'Gama, Nathalie Jurisch-Yaksi, Sigrun I Korsching

引用次数: 0

Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman's gland. 小鼠 AQP5 基因的消减会导致鲍曼腺分泌不足引起嗅觉功能障碍。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad030

Xinnan Zhao, Gang Liu, Xin Yu, Xiaohan Yang, Wenting Gao, Zinan Zhao, Tonghui Ma, Jianmei Ma

{"title":"Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman's gland.","authors":"Xinnan Zhao, Gang Liu, Xin Yu, Xiaohan Yang, Wenting Gao, Zinan Zhao, Tonghui Ma, Jianmei Ma","doi":"10.1093/chemse/bjad030","DOIUrl":"10.1093/chemse/bjad030","url":null,"abstract":"Smell detection depends on nasal airflow, which can make absorption of odors to the olfactory epithelium by diffusion through the mucus layer. The odors then act on the chemo-sensitive epithelium of olfactory sensory neurons (OSNs). Therefore, any pathological changes in the olfactory area, for instance, dry nose caused by Sjögren's Syndrome (SS) may interfere with olfactory function. SS is an autoimmune disease in which aquaporin (AQP) 5 autoantibodies have been detected in the serum. However, the expression of AQP5 in olfactory mucosa and its function in olfaction is still unknown. Based on the study of the expression characteristics of AQP5 protein in the nasal mucosa, the olfaction dysfunction in AQP5 knockout (KO) mice was found by olfactory behavior analysis, which was accompanied by reduced secretion volume of Bowman's gland by using in vitro secretion measure system, and the change of acid mucin in nasal mucus layer was identified. By excluding the possibility that olfactory disturbance was caused by changes in OSNs, the result indicated that AQP5 contributes to olfactory functions by regulating the volume and composition of OE mucus layer, which is the medium for the dissolution of odor molecules. Our results indicate that AQP5 can affect the olfactory functions by regulating the water supply of BGs and the mucus layer upper the OE that can explain the olfactory loss in the patients of SS, and AQP5 KO mice might be used as an ideal model to study the olfactory dysfunction.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mobile APP-based, customizable automated device for self-administered olfactory testing and an implementation of smell identification test. 基于移动 APP 的可定制自动设备，用于自控嗅觉测试和气味识别测试的实施。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad022

Zhihao Lan, Qing X Yang, Zhi-Hong Lyu, Cailing Feng, Liansheng Wang, Baowei Ji, Xuefei Yu, Sherman Xuegang Xin

{"title":"A mobile APP-based, customizable automated device for self-administered olfactory testing and an implementation of smell identification test.","authors":"Zhihao Lan, Qing X Yang, Zhi-Hong Lyu, Cailing Feng, Liansheng Wang, Baowei Ji, Xuefei Yu, Sherman Xuegang Xin","doi":"10.1093/chemse/bjad022","DOIUrl":"10.1093/chemse/bjad022","url":null,"abstract":"Olfactory tests are used for the evaluation of ability to detect and identify common odors in humans psychophysically. Olfactory tests are currently administered by professionals with a set of given odorants. Manual administration of such tests can be labor and cost intensive and data collected as such are confounded with experimental variables, which adds personnel costs and introduces potential errors and data variability. For large-scale and longitudinal studies, manually recorded data must be collected and compiled from multiple sites. It is difficult to standardize the way data are collected and recorded. There is a need for a computerized smell test system for psychophysical and clinical applications. A mobile digital olfactory testing system (DOTS) was developed, consisting of an odor delivery system (DOTS-ODD) and a mobile application program (DOTS-APP) connected wirelessly. The University of Pennsylvania Smell Identification Test was implemented in DOTS and compared to its commercial product on a cohort of 80 normosmic subjects and a clinical cohort of 12 Parkinson's disease patients. A test-retest was conducted on 29 subjects of the normal cohort. The smell identification scores obtained from the DOTS and standard UPSIT commercial test are highly correlated (r = 0.714, P < 0.001), and test-retest reliability coefficient was 0.807 (r = 0.807, P < 0.001). The DOTS is customizable and mobile compatible, which allows for the implementation of standardized olfactory tests and the customization of investigators' experimental paradigms. The DOTS-APP on mobile devices offers capabilities for a broad range of on-site, online, or remote clinical and scientific chemosensory applications.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10055515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Masking effects on iso-valeric acid recognition by sub-threshold odor mixture. 亚阈值混合气味对异戊酸识别的掩蔽效应。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad047

Jianbo Huang, Jiehua Lin, Rachel Yueng, Shuyi Wu, Leto Solla, Terry Acree

{"title":"Masking effects on iso-valeric acid recognition by sub-threshold odor mixture.","authors":"Jianbo Huang, Jiehua Lin, Rachel Yueng, Shuyi Wu, Leto Solla, Terry Acree","doi":"10.1093/chemse/bjad047","DOIUrl":"10.1093/chemse/bjad047","url":null,"abstract":"Masking unpleasant odors with pleasant-smelling odorants has a long history and is utilized in various industries, including perfumery and consumer products. However, the effectiveness of odor masking is idiosyncratic and temporary. In this study, we employed Sniff olfactometry (SO) to investigate the psychophysics of masking using brief 70 ms stimulations with mixtures of the mal-odorant iso-valeric acid (IVA) and different masking agents. IVA is a component of human sweat that can overpower its smell and is often associated with unpleasant descriptors such as \"gym locker,\" \"smelly feet,\" \"dirty clothes,\" and so on. Traditionally, high concentrations of pleasant-smelling odorants are used to mitigate the unpleasantness of IVA in situations involving clothing or environments contaminated with IVA. To examine the masking effects of sub-threshold levels of various masking agents (neohivernal, geraniol, florhydral, decanal, iso-longifolanone, methyl iso-eugenol, and s-limonene) on IVA, we conducted experiments using SO to measure the probability of recognizing IVA after 70 ms stimulations with headspaces containing mixtures of super-threshold concentrations of IVA and sub-threshold concentrations of IVA suppressors. The study involved nine subjects, and on average, a single masking agent was found to decrease IVA recognition probability by 14-72%. Moreover, a sub-threshold odor mixture consisting of 6 masking agents demonstrated a substantial decrease in IVA recognition, with a reduction of 96%.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XLV Annual Meeting of the Association for Chemoreception Sciences Program Chair: Marta Yanina Pepino, PhD Bonita Springs, Florida | April 19–22, 2023 第XLV化学接受科学协会年会项目主席:Marta Yanina Pepino博士，博尼塔斯普林斯，佛罗里达州| 2023年4月19日至22日

4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad029

引用次数: 0

Effects of zinc deficiency on the regeneration of olfactory epithelium in mice. 缺锌对小鼠嗅上皮再生的影响。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad023

Hiroyuki Ikushima, Jun Suzuki, Tomotaka Hemmi, Ryoukichi Ikeda, Yuta Kobayashi, Nobuo Ohta, Yukio Katori

{"title":"Effects of zinc deficiency on the regeneration of olfactory epithelium in mice.","authors":"Hiroyuki Ikushima, Jun Suzuki, Tomotaka Hemmi, Ryoukichi Ikeda, Yuta Kobayashi, Nobuo Ohta, Yukio Katori","doi":"10.1093/chemse/bjad023","DOIUrl":"https://doi.org/10.1093/chemse/bjad023","url":null,"abstract":"The olfactory epithelium can regenerate after damage; however, the regeneration process is affected by various factors, such as viral infections, head trauma, and medications. Zinc is an essential trace element that has important roles in organ development, growth, and maturation. Zinc also helps regulate neurotransmission in the brain; nevertheless, its relationship with olfactory epithelium regeneration remains unclear. Therefore, we used a severe zinc deficiency mouse model to investigate the effects of zinc deficiency on olfactory epithelium regeneration. Male wild-type C57BL/6 mice were divided into zinc-deficient and control diet groups at the age of 4 weeks, and methimazole was administered at the age of 8 weeks to induce severe olfactory epithelium damage. We evaluated the olfactory epithelium before and 7, 14, and 28 days after methimazole administration by histologically analyzing paraffin sections. RNA sequencing was also performed at the age of 8 weeks before methimazole administration to examine changes in gene expression caused by zinc deficiency. In the zinc-deficient group, the regenerated olfactory epithelium thickness was decreased at all time points, and the numbers of Ki-67-positive, GAP43-positive, and olfactory marker protein-positive cells (i.e. proliferating cells, immature olfactory neurons, and mature olfactory neurons, respectively) failed to increase at some time points. Additionally, RNA sequencing revealed several changes in gene expression, such as a decrease in the expression of extracellular matrix-related genes and an increase in that of inflammatory response-related genes, in the zinc-deficient group. Therefore, zinc deficiency delays olfactory epithelium regeneration after damage in mice.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"48 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10140578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umami taste perception and preferences of the domestic cat (Felis catus), an obligate carnivore. 专性食肉动物家猫(Felis catus)的鲜味感知和偏好。

IF 3.5 4区心理学

Chemical Senses Pub Date : 2023-01-01 DOI: 10.1093/chemse/bjad026

Scott J McGrane, Matthew Gibbs, Carlos Hernangomez de Alvaro, Nicola Dunlop, Marcel Winnig, Boris Klebansky, Daniel Waller

{"title":"Umami taste perception and preferences of the domestic cat (Felis catus), an obligate carnivore.","authors":"Scott J McGrane, Matthew Gibbs, Carlos Hernangomez de Alvaro, Nicola Dunlop, Marcel Winnig, Boris Klebansky, Daniel Waller","doi":"10.1093/chemse/bjad026","DOIUrl":"https://doi.org/10.1093/chemse/bjad026","url":null,"abstract":"The domestic cat (Felis catus) is an obligate carnivore, and as such has a meat-based diet. Several studies on the taste perception of cats have been reported, indicating that their sense of taste has evolved based on their carnivorous diet. Here, we propose that umami (mediated by Tas1r1-Tas1r3) is the main appetitive taste modality for the domestic cat by characterizing the umami taste of a range of nucleotides, amino acids, and their mixtures for cats obtained using complementary methods. We show for the first time that cats express Tas1r1 in taste papillae. The cat umami receptor responds to a range of nucleotides as agonists, with the purine nucleotides having the highest activity. Their umami receptor does not respond to any amino acids alone; however, 11 l-amino acids with a range of chemical characteristics act as enhancers in combination with a nucleotide. l-Glutamic acid and l-Aspartic acid are not active as either agonists or enhancers of the cat umami receptor due to changes in key binding residues at positions 170 and 302. Overall, cats have an appetitive behavioral response for nucleotides, l-amino acids, and their mixtures. We postulate that the renowned palatability of tuna for cats may be due, at least in part, to its specific combination of high levels of inosine monophosphate and free l-Histidine that produces a strong synergistic umami taste enhancement. These results demonstrate the critical role that the umami receptor plays in enabling cats to detect key taste compounds present in meat.","PeriodicalId":9771,"journal":{"name":"Chemical Senses","volume":"48 ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0