TAS1R味觉受体与心脏代谢疾病治疗相关的基因表达分析。

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES
Mariah R Stavrou, Sean Souchiart So, Angela M Finch, Sara Ballouz, Nicola J Smith
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引用次数: 0

摘要

甜味受体(STR)是一种G蛋白偶联受体(GPCR),负责介导细胞对甜味刺激的反应。早期证据表明,STR信号系统的元件存在于舌头以外的代谢活跃组织中,在那里它可能充当口外葡萄糖传感器。本研究旨在使用公开的RNA测序库来描述STR在口腔外组织中的表达。对涉及STR结构和功能的所有基因和对照基因的基因表达数据进行了挖掘,包括相关组织中高表达的代谢基因、在代谢中具有生理作用的其他GPCR和效应G蛋白,以及仅在代谢组织外表达的其他GPCr。由于STR在口腔外组织中的生理作用可能与葡萄糖感应有关,因此检测了与葡萄糖感应障碍相关的疾病(如2型糖尿病)中的表达。然后生成聚集共表达网络,以精确确定这些组织中STR基因之间的共表达模式。我们发现STR基因在人类胰腺和脂肪组织中的表达可以忽略不计,而在肠道组织中的低表达。编码STR的基因在这些组织中没有显示出与其他功能基因的显著共表达或连接。此外,STR在小鼠胰腺和脂肪组织中的表达更高,在肠道组织中与人类相当。我们的研究结果表明,STR在小鼠中的表达不能代表人类中的表达,该受体不太可能成为人类心脏代谢疾病的一个有前途的口外靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.

The sweet taste receptor (STR) is a G protein-coupled receptor (GPCR) responsible for mediating cellular responses to sweet stimuli. Early evidence suggests that elements of the STR signaling system are present beyond the tongue in metabolically active tissues, where it may act as an extraoral glucose sensor. This study aimed to delineate expression of the STR in extraoral tissues using publicly available RNA-sequencing repositories. Gene expression data was mined for all genes implicated in the structure and function of the STR, and control genes including highly expressed metabolic genes in relevant tissues, other GPCRs and effector G proteins with physiological roles in metabolism, and other GPCRs with expression exclusively outside the metabolic tissues. Since the physiological role of the STR in extraoral tissues is likely related to glucose sensing, expression was then examined in diseases related to glucose-sensing impairment such as type 2 diabetes. An aggregate co-expression network was then generated to precisely determine co-expression patterns among the STR genes in these tissues. We found that STR gene expression was negligible in human pancreatic and adipose tissues, and low in intestinal tissue. Genes encoding the STR did not show significant co-expression or connectivity with other functional genes in these tissues. In addition, STR expression was higher in mouse pancreatic and adipose tissues, and equivalent to human in intestinal tissue. Our results suggest that STR expression in mice is not representative of expression in humans, and the receptor is unlikely to be a promising extraoral target in human cardiometabolic disease.

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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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