Chemical Physics Impact最新文献

{"title":"Anticancer activity of phytocompounds of black ginger (Kaempferia parviflora Wall. Ex Baker): In silico approach","authors":"Em Canh Pham,&nbsp;Huong Ha Ly Hong","doi":"10.1016/j.chphi.2025.100903","DOIUrl":"10.1016/j.chphi.2025.100903","url":null,"abstract":"<div><h3>Background</h3><div>The main components of black ginger (BG, <em>Kaempferia parviflora</em> Wall. Ex Baker) show diverse biological effects, especially potential anticancer activity. Furthermore, <em>in silico</em> computational approaches offer a powerful strategy for discovering novel therapeutic candidates from medicinal plants, providing an innovative solution to address the increasing global burden of cancer.</div></div><div><h3>Methods</h3><div>Tentative identification of phytocompounds of BG extracts was performed using the LC-MS method. Thirty-five phytocompounds of BG were screened using molecular docking with AutoDock Vina software against eleven anticancer targets.</div></div><div><h3>Results</h3><div>Five BG phytocompounds KP1, KP2, Viscumneoside VI, and 5-Hydroxy-7-methoxyflavone (5H7M) showed the strongest interactions with multiple anticancer targets compared to the reference drugs. KP1 showed good binding affinity (BA) against five targets (HDAC6 (−8.6 Kcal/mol), EGFR (−9.5 Kcal/mol), mTOR (−9.7 Kcal/mol), PI3K (−10.3 Kcal/mol), and PD1 (−7.9 Kcal/mol)). Meanwhile, Viscumneoside VI exhibited good BA against five targets (HDAC6, CDK2, EGFR, PI3K, and PD1 (−7.9 to −9.4 Kcal/mol)), and 5H7M showed good binding affinity against four targets (DHFR, PI3K, KDR, and PDL1 (−9.5 to 10.0 Kcal/mol)). In particular, KP2 showed good binding affinity and hydrogen bond (HB) formation against six targets, including KDR (−9.8 Kcal/mol) and five targets similar to KP1 (−8.3 to −9.9 Kcal/mol). Phytocompounds KP1, KP2, Viscumneoside VI, and 5H7M exhibited some interactions (HB, electrostatic, and hydrophobic) with amino acid residues of DHFR, HDAC6, CDK2, EGFR, PI3K, ALK, and KDR similar to the reference drugs. Furthermore, these phytocompounds showed good <em>in silico</em> ADMET profiles compared to anticancer drugs.</div></div><div><h3>Conclusion</h3><div>These potential phytocompounds need to be isolated, synthesized and researched more in-depth for the development of new cancer drugs, especially KP1 and KP2.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100903"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of pheophytin in power generation of photosynthetic fuel cells","authors":"Hitoki Semizo,&nbsp;Ichiro Horii,&nbsp;Reoto Ueda,&nbsp;Yusuke Takahashi,&nbsp;Yasumitsu Matsuo,&nbsp;Hinako Kawakami","doi":"10.1016/j.chphi.2025.100948","DOIUrl":"10.1016/j.chphi.2025.100948","url":null,"abstract":"<div><div>Photosynthetic fuel cells, which yield hydrogen energy from photosynthesis, are attracting attention as a next-generation clean energy source. However, the relationship between the power density of photosynthetic fuel cells and the wavelength of incident light has not been made clear despite being an important factor concerning light absorption. In this study, we have measured the dependence of the power generation in photosynthetic fuel cells for the wavelength of incident light and investigated the key molecules that lead to the power generation. It was found that the power density peaks around the wavelength of the light absorption of chlorophyll. These results indicate that the electron generated by the light absorption in chlorophyll <em>b</em>ecomes the trigger of power generation, the same as the electrons created by the light absorption of chlorophyll <em>b</em>ecome the trigger of the photosynthetic reaction. In addition, we observed the power density enhancement around the light’s wavelength of 520 nm. Considering that the absorption of chlorophyll cannot be observed at around 520 nm, this result indicates that in the power generation of photosynthetic fuel cells, another molecule besides chlorophyll also leads to power generation. Furthermore, we found that Photosynthetic fuel cells using the pheophytin degraded by the desorption of the Mg ion from chlorophyll can also generate power density by light irradiation. From the fact that pheophytin exhibits light absorption at 520 nm, where power density becomes enhanced, the power generation of photosynthetic fuel cells is caused by not only the light absorption of chlorophyll <em>b</em>ut also the light absorption of pheophytin is also important for the power generation.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100948"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of surface wettability on thermal conductance of Cu-water interface: A molecular dynamics study","authors":"Yanfeng Li ,&nbsp;Ming Ma ,&nbsp;Xiaohui Zhang ,&nbsp;Luyang Chen ,&nbsp;Hua Wang ,&nbsp;Rong Chen","doi":"10.1016/j.chphi.2025.100951","DOIUrl":"10.1016/j.chphi.2025.100951","url":null,"abstract":"<div><div>As micro and nano-scale devices move toward higher integration and miniaturization, efficient thermal management has become increasingly vital. Among the key factors influencing heat dissipation at the nano-scale is the regulation of solid-liquid interfaces. However, the mechanism by which surface wettability alters the interfacial water structure—and consequently affects interfacial thermal transport—remains insufficiently understood. To address this gap, molecular dynamics (MD) simulations were employed to investigate interfacial thermal transport behaviors in Cu-water nanochannels, with a specific focus on the role of wettability in modulating the dynamic characteristics of interfacial water molecules. The results demonstrate that increased wettability significantly enhances thermal boundary conductance (TBC), primarily by promoting the formation of denser and more stable H-bond networks at the interface. This study highlights the critical role of interfacial H-bonding in regulating thermal transport and provides valuable insights for optimizing thermal efficiency in nanofluidic and nanoelectronic systems.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100951"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DFT study of interaction of acetylene and C70 fullerene molecules","authors":"Oksana S. Kremen ,&nbsp;Igor B. Bychko ,&nbsp;Victor V. Lobanov ,&nbsp;Peter E. Strizhak","doi":"10.1016/j.chphi.2025.100961","DOIUrl":"10.1016/j.chphi.2025.100961","url":null,"abstract":"<div><div>The interaction between the C₇₀ fullerene and acetylene was investigated using DFT calculations (DFT/B3LYP/6–31G (d, p)). It is shown that the C₇₂H₂ formation proceeds through sequential [2 + 1], [2 + 2], and [3 + 2] cycloaddition reactions. The [2 + 1] and [2 + 2] pathways lead to the formation of various isomers with closed- and open-cages due to the cleavage of the C–C bond in C₇₀. Geometrical parameters, charge distribution, and formation energies of the fullerene-acetylene reactive complexes and the C₇₂H₂ molecules were determined for eight different types of bonds in C₇₀. Transition-state structures were also characterized. Cycloadduct formation via acetylene activation by C₇₀ requires high activation energies, ranging from 205.67 to 218.02 kJ/mol. In contrast, the [2 + 1] and [3 + 2] cycloadducts can transform to [2 + 2] cycloadduct with activation energies ranging from 4.55 to 37.59 kJ/mol, and high exothermic effect ranges from −217.11 to −302.75 kJ/mol. The [2 + 2] cycloadduct can transform to C₇₂H₂ with an attached hydrogen atom and a –С<img>СН fragment, which requires activation energies of 378.35 kJ/mol. The results elucidate the multi-step reaction mechanisms and energy profiles underlying acetylene addition to C₇₀, providing theoretical insight into the reactivity and stability of fullerene derivatives and guidance for understanding fullerene-based chemical processes in catalysis, particularly in conversions of hydrocarbons, and in the design of novel carbon nanostructures.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100961"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A greenery rodlike ZnO and Fe-doped ZnO photocatalysts for efficient dye removal from wastewater","authors":"S. Renuka ,&nbsp;K. Dhanaraj ,&nbsp;G. Suresh ,&nbsp;E. Thenpandiyan ,&nbsp;S․ Rubesh Ashok Kumar ,&nbsp;K. Ramachandran","doi":"10.1016/j.chphi.2025.100979","DOIUrl":"10.1016/j.chphi.2025.100979","url":null,"abstract":"<div><div>An eco-friendly and affordable green synthetic approach was employed to synthesize</div><div>ZnO-A and Fe-doped ZnO-A (Fe/ZnO-A) nanoparticles (NPs) using the leaf extract of <em>Aerva lanata</em> to assess their photocatalytic degradation against the major organic dyes Congo Red (CR) and Orange G (OG) under sunlight. FTIR, XRD, UV–Vis, Photoluminescence, SEM, and TEM were used to characterise the products. The results of the above characterisation techniques FTIR, XRD, UV–Vis, and TEM-indicate the formation of ZnO-A and the incorporation of iron ions into the ZnO-A lattice. The strong absorption at 301 nm in the UV region is due to surface plasmon resonance (SPR). The estimated band gap energies of ZnO-A and Fe/ZnO-A are 5.14 and 4.90 eV, respectively. The crystallite sizes of ZnO-A and Fe/ZnO-A nanoparticles were estimated to be 32 and 38 nm, respectively. The nano-hexagonal phase with a wurtzite structure was observed. Morphological analysis confirmed the formation of well-defined rodlike structures, providing a high surface area for catalytic interactions. The reaction kinetics, rate constant calculation, and UV–Vis full-spectrum analysis were analysed for Fe/ZnO-A against the CR dye. The photocatalytic activity results indicate that higher degradation efficiency was observed with Fe/ZnO-A nanoparticles, achieving 99.6 % for CR dyes compared to undoped ZnO-A nanoparticles. These findings highlight the potential of Fe-doped ZnO nanostructures as an eco-friendly, cost-effective material for wastewater treatment.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100979"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly BaO-enriched zinc-calcium-erbium-borate glasses as dual radiation barriers for small modular reactors","authors":"Manjunatha ,&nbsp;M.M. Hosamani ,&nbsp;A.S. Bennal ,&nbsp;M.I. Sayyed","doi":"10.1016/j.chphi.2025.100981","DOIUrl":"10.1016/j.chphi.2025.100981","url":null,"abstract":"<div><div>This study reports the eco-friendly BaO-enriched zinc-calcium-erbium-borate glasses with the nominal composition xBaO-(79-x)B₂O₃–13ZnO-7CaO-1Er₂O₃ (<em>x</em> = 23, 27, 31 and 35 mol% and labelled as BaE1, BaE2, BaE3, and BaE4) developed via the conventional melt-quenching method. The amorphous nature of the glasses was confirmed by X-ray diffraction (XRD) analysis. The doping of BaO composition on density, radiation attenuation and neutron moderation properties was thoroughly examined to explore its potential as a dual nuclear radiation barrier for small modular reactors (SMRs). Experimental gamma ray shielding properties were assessed in narrow beam geometry using gamma sources (¹³³Ba, ²²Na, ⁶⁰Co and ¹³⁷Cs) and a NaI(Tl) detector. The linear attenuation coefficients were experimentally determined and validated with Phy-X/PSD data, showing good agreement with a relative difference of less than 8 %. The prepared glasses demonstrate superior lower HVL and MFP values at 662 keV compared to other glasses. Neutron moderation parameters, such as logarithmic energy decrement (ξ), required number of collisions (η), relative thermal lethargy (Z_th), energy transfer per collision (<span><math><msub><mi>E</mi><mrow><mi>s</mi><mi>h</mi><mi>a</mi><mi>r</mi><mi>e</mi></mrow></msub></math></span>) and macroscopic removal cross-sections<span><math><mrow><mspace></mspace><mo>(</mo><msub><mi>∑</mi><mi>R</mi></msub><mo>)</mo></mrow></math></span> at neutron energies of 4 MeV and 25.4 meV were also investigated. This study’s findings reveal that increasing BaO composition improves the nuclear radiation shielding capabilities. Lower BaO content glasses (BaE1 and BaE2) show better neutron moderation, while higher BaO glasses (BaE3 and BaE4) give superior gamma attenuation. The optimised composition exhibited dual radiation shielding efficiency, promoting it as a potential material for nuclear reactor systems</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100981"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large π-π interconnected guanidine based high-energy compounds and their trigger bonds","authors":"Luehao Shen ,&nbsp;Zhipeng Li ,&nbsp;Xiao Li ,&nbsp;Xinping Long ,&nbsp;Bisheng Tan","doi":"10.1016/j.chphi.2025.100918","DOIUrl":"10.1016/j.chphi.2025.100918","url":null,"abstract":"<div><div>TNB, triazole, tetrazole, furoxan, guanidine, etc. are the basic building blocks for building high-energy compounds. Compounds with different structures and properties can be obtained by combining them in different ways (through atomic or group bridging, spiking, fusing, etc.). How to measure the effectiveness of their connection is what we must consider when designing high-energy compounds. Guanidine is Y-aromatic, and it is connected with other single or several aromatic rings to form large π-π interconnected compounds. The large π-π separation energy can measure the additional stabilization energy of large π-π interconnected structures due to electron delocalization, which is a new index of aromatic extension or aromaticity of compounds. It is also a major index of molecular deformability of high-energy compounds proposed by us (such as resonance energy, strain energy, large π-π separation energy, molecular polarizability, etc.), how these molecular deformability indicators affect the energy and stability of explosive molecules is a question that needs to be answered. In this paper, the large π-π separation energies of large π-π interconnected guanidine derivatives are calculated by the density functional method and the design of isodesmic reactions. The influence of molecular deformability on trigger bonds is revealed, and the understanding of the nature of trigger bonds is improved.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100918"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CdTe-MSA quantum dots prepared by a green hydrothermal route as highly selective ‘turn-off’ fluorescent nanosensors for Lead(II) detection in environmental water monitoring","authors":"Faiza I.A. Abdella ,&nbsp;Mohamed Ajroud ,&nbsp;Tahani D. Alanezi ,&nbsp;Dalal Alardan ,&nbsp;Mohamed Bouzidi ,&nbsp;Sarra Boudriga","doi":"10.1016/j.chphi.2025.100952","DOIUrl":"10.1016/j.chphi.2025.100952","url":null,"abstract":"<div><div>In this study, water-dispersible CdTe quantum dots (QDs) capped with mercaptosuccinic acid (MSA) were synthesized via a green one-pot hydrothermal route and explored as efficient fluorescent probes for Pb²⁺ detection in aqueous media. The obtained QDs, with an average diameter of 3.4 nm, exhibited high colloidal stability, strong fluorescence, and a narrow emission profile. Remarkably, a selective fluorescence \"turn-off\" response was observed exclusively in the presence of Pb²⁺ ions, with no significant interference from other tested metal cations. Quantitative analysis using the Stern–Volmer model revealed a linear detection range of 0.2–4 µM (R² = 0.9948) and a low detection limit of 72 nM. Taken with the Benesi–Hildebrand analysis, results confirmed a static quenching mechanism arising from strong Pb²⁺-carboxylate binding, followed by electron transfer and formation of a non-emissive ground-state complex. Adsorption experiments demonstrated that Pb²⁺ uptake follows pseudo-first-order kinetics and fits the Langmuir isotherm model, indicating monolayer adsorption on homogeneous active sites. Recovery tests in spiked real tap water samples achieved 95–109 % recoveries with RSD &lt; 5 %, underscoring the probe's reliability under realistic conditions. These results highlight CdTe-MSA QDs as cost-effective, selective, and sensitive chemosensors with strong potential for environmental monitoring of lead contamination.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100952"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of eco-friendly fluorescent carbon dots from Polyalthia longifolia leaves for enhanced photoactivated antimicrobial activity and biocompatibility","authors":"Anisha Kaur Johl Pritam Singh ,&nbsp;Mohd Adnan ,&nbsp;Mitesh Patel ,&nbsp;Sreenivasan Sasidharan","doi":"10.1016/j.chphi.2025.100955","DOIUrl":"10.1016/j.chphi.2025.100955","url":null,"abstract":"<div><div>The threat of antibiotic-resistant pathogens has created an urgent demand for novel, and sustainable antimicrobial agents. Carbon dots (C-Dots), due to their unique physicochemical properties and ease of surface functionalization, have emerged as promising candidates in nanomedicine. This study focuses on the green synthesis of C-Dots using <em>Polyalthia longifolia</em> leaves, a medicinal plant known for its therapeutic properties, through a simple and cost-effective pyrolysis method. The synthesized C-Dots exhibited strong blue-green fluorescence under UV light, high water dispersibility, and a quantum yield of 8.88%. Physicochemical characterization using spectroscopic and microscopic techniques revealed that the C-Dots exhibited a predominantly spherical morphology, were nanoscale in size, negatively charged, and rich in functional groups such as hydroxyl (–OH), carboxyl (–CO), sulfonate (–SO), amine (–NH), and methyl (–CH), all of which contribute to their stability and bioactivity. The antimicrobial potential of the C-Dots was assessed against common bacterial and fungal pathogens using the Kirby-Bauer disk diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill assays. Results indicated that the C-Dots possessed significant antibacterial activity, particularly against <em>Staphylococcus aureus</em>, with enhanced effects observed under photoactivation. Scanning electron microscopy (SEM) analysis confirmed the morphological damage to bacterial cells, supporting the observed antimicrobial effects. Additionally, the cytotoxicity of the C-Dots was evaluated using the MTT assay on HeLa cells, yielding an IC₅₀ value of 8.23 mg/mL, indicating good biocompatibility. Overall, this research demonstrates that green-synthesized C-Dots from <em>P. longifolia</em> leaves hold substantial promise as multifunctional nanomaterials for antimicrobial applications and potentially broader biomedical use, aligning with sustainable and eco-friendly approaches in nanotechnology.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100955"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blockage of action potential-like spiking in D2O-suspended proteinoid microspheres","authors":"Panagiotis Mougkogiannis,&nbsp;Andrew Adamatzky","doi":"10.1016/j.chphi.2025.100922","DOIUrl":"10.1016/j.chphi.2025.100922","url":null,"abstract":"<div><div>This study investigates the effects of heavy water (D<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O) on action potential-like electrical activity in proteinoid microspheres. We demonstrate that D<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O completely suppresses spontaneous electrical spiking, contrasting with the robust spiking patterns observed in deionized water (mean amplitude 5.39–9.81 mV, period 2489–2826 s). Electrochemical impedance spectroscopy shows that charge transport differs between the two environments: deionized water has charge transfer behavior (<span><math><mrow><msubsup><mrow><mi>Z</mi></mrow><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow><mrow><mo>′</mo></mrow></msubsup><mo>≈</mo><mn>8</mn></mrow></math></span> k<span><math><mi>Ω</mi></math></span>), while D₂O exhibits diffusion-dominated responses (<span><math><mrow><msubsup><mrow><mi>Z</mi></mrow><mrow><mi>m</mi><mi>a</mi><mi>x</mi></mrow><mrow><mo>′</mo></mrow></msubsup><mo>≈</mo><mn>120</mn></mrow></math></span> k<span><math><mi>Ω</mi></math></span>). Cyclic voltammetry measurements show different behaviors for D₂O and H₂O. D₂O has stable current responses up to 900 mV/s. Then, at 1000 mV/s, there is a sharp rise (I_a = <span><math><mrow><mn>22</mn><mo>.</mo><mn>71</mn><mspace></mspace><mi>μ</mi><mi>A</mi></mrow></math></span>, I_c = <span><math><mrow><mo>−</mo><mn>22</mn><mo>.</mo><mn>19</mn><mspace></mspace><mi>μ</mi><mi>A</mi></mrow></math></span>). H₂O, on the other hand, shows gradual current increases as the scan rate rises. Statistical analysis shows significant differences (<span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0</mn><mo>.</mo><mn>0001</mn></mrow></math></span>) in membrane potential dynamics between the two conditions, with D<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O showing reduced variability (<span><math><mrow><msub><mrow><mi>σ</mi></mrow><mrow><msub><mrow><mi>D</mi></mrow><mrow><mn>2</mn></mrow></msub><mi>O</mi></mrow></msub><mo>=</mo><mn>1</mn><mo>.</mo><mn>70</mn><mo>−</mo><mn>15</mn><mo>.</mo><mn>08</mn></mrow></math></span> mV vs <span><math><mrow><msub><mrow><mi>σ</mi></mrow><mrow><mi>D</mi><mi>I</mi></mrow></msub><mo>=</mo><mn>12</mn><mo>.</mo><mn>01</mn><mo>−</mo><mn>22</mn><mo>.</mo><mn>40</mn></mrow></math></span> mV). Using an R(CW)RO topology for equivalent circuit modeling shows enhanced diffusion limits in D<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O. This suggests changes in charge transport mechanisms. The model has a <span><math><msup><mrow><mi>χ</mi></mrow><mrow><mn>2</mn></mrow></msup></math></span> of 0.0736. These findings show how cellular bioelectricity works. They highlight the important role of proton dynamics in creating the basic membrane potential.</div></div>","PeriodicalId":9758,"journal":{"name":"Chemical Physics Impact","volume":"11 ","pages":"Article 100922"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}